telemetry.emka.fr

Acquisition and analysis for neurologic data

physiologypharmacology

toxicology

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Rodent EEG telemetry

Wireless, low cost, head-mounted EEG for rats

rodentPACK2 is a wireless, head-mounted telemetry system for rodents. It enables the acquisition of EEG and other biopotential signals, as well as temperature and activity/positional data - applications are varied, e.g. sleep and epilepsy studies, ECG recording.

rodentPACK2 transmits data via radiotelemetry, offering a well-tolerated, humane alternative to tethered EEG.

Direct inputs from the device to cortical and deep brain regions provide a high signal to noise ratio, facilitating the detection of EEG events.

rodentPACK2 consists of:

» a skull connector permanently implanted » a transmitter, connected to skull implant only during recordings » a receiver for 4 animals

9 signals are acquired for each rodentPACK2

» 4 biopotentials (EEG, ECG, EMG), sampled at up to 1000Hz » x/y/z accelerations sampled at 50Hz » global acceleration (computed from 3 axes), for activity assessment » core temperature

Advantages

» compact, light and noise free transmitter » no refurbishment, batteries cost less than 2$/recording » same transmitter may be used on any implanted animal » x/y/z acceleration signals allow for postural information » total acceleration useful for validating events on EEG/EMG traces

(seizure, movement) » rapid acclimation: rats are not restrained in their activities » animal is freely moving: ideal alternative to tethered system

Key features

» rodentPACK2 only weighs 4.4g with batteries - suitable for animals 50g and upwards

» transmission range up to 5 m » 150 hours of continuous recording with same batteries » group housing with multiple animals in same cage » up to 32 animals in same room with no required shielding » only 1 receiver for 4 animals » fully digital: only 1 Ethernet cable per receiver handles data & power » rodentPACK2 may be fixed to the cranium or used as a transmitter

alone (jacket ECG for instance)

rodentPACK2 receiver

LAN

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CNS analysis software

Power spectrum analysis

The software allows the scientist to easily generate FFT power spectrums with user defined frequency bands.

» power in up to 6 adjustable frequency ranges » absolute and relative power values » versatile scheduling of analysis, epoch lengths, overlap factor,

windowing

Sleep scoring

Our high throughput, automated sleep scoring module differentiates between four sleep stages and calculates global sleep scores.

» define threshold values applicable to any parameter from any input » software applies logical rules to attribute 1 out of 4 sleep stages to

each epoch » trend graph displays parameters as well as sleep stages » adjust, on the fly, thresholds and see the effect on sleep scoringOptional video for confirmation of sleep score and classification of seizure type is also available.

Epilepsy seizure detection

The EEG analyzer module can also be used to detect epilepsy seizures from EEG traces:

» automatic software seizures detection is performed using combined analysis of various parameters

» all detected seizures are logged in a table » manual edition of seizures limits is possible » invalid seizures can be deleted » undetected seizures can be created » valid seizures can be exported to text file

*Concurrent ECG, hemodynamic, or pulmonary data analysis is also available.

EEG analyzer module within ecgAUTO software*

ecgAUTO 3-D display of average spectrums over time

ecgAUTO epoch power spectrum (EEG analyzer)

4 epilepsy seizures detected (EEG acquired with rodentPACK2)

ecgAUTO sleep scoring module. from top: cortex, hippocampus, muscle, sleep score,

active wake, quiet wake, REM sleep, SW sleep

Neurobehavioral observationsemka TECHNOLOGIES’ integrated video capabilities facilitate behavioral observations without the confounding effects of investigator interaction.

Our secured video data is embedded in our data files and can be linked with other physiological signals, allowing the scientist to click on a change in a physiological parameter and observe the associated behavior.

The system features adjustable image resolution, and infrared recording for nighttime observations.

Link from telemetry implants to emka TECHNOLOGIES software suite » reads signal from all DSI™ implants, including new HD models » ideal to extend existing telemetry setup or to upgrade old systems » records calibrated data in iox2, without the need of OpenART™ or

acquisition card in computer » contains its own ambient pressure transducer » up to 16 implant receivers and 8 analog inputs connect to a single

easyMATRIX

» perfect synchronization of all signals from receivers or analog inputs » handles cases with 1, 2 or 4 receivers used for each subject » up to 4 easyMATRIX can be connected to a single computer

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Let us help you advance your research, contact us !

north america

emka TECHNOLOGIES Inc 307 Annandale Road, suite 203 Falls Church, VA 22042 – USA tel: +1 (703) 237-9001fax: +1 (703) 237-9006emkatech@emkatech.comwww.emkatech.com SCIREQ 6600 St-Urbain, Suite 300AMontréal, QC H2S 3G8 – Canadatel: +1 (514) 286-1429toll free: +1 (877) 572-4737fax: +1 (514) 286-1427sales@scireq.comwww.scireq.com

worldwide distributionTo find your local distributor, in Israel, India, Korea, Taiwan, Brasil etc., consult our website on www.emka.fr

middle-east

emka TECHNOLOGIES SASRiyadh, PO Box 261632 Riyadh 11342Kingdom of Saudi Arabia

emka@dce-ksa.comwww.emka.fr

europe

emka TECHNOLOGIES SAS59, bd. Général Martial Valin75015 Paris – France tel: +33 (0)1 40 60 76 00 fax: +33 (0)1 40 60 65 55emka@emka.frwww.emka.fr

china

emka BIOTECH Beijing Co Ltd Rm 935 Laho Studio, No.15-A1 East Jianguo Road Chaoyang District, Beijing 100024, Chinatel: +86-(0)10-85376382 or 400-661-8288fax: +86-(0)10-85376384info@bjgyd.com / www.bjgyd.com emka BIOTECH Shanghai Co LtdRm 710 Building 3, No.2288 Zhuchongzhi Road, Pudong District Shanghai 201203 – Chinatel: +86-21-61097518 fax: +86-21-61097518 emka BIOTECH Hong Kong Co Ltd Rms 1318-20, Hollywood Plaza, 610 Nathan Road, Monkok, Kowloon, HK – China tel: 00852-35000568  or 00852-27108200-3296 fax: 00852-29978306 info@bjgyd.com / www.emkabiotech.cn

japan

emka TECHNOLOGIES Japan Urban Ace Sannomiya Building 10F4-1-22, Onoe-dori, Chuou-kuKobe 651-0088 – Japantel: +81 (0)50 5830-9882info@emkatech.jp www.emkatech.jp