A case of primary signet ring cell carcinoma of the lung
1
Absrracfs / Lung Cancer 12 (1995) 265-329 A case of primary signet ring cell carcinomaof the lung Choi WI, Sohn JH, Kwon OY, Hur JS, Hwang JS, Han SB et al. Deparbnenl o/ In&nmIMedicine, School c$Uedicme, Keimymg Umiwsi@, Taegu. Tubzc Rspir Dis 1994,4 1562-7. Signet ring cell carcinoma has been previously described in many organs, mast frequently in the stomach, and rarely in the colon, rectum, gallbladder, pancnas, breast, nadstd cavity, prostate, urinary bladder end ureter. Sign& ring cell osrcinomas in the lung, especially, when examined by small biopsies are generally believed to be m&static. This case was diagnosed by brunchoscopic biopsy. We also examined various organs by noninvasive method, including UGI series. barium enema and abdomen CT scan, but all studies were. normal. Patient received cisplatin and etoposidc combination chemotherapy followed by local radiotherapy as a primary non-small cell lung cancer. Patient died of his disease 6 months after diagnosis. Now we report a case of primary signet ring cell carcinoma of the lung. Bmoehogeoieenrcimmr UtilityofCTintbeevaluationafp~~~ suspected lesions Primack SL, Kyung, SL, Logan PM, Miller RR, Muller NL. Deparbnent of Radiology Vrcouwr HoJpirol. Health Sciences Centi, 85.5 W I21h Ave. Vancouxy EC VSZ IM9. Radiology 1994;193:795-800. Purpose: To assess the utility of computed tomography (CT) in the evaluation of suspected bronchogcnic careinoms. Molerials anti Methods: CT scans were reviewed of 362 patients who had undergone CT for suspected bmnchogenic carcinoma. Resw/f.r: CT fmdings of 275 patients were consistent with bronchogenic carcinoma. Sixty-five tumors were deemed unrescctablc on the basis of CT findings, 21 were deemed unresectable on the basis of CT tindings and poor surgical tisk, 26 proved to be benign, six were mctastatic disease from an extrathoracic primary tumor, end 157 wcrc potentially resectable bronchogenic carcinoma. Surgical mcdiastinal nodal sampling enabled documentation of metastases in 60 of 159 patients. According to nodal station, the sensitivity of CT for metsstases was 67% for nodes measured in the long axis and 58% for nodes measured in the short axis; specificity was 56% and 86%. respectively. Conclusion: CT can be used to confirm or exclude the presence of bronchogenic carcinoma and to obviate thoracotomy. The spcciticity of CT is limited, and a histologic diagnosis or follow-up evaluation is necessary. CT has limited value m staging mediastinal lymph nodes. BronchidoalvedarceU carcinoma in solitary pulmonary noduk(SPN) with cabitary lesiaa Shim JJ, Lee JG, Cho JY, Ihn KH, Yoo SH, Kang KH. Departmenf ofInternal Medicine, College of Medicine. Korea Universi@, Seoul. Tuberc Rcspir Dis I994;41:435-9. Lung cancer is the most common fatal malignant lesion in both sexes. Detection of the solitary pulmonary nodule is important because surgical series up to a third of solitary pulmonary nodules arc bronchogcnic carcinoma. Bmnchioloalveolar cell carcinoma is a ran primary lung cancer and surgery is treatment of choice in brochioloalvcolar cell carcinoma. WC expericnccd a case of bronchioloalveolar cell carcinoma in solitary pulmonary nodule with c&tory lesion in chest CT scan, which is an uncammon finding in brochioloalveolar cell carcinoma. GindvplmetPJtaPispsRrstsi~o~~~uadaterrntintedeveiaomaotthe lung Pcris K, Ccrroni L, Paoloni hi, Margiotta V, Chimcnti S. Deporhnenr o/ Demwtoiogy. Universi& of L Xquila. Collemaggio, 67100 L. Xquila. J Dcmtatal surg Oncol l994;20:407-9. Bac&xmd: Mctastascs of internal tumors to the oral cavity are unusual and involve in most cases maxilla and mandible. M&stases to the gingival sotl tissue an cx&mely rare. Objective: To report a case of gingival metastasis from undifferentiated carcinoma of the lung. Methods: The lesion was removed and hematoxylin and cosin sections were performed. Immunohistochcmicel investigations were performed with a standard three-step immunopemxidase technique on formalin-fixed, parafin-cmbedded tissue sections using anti-CEA, anti-S-100,HMB45,andanti-LCA antibodies.Rmdrs: