A Call to Action: Prevention and Early Detection of Colorectal Cancer (CRC)
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Transcript of A Call to Action: Prevention and Early Detection of Colorectal Cancer (CRC)
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A Call to Action:Prevention and Early
Detection of Colorectal Cancer (CRC)
A Call to Action:Prevention and Early
Detection of Colorectal Cancer (CRC)
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5 Key Messages 5 Key Messages
Screening reduces mortality from CRC All persons aged 50 years and older should begin
regular screening High-risk individuals may need to begin
screening earlier Colorectal cancer can be prevented Insufficient evidence to suggest a best test;
any screening test is better than no screening test
Screening reduces mortality from CRC All persons aged 50 years and older should begin
regular screening High-risk individuals may need to begin
screening earlier Colorectal cancer can be prevented Insufficient evidence to suggest a best test;
any screening test is better than no screening test
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Making the CaseMaking the Case
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Burden of DiseaseBurden of Disease
Second leading cause of cancer death in US Both women and men All races American Cancer Society 2003 estimates:
• 147,500 new cases• 57,100 deaths
Treatment costs over $6.5 billion per year• Among malignancies, second only to breast
cancer at $6.6 billion per year
Second leading cause of cancer death in US Both women and men All races American Cancer Society 2003 estimates:
• 147,500 new cases• 57,100 deaths
Treatment costs over $6.5 billion per year• Among malignancies, second only to breast
cancer at $6.6 billion per year
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0
100
200
300
400
500
600
30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+
Age Group
Rate
per
100
,000
Incidence Male
Incidence Female
Mortality Male
Mortality Male
Cancers of the Colon and Rectum (Invasive):Average Annual Age-Specific SEER Incidence and U.S. Mortality Rates By Gender, 1995-1999
Source: SEER Cancer Statistics Review, 1973-1999
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Colorectal Cancer (CRC) Colorectal Cancer (CRC)
Sporadic Sporadic (average risk) (65%–(average risk) (65%–85%)85%)
FamilyFamilyhistoryhistory(10%–30%)(10%–30%)
Hereditary nonpolyposis Hereditary nonpolyposis colorectal cancer colorectal cancer
(HNPCC) (5%)(HNPCC) (5%)Familial adenomatous Familial adenomatous polyposis (FAP) (1%)polyposis (FAP) (1%)
Rare Rare syndromes syndromes
(<0.1%)(<0.1%)
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Natural HistoryNatural History
PolypPolypAdvanced Advanced
cancercancer
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Screening=Prevention & Early DetectionScreening=Prevention & Early Detection
Prevention = polyp removal
Decreased Incidence
Early Detection
Decreased Mortality
Prevention = polyp removal
Decreased Incidence
Early Detection
Decreased Mortality
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Colorectal Cancer Screening Guidelines for Average Risk Persons Age > 50Colorectal Cancer Screening Guidelines for Average Risk Persons Age > 50
U.S. Preventive Services Task Force, 1996• Updated 2002
American Cancer Society, 1997• Updated 2001
Interdisciplinary task force, 1997• To be updated 2002
U.S. Preventive Services Task Force, 1996• Updated 2002
American Cancer Society, 1997• Updated 2001
Interdisciplinary task force, 1997• To be updated 2002
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Screening MethodsScreening Methods
Annual Fecal Occult Blood Test (FOBT) Flexible Sigmoidoscopy every 5 years Annual FOBT + Flexible Sigmoidoscopy
every 5 years Colonoscopy every 10 years Double Contrast Barium Enema (DCBE)
every 5 years
Insufficient evidence for “best” test
Annual Fecal Occult Blood Test (FOBT) Flexible Sigmoidoscopy every 5 years Annual FOBT + Flexible Sigmoidoscopy
every 5 years Colonoscopy every 10 years Double Contrast Barium Enema (DCBE)
