990 Return ofOrganization Exempt...

l efile GRAPHIC p rint - DO NOT PROCESS I As Filed Data - I DLN: 93493109008027

Form990 Return of Organization Exempt From Income Tax OMB No 1545-0047

Under section 501(c ), 527, or 4947 ( a)(1) of the Internal Revenue Code ( except private2p 1 5foundations)

Department of the ► Do not enter social security numbers on this form as it may be made public • _

Treasury ► Information about Form 990 and its instructions is at www IRS gov/form990

Internal Revenue Service

A For the 2015 calendar year, or tax year be inning 09-01 -2015 , and endinq 08-31-2016

C Name of organizationB Check if applicable

Howard Hughes Medical InstituteAddress change

F Name change

Initial returnDoing business as

F_ Finalreturn / terminated Number and street ( or P 0 box if mail is not delivered to street address ) Room/sui

4000 JONES BRIDGE ROADAmended return

F-Application Pending City or town, state or province , country, and ZIP or foreign postal codeCHEVY CHASE, MD 20815

F Name and address of principal officerERIN K O'SHEA PHD4000 JONES BRIDGE ROAD

CHEVY CHASE, MD 20815

I Tax-exempt status1 501(c)(3) F_ 501 (c) ( ) 1 (insert no ) F_ 4947(a)(1) or F 527

3 Website WWW HHMI ORG

K Form of organization I Corporation 1 Trust F Association 1 Other ►

V

ti

7

L5

D Employer identification number

59-0735717

E Telephone number

(301)215-8500

I G Gross receipts $ 60,901,814,102

H(a) Is this a group return for

subordinates? [ YesNo

H(b) Are all subordinatesIYes [ No

included?

If"No," attach a list (see instructions)

H(c) GrouD exemption number ►L Year of formation 1953 1 M State of legal domicile DE

© Summary

1Briefly describe the organization 's mission or most significant activitiesTHE HOWARD HUGHES MEDICAL INSTITUTE IS A PHILANTHROPY THAT SERVES SOCIETY THROUGH THE DIRECTCONDUCT OF BIOMEDICAL RESEARCH AND SUPPORT FOR PROGRAMS IN SCIENCE EDUCATION

2 Check this box ► F-if the organization discontinued its operations or disposed of more than 25% of its net assets

3 Number of voting members of the governing body (Part VI, line 1a) . . . . . . . 3 10

4 Number of independent voting members of the governing body (Part VI, line 1b) . . . . 4 10

5 Total number of individuals employed in calendar year 2015 (Part V, line 2a) . . . . . 5 3,383VQ 6 Total number of volunteers (estimate if necessary) . 6 0

7a Total unrelated business revenue from Part VIII, column (C), line 12 . . . . . . . 7a -1,833,057

b Net unrelated business taxable income from Form 990-T, line 34 . . . . . . . . 7b 0

Prior Year Current Year

8 Contributions and grants (Part VIII, line Ih) . 66,401 19,321,241

9 Program service revenue (Part VIII, line 2g) . . . . . . . . 2,033,219 2,223,162

10 Investment income (Part V I I I , column (A), l i n e s 3 , 4 , and 7d ) . 1,963,222,595 921,724,327

11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and l le) 17,244,324 257,052,143

12 Total revenue-add l i n e s 8 through 1 1 (must equal Part V I I I , column ( A ) , l i n e 1,982,566,539 1,200,320,87312)

13 Grants and similar amounts paid (Part IX, column (A), lines 1-3 ) . . 46,910,392 138,793,048

14 Benefits paid to or for members (Part IX, column (A ), line 4) . 0

15 Salaries, other compensation, employee benefits (Part IX, column (A ), lines422 462 257 438 554 171

5-10), , , ,

16a Professional fundraising fees (Part IX, column (A), line 11e) 0

aCLIJ

b Total fundraising expenses (Part IX, column (D), line 25) ► 0

17 Other expenses (Part IX, column (A), lines 11a-11d, 1if-24e) . . . . 544,226,576 556,129,969

18 Total expenses Add l i n e s 1 3 - 1 7 (must equal Part I X , column ( A ) , l i n e 2 5 ) 1,013,599,225 1,133,477,188

19 Revenue less expenses Subtract line 18 from line 12 . 968,967,314 66,843,685

T8 Beginning of Current Year End of Year

m20 Total assets (Part X, line 16) . . . . . . . . . . . . 21,693,736,438 21,082,502,290

Q21 Total l i a b i l i t i e s (Part X , l i n e 2 6 ) . . . . . . . . . . 3,522,501,322 3,306,942,737

Z1 22 Net assets or fund balances Subtract l i n e 2 1 from l i n e 2 0 18,171,235,116 17,775,559,553

EMSTE Si g nature BlockUnder penalties of perjury, I declare that I have examined this return, 1my knowledge and belief, it is true, correct, and complete Declarationpreparer has any knowledge

SignSignature of officer

Here Nitin V Kotak CFO & Treasurer

Type or print name and title

Print/Type preparer's name Preparer's signature

PaidMara Krause Mara Krause

PreparerFirm's name ► PRICEWATERHOUSECOOPERS LLP

Firm's address ► 600 13TH STREET NW STE 1000

Use OnlyWASHINGTON, DC 20005

May the IRS discuss this return with the preparer shown above? (see it

For Paperwork Reduction Act Notice, see the separate instructions.

Form 990 (2015)

Statement of Program Service Accomplishments

Check if Schedule 0 contains a response or note to any line in this Part III .

1 Briefly describe the organization's mission

THE HOWARD HUGHES MEDICAL INSTITUTE ("INSTITUTE" OR "HHMI") IS THE NATION'S LARGEST PRIVATE BIOMEDICALRESEARCH INSTITUTION, WITH JUST UNDER $18 BILLION IN NET ASSETS AT THE END OF ITS 2016 FISCAL YEAR THE MISSIONOF THE INSTITUTE HAS REMAINED CONSTANT SINCE ITS FOUNDING IN 1953 AS ITS CHARTER STATES THE PRIMARYPURPOSE AND OBJECTIVE OF THE HOWARD HUGHES MEDICAL INSTITUTE SHALL BE THE PROMOTION OF HUMAN KNOWLEDGEWITHIN THE FIELD OF BASIC SCIENCES (PRINCIPALLY THE FIELD OF MEDICAL RESEARCH AND EDUCATION) AND THEEFFECTIVE APPLICATION THEREOF FOR THE BENEFIT OF MANKIND "

2 Did the organization undertake any significant program services during the year which were not listed on

the prior Form 990 or 990-EZ? . . . . . . . . . . . . . . . . . . . . . EYes [7No

If "Yes," describe these new services on Schedule 0

3 Did the organization cease conducting, or make significant changes in how it conducts, any program

services? . . . . . . . . . . . . . . . . . . . . . . . . . . . EYes [No

If "Yes," describe these changes on Schedule 0

4 Describe the organization's program service accomplishments for each of its three largest program services, as measured byexpenses Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others,the total expenses, and revenue, if any, for each program service reported

4a (Code ) ( Expenses $ 711,129,790 including grants of $ 0 ) (Revenue $ 2,169,244 )

MEDICAL RESEARCH ORGANIZATION ACTIVITIES (A) THE HHMI INVESTIGATOR PROGRAM (B) JANELIA RESEARCH CAMPUS (C) HIGHLIGHTS FROM HHMI RESEARCHLABORATORIES (FISCAL YEAR 2016) (D) HONORS AND AWARDS RECEIVED BY HHMI SCIENTISTS (A) THE HHMI INVESTIGATOR PROGRAM THE HOWARD HUGHESMEDICAL INSTITUTE'S APPROACH TO BIOMEDICAL RESEARCH CAN BE SUMMARIZED IN THREE WORDS PEOPLE, NOT PROJECTS BY EMPLOYING SCIENTISTS ASHHMI INVESTIGATORS - RATHER THAN AWARDING RESEARCH GRANTS - THE INSTITUTE PROVIDES LONG-TERM, FLEXIBLE FUNDING THAT ENABLES ITSRESEARCHERS TO PURSUE THEIR SCIENTIFIC INTERESTS WHEREVER THEY LEAD HHMI BELIEVES THAT SCIENTISTS OF EXCEPTIONAL TALENT AND IMAGINATIONWILL MAKE FUNDAMENTAL DISCOVERIES OF LASTING SCIENTIFIC VALUE AND BENEFIT TO HUMANITY IF THEY ARE GIVEN THE RESOURCES, TIME, AND FREEDOMTO PURSUE CHALLENGING QUESTIONS THE INSTITUTE NURTURES THE CREATIVITY AND INTELLECTUAL DARING OF SCIENTISTS WHO ARE WILLING TO SET ASIDECONVENTIONAL WISDOM OR THE "EASY" QUESTION FOR A FUNDAMENTAL PROBLEM THAT MAY TAKE MANY YEARS TO SOLVE AMONG THE CHARACTERISTICS THATDISTINGUISH THIS GROUP OF SCIENTISTS ARE QUALITIES SUCH AS CREATIVITY, A PENCHANT FOR RISK-TAKING, AND A COMMITMENT TO DISCOVERY,PRODUCTIVITY, AND PERSEVERANCE THIS UNIQUE RESEARCH MODEL IS AN IMAGINATIVE AND POWERFUL ALTERNATIVE TO FUNDING BIOMEDICAL RESEARCHTHROUGH GRANTS THE HHMI INVESTIGATOR PROGRAM EMPLOYS MORE THAN 300 HHMI INVESTIGATORS, AMONG THEM 17 NOBEL LAUREATES AND 192 MEMBERSOF THE NATIONAL ACADEMY OF SCIENCES HHMI INVESTIGATORS DIRECT INSTITUTE RESEARCH LABORATORIES ON THE CAMPUSES OF 65 UNIVERSITIES ANDOTHER RESEARCH ORGANIZATIONS THROUGHOUT THE UNITED STATES SINCE THE EARLY 19905, INVESTIGATORS HAVE BEEN SELECTED THROUGH RIGOROUSNATIONAL COMPETITIONS THE INSTITUTE SOLICITS APPLICATIONS DIRECTLY FROM SCIENTISTS AT MEDICAL SCHOOLS AND OTHER RESEARCH INSTITUTIONS INTHE UNITED STATES, WITH THE AIM OF IDENTIFYING THOSE WHO HAVE THE POTENTIAL TO MAKE SIGNIFICANT CONTRIBUTIONS TO SCIENCE HHMI EMPLOYS ANOPEN APPLICATION PROCESS TO ENSURE THAT IT IS SELECTING ITS RESEARCHERS FROM A BROAD AND DEEP POOL OF SCIENTIFIC TALENT In October 2015, theRoyal Swedish Academy of Sciences selected Paul Modrich, an HHMI investigator at Duke University, together with Tomas Lindahl of the Francis Crick Institute andClare Hall Laboratory in the UK and Aziz Sancar of University of North Carolina, Chapel Hill, as recipients of the 2015 Nobel Prize in Chemistry for mechanistic studiesof DNA repair The trio was honored for mapping, at a molecular level, how cells repair damaged DNA and safeguard the genetic information According to the NobelFoundation, their work has provided fundamental knowledge of how a living cell functions and is, for instance, used for the development of new cancer treatmentsIn June 2016, the HHMI Trustees elected David E Clapham, MD, PhD, an HHMI investigator at Boston Children's Hospital, as Vice President and Chief ScientificOfficer Clapham was the Aldo R Castaneda Professor of Cardiovascular Research at Children's Hospital Boston and Professor of Neurobiology and Pediatrics atHarvard Medical School A member of both the National Academy of Sciences and the American Academy of Arts and Sciences, he is a leader in the field of ionchannel research His research focuses on the role of calcium as an intracellular messenger and on the signals that control ion channels that carry calcium betweencells The identification and characterization of ion channels may make it possible to develop drugs that alleviate many disorders Clapham succeeds Erin O'Shea,PhD, who was named president of HHMI In HHMI launched the Transformative Technology Program that allows HHMI Investigators to acquire cutting-edgeresearch equipment for their institution that simultaneously benefits their HHMI and non-HHMI colleagues Through cost sharing with host institutions, theTransformative Technology Program provides a path by which HHMI scientists and colleagues can obtain research equipment that's typically difficult to fund Ingeneral, this program will purchase and own the major equipment items, while the host institution's cost-sharing funds will support the ongoing setup and operationof the core facilities that house the instruments In this initial competition, HHMI invested a total of $18 8 million for six projects that will benefit researchers aroundthe country This year, HHMI, the Simons Foundation, and the Bill & Melinda Gates Foundation selected 84 Faculty Scholars, early-career scientists who have greatpotential to make unique contributions to their field The scientists represent 43 institutions across the United States Through the new Faculty Scholars Program, thephilanthropies will spend about $83 million over five years to support the first cohort of scientists selected to receive grants The range of five-year grant awardtotals is $600,000-$1 8 million, including indirect costs Faculty Scholars are required to devote at least 50 percent of their total effort to the direct conduct ofresearch Highlights of research conducted, and awards received, by HHMI scientists during its year ended August 31, 2016 are included below (B) Janelia ResearchCampus The Janelia Research Campus offers a collaborative research environment for scientists across an array of disciplines who have focused on two broadscientific areas of scientific inquiry the identification of general principles governing how neuronal circuits process information and development of imagingtechnologies and computational methods that support image analysis In the current fiscal year, there were 47 group leaders at Janelia, in addition to graduatestudents, other scientific trainees, and visiting scientists Janelia also operates a vibrant scientific conference program, bringing many scientists to its campus eachyear for educational meetings In 2016, Janelia expanded its research program by launching a Neuronal Cell Biology Program that will support scientistsinvestigating the structural and functional details of discrete neurons and exploring the inner landscape of these cells in dynamic neural environments, and leverageexisting research and tools created at Janelia, such as the lattice light sheet microscope The program will be led by Jennifer Lippincott-Schwartz, who moved toJanelia after 23 years as chief of the section on organelle biology in the Cell Biology and Metabolism Program, in the Division of Intramural Research at the NationalInstitutes of Health (NIH)

4b (Code ) (Expenses $ 147,854,974 including grants of $ 117,992,048 ) (Revenue $ 53,918 )

SCIENCE EDUCATION PROGRAMS (A) GRADUATE SCIENCE EDUCATION AND MEDICAL RESEARCH TRAINING (B) PRECOLLEGE AND UNDERGRADUATE SCIENCEEDUCATION PROGRAM (C) EDUCATIONAL MEDIA (D) TANGLED BANK STUDIOS (E) ELIFE - OPEN ACCESS JOURNAL HHMI'S DEPARTMENT OF SCIENCE EDUCATIONEMPHASIZES INITIATIVES WITH THE POWER TO TRANSFORM GRADUATE, UNDERGRADUATE, AND PRECOLLEGE EDUCATION IN THE LIFE SCIENCES HHMI IS THELARGEST PRIVATE FUNDER OF SCIENCE EDUCATION IN THE UNITED STATES DURING THE FISCAL YEAR, THE INSTITUTE DISTRIBUTED $57 MILLION IN GRANTS TOSUPPORT SCIENCE EDUCATION The Institute's science education programs support ties between scientific research and teaching with the goal of increasing andenhancing student research opportunities, improving science courses, curricula, and instruction, and providing enhanced graduate and medical training opportunitiesMost HHMI grants are awarded through competitions with specific objectives and eligibility criteria and awards are generally made following a stringent process ofpeer review HHMI's educational activities are funded through three major programs, the goals of each program and the major activities for the year aresummarized below (A) Graduate Science Education and Medical Research Training These programs focus on the development of innovative graduate educationthrough grants to institutions and fellowships to students They support research fellowships for medical students, doctoral fellowships for students who arecommitted to increasing diversity among scientists, doctoral fellowships for international students pursuing the PhD at U S institutions This fiscal year, HHMIselected 66 medical and veterinary students to participate in the Medical Research Fellows Program The fellowships enable students to take a year off fromprofessional school to conduct laboratory research The hope is that these students will one day choose to work at the crossroads of basic research and clinicalmedicine Six fellows in this year's class of 66 initial awardees are supported by HHMI's funding partners Burroughs Wellcome Fund (BWF), Citizens United forResearch in Epilepsy (CURE), the Duchenne Research Fund (DRF), and the Society of Interventional Radiology Foundation (SIRF) The program has funded morethan 1,700 students since its start in 1989 This year, 13 fellows from the 2015 class are supported by HHMI for an additional year, making it the largest class ofsecond-year fellows in the program's history The program usually averages six second-year fellows per year The International Predoctoral Fellowship programidentifies accomplished and promising graduate students whose home countries are outside of the United States and who are ineligible for U S federal training grantsupport Each fellowship is for three years, and pays a stipend, institutional allowance, and research allowance totaling $43,000 per year In fiscal year 2016, HHMIselected 20 graduate students as International Predoctoral Fellows HHMI's Gilliam Fellowships for Advanced Study Program awarded 34 fellowships to outstandingstudents who are pursuing a PhD in the life sciences and who are committed to increasing diversity among scientists Each fellow will receive an annual awardtotaling $46,000, which includes a stipend, a training allowance, and an allowance for each fellow's institution, for up to three years The applicant pool for theGilliam fellowships consists of graduate students nominated by the principal investigators of non-MSTP T32 training grants awarded through the National Institute ofGeneral Medical Sciences (NIGMS), and alumni of HHMI's Exceptional Research Opportunities Program (EXROP), an initiative that provides undergraduate minoritystudents with the opportunity to conduct research under the mentorship of HHMI scientists A total of 142 students applied for the fellowships this year, including 18EXROP alumni (B) Precollege and Undergraduate Science Education Program These programs recruit and develop the future leaders of science and enhance scienceliteracy among all students Precollege grants support teacher training and inquiry-based student learning Grants to colleges and universities support undergraduatestudent research, faculty and curriculum development, and science education outreach activities In the 2016 fiscal year HHMI has invited 91 schools to submit fullproposals to apply for grants through HHMI's $60 million Inclusive Excellence initiative that is encouraging colleges and universities to broaden access to scienceexcellence for all students The proposals will be considered for first-round awards that will begin in September 2017 HHMI plans to award approximately 60 grantsin two rounds of open competitions, each of which will follow the same format In this round of the competition, HHMI will award up to 30 grants to institutions thatare committed to inclusive science education and are well positioned to work over the next five years to improve their ability to become more inclusive of allstudents HHMI's long-term aim is for successful strategies pioneered by the grantee institutions to serve as models to be adapted and adopted by other institutionsThe 91 schools were selected from 511 that submitted pre-proposals in response to HHMI's launch of the initiative in May 2015 HHMI continued its partnership withthe University of Maryland, Baltimore County (UMBC), the Pennsylvania State University, and the University of North Carolina at Chapel Hill (UNC), to launch thecollaborative Meyerhoff Adaptation Project The project aims to learn whether elements of UMBC's highly regarded Meyerhoff Scholars Program can be adapted atPenn State and UNC The participating schools hope to share what they learn so other institutions might follow During the five-year Meyerhoff Adaptation Project,Penn State and UNC, working closely with UMBC and HHMI, will expand and study the Meyerhoff model, while applying it to newly created programs on theircampuses The HHMI Professors Program empowers research scientists who can convey the excitement of science to undergraduates The professors modelfundamental reform in the way undergraduate science is taught at research universities through innovative teaching that demonstrates the rigor and value ofscientific research HHMI professors are committed to expanding and enhancing research opportunities for undergraduates and are encouraged to share ideas andcollaborate with their peers to improve science education Fifty-five scientists have been named HHMI professors since the program began in 2002 In addition totheir commitment to student learning, these highly visible scientists have developed new educational resources and implemented novel mentoring programs tosupport students In April 2016, HHMI announced a competition to select up to 15 new HHMI professors who will each receive a five-year, nonrenewable granttotaling $1 million, these awards will be made in the fall of 2017 The HHMI's Exceptional Research Opportunities Program (EXROP) is designed to encouragetalented students to pursue careers in science by placing selected undergraduates in summer research experiences in the labs of HHMI investigators, professors, andat the Janelia Research Campus In 2016, a total of 102 college students (69 first-year students and 33 second-year, "EXROP Capstone" students) were selected toparticipate in EXROP The 2016 cohort marked the 14th year of the program