Basedon clinicopathologic findings, a diagnosis of metastasis from undifferentiated carcinoma of the lung was established. Further investigations revealed a primary undifferentiated carcinoma of the lung. Conclusion: Metastasis from internal neoplasms should be considered among other differential diagnoses in the evaluation of gingival tumors. In the present case, onset of oral lesion preceded detection of the primary lung tumor. Complete screening of the patient should therefore follow a diagnosis of gingival neoplasm of unknown origin. Cliiical significance of S-phase fraction in small cell lung cancer Kim HJ, Jung BH, Jmng ET. Deparbnen~ of Internal Medicine. SDA Hospilol, Seoul. Tukcrc Respir Dis 1994;41:363-71. Bockground: DNA content analysis of human solid tumor is now widely performed by flow cytometric tidy One of the most inbzrcsting and potentially important observation in this field is that pmlifemtive activity (S-phase fraction of cell cycle) may profoundly affect the prognosis. Merhod: S-phase fraction (SPF) have beam measured by flow cytometric method using tumor cells isolated from paraffin embedded tissue. To evaluate the prognostic significance, SPF of small lung cancer cell was assessed in 42 patients who died after receiving anticancer chemotherapy. Resulfs: I) Mm survival time of patients with small cell lung cancer was 190 (+ 156) days. Survival times were shortened, when TNM stage and PS scale were. advanced. 2) Mean value of SPF of patients with small cell lung cancer was 27.4 (i S.S)?/.. SPF had nothing to do with advance of TNM stage and PS scale. 3) In each identical TNM stage. there were no statistic significnncc between SPF and survival times. 4) There was r~ tendency like that higher SPF, bcttcr chemotherapeutic response. Conc/usion: We could not find statistic significance behvecn SPF and survival times, but SPF was .s goad predictive factor for chemotherapeutic response. Inter-rel~pshetweasioglccastn~tmits’mctahdi~ andrestiug cne~eqenditurein wci@MoaingpatimtswtthsmaU~ lungcancer. Effects of mcthionioc supply and chemotherapy Scngclov H, Hansen OP, Simonscn L, Bulow J, Nielsen OJ, Ovcscn L. Deporfmenf of Medicine, Bispebjerg Hospi:al. Bispebjwg Bakke 23, DK-2400 Copenhagen. Eur J Cnacer Part A Gen Top l994;30:1616-20. The one-carbon unit metabolism was investigated in 8 weight-losing patients with small cell carcinoma of the lung (SCLC). At diagnosis, 6 of the 8 patients had elevated formiminoglutamic acid (FIGLU) ncreticm a&r a histidinc load, suggesting a lack of one-carbon units. In accordance, II significant decrease of FIGLU excretion was observed in the patients after oral administration of DL- methioninc for 4 days. The elevated FIGLU excretion was positively correlated to weight loss prior to diagnosis and negatively comlated to serum albumin at time of diagnosis. After 3 months of combination chemotherapy, FIGLU excretion was reduced in all @icnts except I, who had progressive disease. Despite the elevated FIGLU excretions, all patients had normal blood folatc levels. The resting enc%y expenditure (REE) was recorded in 7 patients, and a significant, postivc correlation was observed between pretreatment FIGLU excretion and REE, although the REE measunxl in this group of patients was within the normal range. These data demonstrate an increased demand of ‘active’ one-carbon units in energy consumption in a group of weight-losing cancer patients. The one-carbon unit deficit was reconditioned by oral administration of the one-carbon unit donor DGmcthioninc. Case report; metastasis of lung adenocarciooma simulating a fair meningioma Akiyama Y, Inagawa S, Koide T, Kojima M. Kumai J, Nishikawa M et al. Deporbnent of Neumsurgcry. Hamamati Rosai Hospital, Hamamatsu. Jpn J Clin Radio1 1994;39:161 l-4. A 64-year+ld male who had no history of cancer admitted to our hospital presented with headache and seizure. CT and MRI revealed falcine tumor and it demonstrated many characteristics of falx meningioma. But histological finding revealed metastasis of lung adcnocarcinoma. Chest rwntgcnogram had already demonstrated occult abnormal shadow.
