Nov – Dec 2019ReseaRch Bulletin

HSDM PreSiDential ScHolarSadvancing Research, teaching, and Oral healthEight HSDM advanced graduate education students have been awarded Harvard Presidential Scholarships for the 2019-20 academic year. The full-tuition scholarship is awarded to DMSc students who have committed themselves to careers in public service or academia. This year’s accomplished recipients’ academic interests range from pursuing clinical and basic science research, to teaching and mentoring students, to furthering oral health policy and information systems. They “pay back” the scholarship by working in public service or academia full-time for as many years as they received the scholarship.

Dr. chiho ahn, a DMSc candidate in the Periodontology program, is working in the Baron/Gori Lab investigating the role of Sfrp4, a Wnt signaling inhibitor in bone repair and regeneration.

Dr. Yu-chun lin, a DMSc candidate in the Prosthodontics program, is working in the Bidlack-Pugach Lab at the Forsyth Institute investigating enamel development at different stages in developing mice ameloblast.

Dr. Wonwoo Jang, a DMSc candidate in the Periodontics program, is working in the Nagai Lab investigating the establishment of biomimetic soft tissue integration to zirconium surface coated with platelet-activating peptide.

Dr. Jevae l. nelson, a DMSc candidate in the Dental Public Health program, is focused on using national data to deepen her understanding of fluoride and its impact on population health.

Dr. Bunmi tokede, a DMSc candidate in the Orthodontics program, is conducting a clinical trial on the first fully-customized and 3D-printed orthodontic bracket system.

Dr. Diana Wang, a DMSc candidate in the Oral and Maxillofacial Pathology program, is working in the Murphy/Lian Lab at BWH exploring early re-epithelialization and TET-mediated 5-hydroxymethylcytosine epigenetic regulation in oral mucosal wound healing.

Dr. Frances Yang, a candidate in the Periodontology program, is focused on synthesizing biodegradable nanoparticles for drug delivery to treat bacterial infections.

Dr. anna Yi, a DMSc candidate in the Prosthodontics program, is working in MIT’s Han Lab and with Drs. Sang Lee and Jennifer Gibbs to investigate novel technologies and products involving electrokinetic flow and bone cement.

celebrating Dean Donoff, a dedicated advocate for scientific research

Photos by steve Gilbert

2 Research Bulletin • November – December 2019 • Harvard School of Dental Medicine

PuBlicationSDeveloPMental BiologY

Beygelman Y, Khosravi R, Masoud M, Turpin D, Bollen A. The influence of labiolingual and mesiodistal anterior tooth dimensions on interarch relationships: A modified anterior Bolton analysis. American Journal of Orthodontics and Dentofacial Orthopedics 2019;156(6):727-734.

Castillo, J, Azer D, Manosudprasit A, Bansal N, Hagh A, Allareddy, V, Masoud, M. The relationship between 3d dentofacial photogrammetry measurements and traditional cephalometrics measurements on a group of orthodontic patients. Angle Orthodontics 2019;89(2):275-83.

Clara J, Monge C, Yang Y, Takebe N. Targeting signalling pathways and the immune microenvironment of cancer stem cells - A clinical update. Nature Reviews Clinical Oncology 2019; Dec 2.

O’Keefe R, Tuan R, Lane N, Barry F, Bunnell B, Colnot C, Drake M, Drissi H, Fortier L, Guldberg R, Little D, Marshall M, Mao J, Nakamura N, Robey P, Rosen V, Rowe D, Schwarz E. American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies. Journal of Bone and Mineral Research 2019; Sep 23.

Rits S, Olsen BR, Volloch V. Protein-encoding RNA to RNA information transfer in mammalian cells: RNA-dependent mRNA amplification. Identification of chimeric RNA intermediates and putative RNA end products. Annals of Integrated Molecular Medicine 2019;1(1):23-47.

Volloch V, Rits S, Olsen BR. RNA-dependent amplification of mammalian mRNA encoding extracellullar matrix proteins: Identification of chimeric RNA intermediates for α1, β1, and γ1 chains of laminin. Annals of Integrated Molecular Medicine 2019;1(1):48-60.

