ADRENAL CORTEX CUSHING, CONN AND ADDISON DISEASE Snjeana VukeliMentor: A. mega Horvat

Adrenal cortex

Hormones secreted by cortex CORTICOSTEROIDSGlucocorticoids Mineralocorticoids CORTISOLALDOSTERON

immune system glucose stress

blood pressure water and salt balance

Cushing's syndrome

Cushing's syndrome Pituitary adenomas Ectopic ACTH sy Adrenal tumors Familial Cushings Drug related

24-hour urinary free cortisol levelCushings disease

Cushing's syndromeTREATMENT SURGERY

RADIATION

CHEMOTHERAPY

CORTISOL-INHIBITING DRUGS

Conn's syndrome HYPERTENSION

TIREDNESS MUSCLE WEAKNESS POLYURIA BLOOD POTASSIUMADRENAL ADENOMA

Conn's syndromeTREATMENT SURGICAL REMOVAL (UNILATERAL ADRENALECTOMY)

SPIRINOLACTONE

Addisons disease WEIGHT LOSS MUSCLE WEAKNESS FATIGUE LOW BLOOD PRESSURE DARKENING OF SKIN

Addisons diseasePRIMARYdestruction of adrenal cortex - autoimmune disorders - tuberculosis - chronic infection

SECONDARYLack of ACTH - drugs - tumors and infections of pituitary gland

CORTISOLALDOSTERONECORTISOL

Addisons diseaseDIAGNOSISACTH STIMULATION TESTTREATMENTREPLACEMENT THERAPYCORTISOLHYDROCORTISONEALDOSTERONEFLUDROCORTISONE

Addisons diseaseADDISONIAN CRISISACUTE ADRENAL INSUFFICIENCY- SUDDEN PENETRATING PAIN IN LOWER BACK, ABDOMEN OR LEGS

- SEVERE VOMITING AND DIARRHEA, FOLLOWED BY DEHYDRATION

- LOW BLOOD PRESSURE

- LOSS OF CONSCIOUSNESS- HYDROCORTISONE i.v.- 0,9 % NaCl i.v.- DEXTROSE

Literaturehttp://en.wikipedia.org/wiki/Adrenal_gland#Adrenal_cortexhttp://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Adrenals.htmlhttp://www.endocrineweb.com/adrenal.html

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