every 5 years
Insufficient evidence for “best” test
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FOBT testingFOBT testing
Three-card at home FOBT• Supported by trial data (Mandel 1993,
Hardcastle 1996, Kronburg 1996)
In-Office FOBT (not recommended)• Commonly done in practice (Nadel, NHIS,
2002)• No studies on CRC incidence or mortality• Less sensitive
Three-card at home FOBT• Supported by trial data (Mandel 1993,
Hardcastle 1996, Kronburg 1996)
In-Office FOBT (not recommended)• Commonly done in practice (Nadel, NHIS,
2002)• No studies on CRC incidence or mortality• Less sensitive
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FOBTFOBT
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FOBT: EvidenceFOBT: Evidence
Minn, 1993
Minn, 1999
UK, 1996
Denmark, 1996
Frequency
of TestingAnnual Biennial Biennial Biennial
Duration (years)
18 18 8 13
Slide rehydration
Yes Yes No No
% requiring colonoscopy
30% 30% 5% 5%
Mortality reduction
33% 21% 15% 18%
Incidence
reduction20% 17%
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FOBT: ImplementationFOBT: Implementation
Preparation Periodicity Provider capacity Follow-up
• Positive FOBT requires total colon exam• After a negative total colon exam, suspend annual
FOBT for 5 to 10 years• Negative FOBT requires repeat FOBT in 1 year
Preparation Periodicity Provider capacity Follow-up
• Positive FOBT requires total colon exam• After a negative total colon exam, suspend annual
FOBT for 5 to 10 years• Negative FOBT requires repeat FOBT in 1 year
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To Begin a Home FOBT Screening Program To Begin a Home FOBT Screening Program
You will need FOBT card kits Assigned roles for office staff
• Instructing and encouraging patients
• Developing cards
• Recording results
• Notifying patient and clinician
You will need FOBT card kits Assigned roles for office staff
• Instructing and encouraging patients
• Developing cards
• Recording results
• Notifying patient and clinician
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FOBT: Counseling Your PatientsFOBT: Counseling Your Patients
Explain exactly what to expect Don’t rely solely on instructions in kit Consider using a reminder system to
increase adherence
Explain exactly what to expect Don’t rely solely on instructions in kit Consider using a reminder system to
increase adherence
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Flexible SigmoidoscopyFlexible Sigmoidoscopy
Fiberoptic sigmoidoscopeFiberoptic sigmoidoscope
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Diagram of the Colon and RectumDiagram of the Colon and Rectum
Splenic
flexure
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Ongoing Flexible Sigmoidoscopy Randomized TrialsOngoing Flexible Sigmoidoscopy Randomized Trials
United Kingdom, Atkin– Once only sigmoidoscopy
Prostate, Lung, Colorectal,Ovarian, NCI– Sigmoidoscopy every 5 years with regular FOBT
United Kingdom, Atkin– Once only sigmoidoscopy
Prostate, Lung, Colorectal,Ovarian, NCI– Sigmoidoscopy every 5 years with regular FOBT
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Flexible Sigmoidoscopy: EvidenceFlexible Sigmoidoscopy: Evidence
Case-control study (Selby, 1992)• 59% mortality reduction in cancers within reach of
sigmoidoscope
• No mortality reduction in proximal cancers
• Primarily rigid sigmoidoscopes
Case-control study (Newcomb, 1992)• 79% mortality reduction in cancers within reach of
sigmoidoscope
• Primarily flexible sigmoidoscopes
Case-control study (Selby, 1992)• 59% mortality reduction in cancers within reach of
sigmoidoscope
• No mortality reduction in proximal cancers
• Primarily rigid sigmoidoscopes
Case-control study (Newcomb, 1992)• 79% mortality reduction in cancers within reach of
sigmoidoscope
• Primarily flexible sigmoidoscopes
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Flexible Sigmoidoscopy: ImplementationFlexible Sigmoidoscopy: Implementation
Preparation Periodicity Provider capacity Follow-up
• 5% to 15% will have a positive result• Positive result requires total colon exam• To biopsy or not?