4c (Code ) (Expenses $ 20,914,932 including grants of $ 20,801,000 ) (Revenue $ 0 )

SUPPORT FOR INTERNATIONAL SCIENCE (A) NEW INTERNATIONAL RESEARCH SCHOLARS PROGRAM (B) SENIOR INTERNATIONAL RESEARCH SCHOLARS PROGRAM(C) INTERNATIONAL EARLY CAREER SCIENTIST PROGRAM (D) AFRICA HEALTH RESEARCH INSTITUTE LAUNCHES IN SOUTH AFRICA (A) New International ResearchScholars Program HHMI, together with the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation, announced aninternational program to provide research support for up to 40 outstanding early career scientists The program's aim is to help develop scientific talent worldwide ina wide variety of biomedical research fields Awardees will be notified in April 2017 HHMI and its partners have committed a total of $30 million for the InternationalResearch Scholars Program and will award each scientist who is selected a total of $650,000 over five years The competition is open to scientists who have trainedin the U S or United Kingdom for at least one year and who have run their own labs for less than seven years (B) Senior International Research Scholars ProgramHHMI continues to support 13 of the world's leading basic science researchers as Senior International Research Scholar (SIRS) The awards support outstandingbiomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences The SIRSawardees, selected from a group of previous HHMI international research scholars, are respected leaders in their fields Each HHMI senior international researchscholar receives a grant of $100,000 per year over five years, and presents their research at scientific meetings held at HHMI The gatherings are intended tofacilitate the exchange of ideas, stimulate new research, and provide an opportunity for collaboration with other HHMI scientists The senior international researchscholars' participation helps strengthen the growing network of international biomedical researchers (C) International Early Career Scientist Program HHMI continuesto support 24 international early career scientists who were selected for awards in 2012 Each selected scientist will receive $650,000 over a period of five yearswith the goal of helping these talented individuals establish independent research programs In this pilot program, HHMI identified scientists who are, or have thepotential to become, scientific leaders The 24 HHMI international early career scientists conduct research at 20 institutions in 12 countries Each scientist who wasselected had directed his or her own laboratory for less than seven years when they applied to HHMI The countries represented by the HHMI international earlycareer scientists are Argentina, Brazil, Chile, China, Hungary, India, Italy, Poland, Portugal, South Africa, Spain, and South Korea (D) Africa Health ResearchInstitute Launches in South Africa In 2009, HHMI helped launch the KwaZulu-Natal Research Institute for TB-HIV (K-RITH) in collaboration with the University ofKwaZulu-Natal (UKZN), and has provided significant funding to support its research efforts In 2016, in a move to improve the health of people locally and globally,K-RITH joined forces with the Africa Centre for Population Health to form a groundbreaking new interdisciplinary institute to fight tuberculosis (TB), HIV and relateddiseases The new organization, the Africa Health Research Institute, is located at the heart of South Africa's TB and HIV co-epidemic in KwaZulu-Natal Province Theeffort brings together the Africa Centre's detailed population data from over 100,000 participants, with K-RITH's expertise in basic science and its world-classlaboratory facilities The new venture is made possible through grants from HHMI and Wellcome Trust, with the University College London and UKZN as significantacademic partners The Africa Health Research Institute is committed to working towards the elimination of HIV and TB To achieve this, the institute will bringtogether leading researchers from different fields, use cutting-edge science to improve people's health, and will help to train the next generation of African scientists

4d Other program services (Describe in Schedule 0 )

(Expenses $ including grants of $ ) (Revenue $

4e Total program service expenses 00, 879,899,696

Form 990 (2015)

Form 990 (2015)

Checklist of Re q uired Schedules

Yes No

1 Is the organization described in section 501(c)(3) or4947(a)(1) (other than a private foundation)? If "Yes," Yes

complete Schedule A . . . . . . . . . . . . . . . . . . . . . . 1

2 Is the organization required to complete Schedule B, Schedule of Contributors (see instructions)? IJ . 2 Yes

3 Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to Nocandidates for public office? If "Yes," complete Schedule C, Part I 3

4 Section 501(c )( 3) organizations.Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year?

If "Yes, " complete Schedule C, Part II 1i . . . . . . . . . . . . . . 4 Yes

5 Is the organization a section 501 (c)(4), 501(c)(5), or 501 (c)(6) organization that receives membership dues,assessments, or similar amounts as defined in Revenue Procedure 98-19?If "Yes," complete Schedule C, Part III . . . . . . . . . . . . . . . . 5 N o

6 Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have theright to provide advice on the distribution or investment of amounts in such funds or accounts?If "Yes," complete Schedule D, Part I . . . . . . . . . . . . . . . . . 6 N o

7 Did the organization receive or hold a conservation easement, including easements to preserve open space,the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part II 7 No

8 Did the organization maintain collections of works of art, historical treasures, or other similar assets?If "Yes," complete Schedule D, Part III . . . . . . . . . . . . 8 N o

9 Did the organization report an amount in Part X, line 21 for escrow or custodial account liability, serve as acustodian for amounts not listed in Part X, or provide credit counseling, debt management, credit repair, or debtnegotiation services?If "Yes," complete Schedule D, Part IV . . . . . . . . . . . . . . 9 No

10 Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, 10 Nopermanent endowments, or quasi-endowments' If "Yes, " complete Schedule D, Part V .

11 If the organization's answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII,VIII, IX, or X as applicable

a Did the organization report an amount for land, buildings, and equipment in Part X, line 10?

If "Yes, " complete Schedule D, Part VI Ij . . . . . . . . . . . . . . . . . . . Ila Yes

b Did the organization report an amount for investments-other securities in Part X, line 12 that is 5% or more of

its total assets reported in Part X, line 167 If "Yes," complete Schedule D, Part VII Jj . . . . . . 11b Yes

c Did the organization report an amount for investments-program related in Part X, line 13 that is 5% or more ofits total assets reported in Part X, line 167 If "Yes," complete Schedule D, Part VIII llc No

d Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assetsreported in Part X, line 16? If "Yes, " complete Schedule D, Part IX Sld No

e Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part Xij Ile Yes

f Did the organization's separate or consolidated financial statements for the tax year include a footnote thatllf No

addresses the organization's liability for uncertain tax positions under FIN 48 (ASC 740)?If "Yes," complete Schedule D, Part X

12a Did the organization obtain separate, independent audited financial statements for the tax year?If "Yes," complete Schedule D, Parts XI and XII . . . . . . . . . . . . . . . . 12a N o

b Was the organization included in consolidated, independent audited financial statements for the tax year?12b Yes

If "Yes,"and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional °^

13 Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E13 No

14a Did the organization maintain an office, employees, or agents outside of the United States? . 14a Yes

b Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising,business, investment, and program service activities outside the United States, or aggregate foreign investments

valued at $ 100,000 or more? If "Yes," complete Schedule F, Parts I and IV . . . . . . . . .Ij 14b Yes

15 Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or

for any foreign organization? If "Yes," complete Schedule F, Parts II and IV . . °^ 15 Yes

16 Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other

assistance to or for foreign individuals? If "Yes," complete Schedule F, Parts III and IV . . tj 16 Yes

17 Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part 17 NoIX, column (A), lines 6 and lle? If "Yes," complete Schedule G, Part I (see instructions) . .

18 Did the organization report more than $15,000 total offundraising event gross income and contributions on PartVIII, lines lc and 8a'' If "Yes," complete Schedule G, PartIl . . . . . . . . . . . 18 No

19 Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If"Yes, " complete Schedule G, Part III . . . . . . . . . . . . . . . . . 19 No

20a Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H . 20a No

b If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return?20b

Form 990 (2015)

Form 990 (2015)

Checklist of Required Schedules (continued)

21 Did the organization report more than $5,000 of grants or other assistance to any domestic organization or

domestic government on Part IX, column (A), line 1z If "Yes," complete Schedule I, Parts I and II . . . . Ij

22 Did the organization report more than $5,000 of grants or other assistance to or for domestic individuals on Part

IX, column (A), line 2? If "Yes," complete Schedule I, Parts I and III . . . . . . . . Ij

23 Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5 about compensation of the organization'scurrent and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes,"

complete Schedule 3 . . . . . . . . . . . . . . . . . . . . . . . Ij

24a Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000as of the last day of the year, that was issued after December 31, 20027 If "Yes," answer lines 24b through 24d

and complete Schedule K If "No,"go to line 25a . . . . . . . . . . . . . . .Ij

b Did the organization invest any proceeds oftax-exempt bonds beyond a temporary period exception?

c Did the organization maintain an escrow account other than a refunding escrow at any time during the yearto defease any tax-exempt bonds?

d Did the organization act as an "on behalf of issuer for bonds outstanding at any time during the year?

25a Section 501(c )( 3), 501 ( c)(4), and 501(c )( 29) organizations.Did the organization engage in an excess benefit transaction with a disqualified person during the year? If "Yes,"complete Schedule L, Part I . . . . . . . . . . . .

b Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prioryear, and that the transaction has not been reported on any of the organization's prior Forms 990 or 990-EZ?If "Yes," complete Schedule L, Part I . .

26 Did the organization report any amount on Part X, line 5, 6, or 22 for receivables from or payables to any currentor former officers, directors, trustees, key employees, highest compensated employees, or disqualified persons?If "Yes," complete Schedule L, Part II . .

27 Did the organization provide a grant or other assistance to an officer, director, trustee, key employee, substantialcontributor or employee thereof, a grant selection committee member, or to a 35% controlled entity or familymember of any of these persons? If "Yes," complete Schedule L, Part III . .

28 Was the organization a party to a business transaction with one of the following parties (see Schedule L, Part IVinstructions for applicable filing thresholds, conditions, and exceptions)

a A current or former officer, director, trustee, or key employee? If "Yes,"complete Schedule L,Part IV . . . . . . . . . . . . . . . . . . . . . . . .

23 Yes

24aYes

24b N o

24c N o

24d N o

25a N o

25b N o

26 N o

27 N o

28a

b A family member of a current or former officer, director, trustee, or key employee? If "Yes," complete Schedule L,Part IV . . . . . . . . . . . . . . . . . . . . 28b

c A n entity of which a current or former officer, director, trustee, or key employee (or a family member thereof) wasan officer, director, trustee, or direct or indirect owner? If "Yes," complete Schedule L, Part IV . . . 28c

29 Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M 29

30 Did the organization receive contributions of art, historical treasures, or other similar assets, or qualifiedconservation contributions? If "Yes," complete Schedule M . . . . . . . . . . . . 30

31 Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N, Part I31

32 Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets?If "Yes, " complete Schedule N, Part II . .

33 Did the organization own 100% of an entity disregarded as separate from the organization under Regulations

sections 301 7701-2 and 301 7701-3'' If "Yes," complete Schedule R, PartI . .w4i

34 Was the organization related to any tax-exempt or taxable entity' If "Yes, " complete Schedule R, Part II, III, or IV,

and Part V, line 1 . . . . . . . . . . . . . . . . . . . . . . . . .Ij

35a Did the organization have a controlled entity within the meaning of section 512(b)(13)?

b If'Yes'to line 35a, did the organization receive any payment from or engage in any transaction with a controlled

entity within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, Ime 2 . . . 1i

36 Section 501(c )( 3) organizations . Did the organization make any transfers to an exempt non-charitable relatedorganization? If "Yes," complete Schedule R, Part V, line 2 . .

37 Did the organization conduct more than 5% of its activities through an entity that is not a related organizationand that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VI

38 Did the organization complete Schedule 0 and provide explanations in Schedule 0 for Part VI, lines 1lb and 197Note . All Form 990 filers are reouired to complete Schedule 0 .

32

33 Yes

34 Yes

35a Yes

No

No

No

No

No

No

No

No

No

Form 990(2015)

Form 990 (2015)

Statements Regarding Other IRS Filings and Tax Compliance

Check if Schedule 0 contains a res ponse or note to an y line in this Part V

Yes No

la Enter the number reported in Box 3 of Form 1096 Enter -0- if not applicable la 801

b Enter the number of Forms W-2G included in line la Enter -0- if not applicable lb 0

c Did the organization comply with backup withholding rules for reportable payments to vendors and reportablegaming (gambling) winnings to prize winners? . . . . . . . . . . . . . . . . . 1c Yes

2a Enter the number of employees reported on Form W-3, Transmittal of Wage andTax Statements, filed for the calendar year ending with or within the year coveredby this return . . . . . . . . . . . . . . . . . . ^ 2a 3,383

b If at least one is reported on line 2a, did the organization file all required federal employment tax returns? 2b Yes

Note .Ifthe sum of lines la and 2a is greater than 250, you may be required to e-file (see instructions)

3a Did the organization have unrelated business gross income of $1,000 or more during the year? . . . 3a Yes

b If"Yes," has it filed a Form 990-T for this year?If "No"toline3b, provide an explanation in Schedule 0 . . . 3b Yes

4a At any time during the calendar year, did the organization have an interest in, or a signature or other authorityover, a financial account in a foreign country (such as a bank account, securities account, or other financialaccount)? . 4a Yes

b AS , AU , BD , CA , C1 , VI , BR , BE C I , CH , CO , E Z,DA , FI , FR , GM , G R , G K , H K , I N , I D , E l , IT , JA ,JE , KS , LU, MP , MY , MX , NZ , NL , NO , PL , PO , RSS N, SF , SP SW , S Z, T W, T H, T U, A E, U K, RP , A R,EG , EN , HU , IS , JO , KE , MO , NI , PE , RO , CE , UP ,

I f "Yes," enter the name of the foreign country ►UY , V E , ZI

See instructions for filing requirements for FinC EN Form 114, Report of Foreign Bank and Financial Accounts(FBA R)

5a Was the organization a party to a prohibited tax shelter transaction at any time during the tax year? . 5a

b Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction? 5b

c If "Yes," to line 5a or 5b, did the organization file Form 8886-T7

6a Does the organization have annual gross receipts that are normally greater than $100,000, and did theorganization solicit any contributions that were not tax deductible as charitable contributions? . .

b If "Yes," did the organization include with every solicitation an express statement that such contributions or giftswere not tax deductible? . .

7 Organizations that may receive deductible contributions under section 170(c).

a Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods andservices provided to the payor?

b If "Yes," did the organization notify the donor of the value of the goods or services provided?

c Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required tofile Form 8282? . .

d If "Yes," indicate the number of Forms 8282 filed during the year 7d

e Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?

f Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract? . .

g If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 asrequired? . .

h If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file aForm 1098-C? . .

8 Sponsoring organizations maintaining donor advised funds.Did a donor advised fund maintained by the sponsoring organization have excess business holdings at any timeduring the year? . .

9a Did the sponsoring organization make any taxable distributions under section 4966? . .

b Did the sponsoring organization make a distribution to a donor, donor advisor, or re lated person?

10 Section 501(c )( 7) organizations. Enter

a Initiation fees and capital contributions included on Part VIII, line 12 . 10a

b Gross receipts, included on Form 990, Part VIII, line 12, for public use of club 10bfacilities

11 Section 501(c )( 12) organizations. Enter

a Gross income from members or shareholders . . . . . . . . h a

b Gross income from other sources (Do not net amounts due or paid to other sourcesagainst amounts due or received from them ) . . . . . . . . . ilb

12a Section 4947 ( a)(1) non -exempt charitable trusts.Is the organization filing Form 990 in lieu of Form 1041

b If "Yes," enter the amount of tax-exempt interest received or accrued during theyear 12b

13 Section 501(c )( 29) qualified nonprofit health insurance issuers.

Sc

6a

6b

7a

7b

7c

7e

7f

7g

7h

8

9a

9b

12a

a Is the organization licensed to issue qualified health plans in more than one state ''Note . See the instructions foradditional information the organization must report on Schedule 0 13a

b Enter the amount of reserves the organization is required to maintain by the statesin which the organization is licensed to issue qualified health plans 13b

c Enter the amount of reserves on hand 13c

No

No

No

No

No

No

No

14a Did the organization receive any payments for indoor tanning services during the tax year? . . . 14a No

b If "Yes," has it filed a Form 720 to report these payments''If "No," provide an explanation in Schedule 0 . 14b

Form 990 (2015)

Form 990 (2015)

LQ&W Governance , Management, and Disclosure

For each "Yes" response to lines 2 through 7b below, and for a "No" response to lines 8a, 8b, or 10b below,describe the circumstances, processes, or changes in Schedule 0. See instructions.

Check if Schedule 0 contains a response or note to any line in this Part VI

Section A. Governina Bodv and Manaaement

la Enter the number of voting members of the governing body at the end of the taxla 10

year

If there are material differences in voting rights among members of the governingbody, or if the governing body delegated broad authority to an executive committeeor similar committee, explain in Schedule 0

b Enter the number of voting members included in line la, above, who areindependent lb 10

2 Did any officer, director, trustee, or key employee have a family relationship or a business relationship with anyother officer, director, trustee, or key employee?

3 Did the organization delegate control over management duties customarily performed by or under the directsupervision of officers, directors or trustees, or key employees to a management company or other person?

4 Did the organization make any significant changes to its governing documents since the prior Form 990 wasfiled? . .

5 Did the organization become aware during the year of a significant diversion of the organization's assets?

6 Did the organization have members or stockholders?

7a Did the organization have members, stockholders, or other persons who had the power to elect or appoint one ormore members of the governing body? . .

b Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders,or persons other than the governing body?

8 Did the organization contemporaneously document the meetings held or written actions undertaken during theyear by the following

a The governing body? . .

b Each committee with authority to act on behalf of the governing body?

9 Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at theorganization's mailing address? If "Yes,"provide the names and addresses in Schedule 0 . . . . . . .

Yes I No

2 No

3 No

4 No

5 No

6 No

7a N o

7b N o

8a Yes

8b Yes

9 No

Section B. Policies ( This Section B requests information about policies not re quired b y the Internal Revenue Code.)

Yes No

10a Did the organization have local chapters, branches, or affiliates?

b If "Yes," did the organization have written policies and procedures governing the activities of such chapters,affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?

Ila Has the organization provided a complete copy of this Form 990 to all members of its governing body before filingthe form? . .

b Describe in Schedule 0 the process, if any, used by the organization to review this Form 990

12a Did the organization have a written conflict of interest policy? If "No," go to line 13

b Were officers, directors, or trustees, and key employees required to disclose annually interests that could giverise to conflicts? . .

c Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describein Schedule 0 how this was done . . . . . . . . . . . . . . . . . . .

13 Did the organization have a written whistleblower policy?

14 Did the organization have a written document retention and destruction policy?

15 Did the process for determining compensation of the following persons include a review and approval byindependent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?

a The organization's CEO, Executive Director, or top management official . .

b Other officers or key employees of the organization

If "Yes " to line 15a or 15b, describe the process in Schedule 0 (see instructions)

16a Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with ataxable entity during the year? . .

b If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate itsparticipation in joint venture arrangements under applicable federal tax law, and take steps to safeguard theorganization's exempt status with respect to such arrangements?

