Adams ch10 lecture
Transcript of Adams ch10 lecture
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PHARMACOLOGY FOR NURSESPHARMACOLOGY FOR NURSESA Pathophysiological ApproachA Pathophysiological Approach
FOURTH EDITIONFOURTH EDITION
Copyright © 2014, © 2011, © 2008 by Pearson Education, Inc.All Rights Reserved
CHAPTER
Herbal and Alternative Therapies
10
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Complementary and Alternative Complementary and Alternative Medicine (CAM)Medicine (CAM)
• Considered outside mainstream health care
• Very diverse set of therapies and healing systems
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Major Characteristics of CAMMajor Characteristics of CAM
• Treat each person as individual• Consider health care of whole person• Emphasize integration of mind and
body• Promote disease prevention, self-care,
self-healing• Recognize role of spirituality
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
ResearchResearch
• Rigorous research lacking, though underway for many therapies
• Seeks effectiveness or lack of effectiveness
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Nurses and CAMNurses and CAM
• Have long known of healing benefits• Can reduce reliance on some
medications, which reduces adverse effects
• Can bring greater compliance• Advantages and limitations should be
presented to patients.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
CAM Healing MethodsCAM Healing Methods
• Ingested therapies– Herbal therapies, nutritional
supplements, special diets
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
CAM Healing MethodsCAM Healing Methods
• Alternate health care systems– Naturotherapy, homeopathy,
chiropractic– Native American medicine (sweat
lodges, medicine wheels)– Chinese traditional medicine
(acupuncture, Chinese herbals)
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
CAM Healing MethodsCAM Healing Methods
• Manual healing– Massage, pressure-point therapies,
hand-medicated biofield therapies• Mind-body interventions
– Yoga, meditation, hypnotherapy – Guided imagery, biofeedback– Movement-oriented therapies (music
and dance)
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
CAM Healing MethodsCAM Healing Methods
• Spiritual– Shamans, faith, prayer
• Other therapies• Bioelectromagnetics, detoxifying
therapies• Animal-assisted therapy
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.1 Complementary and Alternative Therapies
continued on next slide
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.1 (continued) Complementary and Alternative Therapies
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
HerbsHerbs
• Technically a botanical without any woody tissue such as stems or bark
• Meaning has changed to refer to any plant product with some useful application either as a food enhancer or a medicine.
• Documented use for thousands of years
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.2 Top-Selling Herbal Supplements
continued on next slide
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.2 (continued) Top-Selling Herbal Supplements
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Dietary and Herbal SupplementsDietary and Herbal Supplements
• Use waned with rise of pharmacology.• Marketing, increased awareness, and
availability brought resurgence in 1970s.
• Majority of adult Americans take or have taken botanicals on a regular basis.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Aging PopulationAging Population
• Pain• Arthritis• Hormone-replacement therapy• Prostate difficulty
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
High Cost of Prescription High Cost of Prescription MedicationsMedications
• Leads patients to seek CAM therapies
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Examples of Herbal Examples of Herbal SupplementsSupplements
• Garlic• Soy• St. John's wort• Cranberry • Ginseng• Bilberry
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Active Ingredient(s) in HerbsActive Ingredient(s) in Herbs
• Usually found only in specific part of the plant
• May have multiple active ingredients, unlike most modern drugs
• Potency can depend on where herb was grown or how it was grown or harvested.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Active Chemicals in HerbsActive Chemicals in Herbs
• Work synergistically• May not have same activity if isolated
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Herbal FormulationsHerbal Formulations
• Two basic formulations: solid and liquid
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Solid Formulations of HerbsSolid Formulations of Herbs
• Pills • Tablets• Capsules• Salves • Ointments
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Liquid Formulations of HerbsLiquid Formulations of Herbs
• Tea • Infusion• Decoction• Tincture• Extract
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Figure 10.2 Three different ginkgo formulations: tablets, tea bags, and liquid extract
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.4 Diseases for Which Medical Consensus Exists That Herbal Therapies May Be Useful
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Dietary Supplement Health and Dietary Supplement Health and Education Act of 1994 (DSHEA)Education Act of 1994 (DSHEA)• Regulatory act for dietary supplements• Less rigid than the Food, Drug, and
Cosmetic Act (FDA)• Dietary supplements are exempted
from FDA standards.• Gives FDA power to remove products
considered harmful.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Food, Drug, and Cosmetic Act Food, Drug, and Cosmetic Act Definition of Dietary SupplementsDefinition of Dietary Supplements• Products intended to enhance or
supplement the diet:– Botanicals– Vitamins– Minerals– Metabolites
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
DSHEA WeaknessesDSHEA Weaknesses
• Not necessary to demonstrate effectiveness prior to marketing
• Manufacturer not required to prove efficacy or safety
• Labels not monitored for accuracy in product amounts or claims of benefits of product
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Figure 10.3a Labeling of black cohosh: front label with general health claim
continued on next slide
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Figure 10.3b Labeling of black cohosh: back label with more health claims and FDA disclaimer
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Dietary Supplement and Nonprescription Dietary Supplement and Nonprescription Drug Consumer Protection Act (2007)Drug Consumer Protection Act (2007)
• Companies must– Include contact information on product
labels for reporting adverse events– Notify the FDA of any serious adverse
event reports within 15 days of receiving such reports
– Keep extensive records on reports
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Further FDA RulesFurther FDA Rules
• Manufacturers of dietary supplements required to evaluate the identity, purity, potency, and composition of their products and report on label
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
““NaturalNatural”” Does Not Always Does Not Always Mean SaferMean Safer
• Some active chemicals are the same as in prescription and OTC medications.
