“A Knowledge Environment for Neuroimaging in Child Psychiatry” R01 MH083320

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“A Knowledge Environment for Neuroimaging in Child Psychiatry” R01 MH083320 Clinical Advisors Committee - 1.April.2011 Agenda: Review of CANDIShare grant Objectives Review of current status of data release ( www.nitrc.org/projects/candi_share ) Brief overview of planned releases Discussion of: Usability, advertising, extensions, etc. Other discussion? Adjourn

description

“A Knowledge Environment for Neuroimaging in Child Psychiatry” R01 MH083320. Clinical Advisors Committee - 1.April.2011 Agenda: Review of CANDIShare grant Objectives Review of current status of data release ( www.nitrc.org/projects/candi_share ) Brief overview of planned releases - PowerPoint PPT Presentation

Transcript of “A Knowledge Environment for Neuroimaging in Child Psychiatry” R01 MH083320

Page 1: “A Knowledge Environment for Neuroimaging in Child Psychiatry” R01 MH083320

“A Knowledge Environment for

Neuroimaging in Child Psychiatry”R01 MH083320Clinical Advisors Committee - 1.April.2011

Agenda: Review of CANDIShare grant Objectives Review of current status of data release (www.nitrc.org/projects/candi_share)

Brief overview of planned releases Discussion of: Usability, advertising, extensions, etc. Other discussion? Adjourn

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CANDIShare - Aims

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Aims:• Aim 1: Use the existing resources NITRC to make a large set of MR image and anatomic analysis data available. This will include:

• a. Image data - including structural and diffusion imaging at 1.5 and 3.0 T. Each subject will include a comprehensive set of clinical, demographic and behavioral measures.• b. Segmentation – the segmentation results for ‘general segmentation’ and parcellation (cortical and white matter).• c. Creation and dissemination of static and dynamic probabilistic atlases from specific subsets of these data for use in other segmentation and analysis frameworks.

• Aim 2: Integrate the volumetric data derived from these images into the Internet Brain Volume Database (IBVD), and use the IBVD system to catalogue the representative literature of other published data from these similar age and diagnostic categories of study.

• Aim 3: Create the prototype for a unified Child Psychiatry Neuroimaging Portal that seamlessly integrates information across these resources and to select outside resources (PubMed, BIRN, MRI Study of Normal Brain Development, etc.). Promote the overall framework as a prototype to engender greater sharing of information within the child psychiatric community

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CANDIShare - DataField

Diagnosis Gender N Strength Followup Total Scans Mean STD Min Max N Total N Total

F 28 17 12M 32 17 15

F 5M 5

F 8 7 5M 23 18 14

F 10 7 7M 11 6 6

F 22 10 9M 20 8 6

F 6M 6

F 9 10 6M 17 9 8

F 7 6 6M 22 12 12

F 15 12 9M 17 11 8F 110 69 54M 153 81 69

Abbreviations: ADHD = Attention Deficit Hyperactivity Disorder; AR-BPD = At Risk for Bipolar Disorder; BPD = Bipolar Disorder;BPD w/ psychosis = Bipolar Disorder with Psychotic Features; BPD/ADHD = BPD withcomorbid ADHD; Schiz. = Early-Onset Schizophrenia-Spectrum Illness

Notes: All 3.0 T scans also have 72-direction diffusion tensor acquisitions

Additional acquisitions, under separate funding, are continuing

Continuing analysis are supported by separate fundingFollowup refers to the number of Total Scans that, to date, have been repeated for longitudinal assessment

3.9 21.4 150 123Total 263 11.5 3.133

7.5 19.5 23 17Schiz. 32 14.5 3.21.5 2

7.1 21.4 18 18BPD/ADHD 29 11.6 3.71.5 4

5.6 17.8 19 14BPD w/ psychosis

26 12.3 3.01.5 4

2.2

4.1 19.6 18BPD

1.5

3.0 12

4

13.0 13 13

42 12.8 3.8 15

18.9 25 19

AR-BPD 21 8.4 2.61.5 4 3.9

ADHD 31 12.1 3.81.5 7

5.2 18.6 34 2760 11.5 3.2Control

1.5

3.0 10

8

10.5 2.1

Age (years) Range Segmented Parcellated

9.5

0 0

0 0

7.5 13.7

13.46.1

4.5

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CANDIShare - NITRC

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http://www.nitrc.org/projects/candi_share

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CANDIShare - Release

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CANDIShare - rel notes

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CANDIShare - Release

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CANDIShare - IBVD

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CANDIShare - IBVD

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CANDIShare - dir

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CANDIShare - otl/nii

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THAL

ACPC

PDT

PONS

MO

parolfactory sulcus

PONS

PDT

prcTHAL

LGNHIP

PHa

CAU CAU

prcTHALPUT

AMYHIPPHa

HypoBSFR

CAU

BSFR

NACPUT

SEPT

SC

.otl

nii.gz

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CANDIShare - otl/nii

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CANDIShare - otl/nii

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CANDIShare - future

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Brief overview of planned releases Segmentation * (any moment now) Behavioral/clinical measures

KSADS, Tanner, SES, MRS, GAF, meds Parcellation Diffusion Longitudinal cohort More subjects

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CANDIShare - discussion

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Discussion of: Usability, advertising, extensions, etc. Neuroinformatics Data News Item etc.

Other discussion? ‘Proper Image Database (i.e. XNAT_Central) etc.

Adjourn