A Case Study Of A Man With Leukemia
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Transcript of A Case Study Of A Man With Leukemia
A Case Study Of A Man With Leukemia
A Chromosomal Translocation is Discovered
PDGFR-beta null mutants are embryonically lethal
PDGFR alpha and beta have different downstream consequences
AngiogenesisLymphocytesMetabolism
The PDGF receptor can activate many Different Pathways
The ETV6-PDGFRB fusion causes constitutive dimerization
Chronic Myelomonocytic Leukemia (CMML)Is a Cancer of the Monocytes
Sources
• http://genesdev.cshlp.org/content/8/16/1888.full.pdf+html• http://ac.els-cdn.com/0092867494903220/1-s2.0-009286749
4903220-main.pdf?_tid=a610a68e-95bd-11e2-a4ae-00000aab0f01&acdnat=1364265434_56d0ab4e796e33281e0ce6e81475c3b2
• http://www.cancer.gov/cancertopics/pdq/treatment/mds-mpd/HealthProfessional/page2
• http://clincancerres.aacrjournals.org/content/16/12/3094.full• http://www.sciencedirect.com/science/article/pii/S00256196
11612378#
• http://www.cancer.org/cancer/leukemia-chronicmyelomonocyticcmml/detailedguide/leukemia-chronic-myelomonocytic-diagnosed
• http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003794