Agenda : Certification Platform: Training - I round Beta testers proposals
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Transcript of Agenda : Certification Platform: Training - I round Beta testers proposals
Agenda:
- Certification Platform: Training - I round
- Beta testers proposals
- Congress presentations
- Paper “check for axes”
XIII PMT meeting – October 24, 2012
Platform: Training Phase
2 Images (Scheltens=0,3)
Feedback
6 Images (Scheltens=0,1,2,3,4,4) Feedback +-
Certification set
10 Images (2 x Scheltens=0,1,2,3,4) Feedback +-
Certification set
Platform: Training round I
https://sodium.crulrg.ulaval.ca/hippocampus/
10 naives created account
9 naives completed training round 1
5 tracers are planned to complete segmentations by early November
3 tracers are “uncertain”
3 tracers are lacking
Platform: Training round I
Platform: Training round I
Platform: User Account
Platform: Administrator Visibility
Platform: Uploads UCF
Platform: Uploads UCF
Platform: MultiTracer Version
Platform: Parameters
Platform: Discrepancies in segmentation
Platform: Discrepancies in segmentation
Platform: Statistics - Users
Platform: Statistics - Segmentations
Platform: Statistics - Segmentations
Platform: Statistics - Segmentations
Platform: Statistics - Segmentations
Platform: Statistics - Segmentations
Platform: Statistics - Segmentations
Platform
Expansion SOPs
Sent to 5 possibly interested companies
Proposal by Adam Schwarts
Bioclinica also interested to fund cooperatively
Will promote to next PPSB meeting (next week)
Discussed with Maria Carrillo, she said that the AA may offer a neutral forum through which this could be funded/contracted.
- CTAD (October, 29-31 2012)Definition of the Harmonized Protocol for Hippocampal Segmentation
- DGPPN Symposium 2012 Berlin (Andreas Fellgiebel, Stefan Teipel)Segmentation of the hippocampus: Towards a joint EADC-ADNI harmonized protocol
- AAN (March 16-23, 2013) EADC-ADNI Benchmark Images of Harmonized Hippocampal Segmentation
- AD/PD (March 6-10, 2013)Definition of Harmonized Protocol for Hippocampal Segmentation
Congress Presentations
Papers describing the project
Survey of protocols (preliminary phase; published, JAD 2011)Operationalization (preliminary phase; I revision, Alzheimer’s & Dementia, MS n. ADJ-D-12-00094)
Axes check short report (Brescia Team, in progress)
Delphi consensus (Brescia Team, in progress)Master tracers’ practice and reliability (Brescia Team, in progr)
Development of certification platform (Duchesne and coll)Validation data (Brescia Team – companion paper 1)Protocol definition (Brescia Team – companion paper 2)Validation vs pathology (TBD)
DO
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VALIDATION VS CURRENT PROTOCOLSASSESSMENT OF SOURCES OF
VARIANCE TRAINING SET DEVELOPMENT
VALIDATION VS PATHOLOGY
GOLD STANDARD
Harmonized ProtocolADNI scans: 2 x 5 Scheltens’s
atrophy score x 2 sides x 2 magnet strengths (1.5-3T)
Total per rater: 40 hippos
Harmonized ProtocolADNI scans: 2 sides x 5 Scheltens’s atrophy scores
x 3 time points (bl-1y-2y) x 3 scanners (+ retracing @ bl)
x 2 magnet strengths (1.5-3T)Total per rater: 240 hippos
Assessment of variance due to rater and center
Local ProtocolADNI scans: 2 x 5 Scheltens’s atrophy scores
x 2 sides x 2 magnet strengths (1.5-3T)
Harmonized ProtocolADNI scans: 2 x 5 Scheltens’s atrophy score x
2 sides x 2 magnet strength (1.5-3T)Total per rater: 40 hippos Harmonized Protocol:
Pathological datasets: Mayo Clinic and NYU
Total: about 40 hippos
TrainingADNI scans: 10 at 1.5T x 2 sides x 7
SUs x 2 tracing roundsTotal per rater: 40 hippos
20 naïve tracers 5 master tracers 1 tracer
REFERENCE PROBABILISTIC MASKS
with 95% C.I.
QUALIFICATION QUALIFICATION
Best 5 naïve tracers
Assessment of variance due to side, trace-retrace, atrophy, time, scanner, rater
TRAINING SET
Assessment of agreement with volume on pathology or ex vivo
MRI and correlation with neuronal density
GANTT
Publication Policy
STEERING COMMITTEE (SC)
This is made of: (i) the Principal Investigator (P.I.; G.B. Frisoni) (ii) the co-Principal Investigator (co-P.I.; C.R. Jack); (iii) the leader of the Statistical Working Group (S. Duchesne).The SC is chaired by the P.I. and deliberates by majority.
STANDARD FORM for submission:
TITLE of PROPOSAL:PI / CENTRE:AIM of the PROJECT:METHODS of the PROJECT:WHAT IS ASKED to the SC of the HARMONIZED HIPPOCAMPAL PROTOCOL WHAT IS OFFERED to the HARMONIZED HIPPOCAMPAL PROTOCOL PROJECT/COMMUNITY:
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