• Patient substituting alternative therapy for established medical treatment may prolong condition.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Nurse ResponsibilityNurse Responsibility
• Watch for herbal products with ingredients that interact with prescription drugs
• Ask questions and obtain medical histories
• Pregnant/lactating women need approval from health care provider.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Allergic ReactionsAllergic Reactions
• Natural products may contain several chemicals or ingredients.
• Safer to begin with smaller doses
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Seek Latest Medical Information Seek Latest Medical Information on CAM on CAM
• Keep current with updated information
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Educate PatientsEducate Patients
• Strengths and weaknesses of CAM• Encourage patients to seek information
from reputable sources• Pregnant/lactating women should never
take supplements without approval from health care provider.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Avoid False Hope of CureAvoid False Hope of Cure
• Ensure patients' understanding of uses and limitations of CAM
• Encourage skepticism of claims on manufacturer labels
• Never condemn a patient's desire to use alternative therapies
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Patient Health HistoryPatient Health History
• Aids in avoiding adverse reactions• Aids in identifying drug interactions
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Common Drug–Herb InteractionsCommon Drug–Herb Interactions
• Obtain patient's health history to prevent drug–herb interactions
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.5 Documented Herb–Drug Interactions
continued on next slide
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.5 (continued) Documented Herb–Drug Interactions
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Echinacea Traits (partial) Echinacea Traits (partial)
• Interacts with amiodarone and anabolic steroids
• Results in possible increased hepatotoxicity
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Interactions with Feverfew, Interactions with Feverfew, Ginger, and Ginkgo (partial)Ginger, and Ginkgo (partial)
• Aspirin• Heparin• NSAIDs• Warfarin• Results in possible increased bleeding
potential
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Interactions with Garlic and Interactions with Garlic and Ginseng (partial) Ginseng (partial)
• Insulin• Oral hypoglycemic agents• Results in increased hypoglycemic
effects
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Interaction with Ginkgo (partial) Interaction with Ginkgo (partial)
• Anticonvulsants—decreased effectiveness
• Tricyclic antidepressants—decreased seizure threshold
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Interactions with CNS Depressants Interactions with CNS Depressants
• St. John's wort• Ginseng• Valerian• Results in increased sedative effect
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Specialty SupplementsSpecialty Supplements
• Nonherbal dietary products are used to enhance a wide variety of body functions.
• Occur naturally in the body• Excessive amounts may have harmful
effects.• Example—chondroitin and glucosamine• Link with benefits is unclear.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.6 Selected Specialty Supplements
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Standardizing Herbal Products Standardizing Herbal Products
• Attempts have been made to standardize measurement of active ingredient, but with no comprehensive success yet.
• Uses marker substance such as percent flavones in ginkgo
• Until science is better, it is best to conceptualize the active ingredient of an herb as being the entire herb itself.
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Table 10.3 Standardization of Selected Herb Extracts
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Figure 10.1a Two ginkgo biloba labels: note the lack of standardization in 60 mg of extract, 24% ginkgo flavone glycosides and 6% terpenes
continued on next slide
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Pharmacology for Nursing: A Pathophysiology Approach, Fourth EditionMichael Patrick Adams | Leland N. Holland | Carol Urban
Figure 10.1b Two ginkgo biloba labels: note the lack of standardization in 50:1 ginkgo leaf extract, 24% ginkgo flavone glycosides