A. Converse UW - Madison Positron Emission Tomography (PET) at Madison Alexander K. Converse 1,...
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A. Converse UW - Madison Positron Emission Tomography (PET) at Madison Alexander K. Converse 1 , Andrew D. Roberts 2 , Robert J. Nickles 1 , Paul M. DeLuca, Jr. 1 1 University of Wisconsin - Madison 2 University of Manchester Willy Fest, Madison, 10 June 2005
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Transcript of A. Converse UW - Madison Positron Emission Tomography (PET) at Madison Alexander K. Converse 1,...
A. Converse UW - Madison
Positron Emission Tomography (PET) at Madison
Alexander K. Converse1, Andrew D. Roberts2, Robert J. Nickles1, Paul M. DeLuca, Jr.1
1University of Wisconsin - Madison
2University of Manchester
Willy Fest, Madison, 10 June 2005
A. Converse UW - Madison
Technology
A. Converse UW - Madison
Applications
A. Converse UW - Madison
# studies/yr 100 10 1
‘70 2000
EN TandemNoblesse of Willy, HTR, HHB, PQ
11 MeV cyclotron
NEC tandem
5FU 15O, 13NH3,CH318F,
FDG,. -> several dozen PET tracers in research use
benchmarksFDG goes commercial
35 years of PET tracer production at Wisconsin
pipeline ECAT II CTI 933 GE Advance µPET, PET/CT
Time
A. Converse UW - Madison
Space
NPMPVA
CSWC
8 uL
100 uL
5000 uL
A. Converse UW - Madison
Tracers
Basics
Blood flow [15O]H2O, [17F]CH3F
Blood volume [11C]CO
Oxygen extraction [15O]O2
Glucose metabolism [18F]FDG
pH [11C]CO2
Bone [18F]F-
Dopamine
Synthesis [18F]FDOPA, [18F]FMT
Transporters [11C]MP, [11C]DTBZ
Receptors D1 [11C]SCH23390, D2 [11C]RAC, [18F]FAL,
[18F]desFAL
Serotonin
Transporter [18F]ADAM
Receptors 1A [18F]MPPF
More…
Tumors [18F]Iressa, [124I]NM404, [62Cu]ATSM, [18F]FLT
Microglial activation [11C]PK11195
Anesthesia [18F]halothane
Phantoms 90Y, 76Br, 64Cu, 34mCl
A. Converse UW - Madison
Tracer Kinetics
Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ (1984) A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Annals of Neurology 15:217-227
A. Converse UW - Madison
Dopamine Release
0%
5%
10%
15%
20%
25%
30%
35%
AW25* AV51 AW21 AW92
- B
P
ca
Cd
Pu
0
0.1
0.2
0.3
0.4
0.5
0.6
0 20 40 60 80 100
time (min)
Ci/c
cStr Cb
pre post
b
amph
uC
i/cc
-B
P
A. Converse UW - Madison
Dopaminergic Neuromodulation
tissue (bound)
Cf
plasma tissue (free)
kf1
kf2
Clp Cl
F
kl1
kl2
ClB
kl3
kl4
flow
ligand
Cfp
tissue (bound)
Cf
plasma tissue (free)
kf1
kf2
Clp Cl
F
kl1
kl2
ClB
kl3
kl4
flow
ligand
Cfp
c
time (s)
acti
vity
a
time (s)ac
tivi
ty
d
time (s)
acti
vity
b
time (s)
acti
vity
c
time (s)
acti
vity
c
time (s)
acti
vity
a
time (s)ac
tivi
ty
a
time (s)ac
tivi
ty
d
time (s)
acti
vity
d
time (s)
acti
vity
b
time (s)
acti
vity
b
time (s)
acti
vity
A. Converse UW - Madison
PET People
Jerry Nickles, Ph.D.Onofre DeJesus, Ph.D.Dhanabalan Murali, Ph.D.Leo Flores II, M.D., Ph.D. Alex Converse, Ph.D.Jon Nye, M.S.Miguel Avila-Rodriguez, M.S.Rachel Bartlett, B.S.Corinne Dallas, B.S.Nick Vandehey, B.S. David Dick, PhD ('04)
Michael Schueller, PhD ('01)Michael Taylor, PhD, MD ('98) Tim Mulnix, PhD ('98) Andy Roberts, PhD ('95) Terry Oakes, PhD ('95) Brad Christian, PhD ('94) Chuck Martin, PhD ('92) Marty Satter, PhD ('91) John Sunderland, PhD ('90) John Votaw, PhD ('88) Gary Hutchins, PhD ('84) Margaret Daube-Witherspoon, PhD ('83) Richard Hichwa, PhD ('81) Mark Madsen, PhD ('80)
Dave Abbott, DVMJesus Bianco, M.D.Richard Davidson, Ph.D.Paul DeLuca, Ph.D.Ian Duncan, DVMSean Fain, PhDJim Holden, Ph.D.Ned Kalin, M.D.Steve Kornguth, Ph.DRoss Levine, M.D.Scott Perlman, M.D.Joanne Paul-Murphy DVMMary Schneider, Ph.D.Steve Shelton, Ph.D.Charles K Stone, M.D.Patrick Turski, M.D.Tom Wallhaus, M.D.Jamey Weichert, PhDJim Zagzebski, Ph.D.
A. Converse UW - Madison
Willy
Enthusiasm
Focus
Rigor
“Do the simple experiment first”
