A widespread task-related hemodynamic response in human V1 is … · 2021. 1. 11. · 0 fMRI...
1
0 fMRI response amplitude (% change) 0.75 Atlas-defined V1 S04 A widespread task-related hemodynamic response in human V1 is modulated by task difficulty Minyoung Ryoo 1 , Charlie S. Burlingham 2* , Zvi Roth 1 , Saghar Mirbagheri 2 , David J. Heeger 2,3 & Eli Merriam 1* 1 Laboratory of Brain and Cognition, NIMH. 2 Department of Psychology, New York University. 3 Center for Neural Science, New York University. Task-related hemodynamic responses: • Endogenous responses in the absence of a visual stimulus at the earliest stages of visual cortical processing. • Spatially global and entrained to task timing. Background Easy 10 15 Time (s) -0.1 0 0.2 -0.1 0 0.2 Correct Incorrect 5 0 N = 13 *** Hard 10 15 5 0 N = 13 Correct Incorrect ** *** p < .001 ** p < .005 * p < .05 Modulation index = (Δeasy - Δhard) / (|Δeasy| + |Δhard|) V1, Ispilateral hemisphere: widespread hemodynamic activity unrelated to visual stimulus or spatial attention Experimental Protocol Low Reward 0 • Orientation discrimination task; tone feedback. • Separate runs (of 15 trials) for four conditions (easy vs. hard, low reward vs. high reward). Conclusions • Task-related responses entrained to task timing. • Pupil dilation also modulated by difficulty, reward, and correct/incorrect feedback. -> Task-related responses reflects arousal. *Email: [email protected], [email protected], [email protected] Supported by: NEI grant R01EY025330 (to E.M. & D.H.) and NIMH Intramural Reseach Program. Thanks to: Aniruddha Das. fMRI responses in ipsilateral V1: Pupil responses: Task Difficulty N = 5 160 Time (s) 0 Pupil area (AU) 0 2 4 *** -80 160 0 -80 N = 5 0 2 4 * Low Reward 10 15 Time (s) -0.1 0 0.15 fMRI response (% change) Correct Incorrect 5 0 N = 9 10 15 -0.1 0 0.15 5 N = 9 * High Reward *** Correct Incorrect Incorrect - correct amplitude (std) Easy Hard S01 S02 S05 S03 S04 S09 S06 S07 S08 0 0.1 0.2 0.3 S11 S12 S13 fMRI response (% change) Reward fMRI responses in ipsilateral V1: Pupil responses: S14 S15 S18 S16 S17 0 20 40 60 *** All 0.5 0 Modulation index S19 S02 S04 S21 S06 S20 S10 0 .025 .05 S11 S22 Low High All 0 -0.5 All 0.2 -0.3 0 0 1 All 1 0 S19 S01 S20 S04 S06 S13 S10 S21 S11 S22 S23 0 10 20 30 -25 0 125 -25 0 125 Pupil area (AU) Time (s) 0 2 4 0 2 4 *** ~90% correct stakes: $0.25 Easy N = 11 N = 11 Are task-related hemodynamic responses modulated by task difficulty and reward? Are they linked to arousal? Aim Fourier amplitude 0.1 0.2 0.3 0 0 0.1 0.2 Task frequency (1/15 Hz) Frequency (Hz) 100 0 fMRI response (% change) 200 0 -0.3 0.3 Time (s) Trial onsets ITI 15 s Stimulus 200 ms or Hard ~70% correct stakes: $1.10 High Reward or
Transcript of A widespread task-related hemodynamic response in human V1 is … · 2021. 1. 11. · 0 fMRI...
0
fMRI response amplitude (% change)
0.75Atlas-defined V1
S04
A widespread task-related hemodynamic response in human V1 is modulated by task difficultyMinyoung Ryoo1, Charlie S. Burlingham2*, Zvi Roth1, Saghar Mirbagheri2, David J. Heeger2,3 & Eli Merriam1*
1 Laboratory of Brain and Cognition, NIMH. 2 Department of Psychology, New York University. 3 Center for Neural Science, New York University.
Task-related hemodynamic responses:
• Endogenous responses in the absence of a visual stimulus at the earliest stages of visual cortical processing.
• Spatially global and entrained to task timing.
Background
Easy
10 15Time (s)
-0.1
0
0.2
-0.1
0
0.2CorrectIncorrect
50
N = 13
***
Hard
10 1550
N = 13
CorrectIncorrect
**
*** p < .001** p < .005* p < .05 Modulation index =
(Δeasy - Δhard) / (|Δeasy| + |Δhard|)
V1, Ispilateral hemisphere: widespread hemodynamic activity unrelated to visual stimulus or spatial attention
Experimental ProtocolLow Reward
0
• Orientation discrimination task; tone feedback.
• Separate runs (of 15 trials) for four conditions (easy vs. hard, low reward vs. high reward).
Conclusions
• Task-related responses entrained to task timing.
• Pupil dilation also modulated by difficulty, reward, and correct/incorrect feedback.
-> Task-related responses reflects arousal.
*Email: [email protected], [email protected], [email protected] by: NEI grant R01EY025330 (to E.M. & D.H.) and NIMH Intramural Reseach Program.Thanks to: Aniruddha Das.
fMRI responses in ipsilateral V1:
Pupil responses:
Task Difficulty
N = 5
160
Time (s)
0
Pup
il ar
ea (A
U)
0 2 4
***
-80
160
0
-80 N = 5
0 2 4
*
Low Reward
10 15Time (s)
-0.1
0
0.15
fMR
I res
po
nse
(% c
hang
e)
CorrectIncorrect
50
N = 9
10 15
-0.1
0
0.15
5
N = 9
*
High Reward*** Correct
Incorrect
Inco
rrec
t -
corr
ect
amp
litud
e (s
td)
Easy Hard
S01 S02 S05S03 S04 S09S06 S07 S08
0
0.1
0.2
0.3
S11 S12 S13
fMR
I res
po
nse
(% c
hang
e)
RewardfMRI responses in ipsilateral V1:
Pupil responses:
S14 S15 S18S16 S17
0
20
40
60
***
All
0.5
0
Mo
dul
atio
n in
dex
S19 S02 S04 S21S06 S20 S10
0
.025
.05
S11 S22
Low High
All
0
-0.5
All
0.2
-0.3
0
0
1
All
1
0
S19 S01 S20S04 S06 S13S10 S21 S11 S22 S23
0
10
20
30
-250
125
-250
125
Pup
il ar
ea (A
U)
Time (s)0 2 4 0 2 4
***
~90% correct stakes: $0.25 Easy
N = 11N = 11
Are task-related hemodynamic responses modulated by task difficulty and reward?
Are they linked to arousal?
Aim
Four
ier
amp
litud
e
0.1 0.2 0.30
0
0.1
0.2
Task frequency (1/15 Hz)
Frequency (Hz)1000
fMR
I res
po
nse
(% c
hang
e)
200
0
-0.3
0.3
Time (s)
Trial onsets
ITI 15 s
Stimulus 200 ms
or
Hard~70% correct stakes: $1.10
High Rewardor
