Agilent InfinityLab LC Series

SELECTION GUIDE

AGILENT INFINITYLAB LC SERIES

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The Agilent InfinityLab LC Series offers you an unmatched choice of instrumentation for liquid chromatography. Use this product selection guide to identify which configuration fits best to your laboratory’s requirements.

EFFICIENT LC SOLUTIONS – FOR ANY APPLICATION AND BUDGET

Analytical LC Systems

From routine analysis to cutting-edge research, the Agilent InfinityLab LC Series offers the broadest portfolio of liquid chromatography solutions, helping you to achieve highest operational efficiency while keeping within your budget.

Agilent 1290 Infinity II LC –

The benchmark in efficiency

The 1290 Infinity II LC embodies the next generation of liquid

chromatography instrumentation, setting the benchmark in ultrahigh

performance to deliver the maximum in efficiency.

Agilent 1260 Infinity II LC –

Everyday efficiency

The 1260 Infinity II LC is the trusted platform with the broadest choice of instrumentation, giving

you the best operational efficiency to take you to the next level of confidence – every day in every way.

Agilent 1220 Infinity II LC –

Affordable efficiency

The 1220 Infinity II LC is an affordable, high-quality,

integrated system that puts you on the fast track to highest efficiency – for

maximum return on investment.

Agilent 1260 Infinity II Prime LC – Everyday efficiency

with more convenience

The Agilent 1260 Infinity II Prime LC is the most convenient LC within the 1260 Infinity II LC portfolio. It offers the highest ease-of-use and functionality

for everyday analysis.

NEW

For details of Agilent InfinityLab LC Purification Solutions, see our Selection Guide, publication number 5991-8010EN. 3

InfinityLab GPC/SEC SolutionsCharacterize polymers and biomolecules to give accurate molecular weights, distributions, and structural detail regarding particle shape and size in solution.

InfinityLab Online SPE SolutionsEnrich analytes, remove matrix components or lower detection limits with tailored solutions to match virtually any analytical LC challenge.

InfinityLab SFC SolutionsAchieve superior resolution of stereoisomers through supercritical fluid chromatography with standard- grade CO2. Lower solvent waste and cut purchase and disposal costs.

InfinityLab 2D-LC SolutionsSwitch easily between one-dimensional ultrahigh-performance LC and the ultimate chromatographic power of heart-cutting, multiple heart-cutting and comprehensive 2D-LC.

InfinityLab LC Method Transfer SolutionsExecute any conventional LC or latest UHPLC method while achieving the same chromatographic results. Transfer methods seamlessly between Agilent and other LC systems with Intelligent System Emulation Technology (ISET).

InfinityLab Bio-Inert LC SolutionsCorrosion-resistant and biologically-inert flow path protects your biomolecules and your instruments – for bio-analysis, biopurification, and nonbiological applications requiring an inert flow path.

InfinityLab LC Method Development SolutionsAccelerate your method development with dedicated hardware and software. Utilize up to 26 solvents and 32 columns to create more than 1000 different sets of LC conditions.

InfinityLab Impurity Analysis SolutionsDetect and quantify all components in your sample – in a single run – using the high-dynamic range feature that delivers a 30x wider range, and 30x higher sensitivity.

InfinityLab LC Workflow Solutions

The flexibility of the InfinityLab LC Series allows Agilent to offer the broadest portfolio of liquid chromatography solutions. From LC method development to GPC/SEC and SFC, and from online SPE to 2D-LC, the InfinityLab LC Series gives you infinite possibilities to solve your separation challenges.

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CONFIGURE YOUR LC SYSTEM

AGILENT INFINITYLAB LC SERIES

Instrument Control

InfinityLab LC Companion Handheld instrument controller for 1260 and 1290 Infinity II LCs G7108AA

Solvent Preparation

1260 Infinity II Degasser 4 channels; up to 10 mL/min flow; 12 mL internal volume per channel G7122A

Solvent Delivery

1290 Infinity II High Speed Pump 1300 bar up to 2 mL/min, ramping down to 800 bar at 5 mL/min; binary solvent mixing; integrated degassing unit

G7120A

1290 Infinity II Flexible Pump 1300 bar up to 2 mL/min, ramping down to 800 bar at 5 mL/min; quaternary solvent mixing; integrated degassing unit

