A RARE CASE OF GARLIC INDUCED HYPERSENSITIVITY REACTION

104 | P a g e International Standard Serial Number (ISSN): 2319-8141

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International Journal of Universal Pharmacy and Bio Sciences 3(4): July-August 2014

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A RARE CASE OF GARLIC INDUCED HYPERSENSITIVITY REACTION

Dr. D. Naga SatishBabu, K. Mallikarjun Reddy, G. Raghavendra Kumar, D. Narasimharao,

Dr. J. N. Suresh Kumar, T. Swarupa Rani

Department of Pharmacy practice, Narasaraopet Institute of Pharmaceutical Sciences, Narasaraopet,

Guntur (D.t) A.P.

KEYWORDS:

Contact Dermatitis,

Hypersensitivity,

Hypothyroidism, Garlic.

For Correspondence:

Dr. D.Naga Satish

Babu *

Address: Department of

Pharmacy practice,

Narasaraopet Institute of

Pharmaceutical Sciences,

Narasaraopet, Guntur

(D.t) A.P.

Email ID:

[email protected]

om

ABSTRACT

Aim of the study: The objective of present study is to report a rare

Case of contact dermatitis that was seen in 30 years old female from

Narasaraopet of Guntur district, South India. Place of study: This case

was studied in the outpatient department of Dermatology, Guntur City

Hospital, Guntur. Period of Study: This case was studied and

investigated in detail in the month of May 2014 in the above hospital.

Case Report: A young female aged 30years came with past history of

Hyperthyroidism for the past 11months and Obese. She needed support

to have food. On examination she had Hoarse throat, Body pains

Irregular periods .along with this on application of Raw Garlic for

pimples turned into Contact Dermatitis. This study was compared and

well correlated with available literature. Conclusion: Since this is a rare

case of Garlic Induced Hypersensitivity reaction made us interesting to

study.

mailto:[email protected]

mailto:[email protected]



INTRODUCTION:

Food allergies occur when the immune system identifies the proteins in a particular food as harmful

to the body, subsequently reacting to try to "fight off" the "harmful" proteins (which are in fact

harmless). Garlic allergies are not very common but are especially inconvenient to chefs who have to

handle garlic on a regular basis. Allergic reactions don't occur only when you consume a food

allergen but may also occur when you handle it or even breathe in particles of it.

Some symptoms of a garlic allergy include:

Itching or swelling of the mouth, tongue or lips

Skin reactions (eczema, contact dermatitis hives, swelling and redness of the extremities or

face)

Gastrointestinal symptoms (abdominal pain, nausea, vomiting, diarrhea)

Respiratory symptoms (runny or stuffy nose, coughing, sneezing, wheezing, difficulty

breathing)

Cardiovascular symptoms (drop in blood pressure, lightheadedness, fainting)

If you experience symptoms of anaphylaxis, which include nausea, vomiting, weak or rapid pulse,

difficulty breathing, confusion and loss of consciousness, seek immediate medical attention, as this

can be fatal. Anaphylaxis is a fairly rare reaction to a garlic allergy but has been known to happen. If

you have a severe allergy to garlic you may need to carry epinephrine with you so you can treat

yourself in case you come into contact with garlic at any point. Garlic is usually a trouble-free herb,

providing more benefits than complication, but that's not always the case. Prolonged contact with

garlic may cause irritation to the skin or even lesions. Garlic has very little toxicity, and garlic

allergies are rare occurrences compared with other foods. Even so, it does happen and sometimes

with very serious effects.

Cooked Versus Raw Garlic2

The enzyme in garlic responsible for allergic reactions is also responsible for its healthiest benefits.

The Linus Pauling Institute at Oregon State University reports that the enzyme produces the

chemical compound allicin, which breaks down into other important compounds, some of which

may be effective for fighting cancer. If you want the benefits of garlic without the risk, crush it, let it

sit for 10 minutes and cook it. By letting it sit for a while, you allow time for the enzyme to produce

allicin. Cooking it eliminates the enzymatic activity and most, if not all, of the risk of an allergic

reaction. What doesn't get eliminated are most of the healthy benefits of garlic.

http://health.howstuffworks.com/diseases-conditions/allergies/allergy-basics/10-allergy-myths.htm



Photo: 1 Photo: 2

Case Reports: A young female aged 30years came with past history of Hyperthyroidism for the past

11months. She needed support to have food. On examination she had Hoarse throat, Body pains

Irregular periods .along with this on application of Raw Garlic for pimples turned into Red colored

patches on skin.

Past History: past history of Hyperthyroidism for the past 11months. She needed support to have

food. No past history of weight loss, evening rise of temperature.

Family History: There was no family history of hyperthyroidism, diabetes but her mother has

hypothyroidism

On Examination: she was moderately built and under nourished. She had no cyanosis,

Clubbing, neither jaundice nor lymphadenopathy. But Red colored patches on Skin observed.

No history of trauma, radiation exposure.

All the other systems like respiratory system, cardiovascular systems were normal and abdomen was

soft and no mass felt. All his other parameters were normal.

Investigations: Hormonal Assay shows TSH LEVEL 0.60 Micro/ML which shows abnormal. Skin

prick tests and specific IgE immunoassay with several pollens and foods were performed, as well as

the prick-prick test with young garlic and SDS-PAGE followed by immunoblotting IgE to young

garlic and other Liliaceae species, mustard, sesame, parsley, celery, hazelnut, almond, and pollen of

birch and mugwort.

Conclusion: Garlic is well known to cause contact dermatitis and asthma. However, it is a very rare

cause of skin allergyWe describe IgE-mediated reaction to young garlic in patient sensitized to

pollen and dried fruit.

Take Home Message: Garlic induced anaphylactic reaction is a rare condition how ever be careful

while applying Garlic for pimples for a persons with other co morbid conditions



REFERENCES:

1. http://www.livestrong.com/article/524637-raw-garlic-allergies.

2. http://www. health.howstuffworks.com

3. Anaphylactic reaction to young garlic.Pérez-Pimiento AJ PMID:10435479 [PubMed – indexed for

MEDLINE]

http://www.livestrong.com/article/524637-raw-garlic-allergies

http://www.ncbi.nlm.nih.gov/pubmed?term=P%C3%A9rez-Pimiento%20AJ%5BAuthor%5D&cauthor=true&cauthor_uid=10435479

A RARE CASE OF GARLIC INDUCED HYPERSENSITIVITY REACTION

Healthcare

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