– Which provider?– Which lesions?
• Negative result requires repeat flex sig in 5 years
Preparation Periodicity Provider capacity Follow-up
• 5% to 15% will have a positive result• Positive result requires total colon exam• To biopsy or not?
– Which provider?– Which lesions?
• Negative result requires repeat flex sig in 5 years
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To Begin an Office Flexible Sigmoidoscopy Screening ProgramTo Begin an Office Flexible Sigmoidoscopy Screening Program
You will need Trained clinician(s) Equipment
• Flexible sigmoidoscope • Light source• Suction device• Videoscreen preferable
Procedure room with bathroom nearby Assigned roles for office staff
• Patient scheduling and instruction• Equipment setup, cleaning, and maintenance• Assistance with procedure
Informed consent policy
You will need Trained clinician(s) Equipment
• Flexible sigmoidoscope • Light source• Suction device• Videoscreen preferable
Procedure room with bathroom nearby Assigned roles for office staff
• Patient scheduling and instruction• Equipment setup, cleaning, and maintenance• Assistance with procedure
Informed consent policy
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To Begin a Program of Referring to Another Facility for Flexible Sigmoidoscopy or Colonoscopy
To Begin a Program of Referring to Another Facility for Flexible Sigmoidoscopy or Colonoscopy
You will need Identified partner site Mechanism for direct referral for the procedure
• Includes pre-procedure testing and risk assessment
You will need Identified partner site Mechanism for direct referral for the procedure
• Includes pre-procedure testing and risk assessment
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Flexible Sigmoidoscopy: Counseling Your PatientsFlexible Sigmoidoscopy: Counseling Your Patients
Patient education material Expect moderate discomfort (like gas pain) Most patients report that it’s not as bad as they
thought it would be Sedation not routinely used Exam lasts approximately 20 minutes Patients able to return to work and don’t need a
ride
Patient education material Expect moderate discomfort (like gas pain) Most patients report that it’s not as bad as they
thought it would be Sedation not routinely used Exam lasts approximately 20 minutes Patients able to return to work and don’t need a
ride
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Flexible Sigmoidscopy + FOBTFlexible Sigmoidscopy + FOBT
No randomized trial examining reduction in death using combination of tests
Non-randomized trial (Winawer, 1992)• Sigmoidoscopy + FOBT vs. sigmoidoscopy
alone-- RR for death 0.56
No randomized trial examining reduction in death using combination of tests
Non-randomized trial (Winawer, 1992)• Sigmoidoscopy + FOBT vs. sigmoidoscopy
alone-- RR for death 0.56
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DCBEDCBE
How it works No studies examining reduction in
incidence or death using DCBE National Polyp Study (Winawer, 2000)
• Substudy compared DCBE to colonoscopy• Study limited to post-polypectomy surveillance• Sensitivity of DCBE compared to colonoscopy
– 32% for polyps <0.5cm– 53% for polyps 0.6-1cm– 48% for polyps >1cm
How it works No studies examining reduction in
incidence or death using DCBE National Polyp Study (Winawer, 2000)
• Substudy compared DCBE to colonoscopy• Study limited to post-polypectomy surveillance• Sensitivity of DCBE compared to colonoscopy
– 32% for polyps <0.5cm– 53% for polyps 0.6-1cm– 48% for polyps >1cm
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DCBE: ImplementationDCBE: Implementation
Preparation Periodicity Provider capacity Follow-up
• 5% to 15% will have a positive result• Positive result requires follow-up test, usually
colonoscopy• Negative result requires repeat DCBE every
5 to 10 years
Preparation Periodicity Provider capacity Follow-up
• 5% to 15% will have a positive result• Positive result requires follow-up test, usually
colonoscopy• Negative result requires repeat DCBE every
5 to 10 years
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To Begin a Barium Enema Screening ProgramTo Begin a Barium Enema Screening Program
You will need Identified experienced radiology site Assigned tasks for office staff
• Patient education
• Scheduling
You will need Identified experienced radiology site Assigned tasks for office staff
• Patient education
• Scheduling
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DCBE: Counseling Your PatientsDCBE: Counseling Your Patients