G7104A

1260 Infinity II Flexible Pump 800 bar up to 5 mL/min; quaternary solvent mixing; integrated degassing unit G7104C

1260 Infinity II Binary Pump 600 bar up to 5 mL/min; integrated degassing unit; optional SSV G7112B

1260 Infinity II Quaternary Pump 600 bar up to 5 mL/min; 200 bar up to 10 mL/min; integrated degassing unit G7111B

1260 Infinity II Bio-Inert Pump 600 bar up to 5 mL/min; 200 bar up to 10 mL/min; integrated degassing unit; quaternary mixing; all materials in flow path inert

G5654A

1260 Infinity II Isocratic Pump 600 bar up to 5 mL/min; 200 bar up to 10 mL/min; optional integrated degassing unit and SSV G7110B

1260 Infinity II SFC Binary Pump Delivers supercritical CO2 and modifiers at up to 600 bar and 5 mL/min; binary solvent mixing; integrated degassing unit and two-solvent selection valve for channel B

G4782A

1260 Infinity Capillary Pump1 Up to 20 μL/min; up to 100 µL/min with extended flow range kit; 400 bar; 0.18 to 1.0 mm column id G1376A

1260 Infinity Nanoflow Pump1 Up to 4 μL/min; 400 bar; 0.075 to 0.1 mm column id G2226A

LC Support Modules

1260 Infinity II SFC Control Module Compresses CO2 and houses backpressure regulator; uses liquefied (analytical grade) or gaseous CO2 (beverage grade); low dispersion nozzle for full flow transfer to MS or ELSD

G4301A

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Valve Solutions1290 Infinity Flexible Cube For enhanced injection modes and advanced valve-switching applications such as online SPE G4227A

1290 Infinity Valve Drive Drive unit for any InfinityLab Quick Change valve head G1170A

InfinityLab Quick Change Valves Available in stainless-steel for high-pressure and ultrahigh-pressure applications up to 1300 bar as well as with bio-inert materials in flow paths for bio-chromatographic applications

Get product numbers2

Sample Injection

1290 Infinity II Multisampler 0 to 20 μL or 0 to 100 μL single-stroke injection at 1300 bar; up to 1500 μL with optional kits; sample capacity up to 432 vials and up to 16 microtiter plates; multiwash option for less than 9 ppm carryover; optional sample cooling (Option 100) or thermostatting (Option 101) available; dual-needle option for highest throughput and flexibility

G7167B

1290 Infinity II Vialsampler 0.1 to 20 μL (40 optionally); up to 120 µL with multi-draw mode at 1300 bar; sample capacity up to 132 x 2 mL vials; optional integrated column compartment for column heating up to 80 °C; optional sample cooling (Option 100) or thermostatting (Option 101) available

G7129B

1260 Infinity II Multisampler 0 to 100 μL single-stroke injection at 800 bar; up to 1800 μL with optional kits; sample capacity up to 432 vials and up to 16 microtiter plates; multi-wash option for less than 9 ppm carryover; optional sample cooling (Option 100) or thermostatting (Option 101) available; dual-needle option for highest throughput and flexibility

G7167A

1260 Infinity II Vialsampler 0.1 to 100 μL injection from vials at up to 800 bar; up to 1500 µL with optional kits; optional integrated column compartment for column heating up to 80 °C; optional sample cooling (Option 100) or thermostatting (Option 101) available

G7129C

1260 Infinity II Vialsampler 0.1 to 100 μL injection from vials at up to 600 bar; up to 1800 µL with optional kits; optional integrated column compartment for column heating up to 80 °C; optional sample cooling (Option 100) or thermostatting (Option 101) available

G7129A

1260 Infinity II Bio-Inert Multisampler 0 to 100 μL single-stroke injection at 600 bar; up to 1000 µL with optional kits; sample capacity up to 432 vials and up to 16 plates; multi-wash option for less than 9 ppm carryover; optional sample cooling (Option 100) or thermostatting (Option 101) available; all materials in flow path inert

