About OMICS Group - d2cax41o7ahm5l.cloudfront.net · About OMICS Group OMICS Group International is...
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About OMICS Group About OMICS Group About OMICS Group About OMICS Group About OMICS Group About OMICS Group About OMICS Group About OMICS Group OMICS Group International is an amalgamation of Open Access publications and worldwide international science conferences and events. Established in the year 2007 with the sole aim of making the information on Sciences and technology ‘Open Access’, OMICS Group publishes 400 online open access scholarly journals in all aspects of Science, Engineering, Management and Technology journals. OMICS Group has been instrumental in taking the journals. OMICS Group has been instrumental in taking the knowledge on Science & technology to the doorsteps of ordinary men and women. Research Scholars, Students, Libraries, Educational Institutions, Research centers and the industry are main stakeholders that benefitted greatly from this knowledge dissemination. OMICS Group also organizes 300 International conferences annually across the globe, where knowledge transfer takes place through debates, round table discussions, poster presentations, workshops, symposia and exhibitions.
Transcript of About OMICS Group - d2cax41o7ahm5l.cloudfront.net · About OMICS Group OMICS Group International is...
About OMICS GroupAbout OMICS GroupAbout OMICS GroupAbout OMICS GroupAbout OMICS GroupAbout OMICS GroupAbout OMICS GroupAbout OMICS Group
OMICS Group International is an amalgamation of Open Accesspublications and worldwide international science conferences andevents. Established in the year 2007 with the sole aim of making theinformation on Sciences and technology ‘Open Access’, OMICSGroup publishes 400 online open access scholarly journals in allaspects of Science, Engineering, Management and Technologyjournals. OMICS Group has been instrumental in taking thejournals. OMICS Group has been instrumental in taking theknowledge on Science & technology to the doorsteps of ordinarymen and women. Research Scholars, Students, Libraries,Educational Institutions, Research centers and the industry are mainstakeholders that benefitted greatly from this knowledgedissemination. OMICS Group also organizes 300 Internationalconferences annually across the globe, where knowledge transfertakes place through debates, round table discussions, posterpresentations, workshops, symposia and exhibitions.
About OMICS Group ConferencesAbout OMICS Group ConferencesAbout OMICS Group ConferencesAbout OMICS Group ConferencesAbout OMICS Group ConferencesAbout OMICS Group ConferencesAbout OMICS Group ConferencesAbout OMICS Group Conferences
OMICS Group International is a pioneer and leading science event
organizer, which publishes around 400 open access journals andconducts over 300 Medical, Clinical, Engineering, Life Sciences,Pharma scientific conferences all over the globe annually with thesupport of more than 1000 scientific associations and 30,000editorial board members and 3.5 million followers to its credit.editorial board members and 3.5 million followers to its credit.
OMICS Group has organized 500 conferences, workshops andnational symposiums across the major cities including SanFrancisco, Las Vegas, San Antonio, Omaha, Orlando, Raleigh,Santa Clara, Chicago, Philadelphia, Baltimore, United Kingdom,Valencia, Dubai, Beijing, Hyderabad, Bengaluru and Mumbai.
Ministério da Saúde
FIOCRUZ
Fundação Oswaldo Cruz
Instituto Oswaldo Cruz
Expression of cytokines in tissues and correlation with histopathological changes
in dengue fatal cases from Brazil
Laboratory of Biotechnology and Physiology of Viral Infections /IOC/FIOCRUZ
Dr. Marciano Viana PaesResearch in Public Health
Dengue
�Etiological agent: dengue virus
�Serotypes: DENV-1, DENV-2, DENV-3, DENV-4
�Genus: Flavivirus
�Family: Flaviviridae �Family: Flaviviridae
�Transmitting agent of the disease: Aedes
aegypti
Countries / areas at risk of dengue transmission
2012 (WHO)
Fonte: http://www.healthmap.org/dengue/pt , acessado em abril 2012.
Fonte: http://www.dengue.org.br/dengue_mapas.html, acessado em março 2012.
