A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very...

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A effervescent tablet A effervescent tablet disinfectant disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA SUNGIL PHARMA A concern of A concern of

Transcript of A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very...

Page 1: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

A effervescent tablet disinfectantA effervescent tablet disinfectantA effervescent tablet disinfectantA effervescent tablet disinfectant

Good

Effervescent !

Long Lasting !

High

Effectiveness !

Very Convenient !

Varied

Application !

SUNGIL PHARMASUNGIL PHARMAA concern ofA concern of

Page 2: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Features of Aquagard-TFeatures of Aquagard-T

• Good Effervescent !

• Long Lasting !

• High Effectiveness !

• Very Convenient !

• Varied Application !

Page 3: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Aquagard-T…Aquagard-T…

• Aquagard-T is a effervescent tablet

disinfectant.

• Aquagard-T is a very powerful disinfectant

containing sodium dichloroisocyanurate

(NaDCC) widely applied for the sterilization of

drinking water, or fighting against infectious

diseases, or act as disinfectant in raising

livestock, poultry and fish.

Page 4: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Aquagard-T…Aquagard-T…

• Aquagard-T is an oxidising compound which releases chlorine to produce hypochlorous acid and hypochlorite ion in the presence of water.

It is generally considered that the lethal action on organism is due to chlorination of cell protein or enzyme systems by nonionised hypochlorous acid, causing hydrolysis of peptidic chains of cellular membranes of pathogenic germs. Chlorine-releasing substances are bactericidal to most gram-positive and gram-negative bacteria, bacterial spores and viruses.

Page 5: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

NaDCCNaDCC(Sodium Dichloroisocyanurate)(Sodium Dichloroisocyanurate)

(Structural formula of NaDCC)

Page 6: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

NaDCCNaDCC(Sodium Dichloroisocyanurate)(Sodium Dichloroisocyanurate)

(Hydrolysis of NaDCC)

+ 2H2O

germicidal activity

+ 2HOCl

Hypochlorous acid

H+ + OCl-

Hypochlorite ion

Page 7: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

• The germicidal activity of hypochlorous acid is 80 times higher than hypochlorite ion.

• The presence of HOCl in solution of chlorine containing compound

Aquagard-T : NaDCCAquagard-T : NaDCC(Sodium Dichloroisocyanurate)(Sodium Dichloroisocyanurate)

0

20

40

60

80

100

4 5 6 7 8 9 10

pH

HOCl, %

pH of Aquagard-

T solutions

pH of NaOCl

solutions

Page 8: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Chlorine containing Chlorine containing compoundcompound

Chlorine used widely as a disinfectant and bleaching agent

Inorganic compound Sodium hypochlorite (NaOCl)

Calcium hypochlorite (CaOCl)

Chloline dioxide (ClO2)

unstable, less germicidal activity

Organic compound Sodium dichloroisocyanurate (NaDCC)

very stable, predominantly germicidal activity

Page 9: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Features of Aquagard-TFeatures of Aquagard-T

Good effervescent high technique for making effervescent tablets

Long lasting free available chlorine is present for 5 days in Aquagard-T solutions

High effectiveness broad spectrum disinfectant (active to spore forming bacteria, naked

virus) Very convenient easy to handle and safe Varied application used widely for disinfection of poultry,

pig, cattle and sheep, livestock houses and facilities, drinking water

Page 10: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Very Sensitive

Septic bacteria

(Pasteurella sp)

Sensitive

Enveloped virus

(HC, TGE,

ILT, IB, ND)

Resistant

Non-enveloped virus

(Enterovirus,

Adenovirus, FMD,

IBD, Reo)

Very Resistant

Spore forming bacteria

(B. anthracis,

Clostridium)

Weak Disinfectantssurfactant,

quaternary ammonium chloride

Intermediate Disinfectants

cresol, phenol,

ortho, alcohol

Strong Disinfectants

chlorine, iodine,

Aldehydes,

ethylene oxide

Microbiocidal activity of Microbiocidal activity of various disinfectantsvarious disinfectants

Page 11: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Microbials NaDCC* (ppm)

Staphylococcus aureus 1.12

Escherichia coli 0.83

Salmonella typhi 0.83

Klebsiella pneumoniae 2.36

Serratia marcescens 1.14

Yersinia enterocolitica 0.72

Pseudomonas aeruginosa 2.00

Saccharomyces cerevisiae 72.0

Candida albicans 45.9

Microbiocidal activity of Microbiocidal activity of Aquagard-TAquagard-T

* Total available chlorine

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Test strainsPhenol

coefficiency

Staphylococcus aureus 209P 28.5

Salmonella pullorum 9-25 25.5

Erysipelothrix rhusiopathiae 16.3

Erysipelothrix rhusiopathiae fujisawa

16.3

Bactericidal activity of Bactericidal activity of Aquagard-TAquagard-T

Phenol coefficiency of Aquagard-T against bacteria

Page 13: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Disinfectants

SporeBacillus subtilis

ATCC9372

Bacillus (natto) BN

strain

B. Cereus RIMD

0206001

Cl. Perfringens Type B

NCTC3182Aspergillus

oryzae

Aquagard-T 1:152(5) 1:57(15) 1:380(5)1:950(15) 1:3,800(15) 1:3,420(15)

