ACR – EULAR Classification Criteria for Systemic Sclerosis
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Transcript of ACR – EULAR Classification Criteria for Systemic Sclerosis
ACR – EULAR Classification Criteria for Systemic Sclerosis
May 25, 2013
Sindhu Johnson MD PhD
• Highlight the limitations of pre-existing classification criteria
• To discuss the development of the new classification criteria
• To discuss the application of the 2013 classification criteria
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Learning Objectives
• American College of Rheumatology Classification and Response Criteria Subcommittee of the Committee on Quality Measures.
Disclosures
Co-convenorsJanet PopeFrank van den Hoogen
MembersJaap FransenSindhu JohnsonAlan TyndallMurray BaronMarco Matucci-CerinicDinesh Khanna
CollaboratorsRay NadenChristopher DentonOliver DistlerArmando GabrielliJaap van LaarMaureen MayesVirginia SteenJames SeiboldPhillip ClementsThomas MedsgerGabriela RiemekastenPatricia Carreira
CollaboratorsLorinda ChungBarri FesslerPeter MerkelRichard SilverJohn VargaYannick AllanoreUlf Mueller-LadnerMadelon VonkUlrich WalkerSusanna Cappelli
SSc diagnosis
SSc classificatio
n
Major criterion * Proximal scleroderma
Minor criteria * Sclerodactyly * Digital pitting or scars or loss of substance from finger pad * Bibasilar pulmonary fibrosis
Major criterion or 2 minor criteria
ACR Preliminary Classification Criteria for Systemic Sclerosis
Arthritis Rheum 1980; 23:581-90
Sensitivity 97% of definite SSc cases
Specificity 98% the comparison patients
1 major criterion or ≥ 2 minor criteria
ACR Preliminary Classification Criteria for Systemic Sclerosis
Arthritis Rheum 1980; 23:581-90
Classification schemes – Overview
1980 1990 2000 2010
1980 – American College of Rheumatology
1988 – LeRoy: lcSSc and dcSSc
2001 – LeRoy: lSSc
Limited cutaneous SSc
Early SSc
New knowledge
Nailfold capillaries
SSc- specific antibodies
Limitations of ACR classification criteria for SSc
Miss subsets
SSc diagnosis
SSc classification
20%
Collaboration between experts and clinical epidemiologists
Evaluate psychometric properties of candidate criteria
Balance of expert based and data driven methods
Avoid circularity of reasoning
Classification schemes – Overview
Current:ACR-EULAR Collaboration
1980 1990 2000 2010
1980 – American College of Rheumatology
1988 – LeRoy: lcSSc and dcSSc
2001 – LeRoy: lSSc
Item Generation(Delphi panel) N = 168
Item Reduction(Delphi panel followed by
Nominal Group Technique) N = 23
Evaluate validity of items in SSc and SSc mimickers
Collect prospective data in SSc and SSc mimickers
Consensus M
ethodD
ata-Driven M
ethod
Evaluate operating characteristics of SSc criteria
Item reduction, weighting & scaling
EntryCriterion ? meets
“Threshold”
Multi-CriteriaDecisionAnalysis
AbsoluteCriteria
ExclusionCriteria
NO
Not Systemic Sclerosis
Systemic Sclerosis
YES
YES
NO
YES
Derivation sample(N=200)
Validation sample(N=405)
Validation sample≤ 3 years disease
duration(N=100)
Sensitivity(95% CI)
Specificity(95% CI)
Sensitivity(95% CI)
Specificity(95% CI)
Sensitivity(95% CI)
Specificity(95% CI)
1980 ARA SSc Criteria
0.80
(0.72, 0.87)
0.77
(0.68, 0.84)
0.75
(0.70, 0.80)
0.72
(0.64, 0.79)
0.75
(0.70, 0.80)
0.72
(0.63, 0.79)
2001 LeRoy and Medsger criteria
0.76 (0.68, 0.84)
0.69 (0.68, 0.84)
0.75 (0.70, 0.80)
0.78 (0.70, 0.85)
0.80 (0.69, 0.88)
0.76 (0.53, 0.92)
2013 ACR-EULAR SSc Classification Criteria
0.95 (0.90, 0.98)
0.93 (0.86, 0.97)
0.91 (0.87, 0.94)
0.92 (0.86, 0.96)
0.91 (0.83, 0.96)
0.90 (0.70, 0.99)
• Highlight the limitations of pre-existing classification criteria
• To discuss the development of the new classification criteria
• To discuss the application of the 2013 classification criteria
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Learning Objectives