Transcript of A case of primary signet ring cell carcinoma of the lung
Absrracfs / Lung Cancer 12 (1995) 265-329
A case of primary signet ring cell carcinomaof the lung Choi WI, Sohn JH, Kwon OY, Hur JS, Hwang JS, Han SB et al. Deparbnenl o/ In&nmIMedicine, School c$Uedicme, Keimymg Umiwsi@, Taegu. Tubzc Rspir Dis 1994,4 1562-7.
Signet ring cell carcinoma has been previously described in many organs, mast frequently in the stomach, and rarely in the colon, rectum, gallbladder, pancnas, breast, nadstd cavity, prostate, urinary bladder end ureter. Sign& ring cell osrcinomas in the lung, especially, when examined by small biopsies are generally believed to be m&static. This case was diagnosed by brunchoscopic biopsy. We also examined various organs by noninvasive method, including UGI series. barium enema and abdomen CT scan, but all studies were. normal. Patient received cisplatin and etoposidc combination chemotherapy followed by local radiotherapy as a primary non-small cell lung cancer. Patient died of his disease 6 months after diagnosis. Now we report a case of primary signet ring cell carcinoma of the lung.
Bmoehogeoieenrcimmr UtilityofCTintbeevaluationafp~~~ suspected lesions Primack SL, Kyung, SL, Logan PM, Miller RR, Muller NL. Deparbnent of Radiology Vrcouwr HoJpirol. Health Sciences Centi, 85.5 W I21h Ave. Vancouxy EC VSZ IM9. Radiology 1994;193:795-800.
Purpose: To assess the utility of computed tomography (CT) in the evaluation of suspected bronchogcnic careinoms. Molerials anti Methods: CT scans were reviewed of 362 patients who had undergone CT for suspected bmnchogenic carcinoma. Resw/f.r: CT fmdings of 275 patients were consistent with bronchogenic carcinoma. Sixty-five tumors were deemed unrescctablc on the basis of CT findings, 21 were deemed unresectable on the basis of CT tindings and poor surgical tisk, 26 proved to be benign, six were mctastatic disease from an extrathoracic primary tumor, end 157 wcrc potentially resectable bronchogenic carcinoma. Surgical mcdiastinal nodal sampling enabled documentation of metastases in 60 of 159 patients. According to nodal station, the sensitivity of CT for metsstases was 67% for nodes measured in the long axis and 58% for nodes measured in the short axis; specificity was 56% and 86%. respectively. Conclusion: CT can be used to confirm or exclude the presence of bronchogenic carcinoma and to obviate thoracotomy. The spcciticity of CT is limited, and a histologic diagnosis or follow-up evaluation is necessary. CT has limited value m staging mediastinal lymph nodes.
BronchidoalvedarceU carcinoma in solitary pulmonary noduk(SPN) with cabitary lesiaa Shim JJ, Lee JG, Cho JY, Ihn KH, Yoo SH, Kang KH. Departmenf ofInternal Medicine, College of Medicine. Korea Universi@, Seoul. Tuberc Rcspir Dis I994;41:435-9.
Lung cancer is the most common fatal malignant lesion in both sexes. Detection of the solitary pulmonary nodule is important because surgical series up to a third of solitary pulmonary nodules arc bronchogcnic carcinoma. Bmnchioloalveolar cell carcinoma is a ran primary lung cancer and surgery is treatment of choice in brochioloalvcolar cell carcinoma. WC expericnccd a case of bronchioloalveolar cell carcinoma in solitary pulmonary nodule with c&tory lesion in chest CT scan, which is an uncammon finding in brochioloalveolar cell carcinoma.
GindvplmetPJtaPispsRrstsi~o~~~uadaterrntintedeveiaomaotthe lung Pcris K, Ccrroni L, Paoloni hi, Margiotta V, Chimcnti S. Deporhnenr o/ Demwtoiogy. Universi& of L Xquila. Collemaggio, 67100 L. Xquila. J Dcmtatal surg Oncol l994;20:407-9.