G5668A

1260 Infinity II SFC Multisampler Operates in SFC or LC mode; in SFC mode, injection is done through Feed Injection principle that enables highly reproducible injection with injection volumes from 0.1 to 90 μL at up to 600 bar; in LC mode, injection is done through classic flow-through principle; sample capacity up to 432 vials and up to 16 microtiter plates; optional sample cooling (Option 100) or thermostatting (Option 101) available

G4767A

1260 Infinity High-Performance Micro Autosampler1

0.01 to 8 μL injection from vials and microtiter plates G1377A

1260 Infinity II Manual Injector 5 μL to 20 mL injection loops G1328C

1260 Infinity II Bio-Inert Manual Injector 5 μL to 20 mL injection loops G5628A

1 Check with Agilent for availability in your country. 2 Visit www.agilent.com/chem/lc-valve-solutions for product numbers.

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Column Compartments

1290 Infinity II Multicolumn Thermostat 20 degrees below ambient to 110 °C; up to four 30 cm columns and up to eight 10 cm columns; up to eight individual InfinityLab Quick Connect heat exchangers for standard-flow, high-flow and ultralow dispersion; optional valve drive for InfinityLab Quick Change valve heads

G7116B

1260 Infinity II Multicolumn Thermostat 10 degrees below ambient to 85 °C; up to four 30 cm columns; up to four individual InfinityLab Quick Connect heat exchangers; optional valve drive for InfinityLab Quick Change valve heads (up to 800 bar and up to 4-column selection without replumbing)

G7116A

UV Detection

1290 Infinity II Diode Array Detector ± 0.6 μAU/cm noise (60 mm Max-Light cartridge cell) or ± 3 μAU/cm noise (10 mm Max-Light cell); 240 Hz; spectra; 8 signals; 1 to 8 nm slit; 190 to 640 nm

G7117B

1290 Infinity II Diode Array Detector FS ± 0.6 μAU/cm noise (60 mm Max-Light cartridge cell) or ± 3 μAU/cm noise (10 mm Max-Light cell); 120 Hz; spectra; 8 signals; fixed slit; 190 to 640 nm

G7117A

1290 Infinity II Variable Wavelength Detector ± 1.5 μAU noise; time-programmable, 240 Hz (single wavelength detection); 2.5 Hz (dual wavelength detection); 190 to 600 nm

G7114B

1260 Infinity II Diode Array Detector HS ± 0.6 μAU/cm noise (60 mm Max-Light cell) or ± 3 μAU/cm noise (10 mm Max-Light cell); 120 Hz; spectra; 8 signals; fixed slit; 190 to 640 nm

G7117C

1260 Infinity II Diode Array Detector WR ± 7 μAU/cm noise; 120 Hz; spectra; 8 signals; 190 to 950 nm G7115A

1260 Infinity II Multiple Wavelength Detector ± 7 μAU/cm noise; 120 Hz; 8 signals; 190 to 950 nm G7165A

1260 Infinity II Variable Wavelength Detector ± 2.5 μAU/cm noise; 120 Hz (single wavelength detection); 2.5 Hz (dual wavelength detection); 190 to 600 nm

G7114A

Special Detection

1290 Infinity II Evaporative Light Scattering Detector

For subambient operation; flow range 0.2 to 5 mL/min; evaporator temperature 10 to 80 °C; nebulizer temperature 25 to 90 °C

G7102A

1260 Infinity II Evaporative Light Scattering Detector

For subambient operation; flow range 0.2 to 5 mL/min; evaporator temperature 25 to 120 °C; nebulizer temperature 25 to 90 °C

G4260B

1260 Infinity II Fluorescence Detector Spectra

Multisignal fluorescence detector; online spectra; 4 signals; 148 Hz; 4000 h lamp; Raman (H2O) > 500 (noise reference measured at signal); Raman (H2O) > 3000 (noise reference measured at dark value)

G7121B

1260 Infinity II Fluorescence Detector One signal wavelength, 74 Hz; 4000 h lamp; Raman (H2O) > 500 (noise reference measured at signal); Raman (H2O) > 3000 (noise reference measured at dark value)

G7121A

1290 Infinity II Refractive Index Detector 148 Hz; 1.00 to 1.75 RI range; ±600 x10-6 RIU measurement range; Noise < ±2.5 x10-9 RIU; < 1 h warm-up; 5 degrees above ambient up to 55 °C