Wickström S, Yang Y. Editorial overview: Cell differentiation and development - Wiring principles of transcriptional states, signaling networks and cell fate trajectories. Current Opinions in Cell Biology 2019; Nov 14.

oral MeDicine, inFection anD iMMunitY

Acharya A, Chen T, Chan Y, Watt R, Jin L, Mattheos N. Species-level salivary microbial indicators of well-resolved periodontitis: A preliminary investigation. Frontiers in Cellular and Infection Microbiology 2019;9:347.

Alqaderi H, Goodson J, Agaku I. Association between sleep and severe periodontitis in a nationally representative adult U.S. population. Journal of Periodontology 2019; Nov 21.

Collins A, Murugkar P, Dewhirst F. Complete genome sequence of strain AC001, a novel cultured member of the human oral microbiome from the candidate phylum Saccharibacteria (TM7). Microbiology Resource Announcements 2019;17;8(42).

Demmer R, Trinh P, Rosenbaum M, Li G, LeDuc C, Leibel R, González A, Knight R, Paster B, Colombo P, Desvarieux M, Papapanou P, Jacobs D. Subgingival microbiota and longitudinal glucose change: The oral infections, glucose intolerance and insulin resistance study (ORIGINS). Journal of Dental Research 2019; Oct 17.

Fiorellini J, Luan K, Chang Y, Kim D, Sarmiento H. Peri-implant mucosal tissues and inflammation: Clinical implications. International Journal of Oral and Maxillofacial Implants 2019;34:s25-s33.

Freilich J, Kuten-Shorrer M, Treister N, Woo SB, Villa A. Burning mouth syndrome: a diagnostic challenge. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2019; Oct 12.

Goh C, Trinh P, Colombo P, Genkinger J, Mathema B, Uhlemann A, LeDuc C, Leibel R, Rosenbaum M, Paster B, Desvarieux M, Papapanou P, Jacobs D, Demmer R. Association between nitrate-reducing oral bacteria and cardiometabolic outcomes. Journal of the American Heart Association 2019;8(23):e013324.

Helmi M, AlOsaimy S, Goodson J, Hasturk H, Natto Z. Annual alveolar bone loss in older adults taking oral bisphosphonate: A retrospective cohort study. BMC Oral Health 2019; Nov 27;19(1):260.

Kim D, Bassir S, Nguyen T. Effect of gingival phenotype on the maintenance of periodontal health: An American Academy of Periodontology best evidence review. Journal of Periodontology 2019; Nov 6.

Jennifer Gibbs, PhD, DDS, assistant professor of Restorative Dentistry and Biomaterials Sciences and director of the Division of Endodontics at HSDM, was honored with an Eleanor and Miles Shore Fellowship. More specifically, Gibbs received the HSDM Fellowship in honor of Aina M. Auskaps, DMD. Dr. Gibbs is being recognized for

a project titled, “Risk Factors for Severe or Prolonged Pain After Dental Surgery.” The Shore Fellowship offers junior faculty at HSDM and HMS financial support during a critical time in their academic careers. Congratulations to Jennifer Gibbs on this outstanding accomplishment.

aida Shadrav, DMD candidate class of 2021, was selected to present her research at the Hinman Research Symposium this past November. She presented her project, “7/12 Patient Touch Point Strategy: A Novel Method to Increase Patient

Attendance and Recommendation.” This work was recently published in BDJ Open journal under the mentorship of Dr. Elsbeth Kalendarian, professor at UCSF School of Dentistry.

Xiaohui Wang, PhD, a postdoctoral fellow in the Department of Developmental Biology and member of the Yang Lab, has been selected by the American Association for the Study of Liver Diseases (AASLD) Foundation as an Early Career Investigator Award recipient in basic science for his project, “Mst1 Critically Mediates the Effects

of Alcohol-Caused End Organ Damage.” He received this award at the AASLD annual meeting in Boston this past November.

reSearcH aWarDS

Research Bulletin • November – December 2019 • Harvard School of Dental Medicine 3

Khavanin N, Jazayeri H, Xu T, Pedreira R, Lopez J, Reddy S, Shamliyan T, Peacock Z, Dorafshar A. Management of teeth in the line of mandibular angle fractures treated with open reduction and internal fixation: A systematic review and meta-analysis. Plastic and Reconstructive Surgery 2019;144(6):1393-1402.

