“A Knowledge Environment for Neuroimaging in Child Psychiatry” R01 MH083320
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Transcript of “A Knowledge Environment for Neuroimaging in Child Psychiatry” R01 MH083320
“A Knowledge Environment for
Neuroimaging in Child Psychiatry”R01 MH083320Clinical Advisors Committee - 1.April.2011
Agenda: Review of CANDIShare grant Objectives Review of current status of data release (www.nitrc.org/projects/candi_share)
Brief overview of planned releases Discussion of: Usability, advertising, extensions, etc. Other discussion? Adjourn
CANDIShare - Aims
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Aims:• Aim 1: Use the existing resources NITRC to make a large set of MR image and anatomic analysis data available. This will include:
• a. Image data - including structural and diffusion imaging at 1.5 and 3.0 T. Each subject will include a comprehensive set of clinical, demographic and behavioral measures.• b. Segmentation – the segmentation results for ‘general segmentation’ and parcellation (cortical and white matter).• c. Creation and dissemination of static and dynamic probabilistic atlases from specific subsets of these data for use in other segmentation and analysis frameworks.
• Aim 2: Integrate the volumetric data derived from these images into the Internet Brain Volume Database (IBVD), and use the IBVD system to catalogue the representative literature of other published data from these similar age and diagnostic categories of study.
• Aim 3: Create the prototype for a unified Child Psychiatry Neuroimaging Portal that seamlessly integrates information across these resources and to select outside resources (PubMed, BIRN, MRI Study of Normal Brain Development, etc.). Promote the overall framework as a prototype to engender greater sharing of information within the child psychiatric community
CANDIShare - DataField
Diagnosis Gender N Strength Followup Total Scans Mean STD Min Max N Total N Total
F 28 17 12M 32 17 15
F 5M 5
F 8 7 5M 23 18 14
F 10 7 7M 11 6 6
F 22 10 9M 20 8 6
F 6M 6
F 9 10 6M 17 9 8
F 7 6 6M 22 12 12
F 15 12 9M 17 11 8F 110 69 54M 153 81 69
Abbreviations: ADHD = Attention Deficit Hyperactivity Disorder; AR-BPD = At Risk for Bipolar Disorder; BPD = Bipolar Disorder;BPD w/ psychosis = Bipolar Disorder with Psychotic Features; BPD/ADHD = BPD withcomorbid ADHD; Schiz. = Early-Onset Schizophrenia-Spectrum Illness
Notes: All 3.0 T scans also have 72-direction diffusion tensor acquisitions
Additional acquisitions, under separate funding, are continuing
Continuing analysis are supported by separate fundingFollowup refers to the number of Total Scans that, to date, have been repeated for longitudinal assessment
3.9 21.4 150 123Total 263 11.5 3.133
7.5 19.5 23 17Schiz. 32 14.5 3.21.5 2
7.1 21.4 18 18BPD/ADHD 29 11.6 3.71.5 4
5.6 17.8 19 14BPD w/ psychosis
26 12.3 3.01.5 4
2.2
4.1 19.6 18BPD
1.5
3.0 12
4
13.0 13 13
42 12.8 3.8 15
18.9 25 19
AR-BPD 21 8.4 2.61.5 4 3.9
ADHD 31 12.1 3.81.5 7
5.2 18.6 34 2760 11.5 3.2Control
1.5
3.0 10
8
10.5 2.1
Age (years) Range Segmented Parcellated
9.5
0 0
0 0
7.5 13.7
13.46.1
4.5
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CANDIShare - NITRC
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http://www.nitrc.org/projects/candi_share
CANDIShare - Release
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CANDIShare - rel notes
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CANDIShare - Release
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CANDIShare - IBVD
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CANDIShare - IBVD
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CANDIShare - dir
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CANDIShare - otl/nii
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THAL
ACPC
PDT
PONS
MO
parolfactory sulcus
PONS
PDT
prcTHAL
LGNHIP
PHa
CAU CAU
prcTHALPUT
AMYHIPPHa
HypoBSFR
CAU
BSFR
NACPUT
SEPT
SC
.otl
nii.gz
CANDIShare - otl/nii
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CANDIShare - otl/nii
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CANDIShare - future
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Brief overview of planned releases Segmentation * (any moment now) Behavioral/clinical measures
KSADS, Tanner, SES, MRS, GAF, meds Parcellation Diffusion Longitudinal cohort More subjects
CANDIShare - discussion
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Discussion of: Usability, advertising, extensions, etc. Neuroinformatics Data News Item etc.
Other discussion? ‘Proper Image Database (i.e. XNAT_Central) etc.
Adjourn