Patient education material Expect moderate discomfort Requires patient to change position during exam Sedation is not used Exam lasts about 20 to 30 minutes Patient could return to work but will have frequent
barium stools or constipation
Patient education material Expect moderate discomfort Requires patient to change position during exam Sedation is not used Exam lasts about 20 to 30 minutes Patient could return to work but will have frequent
barium stools or constipation
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ColonoscopyColonoscopy
Most accurate single test for detection of cancer and/or polyps
No prospective trials for effectiveness of screening colonoscopy
Indirect evidence of efficacy from FOBT trials National Polyp Study supports effectiveness of
polyp removal in cancer prevention Several colonoscopy feasibility studies ongoing
in screening populations
Most accurate single test for detection of cancer and/or polyps
No prospective trials for effectiveness of screening colonoscopy
Indirect evidence of efficacy from FOBT trials National Polyp Study supports effectiveness of
polyp removal in cancer prevention Several colonoscopy feasibility studies ongoing
in screening populations
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Colonoscopy: ImplemenationColonoscopy: Implemenation Preparation Periodicity Provider capacity Follow-up
• Positive result frequently treated during screening exam
• Negative result requires repeat colonoscopy in 10 years
Preparation Periodicity Provider capacity Follow-up
• Positive result frequently treated during screening exam
• Negative result requires repeat colonoscopy in 10 years
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Colonoscopy: Counseling Your PatientsColonoscopy: Counseling Your Patients
Patient education material Expect moderate discomfort with preparation, but
actual procedure performed under sedation Some patients experience discomfort during
recovery Exam lasts approximately 30 to 45 minutes Patient requires ride home after procedure and
usually misses a work day
Patient education material Expect moderate discomfort with preparation, but
actual procedure performed under sedation Some patients experience discomfort during
recovery Exam lasts approximately 30 to 45 minutes Patient requires ride home after procedure and
usually misses a work day
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Digital Rectal ExamDigital Rectal Exam
Not recommended as a stand-alone test for colorectal cancer screening
Case-Control study (Herrinton, 1995)• No difference in screening history between
cases and controls
Not recommended as a stand-alone test for colorectal cancer screening
Case-Control study (Herrinton, 1995)• No difference in screening history between
cases and controls
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Cost-Effectiveness (Cost/Year Life Saved)Cost-Effectiveness (Cost/Year Life Saved)
Mandatory motorcycle helmets $2,000 Colorectal cancer screening $25,000 Breast cancer screening $35,000 Dual airbags in cars $120,000 Smoke detectors in homes $210,000 School bus seat belts $1,800,000
Mandatory motorcycle helmets $2,000 Colorectal cancer screening $25,000 Breast cancer screening $35,000 Dual airbags in cars $120,000 Smoke detectors in homes $210,000 School bus seat belts $1,800,000
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0
20
40
60
80
100
Selected Tests
Per
cent
age
* Among appropriate populations that receive screening tests
FOBT
Endoscopy
FOBT and/or
Endoscopy
Mammography
Pap Test
Comparison of Colorectal Cancer Test Use with other Cancer Screening Tests, NHIS 2000*
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Choosing an Appropriate Screening StrategyChoosing an Appropriate Screening Strategy
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When Not To ScreenWhen Not To Screen
Don’t apply screening guidelines to symptomatic patients
Screening patients with terminal illness is unwarranted
Benefits of polyp detection decrease with advanced age
Don’t apply screening guidelines to symptomatic patients
Screening patients with terminal illness is unwarranted
Benefits of polyp detection decrease with advanced age
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Factors to Consider in Choosing a StrategyFactors to Consider in Choosing a Strategy
Patient’s colorectal cancer risk Implementation issues Adverse effects Patient’s preferences