Langeveld M, Bruun R, Koudstaal M, Padwa B. Etiology of cleft lip lower lip deformity: Use of an objective analysis to measure severity.Cleft Palate Craniofacial Journal 2019; 56(10):1333-1339.

Lee K, Wu B, Park E, Chuang S, Koch A. What is the health care burden of treating pediatric dental infections on an inpatient basis? Journal of Oral and Maxillofacial Surgery 2019; Sep 25.

Li J, Gao Y, Yu T, Lange JK, LeBoff M, Gorska A, Luu S, Zhou S, Glowacki J. Obesity and leptin influence vitamin D metabolism and action in human marrow stromal cells. The Journal of Steroid Biochemistry and Molecular Biology 2019;105564.

Nguyen J, Calabrese C, Heaphy K, Koudstaal M, Estroff J, Resnick C. Can Robin Sequence be predicted from prenatal ultrasonography? Journal of Oral and Maxillofacial Surgery 2019; Oct 30.

Resnick C, Middleton J, Calabrese C, Ganjawalla K, Padwa B. Retropalatal cross-sectional area is predictive of obstructive sleep apnea in patients with syndromic craniosynostosis. Cleft Palate Craniofacial Journal 2019; Oct 24.

Stoustrup P, Pedersen T, Nørholt S, Resnick C, Abramowicz S. Interdisciplinary management of dentofacial deformity in juvenile idiopathic arthritis. Oral Maxillofacial Surgery Clinics of North America 2019; Nov 4.

oral HealtH PolicY anD ePiDeMiologY

Natto Z. Dental students’ knowledge and attitudes about electronic cigarettes: A cross-sectional study at one Saudi university. Journal of Dental Research 2019; Oct 14.

Simon L, Beckmann D, Reidy P, Cohen M, Tobey M. Evaluation of an interprofessional student-faculty collaborative clinic in a jail. Journal of Correctional Health Care 2019; Nov 4.

Stojanov I, Schaefer I, Menon R, Wasman J, Gokozan H, Garcia E, Baur D, Woo SB, Sholl L. Biallelic PTCH1 inactivation is a dominant genomic change in sporadic keratocystic odontogenic tumors. American Journal of Surgical Pathology 2019; Nov 12.

Walji M, Yansane A, Hebballi N, Ibarra-Noriega A, Kookal K, Tungare S, Kent K, McPharlin R, Delattre V, Obadan-Udoh E, Tokede O, White J, Kalenderian E. Finding dental harm to patients through electronic health record-based triggers. Journal of Dental Research 2019; Dec 10.

Yu A, Lambert R, Alvarado J, Faerron Guzman C, Seymour B. Integrating competency-based didactic and experiential global health learning for dental students: The Global Health Learning Helix Model. Journal of Dental Education 2019; Dec 9.

Multi-DePartMental

Attaia D, Ting S, Johnson B, Masoud M, Abu El Sadat S, Abu El Fotouh M, Friedland B. Dose reduction in head and neck organs through shielding and application of different scanning parameters in CBCT: An effective dose study using an adult male anthropomorphic phantom. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2019; Nov 28.

Dung T, Ngoc V, Hiep N, Khoi T, Xiem V, Chu-Dinh T, Cieslar-Pobuda A, Stoufi E, Show P, Tao Y, Bac N, Ba N, Le Q, Pham V, Chu D. Author Correction: Evaluation of dental arch dimensions in 12 year-old Vietnamese children - A cross-sectional study of 4565 subjects. Science Reports 2019;9(1):16405.

Klein K, Kaban L, Masoud M. Orthognathic surgery and orthodontics: Inadequate planning leading to complications or unfavorable results. Oral Maxillofacial Surgery Clinics of North America 2020;32(1):71-82.

