A comparison of human papillomavirus genotypes among HIV seropositive and seronegative Mexican...

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Page 1: A comparison of human papillomavirus genotypes among HIV seropositive and seronegative Mexican women: a cross-sectional survey at a tertiary care hospital

Meeting Abstracts

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Published OnlineNovember 3, 2013

National Institute of Perinatology, Mexico City, Mexico (S Flores PhD, R Figueroa MD)

Correspondence to: Dr R Figueroa, National Institute of Perinatology. Montes Urales 800, Lomas Virreyes, CP 11,000, Mexico City, DF, Mexico [email protected]

A comparison of human papillomavirus genotypes among HIV seropositive and seronegative Mexican women: a cross-sectional survey at a tertiary care hospitalS Flores, R Figueroa

AbstractBackground HIV-positive women have a higher risk of developing cervical cancer than do women who are HIV negative. The frequency of HIV/human papillomavirus (HPV) co-infection varies according to geographical area and population. The aim of this study was to assess the frequencies of HPV genotypes among HIV-positive and HIV-negative Mexican women.

Methods We did a cross-sectional survey among 42 HIV-positive women and 36 HIV-negative women attending the National Institute of Perinatology in Mexico City, for pregnancy and/or gynaecological care. Informed consent was obtained from participants, who were selected as a convenience sample from women with previous history of HPV infection, between January, 2012, and December, 2012. The protocol was approved by the Institutional Review Board (number 212250-22761). The two groups showed no diff erences in their demographic and sexual risk profi les, except for history of sexually transmitted infections. Cervical samples were collected from all women, and HPV detection and genotyping were done with the linear array HPV genotyping test (Roche, Branchburg, NJ, USA). Descriptive statistics and squared χ² test were done as appropriate. Confounding variables were controlled by stratifi ed analysis.

Findings 177 HPV genotypes were detected, 112 (63·3%) in the HIV-positive group and 65 (36·7%) in the HIV-negative group (p=0·03). HPV detection rates were 2·6 versus 1·8 genotypes per patient (p=0·02) for HIV-positive and HIV-negative women, respectively. High-risk genotypes were more frequent among HIV-positive women than among HIV-negative women (53 [47·3%] vs 19 [29·2%]; p=0·02). Genotypes HPV-52, HPV-59, HPV-16, and HPV-31 were the most frequent among HIV-positive women, whereas HPV-52 and HPV-51 were most frequently found in HIV-negative women. More than one HPV genotype was found in 27 (64·3%) HIV-positive women and 22 (61·1%) HIV-negative women (p=0·9). HIV-positive women showed a two-fold greater risk for acquisition of high-risk HPV infection than did HIV-negative women (odds ratio 2·17 [95% CI 1·08–4·40]). Antecedents of sexually transmitted infections were acknowledged by 23 (54·7%) HIV-positive and six (16·6%) HIV-negative women. No associations between sexually transmitted infections and HPV infection were found. The stratifi ed analysis revealed an increase in risk of acquisition of high-risk HPV infection in HIV-positive women adjusted by the antecedent of previous sexually transmitted infection (odds ratio 3·72 [95% CI 1·7–6·3]).

Interpretation HIV-positive women are prone to developing cervical cancer, possibly due to the higher frequency of HPV genotypes they carry, and predominant infection with high-risk genotypes. History of previous sexually transmitted infection should be taken into account when assessing the risk of HPV co-infection among HIV-positive women.

Funding None.

Contributors RF did the methodological design and statistical analysis. SF did the HPV genotyping. Both authors have seen and approved the fi nal version of the abstract.

Confl icts of interestWe declare that we have no confl icts of interest.