Section C. Disclosure

10a N o

10b

Ila Yes

12a Yes

12b Yes

12c Yes

13 Yes

14 Yes

15a Yes

15b Yes

16a N o

16b

17 List the States with which a copy of this Form 990 is required to beAK , AZ , CA ,I L,, MD , MA , NY , O K , O R , I N

18 Section 6104 requires an organization to make its Form 1023 (or 1024 if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection Indicate how you made these available Check all that apply

[Own website F-Another's website [Upon request F-Other (explain in Schedule 0)

19 Describe in Schedule 0 whether (and if so, how) the organization made its governing documents, conflict ofinterest policy, and financial statements available to the public during the tax year

20 State the name, address, and telephone number of the person who possesses the organization's books and recordsV KOTAK 4000 JONES BRIDGE ROAD CHEVY CHASE, MD 20815 (301) 215-8500

Form 990(2015)

Form 990 (2015)

Liga= Compensation of Officers , Directors ,Trustees , Key Employees, Highest Compensated

Employees , and Independent Contractors

Check if Schedule 0 contains a response or note to any line in this Part VII E

Section A. Officers , Directors , Trustees , Key Employees , and Highest Compensated Employees

la Complete this table for all persons required to be listed Report compensation for the calendar year ending with or within the organization'stax year

• List all of the organization's current officers, directors, trustees (whether individuals or organizations), regardless of amountof compensation Enter -0- in columns (D), (E), and (F) if no compensation was paid

• List all of the organization's current key employees, if any See instructions for definition of"key employee

• List the organization's five current highest compensated employees (other than an officer, director, trustee or key employee)who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $ 100,000 from theorganization and any related organizations

• List all of the organization's former officers, key employees, or highest compensated employees who received more than $100,000of reportable compensation from the organization and any related organizations

• List all of the organization's former directors or trustees that received, in the capacity as a former director or trustee of theorganization, more than $10,000 of reportable compensation from the organization and any related organizations

List persons in the following order individual trustees or directors, institutional trustees, officers, key employees, highestcompensated employees, and former such persons

Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee

(A)Name and Title

(B)Averagehours perweek (listany hours

(C)Position (do not check

more than one box, unlessperson is both an officerand a director/trustee)

(D)Reportable

compensationfrom the

organization (W-

(E)Reportable

compensationfrom relatedorganizations

(F)Estimated

amount of othercompensation

from thefor related

organizationsbelow

dotted line)

_c

`-1

Co

I•

1

;r

^r

rt.

-in

D

2, =

i,n .i•

^

L

-n

3

2/1099-MISC) (W- 2/1099-MISC)

organization andrelated

organizations

See Additional Data Table

Form 990 (2015)

Form 990 (2015)

Section A . Officers, Directors , Trustees, Key Employees, and Highest Compensated Employees (continued)

(A)Name and Title

(B)Averagehours perweek (listany hours

(C)Position (do not check

more than one box, unlessperson is both an officerand a director/trustee)

(D)Reportable

compensationfrom the

organization (W-

(E)Reportable

compensationfrom related

organizations (W-

(F)Estimated

amount of othercompensation

from thefor related

organizationsbelow

dotted line)

_1' :z,`-1

^o

I•

a

T

;i

_.

rt.

D

T, =Z)

n .i•

^^

T

I

2/1099-MISC) 2/1099-MISC) organization andrelated

organizations


lb Sub-Total . . . . . . . . . . . . . . . . ►c Total from continuation sheets to Part VII, Section A . . . . ►d Total ( add lines lb and 1c) ► 20,066,117 0 1,400,772

2 Total number of individuals (including but not limited to those listed above) who received more than$ 100,000 of reportable compensation from the organization ► 722

Yes I No

3 Did the organization list any former officer, director or trustee, key employee, or highest compensated employee

on line la? If "Yes," complete ScheduleI for such individual . . . . . . . . . . . . . 3 Yes

4 For any individual listed on line la, is the sum of reportable compensation and other compensation from theorganization and related organizations greater than $150,000? If "Yes," complete Schedule I for such

individual . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Yes

5 Did any person listed on line la receive or accrue compensation from any unrelated organization or individual for

services rendered to the organization7If "Yes," complete Schedule] for such person • 5 Yes

Section B. Independent Contractors

1 Complete this table for your five highest compensated independent contractors that received more than $100,000 ofcompensation from the organization Report compensation for the calendar year ending with or within the organization's tax year

(A) (B) (C)Name and business address Description of services Compensation

TOURMALET ADVISORS INVESTMENT MGT 8,603,889

2150 POST ROADFAIRFIELD, CT 06824

ECHO STREET CAPITAL MGR LLC (VIA HHMI II LLC) INVESTMENT MGT 4,641,671

850 THIRD AVENUENEW YORK, NY 10022

ARAMARK HARRISON LODGING CONFERENCE CTR MGT 4,161,191

1101 MARKET STPHILADELPHIA, PA 19107

WORKDAY INC IT SOFTWARE CONSULTING 3,163,837

6230 STONERIDGE MALL ROADPLEASANTON, CA 94588

THE NORTH HIGHLAND COMPANY CONSULTANT 2,963,032

550 PHARRSUITE 850ATLANTA, GA 30305

2 Total number of independent contractors (including but not limited to those listed above) who received more than$ 100,000 of compensation from the organization ► 158

Form 990 (2015)

Form 990 (2015)

Statement of Revenue

Check if Schedule 0 contains a response or note to any line in this Part VIII U/

(A) (B) (C) (D)Total revenue Related or Unrelated Revenue

exempt business excluded fromfunction revenue tax underrevenue sections

512-514

la Federated campaigns . la

b Membership dues . . . . lb

E c Fundraising events . 1cya

d Related organizations . Id

Ey

e Government grants (contributions) le..

O f All other contributions, gifts, grants, and if 19,321,241y similar amounts not included above

^ 0g Noncash contributions included in lines

. . la-1f $c -O h Total . Add lines la-1f . 19,321,241V ►

Business CodeI

ti2a RENTAL INCOME 900099 2,169,244 2,169,244

b TV & Film Royalties 900099 53,918 53,918

c

d

e

Mf All other program service revenue o 0 0 0

0

g Total . Add lines 2a-2f ► 2,223,162

3 Investment income (including dividends, interest,and other similar amounts) . , ► 204,038,300 -12,629,452 216,667,752

4 Income from investment of tax-exempt bond proceeds ►

5 Royalties ► 256,701,667 256,701,667

(i) Real (ii) Personal

6a Gross rents 767,720

b Less rental 1,424,636expenses

c Rental income -656,916 0or (loss)

d Net rental inco me or (loss) . . ► -656,916 -636,333 -20,583

(i) Securities (ii) Other

7a Gross amountfrom sales of 60,406,321,892 11,432,728assets otherthan inventory

b Less cost orother basis and 59,700,068,593sales expenses

c Gain or (loss) 706,253,299 11,432,728

d Net gain or (los s) . .1101 717,686,027 11,432,728 706,253,299

8a Gross income from fundraising4) events (not including

of contributions reported on line 1c)4) See Part IV, line 18cc

a

b Less direct expenses . lb ,

0 c Net income or (loss) from fundraising events . . ►

9a Gross income from gaming activitiesSee Part IV, line 19 . .

a

b Less direct expenses . b

c Net income or (loss) from gaming acti vities . .

00,10a Gross sales of inventory, less

returns and allowances .

a

b Less cost of goods sold . b

c Net income or (loss) from sales of inventory . ►

Miscellaneous Revenue Business Code

I la CAFETERIA INCOME 900099 271,442 271,442

b INVESTMENT EXPENSE 900099 172,767 172,767

REBATE

C CASH DISCOUNTS 900099 132,378 132,378

d All other revenue 430,805 0 0 430,805

e Total .Add lines 11a-11d . ►1,007,392

12 Total revenue . See Instructions ►1,200,320,873 2,223,162 -1,833,057 1,180,609,527

Form 990(2015)

Form 990 (2015)

Ligg= Statement of Functional Expenses

Section 501(c)(3) and 501(c)(4) organizations must complete all columns All other organizations must complete column (A)

Check if Schedule 0 contains a response or note to any line in this Part IX

T

Do not include amounts reported on lines 6b,

7b, 8b, 9b, and 10b of Part VIII .

(A)

Total expenses

(e )Program service

expenses

( C)Management andgeneral expenses

(D)Fundraisingexpenses

1 Grants and other assistance to domestic organizations and

domestic governments See Part IV, line 2131,593,272 31,593,272

2 Grants and other assistance to domestic

individuals See Part IV, line 2286,398,776 86,398,776

3 Grants and other assistance to foreign organizations, foreign

governments, and foreign individuals See Part IV, lines 15

and 16 20,801,000 20,801,000

4 Benefits paid to or for members . .

5 Compensation of current officers, directors, trustees, and

key employees 15,274,181 2,453,676 12,820,505

6 Compensation not included above, to disqualified persons

(as defined under section 4958(f)(1 )) and persons

described in section 4958(c)(3)(B) 220,039 220,039

7 Other salaries and wages 266,923,649 235,196,437 31,727,212

8 Pension plan accruals and contributions (include section 401(k)

and 403(b) employer contributions) 22,662,921 19,940,803 2,722,118

9 Other employee benefits 115,950,973 99,333,829 16,617,144

10 Payroll taxes17,522,408 15,181,179 2,341,229

11 Fees for services (non-employees)

a Management . .

b Legal 3,710,170 2,083,137 1,627,033

c Accounting 971,762 12,212 959,550

d Lobbying

e Professional fundraising services See Part IV, line 17

f Investment management fees 67,458,786 67,458,786

g Other (If line 11g amount exceeds 10% of line 25, column (A)

amount, list line 11g expenses on Schedule O) 40,629,075 26,043,956 14,585,119 0

12 Advertising and promotion . .

13 Office expenses 4,826,570 3,550,890 1,275,680

14 Information technology 9,401,261 659,392 8,741,869

15 Royalties 23,132 6,760 16,372

16 Occupancy 78,412,496 78,779,948 -367,452

17 Travel . . . . . . . . . . . 8,136,399 6,732,161 1,404,238

18 Payments of travel or entertainment expenses for any federal,state, or local public officials

19 Conferences, conventions, and meetings 4,072,244 2,713,796 1,358,448

20 Interest . 76,286,215 308,533 75,977,682

21 Payments to affiliates . .

22 Depreciation, depletion, and amortization 84,426,346 75,119,977 9,306,369

23 Insurance 486,689 164,385 322,304

24 Other expenses Itemize expenses not covered above (Listmiscellaneous expenses in line 24e If line 24e amount exceeds10% of line 25, column (A) amount, list line 24e expenses onSchedule 0 )

a LAB & OTHER SCIENTIFIC SUPPLIES 125,680,795 124,497,069 1,183,726

b MINOR EQUIPMENT & RENOVATIONS 24,377,408 23,268,389 1,109,019

c EQUIPMENT MAINTENANCE 16,250,139 14,809,624 1,440,515

d Income Tax 236,624 236,624

e All other expenses 10,743,858 10,250,495 493,363 0

25 Total functional expenses . Add lines 1 through 24e 11133,477,188 879,899,696 253,577,492 0

26 Joint costs.Complete this line only if the organizationreported in column (B) joint costs from a combinededucational campaign and fundraising solicitation

Check here ► F- iffollowing SOP 98-2 (ASC 958-720)

Form 990 (2015)

Form 990 (2015)

Balance Sheet

Check if Schedule 0 contains a response or note to any line in this Part X P

(A) (B)Beginning ofyear End of year

1 Cash- non-interest- bearing . . . . . . . . . . . . 1

2 Savings and temporary cash investments 261,159,459 2 331,496,720

3 Pledges and grants receivable, net . 3

4 Accounts receivable, net . 4

5 Loans and other receivables from current and former officers, directors,trustees, key employees, and highest compensated employees CompletePart II ofSchedule L . .

5 0

6 Loans and other receivables from other disqualified persons (as defined undersection 4958(f)(1)), persons described in section 4958(c)(3)(B), andcontributing employers and sponsoring organizations of section 501(c)(9)voluntary employees' beneficiary organizations (see instructions) CompletePart II of Schedule L

6 0

Q 7 Notes and loans receivable, net . 7

8 Inventories for sale or use 8

9 Prepaid expenses and deferred charges 12,181,144 9 10,034,921

10a Land, buildings, and equipment cost or otherbasis Complete Part VI of Schedule D 10a 1,787,340,604

b Less accumulated depreciation . . . . 10b 1,048,522,494 761,222,925 10c 738,818,110

11 Investments-publicly traded securities 7,011,005,370 11 6,611,550,109

12 Investments-other securities See Part IV, line 11 13,361,529,118 12 13,078,172,731

13 Investments-program-related See Part IV, line 11 0 13

14 Intangible assets . . . . . . . . . . . . . . 14

15 Other assets See Part IV, line 11 286,638,422 15 312,429,699

16 Total assets.Add lines 1 through 15 (must equal line 34) . 21,693,736,438 16 21,082,502,290

17 Accounts payable and accrued expenses 493,609,336 17 555,985,053

18 Grants payable . . . . . . . . . . . . . . . . 118,378, 619 18 161,167,676

19 Deferred revenue . . . . . . . . . . . . . . . 19

20 Tax-exempt bond liabilities . . . . . . . . . . . . 716,130,000 20 716,130,000

21 Escrow or custodial account liability Complete Part IV of Schedule D . 21V,

22 Loans and other payables to current and former officers, directors, trustees,key employees, highest compensated employees, and disqualified

persons Complete Part II of Schedule L . . . . . . . . . 22fL

23 Secured mortgages and notes payable to unrelated third parties 23

24 Unsecured notes and loans payable to unrelated third parties 1,238,405,223 24 1,234,673,954

25 Other liabilities (including federal income tax, payables to related thirdparties, and other liabilities not included on lines 17-24)Complete Part X of Schedule D

955,978,144 25 638,986,054

26 Total liabilities .Add lines 17 through 25 . 3,522,501,322 26 3,306,942,737

Organizations that follow SFAS 117 (ASC 958 ), check here ► and

complete lines 27 through 29, and lines 33 and 34.

27 Unrestricted net assets 18,171,235,116 27 17,775,559,553

_CZ 28 Temporarily restricted net assets 28

29 Permanently restricted net assets 29

Organizations that do not follow SFAS 117 (ASC 958), check here ► F and

LL complete lines 30 through 34.

30 Capital stock or trust principal, or current funds 30

31 Paid-in or capital surplus, or land, building or equipment fund31

32 Retained earnings, endowment, accumulated income, or other funds 32

ZZ 33 Total net assets or fund balances . . . . . . . . . . 18,171,235,116 33 17,775,559,553

34 Total liabilities and net assets/fund balances . . . . . 21,693,736,438 34 21,082,502,290

Form 990 (2015)

Form 990 (2015)

Reconcilliation of Net Assets

Check if Schedule 0 contains a response or note to any line in this Part XI F

1 Total revenue (must equal Part VIII, column (A), line 12) . .

2 Total expenses (must equal Part IX, column (A), line 25) . .

3 Revenue less expenses Subtract line 2 from line 1

4 Net assets or fund balances at beginning of year (must equal Part X, line 33, column (A))

5 Net unrealized gains (losses) on investments

6 Donated services and use of facilities

7 Investment expenses . .

8 Prior period adjustments . .

9 Other changes in net assets or fund balances (explain in Schedule 0)

10 Net assets or fund balances at end of year Combine lines 3 through 9 (must equal Part X, line 33,column (B))

Financial Statements and Reporting

Check if Schedule 0 contains a response or note to any line in this Part XII .

1 1,200 ,320,873

2 1,133,477,188

3 66,843,685

4 18,171,235,116

5 -462 ,519,248

6

7

8

9 0

10 17 ,775,559,553

Yes No

1 Accounting method used to prepare the Form 990 F-Cash [Accrual F-OtherIf the organization changed its method of accounting from a prior year or checked "Other," explain inSchedule 0

2a Were the organization's financial statements compiled or reviewed by an independent accountant? 2a No

If'Yes,'check a box below to indicate whether the financial statements for the year were compiled or reviewed ona separate basis, consolidated basis, or both

F- Separate basis F- Consolidated basis F- Both consolidated and separate basis

b Were the organization's financial statements audited by an independent accountant? 2b Yes

If'Yes,'check a box below to indicate whether the financial statements for the year were audited on a separatebasis, consolidated basis, or both

F- Separate basis [7 consolidated basis F- Both consolidated and separate basis

c If "Yes," to line 2a or 2b, does the organization have a committee that assumes responsibility for oversightof the audit, review, or compilation of its financial statements and selection of an independent accountant? 2c Yes

If the organization changed either its oversight process or selection process during the tax year, explain inSchedule 0

3a As a result of a federal award, was the organization required to undergo an audit or audits as set forth in theSingle Audit Act and OMB CircularA-133? 3a No

b If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo therequired audit or audits, explain why in Schedule 0 and describe any steps taken to undergo such audits 3b

Form 990 (2015)

Additional Data

Software ID: 15000238

Software Version : 2015v3.0

EIN: 59-0735717

Name : Howard Hughes Medical Institute

Form 990, Part VII - Compensation of Officers, Directors,Trustees, Key Employees, HighestCompensated Employees, and Independent Contractors

(A) (B) (C) (D) (E) (F)Name and Title Average Position (do not check Reportable Reportable Estimated

hours per more than one box, unless compensation compensation amount of otherweek (list person is both an officer from the from related compensationany hours and a director/trustee) organization (W- organizations (W- from thefor related ^. 2,= T 2/1099-MISC) 2/1099-MISC) organization and

organizations !z, S ?'i, relatedbelow = a r organizations

dotted line) C

;D -

I• w

JAMES A BAKER III ESQ 2 0

""""""""' x 40,000 0 0TRUSTEE

CHARLENE BARSHEFSKY ESQ 2 0

""""""""' x 40,000 0 0TRUSTEE

JOSEPH L GOLDSTEIN MD 4 0

""""""""' x 56,000 0 0TRUSTEE, CHAIRMAN RESEARCH COMM

GARNETT L KEITH 4 0

""""""""' x 50,000 0 0TRUSTEE, CHAIRMAN FINANCE COMM until 2/16

FRED R LUMMIS 4 0

TRUSTEE, CHAIRMAN FINANCE COMM starting""""""""' x 40,000 0 0

2/16

PAUL M NURSE PHD 2 0

""""""""' x 46,000 0 0TRUSTEE

ALISON F RICHARD PHD 2 0

""""""""' x 50,000 0 0TRUSTEE, CHAIRMAN EDUCATION COMM

CLAYTON S ROSE PHD 6 0

""""""""' x 50,000 0 0TRUSTEE, CHAIRMAN AUDIT & COMP

KURT L SCHMOKE ESQ 6 0

""""""""' x 60,000 0 0TRUSTEE, CHAIRMAN

DEBORAH -SPAR PHD 2 0................. X 0 0 0

TRUSTEE

Form 990, Part VII - Compensation of Officers, Directors,Trustees, Key EmployeeCompensated Employees, and Independent Contractors