Lin L, Chang E, He K, Huang M, Richards J. Addressing the Chinese food stereotype in health care. Clinical Teaching 2019 Dec 9.

Mayama H, Kuwajima Y, Da Silva J, Khorashadi S, Lambert R, Ishida Y, Ishikawa-Nagai S, Miura H, Satoh K. Cephalometric measurements of non-syndromic oligodontia in early dental age in a Japanese population. Clinical, Cosmetic and Investigational Dentistry 2019;11:357-365.

Kuten-Shorrer M, Menon R, Lerman M. Mucocutaneous diseases. Dental Clinics of North America 2020;64(1):139-162.

Kuwajima Y, Ishida Y, Lee C, Mayama H, Satoh K, Ishikawa-Nagai S. 3D digital analysis of magnetic force-driven orthodontic tooth movement. Heliyon 2019; 5(11): e02861.

Liang S, Wang Z, Zhang Z, Chen K, Lv Z, Wang Y, Cheng P, Sun K, Yang Q, Chen A. Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop. Aging 2019; Oct 11;11.

Li C, Shen Z, Bavarian R, Yang F, Bhattacharya A. Oral cancer: Genetics and the role of precision medicine. Surgery Oncology Clinics of North America 2020; 29(1):127-144.

Murugkar P, Collins A, Dewhirst F. Complete genome sequence of strain PM004, a novel cultured member of the human oral microbiome from the candidate phylum Saccharibacteria (TM7). Microbiology Resource Announcements 2019;8(42).

Sani E, Lara R, Aldawood Z, Bassir S, Nguyen D, Kantarci A, Intini G, Annabi N. An antimicrobial dental light curable bioadhesive hydrogel for treatment of peri-implant diseases. Matter 2019;1(4):926-944.

Shazib M, Woo SB, Sroussi H, Carvo I, Treister N, Farag A, Schoenfeld J, Haddad R, LeBoeuf N, Villa A. Oral immune-related adverse events associated with PD-1 inhibitor therapy. Oral Diseases 2019; Oct 23.

Stojanov I, Schaefer I, Menon R, Wasman J, Gokozan H, Garcia E, Baur D, Woo SB, Sholl L. Biallelic PTCH1 inactivation is a dominant genomic change in sporadic keratocystic odontogenic tumors. American Journal of Surgical Pathology 2019; Nov 12.

Zhou Y, Lu H, Deng L, Lin C, Pennington Klein K, Wu M. HMGB2 is associated with pressure loading in chondrocytes of temporomandibular joint. Cytokine 2019; Oct 16.

Zhou J, You B, Yu Q. Agonist-induced 4-1BB activation prevents the development of Sjogren’s syndrome-like sialadenitis in non-obese diabetic mice. Biochimica et Biophysica Acta - Molecular Basis of Disease 2019; Nov 15;165605.

reStorative DentiStrY anD BioMaterialS ScienceS

Alnasser M, Finkelman M, Papathanasiou A, Suzuki M, Ghaffari R, Ali A. Effect of acidic pH on surface roughness of esthetic dental materials. Journal of Prosthetic Dentistry 2019; Nov 4.

Bowley J, Lai W. Rotational restoration resistance and future possibilities for digital impression technology: Literature review and survey data. Compendium of Continuing Education in Dentistry 2019;40(10):e1-e6.

Holliday A, Gheihman G, Cooper C, Sullivan A, Ohyama H, Leaf D, Leaf R. High prevalence of imposterism among female Harvard medical and dental students. Journal of General Internal Medicine 2019; Oct 25.

Yu A, Pagni S, Park S, Karimbux N. Early clinical exposure in U.S. dental schools and correlation with earlier competencies evaluation. Journal of Dental Education 2019; Oct 28.

oral anD MaXilloFacial SurgerY

Chen Y, Zhang J, Rao N, Han Y, Ferraro N, August M. Do patients with different mandibular plane angles have different time to relapse after bilateral sagittal osteotomy with mandibular advancement? Journal of Oral and Maxillofacial Surgery 2019; Sep 21.