G7162B

1260 Infinity II Refractive Index Detector 74 Hz; 1.00 to 1.75 RI range; ±600 x10-6 RIU measurement range; Noise < ±2.5 x10-9 RIU; < 1 h warm-up; 5 degrees above ambient up to 55 °C

G7162A

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Fraction Collection

1290 Infinity Thermostat 4 to 40 °C (for all fraction collectors) G1330B

1260 Infinity II Analytical-Scale Fraction Collector Up to 10 mL/min flow G1364F

1260 Infinity II Bio-Inert Analytical-Scale Fraction Collector

Up to 10 mL/min flow; all materials in flow path inert G5664B

GPC/SEC Systems

1260 Infinity II GPC Multi-Detector System Single or dual-enclosure system; accommodates any combination of refractive index detector, viscometer, and light scattering detector

G7800A

1260 Infinity II GPC/SEC MDS Refractive Index Detector

660 nm light source; 6 μL cell volume; linearity 250 μRIU; short-term noise < 20 nRIU (< 80 μV); pressure rating 350 kPa (50 psi); temperature range 30 to 60 °C; temperature stability ± 0.2 °C; sensitivity 4 mV/μRIU

G7801A

1260 Infinity II GPC/SEC MDS Viscometer Linearity 0.5 % FS; shear rate (typical) 3000 s-1; sensitivity ηsp 1 x 10-5 Pa.s; temperature range 30 to 60 °C, temperature stability ± 0.2 °C

G7802A

1260 Infinity II GPC/SEC MDS Dual-Angle Light Scattering Detector

Sample cell volume 10 μL; light scattering volume 0.01 μL; laser wavelength/ power 660 nm/50 mW; Rayleigh scattering angles 15° and 90°; temperature range 30 to 60 °C; temperature stability ± 0.2 °C

G7803A

1260 Infinity II High-Temperature GPC System Pump flow range 0.1 to 10.0 mL/min; reproducibility ≤ 0.07 %; oven capacity up to six 6 x 300 mm GPC columns; temperature range ambient to 220 °C; temperature stability < 0.05 °C/h; RID flow cell volume 8 µL; sensitivity 2.5 x 10-7 RIU/mV; noise ≤ 80 µV; wavelength 890 nm; drift ≤ 10 mV/h; autosampler capacity 40 x 2 mL vials; integrated 6-port/2-position valve; flushed fixed loop 5 to 500 μL

G7820B

1260 Infinity II High-Temperature Viscometer Linearity 0.5 % FS; shear rate (typical) 3000 s-1; sensitivity ηsp 1 x 10-5 Pa.s G7821B

1260 Infinity II High-Temperature Light Scattering Detector

Sample cell volume 10 μL; light scattering volume 0.01 μL; laser wavelength/power 680 nm/30 mW; Rayleigh scattering angles 15° and 90°

G7822B

1260 Infinity II High-Temperature Evaporative Light Scattering Detector

Evaporator temperature range 25 to 120 °C; nebulizer and transfer line 25 to 160 °C; short-term noise < 0.2 mV; drift < 1 mV/h; LED light source (480 nm); PMT detection with digital signal processing; flow rate range 0.5 to 5.0 mL/min; gas flow 0.2 to 0.5 SLM

G7826A

SP260VS Sample Preparation System Temperature range ambient to 260 °C; temperature accuracy ± 2 °C; sample capacity 20, minimum 2 mL, maximum 20 mL; filtration 0.5 or 2 µm frit; agitation by horizontal motion with variable speed control

G7823A

Integrated LC Systems

1220 Infinity II Gradient LC Binary gradient solvent pump, autosampler, column oven and diode array detector G4294B

1220 Infinity II Gradient LC Binary gradient solvent pump, autosampler, column oven and variable wavelength detector

G4290B

1220 Infinity II Gradient LC Binary gradient solvent pump, manual injector and variable wavelength detector G4288B

1220 Infinity II Isocratic LC Single solvent pump, manual injector and variable wavelength detector G4286B

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This information is subject to change without notice.

© Agilent Technologies, Inc. 2017Published in the USA, September 1, 20175991-8252EN