(A) (B) (C) (D) (E) (F)Name and Title Average Position (do not check Reportable Reportable Estimated

hours per more than one box, compensation compensation amount ofweek (list unless person is both an from the from related otherany hours officer and a organization organizations compensationfor related director/trustee) (W- 2/1099- (W- 2/1099- from the

organizations7r 'I' = T

MISC) MISC) organizationbelow -- ET q

':1'Z and related

dotted line) n: t organizations

D

I• w

ANNE M TATLOCK 2 0

""""""""' X 40,000 0TRUSTEE

LANDIS ZIMMERMAN40 0

VP & CHIEF """"""""' X 3,611,224 0 56,63:INVESTMENTOFFICER

LAUREN T SPILIOTESESQ 400

DEP""""""""' X 382,251 0 49,55,

GENCOUNSEL/ASSTSEC

SUSAN S PLOTNICK40 0

ASSISTANT """"""""' X 235,740 0 55,20:TREASURER &DIRECTOR-FINANCE

MONIQUE L MARCUS 40 0

""""""""' X 183,211 0 45,64,CONTROLLER

ROBERT TJIAN PHD 40 0

""""""""' X 1,364,377 0 72,24,PRESIDENT

CHERYL A MOORE 400

EXECUTIVE VP &""""""""' X 891,077 0 47,77:

COO

SEAN B CARROLLPHD 400

""""""""' X 690,554 0 53,012VP FOR SCIENCEEDUCATION

HEIDI E HENNINGESQ 400

""""""""' X 565,186 0 54,74,VP,GENERALCOUNSEL/SEC

NITIN V KOTAK 40 0

VP, CFO &""""""""' X 406,965 0 57,15;

TREASURER

Form 990, Part VII - Compensation of Officers, Directors,Trustees, Key Emplo,Compensated Employees, and Independent Contractors

(A) (B) (C) (D) (E) (F)Name and Average Position (do not check Reportable Reportable Estimated

Title hours per more than one box, compensation compensation amount ofweek (list unless person is both an from the from related otherany hours officer and a organization organizations compensationfor related director/trustee) (W- 2/1099- (W- 2/1099- from the

organizations - 2, = MISC) MISC) organizationbelow and related

dotted line) t ^, 3 organizations`

v

T 2 ii

ID

J

^n4! _

pi'

I• ^^

;r El

ERIN K O'SHEAPHD 40 0

•'•'•'••'•'•'•'•' X 753,361 0 45,59£VP & CHIEF SCIOFF

JOHNPALMISANO

40 0

VP FOR •'•'•'••'•'•'•'•' X 31,622 0 3,28_INFORMATIONTECHNOLOGYeffective 11/15

GERALD MRUBIN PHD 40 0

VP&EXEC"•'•'••'•'•'•'•' X 744,485 0 123,16

DIR,JANELIARES CAMPUS

KATHYWYSZYNSKI 40 0

•'•'•'••'•'•'•'•' X 279,928 0 40,53VP, HUMANRESOURCES

RICHARD APENDER 40 0

•'•'•'••'•'•'•'•' X 976,092 0 53,71CMAN DIR - USEQUITIES

ROBERT JKOLYER JR 40 0

MAN DIR -"•'•'••'•'•'•'•' X 1,459,392 0 54,77_

DIVERSIFIEDASSETS

MARK ABARNARD 40 0

MAN DIR -"•'•'••'•'•'•'•' X 1,280,482 0 58,40_

PRIVATEEQUITIES

STEPHEN MKITSOULIS 40 0

••••••••••••••••• X 903,019 0 47,19£MAN DIR -FIXED INCOME

GREGORYDENINNO 40 0

MAN DIR -•••••••••••••••• X 587,265 0 56,99E

PRIVATEEQUITIES

ANIL MADHOK40 0

MAN DIR - •'•'•'••'•'•'•'•' X 1,118,843 0 41,031INVESTMENTS &COO

Form 990, Part VII - Compensation of Officers, Directors,Trustees, Key Emplo,Compensated Employees, and Independent Contractors

(A) (B) (C) (D) (E) (F)Name and Average Position (do not check Reportable Reportable Estimated

Title hours per more than one box, compensation compensation amount ofweek (list unless person is both an from the from related otherany hours officer and a organization organizations compensationfor related director/trustee) (W- 2/1099- (W- 2/1099- from the

organizations MISC) MISC) organizationbelow 3 T_ and related

dotted line) ` organizations

T 2 0

.1 :5

^n4! _

'Di'

I• ^^

;r El

DONALD KOCH40 0

MAN DIR - """"""""' X 978,620 0 58,52'PORTFOLIOSTRATEGY

THOMAS R 40 0CECH PHD ,,,,,,,,,,,,,,,,,

x 629,730 0 52,251

INVESTIGATOR

RYAN L MATNEY40 0

DIRECTOR- ••••••••••••••••• X 603,568 0 56,281DIVERSIFIEDASSETS

ERIC R KANDELMD 40 0

""""""""' X 596,905 0 58,43'SENIORINVESTIGATOR

MOHAMOUDJIBRELL 40 0

VP FOR""""""""' X 320,220 0 158,621.

INFORMATIONTECHNOLOGY


SCHEDULE A Public Charity Status and Public SupportOMB No 1545-0047

(Form 990 or Complete if the organization is a section 501(c)( 3) organization or a section

20 1 5990EZ ) 4947 ( a)(1) nonexempt charitable trust.► Attach to Form 990 or Form 990-EZ.

Open to Public -Department of the ► Information about Schedule A (Form 990 or 990-EZ) and its instructions is at

InspectionTreasury www.irs.gov /form990.

Internal Ravenna Semite

Name of the organizationHoward Hughes Medical Institute

Employer identification number

59-0735717

J Reason for Public Charity Status (All organizations must complete this part.) See instructions.

The organization is not a private foundation because it is (For lines 1 through 11, check only one box )

1 F- A church, convention of churches, or association of churches described in section 170(b )( 1)(A)(i).

2 F A school described in section 170(b )(1)(A)(ii).(Attach Schedule E (Form 990 or 990-EZ))

3 p A hospital or a cooperative hospital service organization described in section 170(b)(1)(A)(iii).

4W,

A medical research organization operated in conjunction with a hospital described in section 170(b )( 1)(A)(iii)

hospital's name, city, and stateBrigham Womens Hospital,

Boston, MA5 p A n organization operated for the benefit of a college or university owned or operated by a governmental unit described in section

170(b )(1)(A)(iv). (Complete Part II )6 p A federal, state, or local government or governmental unit described in section 170(b)(1)(A)(v).

7 p A n organization that normally receives a substantial part of its support from a governmental unit or from the general publicdescribed in section 170(b )(1)(A)(vi). (Complete Part II )

8 p A community trust described in section 170(b )(1)(A)(vi) (Complete Part II )

9 p An organization that normally receives (1) more than 331/3% of its support from contributions, membership fees, and grossreceipts from activities related to its exempt functions-subject to certain exceptions, and (2) no more than 331/3% of its supportfrom gross investment income and unrelated business taxable income (less section 511 tax) from businesses acquired by theorganization after June 30, 1975 Seesection 509(a )(2). (Complete Part III )

10 p A n organization organized and operated exclusively to test for public safety See section 509(a)(4).

11 p An organization organized and operated exclusively for the benefit of, to perform the functions of, or to carry out the purposes ofone or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2) See section 509(a)(3). Checkthe box in lines 1la through l Id that describes the type of supporting organization and complete lines l le, 11f, and 11g

a p Type I. A supporting organization operated, supervised, or controlled by its supported organization(s), typically by giving thesupported organization(s) the power to regularly appoint or elect a majority of the directors or trustees of the supportingorganization You must complete Part IV, Sections A and B.

b p Type II. A supporting organization supervised or controlled in connection with its supported organization(s), by having control ormanagement of the supporting organization vested in the same persons that control or manage the supported organization(s) Youmust complete Part IV, Sections A and C.

c p Type III functionally integrated . A supporting organization operated in connection with, and functionally integrated with, itssupported organization(s) (see instructions) You must complete Part IV, Sections A , D, and E.

d p Type III non -functionally integrated . A supporting organization operated in connection with its supported organization(s) that isnot functionally integrated The organization generally must satisfy a distribution requirement and an attentiveness requirement(see instructions) You must complete Part IV , Sections A and D, and Part V.

e p Check this box if the organization received a written determination from the IRS that it is a Type I, Type II, Type III functionallyintegrated, or Type III non-functionally integrated supporting organization

f Enter the number of supported organizations . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Provide the following information about the supported organization(s)

(i)Name of supported organization

(ii)EIN (iii)Type of

organization(described on lines1- 9 above (see

instructions))

(iv)Is the organization

listed in your governingdocument?

(v)Amount of

monetary support(see instructions)

(vi)Amount of othersupport (seeinstructions)

Yes No

Total

Enter the

For Paperwork Reduction Act Notice , see the Instructions for Form 990 or 990EZ . Cat No 11285FSchedule A (Form 990 or 990-EZ) 2015

Schedule A (Form 990 or 990-EZ) 2015 Page 2

Support Schedule for Organizations Described in Sections 170(b )( 1)(A)(iv) and 170(b )( 1)(A)(vi)(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify underPart III. If the organization fails to qualify under the tests listed below, please complete Part III.)

Section A. Public Support

Calendar year(or fiscal year beginning in) ►

(a)2011 (b)2012 (c)2013 (d)2014 (e)2015 (f)Total

1 Gifts, grants, contributions, andmembership fees received (Donot include any unusual grants

2 Tax revenues levied for theorganization's benefit and eitherpaid to or expended on its behalf

3 The value of services or facilitiesfurnished by a governmental unitto the organization without charge

4 Total . Add lines 1 through 3

5 The portion of total contributionsby each person (other than agovernmental unit or publiclysupported organization) includedon line 1 that exceeds 2% of theamount shown on line 11, column(f)

6 Public support . Subtract line 5from line 4

Section B. Total Support

Calendar year(or fiscal year beginning in) ►7 Amounts from line 4

8 Gross income from interest,dividends, payments received onsecurities loans, rents, royaltiesand income from similar sources

9 Net income from unrelatedbusiness activities, whether ornot the business is regularlycarried on

10 Other income Do not includegain or loss from the sale ofcapital assets (Explain in PartVI)

11 Total support . Add lines 7through 10

(a)2011 (b)2012 (c)2013 (d)2014 (e)2015 (f)Total

12 Gross receipts from related activities, etc (see instructions) 12

13 First five years .If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization,

check this box and stop here ► E. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Section C . Computation of Public Support Percentage

14 Public support percentage for 2015 (line 6, column (f) divided by line 11, column (f)) 14

15 Public support percentage for 2014 Schedule A, Part II, line 14 15

16a 331 / 3% support test - 2015 .Ifthe organization did not check the box on line 13, and line 14 is 33 1/3% or more, check this box

and stop here . The organization qualifies as a publicly supported organization ► Fb 331 / 3% support test - 2014.Ifthe organization did not check a box on line 13 or 16a, and line 15 is 33 1/3% or more, check this

box and stop here . The organization qualifies as a publicly supported organization ► F17a 10%-facts-and-circumstances test -2015.Ifthe organization did not check a box on line 13, 16a, or 16b, and line 14

is 10% or more, and if the organization meets the facts-and-circumstances test, check this box and stop here . Explainin Part VI how the organization meets the "facts -and-circumstances" test The organization qualifies as a publicly supported

organization ► Fb 10%-facts-and-circumstances test -2014.Ifthe organization did not check a box on line 13, 16a, 16b, or 17a, and line

15 is 10% or more, and if the organization meets the "facts -and-circumstances" test, check this box and stop here.Explain in Part VI how the organization meets the "facts -and-circumstances" test The organization qualifies as a publicly

supported organization ► p18 Private foundation .If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see

instructions ► F

Schedule A (Form 990 or 990-EZ) 2015


IMMISTM Support Schedule for Organizations Described in Section 509(a)(2)(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under PartII. If the organization fails to qualify under the tests listed below, please complete Part II.)

Section A. Public SupportCalendar year

(a)2011 (b)2012 (c)2013 (d)2014 (e)2015 (f)Total(or fiscal year beginning in) ►1 Gifts, grants, contributions, and

membership fees received (Donot include any "unusual grants ')

2 Gross receipts from admissions,merchandise sold or servicesperformed, or facilities furnishedin any activity that is related tothe organization's tax-exemptpurpose

3 Gross receipts from activitiesthat are not an unrelated trade orbusiness under section 513

4 Tax revenues levied for theorganization's benefit and eitherpaid to or expended on its behalf

5 The value of services or facilitiesfurnished by a governmental unitto the organization without charge

6 Total . Add lines 1 through 5

7a Amounts included on lines 1, 2,and 3 received from disqualifiedpersons

b Amounts included on lines 2 and3 received from other thandisqualified persons that exceedthe greater of $5,000 or 1% ofthe amount on line 13 for the year

c Add lines 7a and 7b

8 Public support . (Subtract line 7cfrom line 6 )

Section B. Total Support

Calendar year(a)2011 (b)2012 (c)2013 (d)2014 (e)2015 (f)Total

(or fiscal year beginning in) ►9 Amounts from line 6

10a Gross income from interest,dividends, payments received onsecurities loans, rents, royaltiesand income from similar sources

b Unrelated business taxableincome (less section 511 taxes)from businesses acquired afterJune 30, 1975

c Add lines 10a and 10b

11 Net income from unrelatedbusiness activities not includedin line lob, whether or not thebusiness is regularly carried on

12 Other income Do not includegain or loss from the sale ofcapital assets (Explain in PartVI )

13 Total support . (Add lines 9, 10c,11, and 12 )

14 First five years .If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization,

check this box and stop here ► ESection C . Computation of Public Support Percentage

15 Public support percentage for 2015 (line 8, column (f) divided by line 13, column (f))

16 Public support percentage from 2014 Schedule A, Part III, line 15

Section D. Computation of Investment Income Percentage

17 Investment income percentage for 2015 (line l Oc, column (f) divided by line 13, column (f))

18 Investment income percentage from 2014 Schedule A, Part III, line 17

19a 331 / 3% support tests- 2015 .Ifthe organization did not check the box on line 14, and line 15 is more than 33 1/3%, and line 17 is not

more than 33 1/3%, check this box and stop here . The organization qualifies as a publicly supported organization ► Fb 331 / 3% support tests- 2014.Ifthe organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3% and line

18 is not more than 33 1/3%, check this box and stop here . The organization qualifies as a publicly supported organization ► F20 Private foundation . Ifthe organization did not check a box on line 14, 19a, or 19b, check this box and see instructions ► F



Supporting Organizations

(Complete only if you checked a box on line 11 of Part I If you checked 11a of Part I, complete Sections A and B If you checked1lb of Part I, complete Sections A and C If you checked 1Ic of Part I, complete Sections A, D, and E If you checked l ld of PartI, complete Sections A and D, and complete Part V

Section A. All Supportincl Organizations

No

1 Are all of the organization's supported organizations listed by name in the organization's governing documents?If "No," describe in Part VI how the supported organizations are designated If designated by class or purpose,describe the designation If historic and continuing relationship, explain

2 Did the organization have any supported organization that does not have an IRS determination of status undersection 509(a)(1 ) or (2 )?If "Yes," explain in Part VZ how the organization determined that the supported organization was described in section509(a)(1) or (2)

3a Did the organization have a supported organization described in section 501(c)(4), (5), or (6)?If "Yes," answer (b) and (c) below

b Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) andsatisfied the public support tests under section 509(a)(2)''If "Yes," describe in Part VZ when and how the organization made the determination

c Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B)purposes?If "Yes," explain in Part VZ what controls the organization put rn place to ensure such use

4a Was any supported organization not organized in the United States ("foreign supported organization")?If "Yes"and if you checked 11a or 11b rn Part I, answer (b) and (c) below 4a

b Did the organization have ultimate control and discretion in deciding whether to make grants to the foreignsupported organization?If "Yes,"describe in Part VI how the organization had such control and discretion despite being controlled or supervised 4b

by or in connection with Its supported organizations

c Did the organization support any foreign supported organization that does not have an IRS determination undersections 501(c)(3) and 509(a)(1) or (2)?If "Yes,"explain in Part VI what controls the organization used to ensure that all support to the foreign supportedorganization was used exclusively for section 170(c)(2)(B) purposes

5a Did the organization add, substitute, or remove any supported organizations during the tax year?If "Yes,"answer (b) and (c) below (if applicable) Also, provide detail in Part VI, including (r) the names and EINnumbers of the supported organizations added, substituted, or removed, (n) the reasons for each such action, (III) theauthority under the organization's organizing document authorizing such action, and (iv) how the action wasaccomplished (such as by amendment to the organizing document)

b Type I or Type II only . Was any added or substituted supported organization part of a class already designated itthe organization's organizing document?

c Substitutions only. Was the substitution the result of an event beyond the organization's control?

6 Did the organization provide support (whether in the form of grants or the provision of services or facilities) toanyone other than (a) its supported organizations, (b) individuals that are part of the charitable class benefited bone or more of its supported organizations, or (c) other supporting organizations that also support or benefit oneor more of the filing organization's supported organizations? If "Yes, "provide detail in Part VI.

7 Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor(defined in IRC 4958(c)(3)(C)), a family member ofa substantial contributor, or a 35-percent controlled entitywith regard to a substantial contributor? If "Yes,"complete Part l of Schedule L (Form 990)

8 Did the organization make a loan to a disqualified person (as defined in section 4958) not described in line 7?If "Yes," complete Part II of Schedule L (Form 990)

9a Was the organization controlled directly or indirectly at any time during the tax year by one or more disqualifiedpersons as defined in section 4946 (other than foundation managers and organizations described in section 509(a)(1) or (2))? If "Yes,"provide detail rn Part VI.

b Did one or more disqualified persons (as defined in line 9(a)) hold a controlling interest in any entity in which thesupporting organization had an interest? If "Yes,"provide detail rn Part V7.

c Did a disqualified person (as defined in line 9(a)) have an ownership interest in, or derive any personal benefitfrom, assets in which the supporting organization also had an interest? If "Yes,"provide detail rn Part V7.

10a Was the organization subject to the excess business holdings rules of IRC 4943 because of IRC 4943(f)(regarding certain Type II supporting organizations, and all Type III non-functionally integrated supportingorganizations)? If "Yes,"answer b below

b Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to determinewhether the organization had excess business holdings)

11 Has the organization accepted a gift or contribution from any of the following persons?

a A person who directly or indirectly controls, either alone or together with persons described in (b) and (c) below,the governing body of a supported organization?

b A family member of a person described in (a) above?

c A 35% controlled entity of a person described in (a) or (b) above''If "Yes "to a, b, or c, provide detail in Part VI


4c


Supporting organizations (continued)

Section B. Type I Supporting Organizations

Did the directors, trustees, or membership of one or more supported organizations have the power to regularlyappoint or elect at least a majority of the organization's directors or trustees at all times during the tax year?If "No,"describe rn Part VI how the supported organization(s) effectively operated, supervised, or controlled theorganization's activities If the organization had more than one supported organization, describe how the powers toappoint and/or remove directors or trustees were allocated among the supported organizations and what conditions orrestrictions, if any, applied to such powers during the tax year

2 Did the organization operate for the benefit of any supported organization other than the supported organization(sthat operated, supervised, or controlled the supporting organization?If "Yes,"explain in Part VZ how providing such benefit carried out the purposes of the supported organization(s) thatoperated, supervised or controlled the supporting organization

No

Section C. Type II Supporting Organizations

Were a majority of the organization's directors or trustees during the tax year also a majority of the directors ortrustees of each of the organization's supported organization(s)'If "No,"describe rn Part VI how control or management of the supporting organization was vested in the same personsthat controlled or managed the supported organization(s)

No

Did the organization provide to each of its supported organizations, by the last day of the fifth month of theorganization's tax year, (1) a written notice describing the type and amount of support provided during the priortax year, (2) a copy of the Form 990 that was most recently filed as of the date of notification, and (3) copies ofthe organization's governing documents in effect on the date of notification, to the extent not previously provided?