Iodine 1:10(30) <1:10(30) 1:10(15) <1:10 1:1,000(15)

Benzalkonium chloride 1:150(5) 1:100(5) 1:50(5)

1:100(5) <1:10 1:1,500(15)

Amphotericsurfactant 1:50(15) 1:20(5)

1:25(15)1:10(5)

<1:50(15) <1:10 1:1,000(15)

Chlorhexidine

1:200(5)1:300(15) 1:100(15) 1:10(5)

<1:50(15) <1:10 1:1,200(15)

Bactericidal activity of Bactericidal activity of Aquagard-TAquagard-T

Effectiveness of Aquagard-T against spore forming

bacteria

Effective dilution rate, ( ) : Exposure time

Page 14: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Test strains NaDCC NaOCl Remarks

Bacillus cereus

17.2 1,060>62

times

Bacillus subtilis

30.9 1,510>49

times

Bactericidal activity of Bactericidal activity of Aquagard-TAquagard-T

The sporicidal activity of disinfectants

Page 15: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Adenovirus

IBD virusILT

virusND

virus

NaDCC ○ ○ ○ ○

Iodine × ○ ○ ○

Benzalkonium chloride

× × ○ ○

Virucidal activity of Aquagard-TVirucidal activity of Aquagard-T

Virucidal activity against poultry viruses

○ : inactivated, × : not inactivated

Page 16: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

FMDvirus

Adeno

virus

JE viru

s

TGEvirus

Aujeszky’s disease

virus

Rota virus

HC virus

NaDCC ○ ○ ○ ○ ○ ○ ○

Iodine ○ × × × ○ × ○

Virucidal activity of Aquagard-TVirucidal activity of Aquagard-T

Virucidal activity against pig viruses

○ : inactivated, × : not inactivated

Page 17: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Test fungi MIC (mcg/ml) of Aquagard-T

Candida albicans 2.6

Candida krusei 26.3

Aspergillus niger 263.2

Aspergillus fumigatus 263.2

Penicillium citrinum 263.2

Trichophyton verrucosum 263.2

Microsporum canis 263.2

Trichophyton mentagrophytes 263.2

Fungicidal activity of Fungicidal activity of Aquagard-TAquagard-T

Page 18: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

DisinfectantsChlorine

contents or dilution rate

Elapsed days (day)

0 1 3 5

Aquagard-T 418ppm - - - 2.0×103

NaOCl 418ppm - - 2.4×105 1.7×105

Quaternary ammonium chloride 1:200 - - 7.0×102 8.3×105

Iodine 1:250 - - 4.0×101 7.0×103

Orthodichlorobenzene 1:250 - 2.0×103 7.0×103 8.7×103

Control - - 5.0×104 2.0×108 3.2×107

The efficacy test scopeThe efficacy test scope

Total bacterial colony counts on foot bath in entrance of farm

Unit : CFU/ml, - : <1×101CFU/ml

Page 19: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Bactericidal activityBactericidal activity

• Method : According to regulation of NVRQS • Experiment : Research Institute for Veterinary Science in Konkuk

Univ.• Results :

DiseaseCondition

Light waterOrganic

substance

Salmonella spp. 1:7,200 1:540

Brucella spp. 1:3,500 1:400

Streptococcus spp. 1:8,000 1:720

Page 20: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Virucidal activityVirucidal activity• Method : According to regulation of NVRQS • Experiment : Research Institute for Veterinary Science in

Gyeongsang National Univ. and Cheonbuk National Univ.• Results :

DiseaseCondition

Light waterOrganic

substance

Hog cholera virus 1:12,000 1:1,000

PRRS virus 1:12,500 1:750

New castle virus 1:9,000 1:1,000

Avian Influenza Virus 1:15,000 1:500

Avian Pneumovirus 1:700 1:50

Inclusion Hepatitis virus 1:500 1:100

Page 21: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

• Each tablet (13g) contains

5g of Sodium dichloroisocyanurate(= 3g of available chlorine)

and

Component A(effervescent agent)

Component B (pH controlling agent)

Composition of Aquagard-TComposition of Aquagard-T

Page 22: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

• Disinfection of virus and bacteria in livestock housing, farms (floor, wall), facilities and equipment, the animal body

• Drinking water treatment

• Teat dip or spray (mastitis prevention)

• Disinfection of pathogen – General bacteria (Salmonella spp.), Brucella spp.,

Streptococcus spp. and so on.

– Foot and Mouth Disease virus, Hog Cholera virus, PRRS virus, Newcastle Disease virus, Avian Influenza Virus, Avian Pneumovirus, Inclusion Body Hepatitis virus and so on

Application of Aquagard-TApplication of Aquagard-T

Page 23: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Use of Aquagard-TUse of Aquagard-T(Bacteria)(Bacteria)Recommended Dilution Rate

Disinfection Target

LowContamination Group

HighContamination Group

Livestock building, the surface of the animal's

body, equipment, General automobiles

The Floor of the Livestock building, Manure,

the body of the animal (dead or alive),

Automobiles/Vehicles

General Bacteria(Salmonella spp.)

