A computational model for the formation of lamin-B mitotic spindle envelope and matrix

by Changji Shi, Wilbur E. Channels, Yixian Zheng, and Pablo A. Iglesias

Interface FocusVolume 4(3):20130063

June 6, 2014

©2014 by The Royal Society

Reactions included in the model.

Changji Shi et al. Interface Focus 2014;4:20130063

©2014 by The Royal Society

Geometric description of the model.

Changji Shi et al. Interface Focus 2014;4:20130063

©2014 by The Royal Society

MT polymerization gives rise to two asters which are pushed away by the MT-based motors.

Changji Shi et al. Interface Focus 2014;4:20130063

©2014 by The Royal Society

The complete model shows that a lamin shell is formed around the MT spindle region.

Changji Shi et al. Interface Focus 2014;4:20130063

©2014 by The Royal Society

Effect of RanGTP on the production of the spindle.

Changji Shi et al. Interface Focus 2014;4:20130063

©2014 by The Royal Society

Comparison of two putative networks for lamin matrix formation.

Changji Shi et al. Interface Focus 2014;4:20130063

©2014 by The Royal Society

Sensitivity analysis for various model parameters.

Changji Shi et al. Interface Focus 2014;4:20130063

©2014 by The Royal Society