2 Were any of the organization's officers, directors, or trustees either (i) appointed or elected by the supportedorganization(s) or (ii) serving on the governing body of a supported organization?If "No," explain rn Part VI how the organization maintained a close and continuous working relationship with thesupported organization(s)

No

3 By reason of the relationship described in (2), did the organization's supported organizations have a significantvoice in the organization's investment policies and in directing the use of the organization's income or assets atall times during the tax year?If "Yes,"describe in Part VZ the role the organization's supported organizations played rn this regard 3

Section E. Tvne III Functionally-Integrated Sunnortina Oraanizations

Check the box next to the method that the organization used to satisfy the Integral Part Test during the year ( see instructions)

F- The organization satisfied the Activities Test Complete line 2 below

p The organization is the parent of each of its supported organizations Complete line 3 below

p The organization supported a governmental entity Describe in Part VI how you supported a government entity (seeinstructions)

Activities Test Answer ( a) and ( b) below.

a Did substantially all of the organization's activities during the tax year directly further the exempt purposes oftFsupported organization(s) to which the organization was responsive?If "Yes,"then rn Part VI identify those supported organizations and exp lain how these activities directlyfurthered their exempt purposes, how the organization was responsive to those supported organizations, and how theorganization determined that these activities constituted substantially all of Its activities

b Did the activities described in (a) constitute activities that, but for the organization's involvement, one or more cthe organization's supported organization(s) would have been engaged in?If "Yes," explain in Part VZ the reasons for the organization's position that Its supported organization(s) would haveengaged rn these activities but for the organization's involvement

3 Parent of Supported Organizations Answer ( a) and ( b) below.

a Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or trusteeseach of the supported organizations? Provide details in Part VI

b Did the organization exercise a substantial degree of direction over the policies, programs and activities of eachof its supported organizations? If "Yes," describe in Part VI the role played by the organization rn this regard



Type III Non - Functionally Integrated 509(a )( 3) Supporting Organizations

1 Check here if the organization satisfied the Integral Part Test as a qualifying trust on Nov 20, 1970 See instructions . All other

Type III non-functionally integrated supporting organizations must complete Sections A through E E

Section A - Adjusted Net Income (A) Prior Year(B) Current Year

(optional)

1 Net short-term capital gain 1

2 Recoveries of prior-year distributions 2

3 Other gross income (see instructions) 3

4 Add lines 1 through 3 4

5 Depreciation and depletion 5

Portion of operating expenses paid or incurred for production or collection of6 gross income or for management, conservation, or maintenance of property

held for production of income (see instructions) 6

7 Other expenses (see instructions) 7

8 Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) 8

Section B - Minimum Asset Amount (A) Prior Year(B) Current Year

(optional)

1 Aggregate fair market value of all non-exempt-use assets (seeinstructions for short tax year or assets held for part of year) 1

a Average monthly value of securities la

b Average monthly cash balances lb

c Fair market value of other non-exempt-use assets Sc

d Total (add lines la, lb, and lc) Id

Discount claimed for blockage or other factorse (explain in detail in Part VI)

2 Acquisition indebtedness applicable to non-exempt use assets 2

3 Subtract line 2 from line Id 3

4 Cash deemed held for exempt use Enter 1-1/2% of line 3 (for greateramount, see instructions) 4

5 Net value of non-exempt-use assets (subtract line 4 from line 3) 5

6 Multiply line 5 by 035 6

7 Recoveries of prior-year distributions 7

8 Minimum Asset Amount (add line 7 to line 6) 8

Section C - Distributable Amount Current Year

1 Adjusted net income for prior year (from Section A, line 8, Column A) 1

2 Enter 85% of line 1 2

3 Minimum asset amount for prior year (from Section B, line 8, Column A) 3

4 Enter greater of line 2 or line 3 4

5 Income tax imposed in prior year 5

6 Distributable Amount . Subtract line 5 from line 4, unless subject toemergency temporary reduction (see instructions) 6

7 Check here if the current year is the organization's first as a non-functionally-integrated Type III supporting organization (see

instructions)



Type III Non - Functionally Integrated 509(a )( 3) Supporting Organizations ( continued)

Section D - Distributions Current Year

1 Amounts paid to supported organizations to accomplish exempt purposes

2 Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, inexcess of income from activity

3 Administrative expenses paid to accomplish exempt purposes ofsupported organizations

4 Amounts paid to acquire exempt-use assets

5 Qualified set-aside amounts (priorIRS approval required)

6 Other distributions (describe in Part VI) See instructions

7 Total annual distributions . Add lines 1 through 6

8 Distributions to attentive supported organizations to which the organization is responsive (providedetails in Part VI) See instructions

9 Distributable amount for 2015 from Section C, line 6

10 Line 8 amount divided by Line 9 amount

Section E - Distribution Allocations ( see

instructions )M

Excess Distributions

(ii)Underdistributions

Pre-2015

(iii)Distributable

Amount for 2015

1 Distributable amount for 2015 from Section C, line6

2 U nderdistributions, if any, for years prior to 2015(reasonable cause required--see instructions)

3 Excess distributions carryover, if any, to 2015

a

b

c

d From 2013.

e From 2014.

f Total of lines 3a through e

g Applied to underdistributions of prior years

h Applied to 2015 distributable amount

i Carryover from 2010 not applied (seeinstructions)

j Remainder Subtract lines 3g, 3h, and 3i from 3f

4 Distributions for 2015 from Section D, line 7

a Applied to underdistributions of prior years

b Applied to 2015 distributable amount

c Remainder Subtract lines 4a and 4b from 4

5 Remaining underdistributions for years prior to2015, if any Subtract lines 3g and 4a from line 2(if amount greater than zero, see instructions)

6 Remaining underdistributions for 2015 Subtractlines 3h and 4b from line 1 (if amount greater thanzero, see instructions)

7 Excess distributions carryover to 2016 . Add lines3j and 4c

8 Breakdown of line 7

a

b

c Excess from 2013. . . . . . .

d From 2014.

e From 2015.

Schedule A (Form 990 or 990-EZ) (2015)


ff^ Supplemental Information.

Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12; Part IV,Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2;Part IV, Section C, line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a and 3b;Part V, line 1; Part V, Section B, line le; Part V Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5,and 6. Also complete this part for any additional information. (See instructions).

Facts And Circumstances Test

Return Reference Explanation



o 1545-0047SCHEDULE C Political Campaign and Lobbying Activities

Oi(Form 990 orFor Organizations Exempt From Income Tax Under section 501 ( c) and section 527 015990-EZ ) ►Complete if the organization is described below . 110- Attach to Form 990 or Form 990-EZ.

about Schedule C (Form 990 or 990- EZ) and its instructions is at Ope nDepartment of the www.irs.gov/form990 . InspectionTreasuryInternal RevenueService

If the organization answered "Yes" on Form 990, Part IV, Line 3 , or Form 990 - EZ, Part V , line 46 (Political Campaign Activities), then

• Section 501(c)(3) organizations Complete Parts I-A and B Do not complete Part I-C

• Section 501(c) (other than section 501(c)(3)) organizations Complete Parts I-A and C below Do not complete Part I-B• Section 527 organizations Complete Part I-A only

If the organization answered "Yes" on Form 990, Part IV, Line 4, or Form 990 - EZ, Part VI , line 47 ( Lobbying Activities), then

• Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)) Complete Part II-A Do not complete Part II-B• Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)) Complete Part II-B Do not complete Part II-A

If the organization answered "Yes" on Form 990, Part IV, Line 5 (Proxy Tax) ( see separate instructions ) or Form 990-EZ , Part V,

line 35c ( Proxy Tax) (see separate instructions), then• Section 501(c)(4), (5), or (6) organizations Complete Part III

Name of the organization I Employer identification numberHoward Hughes Medical Institute

59-0735717

Complete if the organization is exempt under section 501(c) or is a section 527 organization.

1 Provide a description of the organization's direct and indirect political campaign activities in Part IV

2 Political expenditures ► $

3 Volunteer hours

Complete if the organization is exempt under section 501 ( c)(3).

1 Enter the amount of any excise tax incurred by the organization under section 4955 ► $

2 Enter the amount of any excise tax incurred by organization managers under section 4955 ► $

3 If the organization incurred a section 4955 tax, did it file Form 4720 for this year? [ Yes [ No

4a Was a correction made? [ Yes [ No

b If "Yes," describe in Part IV

Complete if the organization is exempt under section 501(c), except section 501(c)(3).

1 Enter the amount directly expended by the filing organization for section 527 exempt function activities ► $

2 Enter the amount of the filing organization's funds contributed to other organizations for section 527exempt function activities ► $

3 Total exempt function expenditures Add lines 1 and 2 Enter here and on Form 1120-PO L, line 17b ► $

4 Did the filing organization fileForm 1120-POL for this year? [ Yes [ No

5 Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filingorganization made payments For each organization listed, enter the amount paid from the filing organization's funds A Iso enter theamount of political contributions received that were promptly and directly delivered to a separate political organization, such as aseparate segregated fund or a political action committee (PAC) If additional space is needed, provide information in Part IV

(a) Name (b) Address ( c) EIN (d ) Amount paid from (e) Amount of politicalfiling organization's contributions received

funds If none, enter -0- and promptly anddirectly delivered to a

separate politicalorganization If none,

enter -0-

2

3

4

5

6

ror raperworK Keauction Act notice, see cne instructions or rorm 99U or 99U-tc. Cat No 50084S Schedule C (Form 990 or 990-EZ) 2015

Schedule C (Form 990 or 990- EZ) 2015 Page 2

Complete if the organization is exempt under section 501 ( c)(3) and filed Form 5768 ( electionunder section 501(h)).

A Check ► [ if the filing organization belongs to an affiliated group (and list in Part IV each affiliated group member's name, address, EIN,expenses, and share of excess lobbying expenditures)

Limits on Lobbying Expenditures( a) Filing (b) Affiliated

organization ' s group totals(The term "expenditures" means amounts paid or incurred.) totals

laTotal lobbying expenditures to influence public opinion (grass rootslobbying)

b Total lobbying expenditures to influence a legislative body (direct lobbying)

Total lobbying expenditures (add lines la and 1b)c

d Other exempt purpose expenditures

Total exempt purpose expenditures ( add lines lc and 1d)e

f Lobbying nontaxable amount Enter the amount from the following table in both columns

If the amount on line le, column ( a) or (b ) is: The lobbying nontaxable amount is:

Not over $500,000 20% of the amount on line le

Over $500,000 but not over $1,000,000 $100,000 plus 15% of the excess over $500,000

Over $1,000,000 but not over $1,500,000 $175,000 plus 10% of the excess over $1,000,000

Over $1,500,000 but not over $17,000,000 $225,000 plus 5% of the excess over $1,500,000

Over $17,000,000 $1,000,000

gGrassroots nontaxable amount (enter 25% of line 1f)

h Subtract line 1g from line la If zero or less, enter -0-

Subtract line if from line 1c If zero or less, enter -0-i

If there is an amount other than zero on either line 1h or line li, did the organization file Form 4720reporting section 4911 tax for this year?

F- Y e s F- No

4-Year Averaging Period Under section 501(h)(Some organizations that made a section 501(h) election do not have to complete all of the five

columns below. See the separate instructions for lines 2a through 2f.)

Lobbvina Expenditures During 4-Year Averaaina Period

Calendar year (or fiscal yearbeginning in)

(a)2012 (b)2013 (c)2014 (d)2015 (e) Total

2a Lobbying nontaxable amount

b Lobbying ceiling amount150% of line 2a, column e

c Total lobbying expenditures

d Grassroots nontaxable amount

e Grassroots ceiling amount(150% of line 2d, column (e))

f Grassroots lobbying expenditures

Schedule C (Form 990 or 990-EZ) 2015

Schedule C (Form 990 or 990-EZ) 2015 Pa g e 3

Complete if the organization is exempt under section 501(c)(3) and has NOTfiled Form 5768 ( election under section 501 ( h )) .

" " ( a (b)For each response on lines la through li below, provide in Part IV a detailed description of the lobbyingYesactivity No Amount

Yes

1 During the year, did the filing organization attempt to influence foreign, national, state or locallegislation, including any attempt to influence public opinion on a legislative matter or referendum,through the use of

a Volunteers? o

b Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? No

c Media advertisements? No

d Mailings to members, legislators, or the public? No

e Publications, or published or broadcast statements? No

f Grants to other organizations for lobbying purposes? No

g Direct contact with legislators, their staffs, government officials, or a legislative body? No

h Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? No

i Other activities? Yes 2,267

j Total Add lines lc through 11 2,267

2a Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? No

b If "Yes," enter the amount of any tax incurred under section 4912

c If "Yes," enter the amount of any tax incurred by organization managers under section 4912

d If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year?

MVISTrUT Complete if the organization is exempt under section 501 ( c)(4), section 501(c )( 5), or section501 ( c )( 6 ) .

Yes No

1 Were substantially all (90% or more) dues received nondeductible by members? 1

2 Did the organization make only in-house lobbying expenditures of $2,000 or less? 2 ::::#

3 Did the organization agree to carry over lobbying and political expenditures from the prior year? 3

Complete if the organization is exempt under section 501 ( c)(4), section 501(c )( 5), or section501(c)(6) and if either ( a) BOTH Part III-A, lines 1 and 2 , are answered " No" OR ( b) Part III-A,line 3, is answered "Yes."

1 Dues, assessments and similar amounts from members 1

2 Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of politicalexpenses for which the section 527(f ) tax was paid).

a Current year 2a

b Carryover from last year 2b

c Total 2c

3 Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues 3

4 If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excessdoes the organization agree to carryover to the reasonable estimate of nondeductible lobbying andpolitical expenditure next year? 4

5 Taxable amount of lobbying and political expenditures (see instructions) 5

Supplemental Information

Provide the descriptions required for Part I-A, line 1 , Part I - B, line 4 , Part I-C, line 5, Part II -A (affiliated group list), Part II-A, lines 1 and2 ( see instructions , and Part II-B , line 1 Also , com p lete this p art for an y additional information


Schedule C, Part II-B, Line 1 OTHER ACTIVITIES, SCHEDULE C, PART II-B, LINE 11 (OTHER ACTIVITIES) DURING THEDETAILED DESCRIPTION OF THE FISCAL YEAR, HHMI WAS A MEMBER OF A NUMBER OF NON -PROFIT ORGANIZATIONS THATLOBBYING ACTIVITY ENGAGED IN LOBBYING ACTIVITIES ON BEHALF OF THEIR MEMBERSHIPS HHMI IS

REPORTING AS LOBBYING EXPENDITURES A PORTION OF THE MEMBERSHIP DUES THATHHMI PAID TO THESE ORGANIZATIONS

Schedule C, Part II-B, Line 1 OTHER ACTIVITIES, SCHEDULE C, PART II-B, LINE 11 (OTHER ACTIVITIES) DURING THEDETAILED DESCRIPTION OF THE FISCAL YEAR, HHMI WAS A MEMBER OF A NUMBER OF NON -PROFIT ORGANIZATIONS THATLOBBYING ACTIVITY ENGAGED IN LOBBYING ACTIVITIES ON BEHALF OF THEIR MEMBERSHIPS HHMI IS

REPORTING AS LOBBYING EXPENDITURES A PORTION OF THE MEMBERSHIP DUES THATHHMI PAID TO THESE ORGANIZATIONS

Schedule C (Form 990 or 990EZ) 2015

lefile GRAPHIC print - DO NOT PROCESS As Filed Data - DLN: 93493109008027

SCHEDULE D OMB No 1545-0047

(Form 990)Supplemental Financial Statements

► Complete if the organization answered "Yes," on Form 990,20 1 5

Part IV, line 6, 7, 8, 9, 10, I l a , llb, 11c, lid, Ile, ilf, 12a, or 12b.Department of the ► Attach to Form 990. Ope n to Pu b licTreasury Information about Schedule D (Form 990 ) and its instructions is at www.irs.gov/form990 . Ins pe cti o nInternal Revenue Service

Name of the organization Employer identification numberHoward Hughes Medical Institute

59-0735717

Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts.

Complete if the organization answered "Yes" on Form 990, Part IV, line 6.

1 Total number at end of year

2 Aggregate value of contributions to (duringyear)

3 Aggregate value of grants from (during year)

4 Aggregate value at end of year

5 Did the organization inform all donors and donor advisors in writing that the assets held in donor advisedfunds are the organization 's property, subject to the organization ' s exclusive legal control ? [Yes [ No

6 Did the organization inform all grantees , donors, and donor advisors in writing that grant funds can beused only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purposeconferring impermissible private benefit? [Yes [No

Conservation Easements. Complete if the organization answered " Yes" on Form 990, Part IV, line 7.

1 Purpose ( s) of conservation easements held by the organization ( check all that apply)

Preservation of land for public use ( e g , recreation oreducation ) [ Preservation of an historically important land area

Protection of natural habitat [ Preservation of a certified historic structure

Preservation of open space

2 Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form ofa conservationeasement on the last day of the tax year

Held at the End of the Year

a Total number of conservation easements 2a

b Total acreage restricted by conservation easements 2b

c N umber of conservation easements on a certified historic structure included in (a) 2c

d N umber of conservation easements included in (c) acquired after 8/17/06, and not on ahistoric structure listed in the National Register 2d

3 Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the

tax year ►

4 Number of states where property subject to conservation easement is located ►

5 Does the organization have a written policy regarding the periodic monitoring, inspection, handling ofviolations, and enforcement of the conservation easements it holds? [ Yes [ No

6 Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during theyear

00,

7 A mount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year

8 Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(1) and section 170(h)(4)(B)(ii)? [ Yes [ No

9 In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, andbalance sheet, and include, if applicable, the text of the footnote to the organization's financial statements that describesthe organization's accounting for conservation easements

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.ComDlete if the oraanization answered "Yes" on Form 990. Part IV. line S.

la Ifthe organization elected, as permitted under SFAS 116 (ASC 958), not to report in its revenue statement and balance sheetworks of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of publicservice, provide, in Part XIII, the text of the footnote to its financial statements that describes these items

b Ifthe organization elected, as permitted under SFAS 116 (ASC 958), to report in its revenue statement and balance sheetworks of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of publicservice, provide the following amounts relating to these items

(i) Revenue included on Form 990, Part VIII, line 1

(ii) Assets included in Form 990, Part X ► $

2 If the organization received or held works of art , historical treasures , or other similar assets for financial gain, provide thefollowing amounts required to be reported under SFAS 116 (ASC 958) relating to these items

a Revenue included on Form 990, Part VIII, line 1

b Assets included in Form 990, Part X

For Paperwork Reduction Act Notice, see the Instructions for Form 990. Cat No 52283D Schedule D (Form 990) 2015

Schedule D (Form 990) 2015 Page 2

171 Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets

(continued)

3 Using the organization's acquisition, accession, and other records, check any of the following that are a significant use of itscollection items (check all that apply)

a [ Public exhibition d [ Loan or exchange programs

b _ Scholarly research e [ Other

c [ Preservation for future generations

4 Provide a description of the organization's collections and explain how they further the organization's exempt purpose inPart XIII

5 During the year, did the organization solicit or receive donations of art, historical treasures or other similarassets to be sold to raise funds rather than to be maintained as part of the organization's collection? Yes No

Escrow and Custodial Arrangements.

Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or reported an amount on Form 990,Part X, line 21.

la Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets notincluded on Form 990, Part X7 E Yes F_ No

b If "Yes ," explain the arrangement in Part XIII and complete the following table Amount

c Beginning balance Sc

d Additions during the year ld

e Distributions during the year le

f Ending balance if

2a Did the organization include an amount on Form 990, Part X , line 21 , for escrow or custodial account liability? F-Yes [ No

b If"Yes," explain the arrangement in Part XIII Check here if the explanation has been provided in Part XIII . . . . . . . . q

IMIMIT-Endowment Funds . Complete if the organization answered "Yes" to Form 990, Part IV, line 10.

(a)Current year (b)Prior year b (c)Two years back (d)Three years back (e)Four years back

la Beginning of year balance . .

b Contributions

c Net investment earnings, gains, andlosses

d Grants or scholarships

e Other expenditures for facilitiesand programs

f Administrative expenses .

g End of year balance

2 Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as

a Board designated or quasi-endowment ►

b Permanent endowment ►

c Temporarily restricted endowment ►The percentages on lines 2a, 2b, and 2c should equal 100%

3a Are there endowment funds not in the possession of the organization that are held and administered for theorganization by Yes No

(i) unrelated organizations . . . . . . . . . . . . . . . . . 3a(i)

(ii) related organizations . . . . . . . . . . . . . . . 3a(ii)

b If "Yes" on 3a(ii), are the related organizations listed as required on Schedule R7 . . I 3b

4 Describe in Part XIII the intended uses of the organization's endowment funds

Lolus Land , Buildings , and Equipment.Comolete if the oraanlzation answered 'Yes' to Form 990. Part IV. line 11a.See Form 990. Part X. line 10.

Description of property (a)Cost or other basis

(investment)

(b)Cost or other basis

(other)

Accumulated(c)depreciation

(d)Book value

la Land . . . . . . . . . . . . . . 807,737 35,488,028 36,295,765

b Buildings10,248,413 751,765,532 267,784,380 494,229,565

c Leasehold improvements . . . . . . . . . . 383,497,469 346,414,306 37,083,163

d Equipment 536,521,827 434,323,808 102,198,019

e Other

. 921,448 68,090,150 69,011,598

Total . Add lines la through le (Column (d) must equal Form 990, Part X, column (B), line 10(c)) . ► 738,818,110

Schedule D (Form 990) 2015


1:M.&Tjol Investments -Other Securities . Complete if the organization answered 'Yes' on Form 990, Part IV, line 11b.Spp Fnrm 9gfl Part X Iina 17

(a) Description of security or category(including name of security)

( b)Book value ( c)Method of valuationCost or end-of-year market value

(1)Financial derivatives

(2)Closely-held equity interests

(3)0 ther(A) PRIVATE EQUITY & REAL ESTATE 5,001,889,119 F

(B) DISTRESSED & CREDIT SENSITIVE 2,259,037,867 F

(C) HEDGED EQUITY 2,317,213,493 F

(D) MARKET NEUTRAL 1,283,983,391 F

(E) EQUITY COMMINGLED 2,216,048,861 F

Total . (Column (b) must equal Form 990, Part X, col ( B) line 12 ) ► 13,078,172,731

l JU 'III Investments-Program Related.Complete if the organization answered 'Yes' on Form 990, Part IV, line 11c-See Form 990 , Part X , line 13.

(a) Description of investment

I I

(b) Book value (c) Method of valuationCost or end-of-year market value

Total . (Column (b) must equal Form 990, Part X, col (B) line 13) 0. 11

MIMI Other Assets . Com p lete if the or g anization answered 'Yes' on Form 990, Part IV, line 11d See Form 990, Part X, line 15

(a) Description (b) Book value

Total . (Column (b) must equal Form 990, Part X, col (B) line 15) . ►

Other Liabilities . Complete if the organization answered 'Yes' on Form 990, Part IV, line 11e or 11f.See Form 990 , Part X line 25.

(a) Description of liability (b) Book value

Federal income taxes


Total . ( Column (b) must equal Form 990, Part X, col ( B) line 25 ) ► I 638,986,054

2. Liability for uncertain tax positions In Part XIII , provide the text of the footnote to the organization ' s financial statements that reports theorganization ' s liability for uncertain tax positions under FIN 48 (ASC 740 ) Check here if the text of the footnote has been provided in Part

XIII fl



Reconciliation of Revenue per Audited Financial Statements With Revenue per ReturnCom p lete if the org anization answered 'Yes' on Form 990 , Part IV line 12a.

1 Total revenue, gains, and other support per audited financial statements . 1 632,634,951

2 Amounts included on line 1 but not on Form 990, Part VIII, line 12

a Net unrealized gains (losses) on investments . . . . 2a -462,519,248

b Donated services and use of facilities . 2b

c Recoveries of prior year grants 2c

d Other (Describe in Part XIII ). 2d 0

e Add lines 2a through 2d . . . . . . . . . . . . . . . . . . . . 2e -462,519,248

3 Subtract line 2e from line 1 . . . . . . . . . . . . . . . . . 3 1,095,154,199

4 Amounts included on Form 990, Part VIII, line 12, but not on line 1

a Investment expenses not included on Form 990, Part VIII, line 7b 4a 106,591,310

b Other (Describe in Part XIII ) . . . . . . . . . . 4b -1,424,636

c Add lines 4a and 4b . . . . . . . . . . . . . . . . . . . c 05,166,674

5 Total revenue Add lines 3 and 4c.(This must equal Form 990, Part I, line 12 . . . . . 5 1,200,320,873

Reconciliation of Expenses per Audited Financial Statements With Expenses per Return.Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.

1 Total expenses and losses per audited financial statements 1 1,028,310,514

2 Amounts included on line 1 but not on Form 990, Part IX, line 25

a Donated services and use of facilities . 2a

b Prior year adjustments 2b

c Other losses . . . . . . . . . . . . . . . 2c

d Other (Describe in Part XIII . . . . . . . . . 2d 0

e Add lines 2a through 2d . . . . . . . . . . . . . . . . . . . 2e 0

3 Subtract line 2e from line 1 . . . . . . . . . . . . . . . . . . 3 1,028,310,514

4 Amounts included on Form 990, Part IX, line 25, but not on line 1:

a Investment expenses not included on Form 990, Part VIII, line 7b 106,591,3104a

b Other (Describe in Part XIII ) . . . . . . . . . 4b -1,424,636

c Add lines 4a and 4b . . . . . . . . . . . . . . . . . . . . c 05,166,674

5 Total expenses Add lines 3 and 4c. (This must equal Form 990, Part I, line 18 ) 5 1,133,477,188

JIMOOM Supplemental Information

Provide the descriptions required for Part II, lines 3, 5, and 9, Part III, lines la and 4, Part IV, lines lb and 2b,Part V, line 4, Part X, line 2, Part XI, lines 2d and 4b, and Part XII, lines 2d and 4b Also complete this part to provide any additionalinformation


Schedule D, Part XI, Line 4(b) Other Rental Expenses - -1424636revenues in form 990 not in auditedfinancial statements



Supplemental Information (continued)

Return Reference I Explanation


Additional Data



EIN: 59-0735717


Form 990, Schedule D, Part X, - Other Liabilities

1 (a) Description of Liability (b) Book Value

DERIVATIVE LIABILITIES 1,803,600

SHORT POSITIONS 327,937,043

INVESTMENT PURCH PENDING SALES 39,830,354

CURRENCY EXCH CONTRACTS PAY 3,755,043

CREDIT DEFAULT SWAP

PAY REALIZED GAINS ON FUTURES 113,838

DEFERRED COMPENSATION LIAB 39,001,217

SWAP UNREALIZED LOSS 219,572,748

INVESTMENT MANAGEMENT FEES PAYABLE 4,424,900

EQUITY SWAP

DEFERRED INCOME 740,712

INTEREST ON REPURCHASE OBLIGATIONS

REPURCHASE OBLIGATIONS

CONTRACT FOR DIFFERENCES LIABILITY 1,806,599


SCHEDULE F Statement of Activities Outside the United StatesOMB No 1545-0047

(Form 990)

2015► Complete if the organization answered " Yes" to Form 990,

Part IV, line 14b , 15, or 16.

► Attach to Form 990.Department of the Treasury ► Information about Schedule F (Form 990) and its instructions is at www.irs.gov/form990. • 'Internal Revenue Service

Name of the organization

Howard Hughes Medical InstituteEmployer identification number

59-0735717

General Information on Activities Outside the United States.Complete if the organization answered "Yes" to Form 990, Part IV, line 14b.

i Forgrantmakers . Does the organization maintain records to substantiate the amount of its grants

and other assistance, the grantees' eligibility for the grants or assistance, and the selection criteria

used to award the grants or assistance? Yes F_ No

2 Forgrantmakers . Describe in Part V the organization's procedures for monitoring the use of its grants and otherassistance outside the United States

3 Activites per Region (The following Part I, line 3 table can be duplicated if additional space is needed )

(a) Region (b) Number of (c) Number of (d) Activities conducted in (e) If activity listed in (d) is (f) Total expendituresoffices in the employees, region (by type) (e g , a program service, describe for and investments

region agents, and fundraising, program specific type of in regionindependent services, investments, grants service(s) in regioncontractors in to recipients located in the

region region)

1) See Add'I Data

( 2)

( 3)

( 4)

( 5)

3a Sub-total 0 1 8,299,671,369

b Total from continuation sheets 0 0 0to Part I

c Totals (add lines 3a and 3b) 0 1 1 1 8,299,671,369

For Paperwork Reduction Act Notice, see the Instructions for Form 990 . Cat N o 50082W Schedule F ( Form 990) 2015

Schedule F (Form 990) 2015 Page 2

Grants and Other Assistance to Organizations or Entities Outside the United States.

Complete if the organization answered "Yes" to Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated ifadditional space is needed.

1 (a) Name of (b) IRS code (c) Region (d) Purpose of (e) Amount of (f) Manner of (g) Amount (h) Description (i) Method oforganization section grant cash grant cash of non-cash of non-cash valuation

and EIN (if disbursement assistance assistance (book, FMV,applicable) appraisal, other)

( 1) Europe (Including EDUCATION IN 21,000 WTIceland and MEDICAL

Greenland ) RESEARCH

(2) Sub-Saharan Africa HIV/TB 21,000,000 WT

(3)

(4)

2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized astax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter . . . . ►

3 Enter total number of other organizations or entities 10.

Schedule F (Form 990) 2015


Grants and Other Assistance to Individuals Outside the United States . Complete if the organization answered "Yes" to Form 990, Part IV, line 16.

Part III can be duplicated if additional space is needed.

(a) Type of grant orassistance

(b) Region (c) Number ofrecipients

(d) Amount ofcash grant

(e) Manner of cashdisbursement

(f) Amount ofnon-cashassistance

(g) Descriptionof non-cashassistance

(h) Method ofvaluation

(book, FMV,

a pp raisal, other )( 1)

( 2)

( 3)

(4)

( 5)

( 6)

( 7)

( 8)

(9)

( 10)

( 11)

( 12)

( 13)

( 14)

( 15)

( 16)

( 17)

( 18)



Foreign Forms

1 Was the organization a U S transferor of property to a foreign corporation during the tax year? If "Yes,"theorganization may be required to file Form 926, Return by a U S Transferor of Property to a Foreign Corporation (seeInstructions for Form 926)

2 Did the organization have an interest in a foreign trust during the tax year? If "Yes,"the organization may berequired to file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain ForeignGifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U S Owner (see Instructions forForms 3520 and 3520-A, do not file with Form 990)

3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," theorganization may be required to file Form 5471, Information Return of U S Persons with Respect to Certain ForeignCorporations (see Instructions for Form 5471)

Fq- Yes F- No

Yes F- No

Yes F- No

4 Was the organization a director indirect shareholder of a passive foreign investment company or a qualifiedelecting fund during the tax year? If "Yes ," the organization may be required to file Form 8621, Information Returnby a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund (see Instructions for Form8621 ) [ Yes F- No

5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," theorganization may be required to file Form 8865, Return of U S Persons with Respect to Certain Foreign Partnerships(see Instructions for Form 8865)

6 Did the organization have any operations in or related to any boycotting countries during the tax year? If"Yes," the organization may be required to file Form 5713, International Boycott Report (see Instructions for Form5713, do not file with Form 990)

Yes F- No

F- Yes No




Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accountingmethod; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III(accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also completethis part to provide any additional information (see instructions).

990 Schedule F, Supplemental Information


Schedule F, Part I, Line 2 Procedures for monitoring use of During its 2016 fiscal year, HHMI continued to support International Research

grant funds Scholars selected through one or more competitions open to all eligible applicants Eligibility

requirements included, but w ere not limited to, a full-time appointment at a nonprofitscientifi

c research organization in a country other than the United States, and a

research focus onbasic biological processes or disease mechanisms Qualified applicants were

evaluated by

a panel of scientific experts with final selections made by HHMI leadership Thedisbursem

ent of grant funds to support the work of International Early Career Scientists

and SeniorInternational Research Scholars is made in accordance with all applicable U S

laws Fund

s are paid to an institutional account In order to monitor the activities andproductivit

y of the grants, each scientist is required to submit an annual progress report

concerninghis or her research and each grantee institution is required to submit annual

financial r

eports These reports are reviewed by HHMI staff site visits and audits areconducted if w

arranted and grantees attend scientific meetings of HHMI US-based scientists In

2009, HHM

I helped launch the Kw aZulu-Natal Research Institute for TB-HIV (K-RITH) incollaboration

with the University of KwaZulu-Natal (UKZN), and has provided significant

funding to support its research efforts As discussed in further detail on Schedule 0, in 2016, in

a move

to improve the health of people locally and globally, K-RITH joined forces with theAfrica

Centre for Population Health to forma groundbreaking new interdisciplinary

institute tofight tuberculosis (TB), HIV and related diseases The new organization, the

Africa Health

Research Institute, is located at the heart of South Africa's TB and HIV co-epidemic in K

w aZulu-Natal Province The effort brings together the Africa Centre's detailed

populationdata from over 100,000 participants, with K-RITH's expertise in basic science

and its w orl

d-class laboratory facilities The new venture is made possible through grantsfrom HHMI a

nd Wellcome Trust, with the University College London and UKZN as significant

academic partners The Africa Health Research Institute is committed to working towards the

elmtinatio

in of HIV and TB

990 Schedule F, Supplemental Information


Schedule F, Part I, Line 2 PROCEDURES FOR MONITORING USE OF During its 2016 fiscal year, HHMI continued to support International

GRANT FUNDS Research Scholars sel

ected through one or more competitions open to all eligible applicantsEligibility requir

ements included, but were not limited to, a full-time appointment at a

nonprofit scientific research organization in a country other than the United States, and a

research focus on

basic biological processes or disease mechanisms Qualified applicants

were evaluated bya panel of scientific experts with final selections made by HHMI leadership

The disbursem

ent of grant funds to support the work of International Early CareerScientists and Senior

International Research Scholars is made in accordance with all applicable

U S laws Funds are paid to an institutional account In order to monitor the activities and

productivit

y of the grants, each scientist is required to submit an annual progressreport concerning

his or her research and each grantee institution is required to submit

annual financial reports These reports are reviewed by HHMI staff site visits and audits are

conducted if w

arranted and grantees attend scientific meetings of HHMI US-basedscientists In 2009, HHM

I helped launch the Kw aZulu-Natal Research Institute for TB-HIV (K-RITH)

in collaborationwith the University of Kw aZulu-Natal (UKZN), and has provided significant

funding to suppo

rt its research efforts As discussed in further detail on Schedule 0, in2016, in a move

to improve the health of people locally and globally, K-RITH joined forces

with the Africa

Centre for Population Health to form a groundbreaking new interdisciplinaryinstitute to

fight tuberculosis (TB), HIV and related diseases The new organization,

the Africa HealthResearch Institute, is located at the heart of South Africa's TB and HIV co-

epidemic in K

w aZulu-Natal Province The effort brings together the Africa Centre'sdetailed population

data from over 100,000 participants, with K-RITH's expertise in basic

science and its w orld-class laboratory facilities The new venture is made possible through

grants from HHMI a

nd Wellcome Trust, with the University College London and UKZN assignificant academic par

tners The Africa Health Research Institute is committed to working

towards the elimination of HIV and TB

Additional Data



EIN: 59-0735717


Form 990 Schedule F Part I - Activities Outside The United States

(a) Region (b) N umber of (c) Number of (d) Activities (e) If activity listed in (f) Total expendituresoffices in the employees or conducted in region (by (d) is a program for region

region agents in type) (i e , fundraising, service, describeregion program services, specific type of service

grants to recipients (s) in regionlocated in the region)

Sub-Saharan Africa 0 1 Grantmaking MEDICAL RESEARCH 21,000,000

Sub-Saharan Africa 0 0 Program Services Medical Research 113,932

Europe (Including Iceland 0 0 Grantmaking Investigator Education 21,000and Greenland)

(a) Region

Sub-Saharan Africa

(b) Number of (c) Number of (d) Activities (e) If activity listed inoffices in the employees or conducted in region (by (d) is a program



n 0 Investments

(f) Total expendituresfor region

41,296,611

North America ( Canada & 0 0 Investments 214,473,645Mexico only)

Europe ( Including Iceland 0 0 Investments 1,267,663,712and Greenland)

(a) Region

East Asia and the Pacific




n 0 Investments


568,220,903

Central America and the 0 0 Investments 6,073,683,993Caribbean

South America 0 (Investments 48,225,203

(a) Region

South Asia

Middle East and North Africa




n 0 Investments

0 (Investments


51,112,999

6,553,062

Russia and Neighboring 0 0 Investments 4,192,930States

(a) Region

Europe (Including Icelandand Greenland)




o 0 Program Services Open Access


3,113,379


Schedule I OMB No 1545-0047

(Form 990 ) Grants and Other Assistance to Organizations,

2p 1 5Governments and Individuals in the United StatesComplete if the organization answered "Yes," on Form 990, Part IV, line 21 or 22.

Department of the ► Attach to Form 990.Treasury ► Information about Schedule I (Form 990 ) and its instructions is at www. irs.gov /form990 .Internal Revenue Service

Name of the organization Employer identification number

Howard Hughes Medical Institute59-0735717

JL^ General information on Grants and Assistance

1 Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, andthe selection criteria used to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . [ Yes [ No

2 Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States

Grants and Other Assistance to Domestic Organizations and Domestic Governments . Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any recipient

that raraivari more than & r n n n Part TT can ha riiinliratari if ariditinnal c nary is naariari

(a) Name and address oforganization

or government

( b) EIN (c ) IRC sectionif applicable

(d) Amount ofcashgrant

(e) Amount of non-cash

assistance

(f ) Method ofvaluation

(book, FMV,appraisal,

other)

(g) Description ofnon-cash assistance

(h) Purpose of grantor assistance


2 Enter total number of section 501(c)(3) and government organizations listed in the line 1 table . ► 81

3 Enter total number of other organizations listed in the line 1 table . ► 4

For Paperwork Reduction Act Notice, see the Instructions for Form 990 . Cat No 50055P Schedule I (Form 990) 2015

Schedule I (Form 990) 2015

Grants and Other Assistance to Domestic Individuals . Complete if the organization answered "Yes" on Form 990, Part IV, line 22Part III can be duplicated if additional space is needed

Pace 2

(a)Type of grant or assistance ( b)Number of

reci p ients

(c)A mount ofcash g rant

(d)Amount ofnon-cash assistance

(e)Method of valuation (book,FMV, a pp raisal, other )

(f)Description of non-cash assistance

(1) EXROP PROGRAM 105 597,563

(2) GILLIAM FELLOWSHIPS 92 4,382,406

(3) SCIENCE EDUCATION FELLOWSHIPS 1 61,919

INTERNATIONAL PREDOCTORAL(4) FELLOWSHIPS

85 1,963,500

(5) MEDICAL RESEARCH FELLOWSHIPS 70 2,893,560

(6) FACULTY SCHOLARS 80 76,500,000

Supplemental Information . Provide the information required in Part I, line 2, Part III, column (b), and any other additional information.