Clinical Aspects
Asymptomatic Symptomatic
Dengue fever
(DF)Dengue Hemorrhagic (DHF) Dengue with
Complications++
Dengue with or without
Warning SignsSevere dengue
Fever
undifferentiated (DF)
Without haemorrhage With hemorrhage
unusual
Without shock With Shock
Syndrome
(DSS)
Complications++
undifferentiated
Dengue Fever (DF)
Fever undifferentiated DengueHemorrhage (DHF)
Without Unusual
Dengue with complications
+ +
Dengue fever with or withoutWarning Signs
Severe dengue
Clinical Aspects
Without hemorrhage
UnusualBleeding
No Shock With ShockSyndrome
(DSS)Main Symptoms:
� fever
� headache
� retro-orbital pain
� vomit
� myalgia
� joint pain
� arthralgia
� rash
Main Symptoms:
� hemorrhagic manifestations
� thrombocytopenia
� hepatomegaly
� fluid accumulation
� alterations of consciousness
� heart failure
• monocytes/macrophages• and dendritic cells
Endothelial cells LiverTissue Mϕ Bone marrow/ stromal cells
Replication
Hemorrhage
Plasma Extravasation
Pathology of the DENV
Modified from
Martina et al., 2009
Apoptosisand necrosis
Production of chemical mediators and cytokines
Clottingdisorder
Endothelialdysfunction
(vascular permeability)
Suppressionofhematopoiesis
CytokineStorns
Extravasation
ShockActivation of lymphocytes
The study of histopathology aspects is difficult in dengue of fatal cases
Studies with autopsies in fatal cases have been performed inonly a small number of these patients, all over the world,specially in Brazil.
�
C.A. Basílio-de-Oliveira1, G.R. Aguiar3, Baldanza M.S.3, O.M. Barth2, W.A.
Eyer-Silva1 and M.V. Paes2
1- Gaffrée and Guinle Teaching Hospital, Federal University of Rio de Janeiro;
2- Virology Department, Oswaldo Cruz Institute, Fiocruz-RJ; 3- São Vicente
Hospital; Rio de Janeiro, RJ, Brazil
Pathologic Study of a Fatal Case of Dengue-3 Virus Infection in Rio de Janeiro, Brazil
Hospital; Rio de Janeiro, RJ, Brazil
Pathological changes
Basilio-de- oliveira et al., 2005
Liver
Histopathological changes and viral antigens
Isolation of DENV-3
C6/36
Basilio-de- oliveira et al., 2005
Lung
Spleen
The pathology of dengue in human fatal cases regarding
histopathology, ultrastructure and virus replication in multiple
organs.
Póvoa TF1, Alves AMB1, Basilio-de-Oliveira CA2, Nuovo GJ3, Chagas VLA4 and
Paes MV1*
Póvoa et al., 2014, Plos One
Paes MV1*
Histopathology and Ultrastructural aspects: Liver
Póvoa et al., 2014, Plos One
anti- DENV (NS3)
Replication: liver
Imunohistochemistry In situ Hybridization(with RNA negative strand)
H En
control
Póvoa et al., 2014, Plos One
DENV
H En
KC
Histopathology and Ultrastructural aspects: Lung
Póvoa et al., 2014, Plos One
control
Replication: lung
anti- DENV (NS3)
Imunohistochemistry In situ Hybridization(with RNA negative strand)
Póvoa et al., 2014 , Plos One
DENV
Histopathology and Ultrastructural aspects: Heart
Póvoa et al., 2014 Plos One
Replication: Heart
anti- DENV (NS3)
Imunohistochemistry In situ Hybridization(with RNA negative strand)
En
Póvoa et al., 2014 , Plos One
En
Mo
Histopathology and Ultrastructural aspects of kidney
Póvoa et al., 2014, Plos One
� LABIFIV
� Dr. Basílio de Oliveira (Hospital Gafrée e Guinle - UNIRIO)
� Hospital Clementino (UFRJ)
� Hospital Miguel Couto
Tiago Fajardo Póvoa - MSc
Dra. Ada M. B. Alves
Acknowledgments
� Hospital Miguel Couto
� Dr. Gerard Nuovo - Anatomic Pathology/ Medical Center at The Ohio
State University
Financial Support
PDTISPDTIS
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International International
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