1:7,200(1tablet per 93L of water)

1:540(1tablet per 7L of water)

Brucella spp.1:3,500

(1tablet per 45L of water)1:400

(1tablet per 5L of water)

Streptococcusspp.

1:8,000(1tablet per 104L of water)

1:720(1tablet per 9.3L of water)

* Dilution rate is the most effective dilution rate of results of determination of the efficacy of disinfectant against general bacteria and specific pathogen.

Page 24: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Use of Aquagard-TUse of Aquagard-T(Virus)(Virus)

Recommended Dilution Rate

Disinfection Target

Low Contamination Group High Contamination Group

Livestock building, the surface of the animal's body, equipment,

General automobiles

The Floor of the Livestock building, Manure, the body of

the animal (dead or alive), Automobiles/Vehicles

Hog Cholera virus1:12,000

(1 tablet per 156L of water)1:1,000

(1 tablet per 13L of water)

PRRS virus1:12,500

(1 tablet per 163L of water)1:750

(1 tablet per 9.7L of water)

ND virus1:9,000

(1 tablet per 117L of water)1:1,000

(1 tablet per 13L of water)

Avian Influenza Virus

1:15,000(1 tablet per 195L of water)

1:500(1 tablet per 6.5L of water)

Avian Pneumovirus

1:700(1 tablet per 9L of water)

1:50(1 tablet per 650ml of water)

Inclusion body hepatitis virus

1:500(1 tablet per 6.5L of water)

1:100(1 tablet per 1.3L of water)

* Dilution rate is the most effective dilution rate of results of determination of the efficacy of disinfectant against general bacteria and specific pathogen.

Page 25: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Use of Aquagard-TUse of Aquagard-T(Water Treatment)(Water Treatment)

• Dissolve Aquagard-T in water tank every other day or

every day if necessary.

• Dilute 1 tablet per 500 ~ 750 L of drinking water

according to water quality and farm condition.

Page 26: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Use program for poultryUse program for poultry

• Poultry houses and facilities - Thorough cleaning with water - Spray Aquagard-T solution not less than 2 times

before placement of chicks. - Spray Aquagard-T solution during growing period if necessary.

Page 27: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Use program for poultryUse program for poultry

• Foot bath - For disinfect boots by dipping before entering

each house, replace the Aquagard-T solutions every 5 days or sooner when soiled by heavy use.

• Transport - For prevention of disease transmission through

trucks and crates by disinfecting them with Aquagard-T.

- Use in wheel baths and renew every 5 days or according to volume of traffic.

Page 28: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Use program for dairyUse program for dairy

• Dairy houses and facilities - Thorough cleaning with water - Spray Aquagard-T solution, eliminate all

bacteria, viruses and fungi.

Page 29: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Use program for dairy to prevent Use program for dairy to prevent MastitisMastitis

• Preparation of disinfection– Dissolve 1 Aquagard-T tablet per 1L

of water and move to dipping cup or sprayer for disinfection.

• Prior to milking - Clean milk starts with clean teats. - Teat and udder spraying will remove

all bacteria, viruses and fungi.

• After milking - Teat dip or spraying will decontaminate the teats and

prevent mastitis

Page 30: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Use program for MilkingUse program for Milking

1) Disinfection prior to milking- Removal of contaminant on teat

Dipping method Spray method

2) Removal of disinfectant- With clean and disinfected towel

3) Prior to milking- More than 5 times

4) Massage and final cleaning

- With clean and disinfected towel

5) Attaching the milking mashing- Vacuum-blocking

6) Disinfection after milking- Prevention of teat canal

Page 31: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Package of Aquagard-TPackage of Aquagard-T

• 10 tablets / plastic container• 100 tablets (1.3kg) / plastic container• 2,000 tablets / carton

Page 32: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Storage and shelf-life of Storage and shelf-life of Aquagard-TAquagard-T

• Storage Keep under cool and dry conditions

and protect from light

• Shelf-life 24 months after manufacturing

Page 33: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Efficacy Test ReportEfficacy Test Report

Page 34: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Effect of Aquagard-T on E. Coli in WaterEffect of Aquagard-T on E. Coli in Water

Page 35: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

Precautions of Aquagard-TPrecautions of Aquagard-T

• Keep out of reach of children.• Do not dissolve in strong alkali (over pH 10) or

acidic (below pH 3) solution.• Do not exceed the recommended dosage.• For 5 days, from before 2 days to after 2 days

of vaccination, do not disinfect drinking water.• Do not place near fire or strong inflammables.• Do not place in metallic vessel more than 2

hours.• In case of drink diluted solution, immediately

seek for medical advice.

Page 36: A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern.

SUNGIL PHARMASUNGIL PHARMAA concern ofA concern of