Schedule I, Part I, Line 2 HHMI awards institutional grants in support of precollege, undergraduate, and graduate education in the US through periodic national competitions forProcedures for monitoring use of which select institutions are eligible to apply Each program sets out specific criteria and objectives, proposals are evaluated by a panel of experts withgrant funds the final selection made by HHMI leadership The Institute also awards fellowships to international predoctoral students, to medical students seeking to

conduct basic laboratory research, and to doctoral students (the Gilliam Fellows) These grants are also awarded on a competitive basis A smallnumber of grants are awarded based on direct application to H H MI for specific initiatives directly related to science education The disbursement offunds occurs principally through biomedical research institutions, universities, and colleges H H MI grantees are required to file annual progress reportsthat detail expenditures in accordance with the terms of the grant, as well as full description of program activities undertaken with the funds These aresubject to careful review and analysis by H H MI staff with more detailed review by the Institute auditors as warranted The Institute continues to assessreporting requirements to ensure the quality and timeliness of both financial and programmatic reports In addition to site visits made by HHMI staff,program directors meet on a regular basis to discuss their activities and share information about best educational practices

Schedule I (Form 990) 2015

Additional Data



EIN: 59-0735717


Form 990,Schedule I, Part II, Grants and Other Assistance to Domestic Organizations and Domestic Governments.

(a) Name and address of ( b) EIN (c ) IRC section (d) Amount ofcash (e) Amount of non- (f) Method of valuation (g) Description of (h) Purpose of grantorganization if applicable grant cash (book, FMV, appraisal, non-cash assistance or assistance

or government assistance other)

Tuskegee University 63-0288878 501 (c) 3 250,000 0 Undergrad InitiativesTuskegee UniversityTuskegee,AL 36088

Hope College 38-1381271 501 (c) 3 39,316 0 Undergrad InitiativesHope CollegeHolland, MI 49423

Millsap College 64-0303084 501 (c) 3 41,462 0 Undergrad InitiativesMillsap CollegeJackson,MS 39210

Form 990.Schedule I. Part II. Grants and Other Assistance to Domestic Organizations and Domestic Governments.



Macalester College 41-0693962 501 (c) 3 50,000 0 Undergrad InitiativesMacalester CollegeStPaul, MN 55105

Assoc ofAmerican Colleges 52-1945674 501 (c) 3 500,000 0 Undergrad Initiatives& Univ1818 R Street NWWashington,DC 20009

Yale University 06-0646973 501 (c) 3 600,000 0 Ugrad Science EdYale UniversityNewHaven,CT 06520




UC - Santa Barbara 95-6006145 501 (c) 3 50,000 0 Ugrad Science EdUC - Santa BarbaraSanta Barbara,CA 93106

UC- Los Angeles 95-6006143 501 (c) 3 50,000 0 Ugrad Science EdUC- Los AngelesLos Angeles, CA 90095

Duke University 56-0532129 501 (c) 3 50,600 0 Ugrad Science EdDuke UniversityDurham,NC 27706


(a) Name and address of ( b) EIN (c ) IRC section (d) Amount of cash (e) Amount of non- (f) Method of valuation (g) Description of (h) Purpose of grantorganization if applicable grant cash (book, FMV, appraisal, non-cash assistance or assistance


Florida International Univ 65-0177616 501 (c) 3 50,000 0 Ugrad Science EdFlorida International UnivMiami,FL 33199

Indiana Univ of Pennsylvania 25-1753112 501 (c) 3 1,860,000 0 Ugrad Science EdIndiana Univ of PennsylvaniaIndiana,PA 15705

UC - San Francisco 94-6036493 501 (c) 3 19,422 0 EXROP Program -UC - San Francisco HousingSan Francisco, CA 94143




Travel Expense paid on behalf 94-3356764 6,068 0 EXROP Program -of grantees-Carl Hotel ravel198 Carl StreetSan Francisco,CA 94117

Univ of Washington 91-6001537 501 (c) 3 7,594 0 EXROP Program -Univ of Washington HousingSeattle, WA 98195

Travel Expense paid on behalf 74-2099724 6,103 0 EXRO P Program -

ofgrantees-United ravel233 S Wacker DriveChicago,IL 60606




Stanford Univ 94-1156365 501 (c) 3 37,035 0 EXROP Program -Stanford Univ HousingPalo Alto, CA 94305

Univ of Michigan 38-6006309 501 (c) 3 9,593 0 EXROP Program -Univ of Michigan HousingAnn Arbor,Ml 48109

Univ of Colorado 84-6000555 501 (c) 3 9,518 0 EXROP Program -Univ of Colorado HousingBoulder,CO 80309




Travel Expense paid on behalf 75-1825172 8,549 0 EXROP Program -of grantees-AMR Corp ravel4333 Amon Carter BlvdFort Worth, TX 76155

UC - Berkeley 94-6002123 501 (c) 3 17,060 0 EXROP Program -UC - Berkeley HousingBerkeley,CA 94720

Travel Expense paid on behalf 58-0218548 6,738 0 EXRO P Program -of grantees-Delta ravelPO Box 20706Atlanta,GA 30354




Columbia University 13-5598093 501 (c) 3 18,100 0 EXROP Program -Columbia University HousingNewYork,NY 10027

Rockefeller University 13-1624158 501 (c) 3 5,082 0 EXROP Program -Rockefeller University HousingNewYork,NY 10065

Harvard University 04-2103580 501 (c) 3 63,503 0 EXROP Program -Harvard University HousingCambridge, MA 02138




MIT 04-2103594 501 (c) 3 18,926 0 EXROP Program -MIT HousingCambridge,MA 02139

UC- San Diego 95-6006144 501 (c) 3 6,966 0 EXROP Program -UC- San Diego HousingLa Jolla,CA 92093

Yale University 06-0646973 501 (c) 3 14,634 0 EXROP Program -Yale University Housing

New Haven,CT 06520


(a) Name and address of (b) EIN (c ) IRC section (d) Amount ofcash (e) Amount of non- (f) Method of valuation (g) Description of (h) Purpose of grantorganization if applicable grant cash (book, FMV, appraisal, non-cash assistance or assistance


St Jude's Childrens Research 62-0646012 501 (c) 3 5,143 0 EXRO P Program -Hospital Housing262 Danny Thomas PlaceMemphis,TN 38105

UC- Los Angeles 95-6006143 501 (c) 3 7,321 0 EXROP Program -UC- Los Angeles HousingLos Angeles, CA 90095

Univ ofTexas 74-6000203 501 (c) 3 5,806 0 EXROP Program -Univ of Texas HousingAustin,TX 78712




UC - Berkeley 94-6002123 501 (c) 3 51,500 0 University (Doctoral)UC - BerkeleyBerkeley,CA 94720

Univ of Maryland 52-6002033 501 (c) 3 10,000 0 Minority Serving InstU niv of M arylandBaltimore, M D 21201

Audubon Naturalist Soc 53-0233715 501 (c) 3 53,750 0 Local Inititative8940 Jones Mill RdChevy Chase,MD 20815


(a) Name and address of (b) EIN (c) IRC section (d) Amount ofcash (e) Amount of non- (f) Method of valuation (g) Description of (h) Purpose of grantorganization if applicable grant cash (book, FMV, appraisal, non-cash assistance or assistance


Chesapeake Bay Foundation 52-6065757 501 (c) 3 162,500 0 Local Inititative162 Prince George StAnnapolis,MD 21401

PG County Public Schools 52-6000992 501 (c) 3 41,875 0 Local Inititative14201 School LaneUpper Marlboro, MD 20772

Montgomery Cty PS Educ 52-1804509 501 (c) 3 545,000 0 Local InititativeFound850 Hungerford DrRockville, MD 20850


(a) Name and address of (b) EIN (c) IRC section (d) Amount of cash (e) Amount of non- (f) Method of valuation (g) Description of (h) Purpose of grantorganization if applicable grant cash (book, FMV, appraisal, non-cash assistance or assistance


Loudoun Cty Public Schools 54-6001395 501 (c) 3 1,000,000 0 Precollege Science -21000 Education Court OtherLeesburg,VA 20176

Yale University 06-0646973 501 (c) 3 30,000 0 Science EducationYale University Alliance

New Haven,CT 06520

Biological Sciences 84-0622557 501 (c) 3 249,948 0 BSCS NOVACurriculum StudyCO State UnivColorado Springs,CO 80918




National Academy of 53-0196932 501 (c) 3 240,000 0 Science EducationSciences2101 Constitution AvenueNWWashington, DC 20001

ResearchAmerica 52-1609875 501 (c) 3 60,000 0 Program Assessment1101 King St Suite 250Chantilly,VA 20153

Grinnell College 43-0680387 501 (c) 3 100,000 0 Science EducationGrinnell CollegeGrinnell,IA 50112




UC- Los Angeles 95-6006143 501 (c) 3 31,950 0 Science EducationUC- Los AngelesLos Angeles, CA 90095

The Conversation US Inc 46-0906774 501 (c) 3 500,000 0 Science Journalism28 Fairfax St

West Newton, M A 02465

UC - San Diego 95-6006144 501 (c) 3 400,000 0 Medical ResearchUC - San DiegoLa Jolla, CA 92093




UC - San Francisco 94-6036493 501 (c) 3 124,781 0 Medical ResearchUC - San FranciscoSan Francisco,CA 94143

CA Inst of Technology 95-1643307 501 (c) 3 2,061,182 0 Medical ResearchCA InstofTechnologyPasadena,CA 91125

NYU 13-5562308 501 (c) 3 390,970 0 Medical ResearchNYUNewYork,NY 10003




Eastern Mennonite Univ 54-0575812 501 (c) 3 130,000 0 Medical ResearchEastern Mennonite UnivHarrisonburg,VA 22802

Allen Institute for Brain 91-2155317 501 (c) 3 42,847 0 Medical ResearchScienceAllen Institute for BrainScienceSeattle, WA 98103

Beth Israel Deaconess 04-2103881 501 (c) 3 400,392 0 Medical ResearchMedical CtrBeth Israel DeaconessMedical CtrBoston,MA 02215




Columbia University 13-5598093 501 (c) 3 483,224 0 Medical ResearchColumbia UniversityNewYork,NY 10027

Duke University 56-0532129 501 (c) 3 1,546,139 0 Medical ResearchDuke UniversityDurham,NC 27706

Fred Hutchinson Cancer 23-7156071 501 (c) 3 367,652 0 Medical ResearchResearch CtrFred Hutchinson CancerResearch CtrSeattle, WA 98109


(a) Name and address of (b) EIN (c ) IRC section (d) Amount of cash (e) Amount of non- (f) Method of valuation (g) Description of (h) Purpose of grantorganization if applicable grant cash (book, FMV, appraisal, non-cash assistance or assistance


Harvard University 04-2103580 501 (c) 3 250,057 0 Medical ResearchHarvard UniversityCambridge,MA 02138

Johns Hopkins Univ 52-0595110 501 (c) 3 199,580 0 Medical ResearchJohns Hopkins UnivBaltimore, M D 21218

Massachusetts General Hosp 04-2697983 501 (c) 3 178,746 0 Medical ResearchMassachusetts General HospBoston,MA 02129




MIT 04-2103594 501 (c) 3 987,288 0 Medical ResearchMITCambridge, MA 02139

Northwestern Univ 36-2167817 501 (c) 3 145,608 0 Medical ResearchNorthwestern UnivEvanston,IL 60208

Oregon Health Science Univ 93-1176109 501 (c) 3 1,708,675 0 Medical ResearchOregon Health Science U nivPortland,OR 97239




Rockefeller University 13-1624158 501 (c) 3 263,084 0 Medical ResearchRockefeller UniversityNewYork,NY 10065

Salk Institute 95-2160097 501 (c) 3 285,996 0 Medical ResearchSalk InstituteLa Jolla,CA 92037

Stanford Univ 94-1156365 501 (c) 3 569,456 0 Medical ResearchStanford Univ

Palo Alto,CA 94305




Univ ofTexas 74-6000203 501 (c) 3 455,760 0 Medical ResearchUniv of TexasAustin,TX 78712

UC - Berkeley 94-6002123 501 (c) 3 497,652 0 Medical ResearchUC - BerkeleyBerkeley,CA 94720

UC - San Diego 95-6006144 501 (c) 3 461,910 0 Medical ResearchUC - San DiegoLa Jolla, CA 92093




Univ of Chicago 36-2177139 501 (c) 3 368,584 0 Medical ResearchUniv of ChicagoChicago,IL 60637

Univ of Colorado 84-6000555 501 (c) 3 470,191 0 Medical ResearchUniv of ColoradoBoulder,CO 80309

Univ of Florida 59-6002052 501 (c) 3 324,262 0 Medical ResearchU niv of FloridaGainesville, FL 32611




Univ of Massachusetts 04-3167352 501 (c) 3 249,438 0 Medical ResearchUniv of MassachusettsWorchester,MA 01605

Univ of Maryland 52-6002033 501 (c) 3 457,440 0 Medical ResearchUniv of MarylandBaltimore, M D 21201

Univ of Michigan 38-6006309 501 (c) 3 458,607 0 Medical ResearchUniv of MichiganAnnArbor,Ml 48109


(a) Name and address of (b) EIN (c ) IRC section (d) Amount of cash (e) Amount of non- (f) Method of valuation (g) Description of (h) Purpose of grantorganization if applicable grant cash (book, FMV, appraisal, non-cash assistance or assistance


Univ of North Carolina 56-6001393 501 (c) 3 216,914 0 Medical ResearchUniv of North CarolinaChapel Hill,NC 27599

Univ of Pennsylvania 23-1352685 501 (c) 3 1,380,218 0 Medical ResearchUniv of PennsylvaniaPhiladelphia,PA 19104

Univ of Utah 87-6000525 501 (c) 3 4,302,416 0 Medical ResearchUniv of UtahSalt Lake City, UT 84112




Univ of Washington 91-6001537 501 (c) 3 1,193,516 0 Medical ResearchUniv of WashingtonSeattle, WA 98195

Yale University 06-0646973 501 (c) 3 276,476 0 Medical ResearchYale University

New Haven,CT 06520

Damon Runyon Cancer 13-1933825 501 (c) 3 1,412,000 0 PostdoctoralResearch Foundation FellowshipsDamon Runyon Cancer ResNewYork,NY 10006




Jane Coffin Childs Memorial 06-6034840 501 (c ) 3 1,259,922 0 PostdoctoralFund for Medical Res FellowshipsJane Coffin Childs Mem FundMed ResNewHaven ,CT 06510

The Helen Hay Whitney 13 -1677403 501 ( c) 3 1,326,000 0 PostdoctoralFoundation FellowshipsThe Helen Hay WhitneyFoundationNewYork,NY 10956

Life Sciences Research 52-1231801 501 (c) 3 1,472, 000 0 PostdoctoralFoundation FellowshipsLife Sciences ResearchFoundationBaltimore ,MD 21218




FIU Foundation Inc 65-0177616 501 (c) 3 10,000 0 UTeach11200 SW 8TH STMiami,FL 33199

University of North Texas 23-7232618 501(c) 3 10,000 0 UTeach1155 UNION CIRCLEDenton,TX 76203

WKU Research Foundation 61-1358086 501 (c) 3 10,000 0 UTeach1906 COLLEGE HEIGHTS

BLVDBowling Green, KY 42101




Drexel University 23-1352630 501 (c) 3 15,000 0 UTeach3141 CHESNUT STPhiladelphia,PA 19104


Schedule J Compensation Information OMB No 1545-0047

(Form 990)For certain Officers, Directors , Trustees, Key Employees, and Highest

Compensated EmployeesComplete if the organization answered "Yes" on Form 990, Part IV, line 23.00, 20 15

► Attach to Form 990.Department of the ► Information about Schedule I ( Form 990 ) and its instructions is at www. irs.gov /form990 . Open to PublicTreasury , , , ,


59-0735717

Questions Regarding Compensation

Yes No

la Check the appropiate box(es) if the organization provided any of the following to or fora person listed on Form990, Part VII, Section A, line la Complete Part III to provide any relevant information regarding these items

First-class or charter travel Housing allowance or residence for personal use

Travel for companions F_ Payments for business use of personal residence

Tax idemnification and gross-up payments F_ Health or social club dues or initiation fees

F_ Discretionary spending account [ Personal services (e g , maid, chauffeur, chef)

b Ifany of the boxes in line la are checked, did the organization follow a written policy regarding payment orreimbursement or provision of all of the expenses described above? If "No," complete Part III to explain lb Yes

2 Did the organization require substantiation prior to reimbursing or allowing expenses incurred by alldirectors, trustees, officers, including the CEO/Executive Director, regarding the items checked in line la? 2 Yes

3 Indicate which, if any, of the following the filing organization used to establish the compensation of theorganization's CEO/Executive Director Check all that apply Do not check any boxes for methodsused by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III

Fq- Compensation committee Written employment contract

Fq- Independent compensation consultant Compensation survey or study

Fq- Form 990 of other organizations Approval by the board or compensation committee

4 During the year, did any person listed on Form 990, Part VII, Section A, line la with respect to the filing organizationor a related organization

a Receive a severance payment or change-of-control payment? 4a Yes

b Participate in, or receive payment from, a supplemental nonqualified retirement plan? 4b No

c Participate in, or receive payment from, an equity-based compensation arrangement? 4c No

If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III

Only 501 ( c)(3), 501 ( c)(4), and 501(c)(29) organizations must complete lines 5-9.

5 For persons listed on Form 990, Part VII, Section A, line la, did the organization pay or accrue anycompensation contingent on the revenues of

a The organization? 5a No

b Any related organization? 5b No

If "Yes," on line 5a or 5b, describe in Part III

6 For persons listed on Form 990, Part VII, Section A, line la, did the organization pay or accrue anycompensation contingent on the net earnings of

a The organization? 6a No

b Any related organization? 6b No

If "Yes," on line 6a or 6b, describe in Part III

7 For persons listed on Form 990, Part VII, Section A, line la, did the organization provide any non-fixedpayments not described in lines 5 and 6? If "Yes," describe in Part III 7 Yes

8 Were any amounts reported on Form 990, Part VII, paid or accured pursuant to a contract that wassubject to the initial contract exception described in Regulations section 53 4958-4(a)(3)? If "Yes," describein Part III 8 Yes

9 If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in Regulationssection 53 4958-6(c)? 9 Yes

For Paperwork Reduction Act Notice , see the Instructions for Form 990 . Cat N o 50053T Schedule 3 ( Form 990) 2015

Schedule J (Form 990) 2015 Page 2

Officers , Directors , Trustees, Key Employees, and Highest Compensated Employees . Use duplicate copies if additional space is needed.