Patient’s colorectal cancer risk Implementation issues Adverse effects Patient’s preferences
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Assessing Individual RiskAssessing Individual Risk
Increased risk includes:• personal history of colorectal cancer or polyps• family history of colorectal cancer or polyps• history of inflammatory bowel disease• certain inherited cancer syndromes• signs/symptoms
– rectal bleeding– iron deficiency anemia
Should undergo evaluation at an earlier age and more frequently
Increased risk includes:• personal history of colorectal cancer or polyps• family history of colorectal cancer or polyps• history of inflammatory bowel disease• certain inherited cancer syndromes• signs/symptoms
– rectal bleeding– iron deficiency anemia
Should undergo evaluation at an earlier age and more frequently
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Assessing Individual Risk (continued)
Assessing Individual Risk (continued)
Assessing Individual Risk (continued)
Assessing Individual Risk (continued)
Average Risk:
Everyone Else 50 and Over
Average Risk:
Everyone Else 50 and Over
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Overarching Implementation and Counseling IssuesOverarching Implementation and Counseling Issues
Benefits and adverse effects Patient education materials Insurance coverage information Explicit policy and mechanisms for
follow-up
Benefits and adverse effects Patient education materials Insurance coverage information Explicit policy and mechanisms for
follow-up
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New HEDIS measure on horizonNew HEDIS measure on horizon
Colorectal cancer screening measure provisionally approved
Subject to results from public comment period in early 2003
2004 would be first year measure for HEDIS, based on performance in 2003
Colorectal cancer screening measure provisionally approved
Subject to results from public comment period in early 2003
2004 would be first year measure for HEDIS, based on performance in 2003
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Potential Adverse Effects of Invasive Screening TestsPotential Adverse Effects of Invasive Screening Tests
Vasovagal syncope Perforation Hemorrhage
Vasovagal syncope Perforation Hemorrhage
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Estimated Costs of Colorectal Cancer Screening OptionsEstimated Costs of Colorectal Cancer Screening Options
FOBT $10 – $25 Flexible sigmoidoscopy $150 – $300 Colonoscopy $800 – $1600 DCBE $250 – $500
FOBT $10 – $25 Flexible sigmoidoscopy $150 – $300 Colonoscopy $800 – $1600 DCBE $250 – $500
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Shared Decision Makingvs.
Provider-Directed Choice
Shared Decision Makingvs.
Provider-Directed Choice
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Outstanding issuesOutstanding issues
Safety of tests Patient acceptability Cost
• Health care coverage for patients• Reimbursement for health care providers
Capacity to perform widespread screening
Safety of tests Patient acceptability Cost
• Health care coverage for patients• Reimbursement for health care providers
Capacity to perform widespread screening
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Future Screening Tests?Future Screening Tests?
Virtual Colonoscopy Stool DNA testing
Virtual Colonoscopy Stool DNA testing
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Primary Prevention of Colorectal CancerPrimary Prevention of Colorectal Cancer
Exercise Low-fat diet rich in fruits and vegetables Fiber? Chemoprophylaxis
• NSAIDs• Calcium• Estrogen• Folate• Selenium
Exercise Low-fat diet rich in fruits and vegetables Fiber? Chemoprophylaxis
• NSAIDs• Calcium• Estrogen• Folate• Selenium
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A Call to Action A Call to Action
Screening reduces mortality from CRC All persons aged 50 years and older should begin
regular screening High-risk individuals may need to begin screening
earlier Colorectal cancer can be prevented Insufficient evidence to suggest a best test;
any screening test is better than no screening test
Screening reduces mortality from CRC All persons aged 50 years and older should begin
regular screening High-risk individuals may need to begin screening
earlier Colorectal cancer can be prevented Insufficient evidence to suggest a best test;
any screening test is better than no screening test