Bac&xmd: Mctastascs of internal tumors to the oral cavity are unusual and involve in most cases maxilla and mandible. M&stases to the gingival sotl tissue an cx&mely rare. Objective: To report a case of gingival metastasis from undifferentiated carcinoma of the lung. Methods: The lesion was removed and hematoxylin and cosin sections were performed. Immunohistochcmicel investigations were performed with a standard three-step immunopemxidase technique on formalin-fixed, parafin-cmbedded tissue sections using anti-CEA, anti-S-100,HMB45,andanti-LCA antibodies.Rmdrs: Basedon clinicopathologic
findings, a diagnosis of metastasis from undifferentiated carcinoma of the lung was established. Further investigations revealed a primary undifferentiated carcinoma of the lung. Conclusion: Metastasis from internal neoplasms should be considered among other differential diagnoses in the evaluation of gingival tumors. In the present case, onset of oral lesion preceded detection of the primary lung tumor. Complete screening of the patient should therefore follow a diagnosis of gingival neoplasm of unknown origin.
Cliiical significance of S-phase fraction in small cell lung cancer Kim HJ, Jung BH, Jmng ET. Deparbnen~ of Internal Medicine. SDA Hospilol, Seoul. Tukcrc Respir Dis 1994;41:363-71.
Bockground: DNA content analysis of human solid tumor is now widely performed by flow cytometric tidy One of the most inbzrcsting and potentially important observation in this field is that pmlifemtive activity (S-phase fraction of cell cycle) may profoundly affect the prognosis. Merhod: S-phase fraction (SPF) have beam measured by flow cytometric method using tumor cells isolated from paraffin embedded tissue. To evaluate the prognostic significance, SPF of small lung cancer cell was assessed in 42 patients who died after receiving anticancer chemotherapy. Resulfs: I) Mm survival time of patients with small cell lung cancer was 190 (+ 156) days. Survival times were shortened, when TNM stage and PS scale were. advanced. 2) Mean value of SPF of patients with small cell lung cancer was 27.4 (i S.S)?/.. SPF had nothing to do with advance of TNM stage and PS scale. 3) In each identical TNM stage. there were no statistic significnncc between SPF and survival times. 4) There was r~ tendency like that higher SPF, bcttcr chemotherapeutic response. Conc/usion: We could not find statistic significance behvecn SPF and survival times, but SPF was .s goad predictive factor for chemotherapeutic response.
Inter-rel~pshetweasioglccastn~tmits’mctahdi~ andrestiug cne~eqenditurein wci@MoaingpatimtswtthsmaU~ lungcancer. Effects of mcthionioc supply and chemotherapy Scngclov H, Hansen OP, Simonscn L, Bulow J, Nielsen OJ, Ovcscn L. Deporfmenf of Medicine, Bispebjerg Hospi:al. Bispebjwg Bakke 23, DK-2400 Copenhagen. Eur J Cnacer Part A Gen Top l994;30:1616-20.
The one-carbon unit metabolism was investigated in 8 weight-losing patients with small cell carcinoma of the lung (SCLC). At diagnosis, 6 of the 8 patients had elevated formiminoglutamic acid (FIGLU) ncreticm a&r a histidinc load, suggesting a lack of one-carbon units. In accordance, II significant decrease of FIGLU excretion was observed in the patients after oral administration of DL- methioninc for 4 days. The elevated FIGLU excretion was positively correlated to weight loss prior to diagnosis and negatively comlated to serum albumin at time of diagnosis. After 3 months of combination chemotherapy, FIGLU excretion was reduced in all @icnts except I, who had progressive disease. Despite the elevated FIGLU excretions, all patients had normal blood folatc levels. The resting enc%y expenditure (REE) was recorded in 7 patients, and a significant, postivc correlation was observed between pretreatment FIGLU excretion and REE, although the REE measunxl in this group of patients was within the normal range. These data demonstrate an increased demand of ‘active’ one-carbon units in energy consumption in a group of weight-losing cancer patients. The one-carbon unit deficit was reconditioned by oral administration of the one-carbon unit donor DGmcthioninc.
Case report; metastasis of lung adenocarciooma simulating a fair meningioma Akiyama Y, Inagawa S, Koide T, Kojima M. Kumai J, Nishikawa M et al. Deporbnent of Neumsurgcry. Hamamati Rosai Hospital, Hamamatsu. Jpn J Clin Radio1 1994;39:161 l-4.
A 64-year+ld male who had no history of cancer admitted to our hospital presented with headache and seizure. CT and MRI revealed falcine tumor and it demonstrated many characteristics of falx meningioma. But histological finding revealed metastasis of lung adcnocarcinoma. Chest rwntgcnogram had already demonstrated occult abnormal shadow.