Chen Y, Zhang J, Rao N, Han Y, Ferraro N, August M. Independent risk factors for long-term skeletal relapse after mandibular advancement with bilateral sagittal split osteotomy. International Journal of Oral and Maxillofacial Surgery 2019; Oct 7.

Citron I, Lee C, Calabrese C, Padwa B. Schneiderian membrane thickness is increased in patients with cleft lip and palate. Cleft Palate Craniofacial Journal 2019; Oct 24.

El Ghoul K, Calabrese C, Koudstaal M, Resnick C. A comparison of airway interventions and gastrostomy tube placement in infants with Robin sequence. International Journal of Oral and Maxillofacial Surgery 2019; Nov 6.

Jazayeri H, Khavanin N, Yu J, Lopez J, Ganjawalla K, Shamliyan T, Tannyhill R, Dorafshar A. Does early repair of orbital fractures result in superior patient outcomes? A systematic review and meta-analysis. Journal of Oral and Maxillofacial Surgery 2019; Oct 10.

4 Research Bulletin • November – December 2019 • Harvard School of Dental Medicine

Save tHe DateS For tHe HSDM Science SPeaKer SerieS11:00 a.m. – 12:00 p.m. HSDM reB auditorium

• January 16, 2020 Dr. eileen Shore (Penn)

• February 13, 2020 Dr. Henry Kronenberg (harvard)

• March 12, 2020 Dr. Matthew Greenblatt (cornell)

• april 16, 2020 Dr. tamara alliston (ucsF)

• May 14, 2020 Dr. catherine Mccusker (uMass)

a PuBlication oF tHe oFFice oF reSearcH Malcolm Whitman, PhD Associate Dean for Basic Science

Yingzi Yang, PhD Associate Dean for Translational Research

Dawn M. Decosta Editor and Layout

heather M. Denny Editing

lia sgourakes Editing

ashley simmonsEditing

countWaY liaiSonMichelle Bass, PhD, is the newly-appointed liaison for HSDM at the Francis A. Countway Library of Medicine. She is the first point of contact for questions regarding instruction, research, and resources.

The Research and Instruction team is using a liaison model

to guide work with the three professional schools on the Longwood campus. Team liaisons work in collaboration with departments and offices. For example, Michelle recently worked with the Office of Research and the Office of Dental Education to craft a HSDM Library course within Canvas for more seamless access between student learning and library resources. This winter, Michelle will be working on updating the Library’s dental medicine research guide highlighting recently acquired additions to the Library’s oral health collection. The best way to get in contact with Michelle is to use the Ask Countway form, or email her directly.

Michelle B. Bass, PhD, Msi, ahiPManager of Research & instruction

countway library of Medicine, Office 245michelle_bass@hms.harvard.edu

617-432-9183

neW reSearcHerS Jiaming Zhang, MD, PhD Jiaming Zhang joined the Baron-Gori Laboratory for two years as a visiting research fellow in the Department of Oral Medicine, Infection and Immunity. Zhang is an orthopedic surgeon with MD, PhD degrees from Tongji Medical College, Huazhong University of Science and Technology, China. Before coming to HSDM, he was a visiting scholar at the

Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill. In the Baron-Gori Lab, Zhang will be working on the role of matrix degradation in osteocytic osteolysis and its influence on osteocyte regulation of skeletal homeostasis.

Han Xu, PhDHan Xu joined the Naveh Laboratory as a research fellow in the Department of Oral Medicine, Infection and Immunity. Originally from Nanjing, China, Xu moved to United States in 2010 to attend Case Western Reserve University, where she received her bachelor’s degree in biomedical engineering with a minor in polymer science and engineering. Xu attended Boston

University and earned her PhD degree in biomedical engineering on tensional homeostasis of vascular cells. In the Naveh Lab, Xu will be working on extracellular matrix cross linking in the periodontal ligament.

hsDM OFFice OF ReseaRch188 longwood avenue, ReB 404Boston, Massachusetts 021156 1 7 - 4 3 2 - 1 1 2 1dawn_decosta@hsdm.harvard.edu