Acta Medica Okayama - CORE · Haiyun Sheng, Motoi Aoe, Hiroyoshi Doihara, Akio Andou, and Nobuyoshi...
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Acta Medica Okayama Volume 54, Issue 3 2000 Article 4 J UNE 2000 Prognostic value of vascular endothelial growth factor expression in primary lung carcinoma. Haiyun Sheng * Motoi Aoe † Hiroyoshi Doihara ‡ Akio Andou ** Nobuyoshi Shimizu †† * Okayama University, † Okayama University, ‡ Okayama University, ** Okayama University, †† Okayama University, Copyright c 1999 OKAYAMA UNIVERSITY MEDICAL SCHOOL. All rights reserved.
Transcript of Acta Medica Okayama - CORE · Haiyun Sheng, Motoi Aoe, Hiroyoshi Doihara, Akio Andou, and Nobuyoshi...
Acta Medica OkayamaVolume 54, Issue 3 2000 Article 4
JUNE 2000
Prognostic value of vascular endothelialgrowth factor expression in primary lung
carcinoma.
Haiyun Sheng∗ Motoi Aoe† Hiroyoshi Doihara‡
Akio Andou∗∗ Nobuyoshi Shimizu††
∗Okayama University,†Okayama University,‡Okayama University,∗∗Okayama University,††Okayama University,
Copyright c©1999 OKAYAMA UNIVERSITY MEDICAL SCHOOL. All rights reserved.
Prognostic value of vascular endothelialgrowth factor expression in primary lung
carcinoma.∗
Haiyun Sheng, Motoi Aoe, Hiroyoshi Doihara, Akio Andou, and NobuyoshiShimizu
Abstract
To investigate whether an association exists between vascular endothelial growth factor (VEGF)expression and tumor prognosis in primary lung carcinoma, we used immunohistochemical tech-niques to analyze microvessel density and VEGF expression in lung carcinoma tissue from 98patients. Tissue had been fresh-frozen at the time of operation and preserved for more than 5years. The results indicated that VEGF expression was positive for 50 of the 98 patients (51.0%),with 27 (27.6%) being weakly positive and 23 (23.5%) being strongly positive. The microvesseldensity in tissue showing weakly positive and strongly positive VEGF expression was significantlyhigher than that in VEGF-negative tumor tissue (P < 0.05: negative vs. weakly positive, P < 0.01:negative vs. strongly positive), we showed demonstrating that VEGF expression was significantlyassociated with intratumoral microvessel density. The 5-year survival rates were 8.7% for stronglyVEGF-positive patients, 43.9% for weakly VEGF-positive patients and 79.2% for VEGF-negativepatients, respectively (P < 0.01: negative vs. weakly positive or strongly positive). Furthermore,multivariate analysis employing multiple regression analysis indicated that VEGF expression cor-relates highly with the overall survival rates of patients with primary lung carcinoma. Two vari-ables, N status and VEGF expression, were found to be significant prognostic factors (P < 0.01).The results of this study suggest that VEGF expression is associated with intratumoral microves-sel density. VEGF expression may constitute important independent prognostic evidence that canhelp us in predicting the outcomes of patients with primary lung carcinomas.
KEYWORDS: prognostic value, vascular endothelial growth factor, neoangiogenesis, multivari-ate analysis, primary lung carcinoma
∗PMID: 10925736 [PubMed - indexed for MEDLINE]Copyright (C) OKAYAMA UNIVERSITY MEDICAL SCHOOL
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Sheng et al.: Prognostic value of vascular endothelial growth factor
Produced by The Berkeley Electronic Press, 2000
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Acta Medica Okayama, Vol. 54 [2000], Iss. 3, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss3/4
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Sheng et al.: Prognostic value of vascular endothelial growth factor
Produced by The Berkeley Electronic Press, 2000
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Acta Medica Okayama, Vol. 54 [2000], Iss. 3, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss3/4
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Sheng et al.: Prognostic value of vascular endothelial growth factor
Produced by The Berkeley Electronic Press, 2000
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Acta Medica Okayama, Vol. 54 [2000], Iss. 3, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss3/4
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Sheng et al.: Prognostic value of vascular endothelial growth factor
Produced by The Berkeley Electronic Press, 2000
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Acta Medica Okayama, Vol. 54 [2000], Iss. 3, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss3/4