For each individual whose compensation must be reported on Schedule 1, report compensation from the organization on row (i) and from related organizations, described in theinstructions, on row (ii) Do not list any individuals that are not listed on Form 990, Part VIINote . The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line la, applicable column (D) and (E) amounts for that individual

(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and (D) Nontaxable (E) Total of columns (F) Compensation in(ii) (iii) other deferred benefits (B)(i)-(D) column(B) reported

Base(i) compensation

Bonus & incentive Other reportable compensation as deferred on prior

compensation compensation Form 990


Schedule 3 (Form 990) 2015

Schedule J (Form 990) 2015 Page 3


Provide the information, explanation, or descriptions reouired for Part I, lines la, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II Also complete this Dart for any additional information


Schedule J, Part I, Line la First- Under HHMI policies, HHMI reimburses its Trustees, President, Vice Presidents, and certain advisory group members forthe reasonable cost of airfare atclass or charter travel one class above coach for domestic or international flights of three hours or more If a particular aircraft does not have a business class section, one

class above coach may be first class In this case H H MI would reimburse the traveling Trustee or officer for the reasonable cost of first-class travel if theflight is three hours or more As an alternative, HHMI may reimburse for the cost of coach airfare plus the cost of an upgrade to travel at one level abovecoach for a flight of three hours or more Such travel reimbursements are excluded from taxable compensation in accordance with HHMI's accountableplan During fiscal year 2016, one key employee, two officers and one trustee flew first class

Schedule J, Part I, Line la Housing In fiscal year 2016, HHMI's President resided in an HHMI-owned apartment on the headquarters campus, for which he paid HHMI at a fair market rentalallowance or residence for personal rate Because HHMI's President was also required to spend time at HHMI's Janelia campus, where he ran a research laboratory as well as attendeduse meetings and participated in conferences, HHM I made a one-bedroom apartment available to him at that location HHMI's Vice President and Executive

Director, Janelia Research Campus, is required as a condition of employment to reside on the Janelia campus in housing built for that purpose HHMI'sVice President and Chief Scientific Officer currently resides in an H H MI-owned house on the headquarters campus, for which she pays H H MI at a fairmarket rental rate The Institute provides a housing assistance program for one individual who relocated to take a position with HHMI, which may be usedto cover such individuals' mortgage or rent payments In each case, the subsidy is treated as additional taxable compensation

Schedule J, Part I, Line 4a Severance V P for Information Technology - Total severance of $230,160 reported as compensation on Schedule J, Part II (B) iii of $ 130,666 and reported asor change-of-control payment deferred compensation on Schedule J, Part II (C) of $99,494

Schedule J, Part I, Line 7 Non-fixed H H MI has an incentive compensation plan for its senior investment staff under which a portion of their compensation is determined based on performancepayments of HHMI's portfolio against market benchmarks HHMI also makes one-time payments to some of its other employees, including but not limited to

officers, in recognition of exceptional performance

Schedule J, Part I, Line 8 Payments When recruiting individuals for high-level positions, HHMI typically enters into initial contracts HHMI has entered into initial contracts with its Presidenton contract that is subject to the and a number of V ice Presidents HH MI's standard practice is to have independent compensation consultants regularly review and confirm theinitial contract exception reasonableness of compensation of H H MI's officers and key employees, regardless of whether the initial contract exception applies

Schedule 3 (Form 990) 2015

Additional Data

-382,303



EIN: 59-0735717


Form 990, Schedule J, Part II - Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees

(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and (D) Nontaxable (E) Total of columns (F) Compensation in(i) (ii) (iii) other deferred benefits (B)(I)-(D) column (B)

Base Bonus & Other compensation reported as deferred

Compensation incentive reportable on prior Form 990

compensation compensation

1LANDISZIMMERMAN (I) 920,705 2,668,499 22,020 26,500 30,131 3,667,855 0VP & CHIEF INVESTMENT

-------------OFFICER

(II) 0--

- - - - - - - - - - - - - - - -

--

- - - - - - - - - - - -

- - - - - - - - - - - - - - - - - - - - - -

0 0 0 - - 00 0

1LAUREN T SPILIOTES ESQ (I) 362,685 0 19,566 26,500 23,052 431,803 0DEP GENCOUNSEL/ASST SEC - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -------------

(II) 0 0 0 0 - - 00 0

2SUSAN S PLOTNICK (I) 231,847 3,000 893 22,450 32,751 290,941 0ASSISTANT TREASURER &DIRECTOR-FINANCE

(II) 0- - - - - - - - - - - - - - - - - - -

0 0 0 - - 00 0

3MONIQUE L MARCUS (I) 182,548 0 663 17,930 27,717 228,858 0CONTROLLER

------------- ------------- ------------- ------------- ------------ ------------ -------------(II) 0 0 0 0 - - 0

0 0

4ROBERT (I) 1,321,750 10,000 32,627 26,500 45,744 1,436,621 0PRESIDENT

------------- ------------- ------------- ------------- ------------ ------------ -------------(II) 0 0 0 0 - - 0

0 0

5CHERYLAMOORE (I) 861,067 10,000 20,010 26,500 21,271 938,848 0EXECUTIVE VP&COO

------------- ------------- ------------- ------------ ------------ -------------(II) 0 0 0 0 - - 0

0 0

6SEAN BCARROLLPHD (I) 659,690 10,000 20,864 26,500 26,514 743,568 0

VPFORSCIENCEEDUCATION(II)

-------------0

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -------------

0 0 0 - - 00 0

7HEIDI E HENNING ESq (I) 544,821 0 20,365 26,500 28,242 619,928 0VP,GENERAL COUNSEL/SEC _ _ _ _ _ _ _ _ _ _ _ _ _

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -------------(II) 0 0 0 0 - - 0

0 0

8NITIN V KOTAK (I) 382,303 5,000 19,662 26,500 30,653 464,118 0VP, CFO & TREASURER

--

(II) 0 0 0 0 - - 00 0

9ERIN K O'SHEA PHD (I) 654,777 10,000 88,584 26,500 19,098 798,959 0

(II) 0 0 0 0 - - 00 0

10GERALD M RUBIN (I) 716769 0 27,716 26,500 96,662 867,647 0--

CAMPUS(II) 0 0 0 0 - - 0

0 0

(I) 255,841 5,000 19,087 26,232 14,300 320,460 0VP, HUMANN

RRESOESOURCES

--

(II) 0 0 0 0 - - 00 0

12RICHARDAPENDER (I) 484903 471,092 20,097 26,500 27,210 1,029,802 0--

(II) 0 0 0 0 - - 00 0

13ROBERTIKOLYERJR (I) 425,254 1,013,297 20,841 26,500 28,273 1,514,165 0--

ASSETS(II) 0 0 0 0 - - 0

0 0

14MARKABARNARD (I) 397,407 860,310 22,765 26,500 31,903 1,338,885 0

MANDIR- PRIVATE EQUITIES(II)

--0 0 0 0 - - 0

0 0

15STEPHEN M KITSOULIS (I) 395,673 505,731 1,615 26,500 20,698 950,217 0--

(II) 0 0 0 0 - - 00 0

16GREGORY DENINNO (I) 246,813 337,799 2,653 24,742 32,254 644,261 0

MANDIR- PRIVATE EQUITIES(II)

--0 0 0 0 - - 0

0 0

(I) 34,3 756,177 18,289 26,500 14,531 1,159,874 0MAN DIR - INVESTMENTS &

---COO

(II) 0 0 0 0 - - 00 0

18DONALD (I) 285,829 674 527 18 264 26 500 32 024 1 037 144 0PORTFOLIO

--------, , , , , ,

STRATEGY(II) 0

- - - - - - - - - - - - - - - - - - -

0 0 0 - - 00 0

19THOMAS R CECH PHD (I) 604,112 0 25,618 26,500 25,758 681,988 0INVESTIGATOR

------------- ------------- ------------- ------------ ------------ -------------(II) 0 0 0 0 - - 0

0 0

Form 990. Schedule J. Part II - Officers. Directors. Trustees. Kev EmDlovees. and Hiahest Compensated Emolovees

(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and (D) Nontaxable (E) Total ofcolumns (F) Compensation in

(i) (ii) (iii) other deferred benefits (B)(I)-(D) column (B)

Base Bonus & Other compensation reported as deferred

Compensation incentive reportable on prior Form 990

compensation compensation

21RYAN LMATNEY (I) 246,409 338,909 18,250 26,019 30,267 659,854 0DIRECTOR-DIVERSIFIED

-------------ASSETS

(II) 0 0 0 0 - - 00 0

SERIC R KANDEL MD (I) 569,338 0 27,567 26,500 31,934 655,339 0SENIOR INVESTIGATOR

------------- ------------- ------------- ------------- ------------ ------------ -------------(II) 0 0 0 0 - - 0

0 0

2MOHAMOUDJIBRELL (I) 179,094 0 141,126 125,994 32,635 478,849 0VP FOR INFORMATION

-------------TECHNOLOGY

II) 0- - - - - - - - - - - - - - - - - - - -

0 0 0 - - 00 0


Schedule K OMB No 1545-0047

(Form 990 ) Supplemental Information on Tax Exempt Bonds

2p 1 5► Complete if the organization answered "Yes" to Form 990, Part IV, line 24a . Provide descriptions,

explanations, and any additional information in Part VI.

Department of the Treasury ► Attach to Form 990.Open to Public

about Schedule K (Form 990 ) and its instructions is at www. irs.gov /form990 . , ,



Bond Issues

(a) Issuer name ( b) Issuer EIN (c) CUSIP # ( d) Date issued ( e) Issue price (f) Description of purpose (g) Defeased ( h) On (i) Poolbe half of financingissuer

Yes No Yes No Yes No

A LOUDOUN COUNTY IDA 52-1310230 545910AL5 02-27-2003 500,000,000 FINANCE CONSTRUCTION OF X X XJANELIA RESEARCH CAMPUS

B LOUDOUN COUNTY IDA 52-1310230 545910AP6 10-02-2009 23,000,000 FINANCE CONSTRUCTION OF X X XJANELIA APT

C LOUDOUN COUNTY IDA 52-1310230 545910AQ4 05-15-2013 33,130,000 FINANCE CONSTRUCTION OF X X XJANELIA APT B

D MEDCO 52-1376562 574205FY1 02-15-2008 83,500,000 FINANCE CONSTRUCTION OF X X XHQ EXPANSION

Proceeds

A B C D

1 Amount of bonds retired . 0 0 0 0

2 Amount of bonds legally defeased . . . . . . . . . . . . . 0 0 0 0

3 Total proceeds of issue. . . . . . . . . . . . . . . . . .

534,028,000 23,022,042 33,145,417 84,953,297

4 Gross proceeds in reserve funds . 0 0 0 0

5 Capitalized interest from proceeds . . . . . . . . . . . . 54,203,000 904,914 1,173,864 5,954,687

6 Proceeds in refunding escrows . 0 0 0 0

7 Issuance costs from proceeds . . . . . . . . . . . . . . 200,000 0 397,311 631,673

8 Credit enhancement from proceeds . . . . . . . . . . . . 0 0 0 0

9 Working capital expenditures from proceeds . 0 43,305 0 0

10 Capital expenditures from proceeds . . . . . . . . . . . . 479,625,000 22,073,823 31,574,242 78,366,937

11 Other spent proceeds 0 0 0 0

12 Other unspent proceeds 0 0 0 0

13 Year of substantial completion . . . . . . . . . . . . 2006 2011 2015 2010

Yes No Yes No Yes No Yes No

14 Were the bonds issued as part ofa current refunding issue? . X X X X

15 Were the bonds issued as part of an advance refunding issue's X X X X

16 Has the final allocation of proceeds been made? . . . . . . . . . X X X X

17 Does the organization maintain adequate books and records to support the finalallocation of proceeds? X X X X

LjQa= Private Business Use

A B C D


1 Was the organization a partner in a partnership, or a member of an LLC, which ownedX X X X

property financed by tax-exempt bonds? .

2 Are there any lease arrangements that may result in private business use of bond-X X X X

financed property? .

For Paperwork Reduction Act Notice , see the Instructions for Form 990 . Cat N o 50193E Schedule K (Form 990) 2015

Schedule K (Form 990) 2015 Pa g e 2

Private Business Use (Continued)

A B C D


3a Are there any management or service contracts that may result in private business useX X X X

of bond-financed property? .

b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outsidecounsel to review any management or service contracts relating to the financed X X X X

property?

c Are there any research agreements that may result in private business use ofbond-financed property? . X X X X

d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outsidecounsel to review any research agreements relating to the financed property? X

4 Enter the percentage of financed property used in a private business use by entitiesother than a section 501(c)(3) organization or a state or local government . . . 0 %o 0 % 0 %o 0

5 Enter the percentage of financed property used in a private business use as a result ofunrelated trade or business activity carried on by your organization, another section 0 %o 0 % 0 %o 0501(c)(3) organization, or a state or local government . .110.

6 Total of lines 4 and 5. 0 0 0%o 0

7 Does the bond issue meet the private security or payment test? . . . X X X X

8a Has there been a sale or disposition of any of the bond-financed property to anongovernmental person other than a 501(c)(3) organization since the bonds were X X X Xissued?.

b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of

c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections1 141-12 and 1 145-27 .

g Has the organization established written procedures to ensure that all nonqualifiedbonds of the issue are remediated in accordance with the requirements under X X X XRegulations sections 1 141-12 and 1 145-2''.

Arbitrage

A B C D


1 Has the issuer filed Form 8038-T, Arbitrage Rebate, YieldReduction and Penalty in Lieu ofArbitrage Rebate? .

X X X X

2 If "No" to line 1, did the following apply? . .

a Rebate not due yeti X X X

b Exception to rebate? X X

c No rebate due? . X X

If "Yes" to line 2c, provide in Part VI the date the rebatecomputation was performed .

3 Is the bond issue a variable rate issue? . X X X X

4a Has the organization or the governmental issuer enteredinto a qualified hedge with respect to the bond issue?

X X X X

b Name of provider. . . . . . . . . WELLS FARGO JPMORGAN CHASE WELLS FARGO BANK JP MORGAN

c Term of hedge . 2000 % 3000 % 3000 % 3000 %

d Was the hedge superintegrated? . X X X X

e Was the hedge terminated? . X X X X

Schedule K (Form 990) 2015

Schedule K (Form 990) 2015 Page 3

Arbitrage (Continued)

A B C D


5a Were gross proceeds invested in a guaranteed investmentX X X X

contract (GIC)7

b Name of provider . . . . . . . . . .

c Term ofGIC . . . . . . . . .

d Was the regulatory safe harbor for establishing the fair marketvalue of the GIC satisfied? .

6 Were any gross proceeds invested beyond an available temporaryX X X X

period?

7 Has the organization established written procedures to monitorX X X X

the requirements of section 1487 .

Procedures To Undertake Corrective Action

A I B I C I D

Yes I No I Yes I No I Yes I No I Yes I No

Has the organization established written procedures to ensurethat violations of federal tax requirements are timely identified

X X X Xand corrected through the voluntary closing agreement program ifself-remediation is not available under applicable regulations?

Supplemental Information . Provide additional information for responses to questions on Schedule K (see instructions).


Schedule K, Part I Part I 1The bond issued February 27, 2003 also includes CUSIPS 545910AM3, 545910AG6, 545910AH4,545910A30.and545910AK7

Return ExplanationReference

The bondsissued on2/27/2003,10/2/2009,2/15/2008

Schedule K, 5and/15/2013

Part II,included

Line 3 PartII, Line 3 - interest

Totalincome that

Proceedsmade up thedifferencebetween theamount of thebond issue andthe totalproceeds


For the bondissued on2/27/2003$375 millionnotional amountof the $500million notionalamount ofswap<

Schedule Kpertaining to

,this bond were

Part IVintegrated The

Part IV -other

Name ofProvider

counterpartiespertaining to thebond issued on2/27/2003 wereBank ofAmericE(30 years),Goldman Sachs(30 years) andJP Morgan (30years )


Yes, In part forthe bonds

Schedule K, issued onPart IV, 2/27/2003,Line 4a 10/2/2009,Part IV, 2/15/2008,Line 4a 5/15/2008

and5/15/2013


Issuer nameLOUDOUN

Schedule K,COUNTY IDA

Part IV, cThealculation for

Line 2ccomputing no

COLUMN B rebate due wasperformed or10/08/2014


Issuer name

Schedule K ,MEDCO Thecalculation for

Partrt IV,computing no

COLUMN Drebate due wasperformed on02/12/2013


Schedule K OMB No 1545-0047

(Form 990 ) Supplemental Information on Tax Exempt Bonds

2p 1 5► Complete if the organization answered "Yes" to Form 990, Part IV, line 24a . Provide descriptions,

explanations, and any additional information in Part VI.

Department of the Treasury ► Attach to Form 990.Open to Public

about Schedule K (Form 990 ) and its instructions is at www.irs.gov /form990 . , ,



Bond Issues

(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On (i) Poolbehalf of financingissuer

Yes No Yes No Yes No

A MEDCO 52-1376562 574205FZ8 05-15-2008 76,500,000 REFUNDING OF ISSUE TO X X XFINANCE HQ CONSTRUCTION

I ^ I

Proceeds

A B C D

1 Amount of bonds retired 0

2 Amount of bonds legally defeased . . . . . . . . . . . . . 0

3 Total proceeds of issue. . . . . . . . . . . . . . . . . .

76,500,000

4 Gross proceeds in reserve funds . 0

5 Capitalized interest from proceeds . 0

6 Proceeds in refunding escrows . 0

7 Issuance costs from proceeds . 0

8 Credit enhancement from proceeds . . . . . . . . . . . . 0

9 Working capital expenditures from proceeds 0

10 Capital expenditures from proceeds . 0

11 Other spent proceeds . 76,500,000

12 Other unspent proceeds 0

13 Year of substantial completion . 1993


14 Were the bonds issued as part ofa current refunding issue? . X

15 Were the bonds issued as part of an advance refunding issue's X

16 Has the final allocation of proceeds been made? . X

17 Does the organization maintain adequate books and records to support the finalallocation of proceeds? X

Private Business Use

A B C D


1 Was the organization a partner in a partnership, or a member of an LLC, which ownedproperty financed by tax-exempt bonds? .

2 Are there any lease arrangements that may result in private business use ofbond-financed property? .

For Paperwork Reduction Act Notice, see the Instructions for Form 990 . Cat N o 50193E Schedule K (Form 990) 2015

Schedule K (Form 990) 2015 Pa g e 2

Private Business Use (Continued)

A B C D


3a Are there any management or service contracts that may result in private business useof bond-financed property? .

b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outsidecounsel to review any management or service contracts relating to the financed

property?

c Are there any research agreements that may result in private business use ofbond-financed property? . . . . . . . . . . . . .

d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outsidecounsel to review any research agreements relating to the financed property?

4 Enter the percentage of financed property used in a private business use by entitiesother than a section 501(c)(3) organization or a state or local government . . . 0

5 Enter the percentage of financed property used in a private business use as a result ofunrelated trade or business activity carried on by your organization, another section 0 %501(c)(3) organization, or a state or local government . .110.

6 Total of lines 4 and 5 . 0

7 Does the bond issue meet the private security or payment test? . .

8a Has there been a sale or disposition of any of the bond-financed property to anongovernmental person other than a 501(c)(3) organization since the bonds wereissued?.

b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of

c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections1 141-12 and 1 145-27 .

g Has the organization established written procedures to ensure that all nonqualifiedbonds of the issue are remediated in accordance with the requirements underRegulations sections 1 141-12 and 1 145-2''.

Arbitrage

A B C D


1 Has the issuer filed Form 8038-T, Arbitrage Rebate, YieldReduction and Penalty in Lieu ofArbitrage Rebate? .

X

2 If "No" to line 1, did the following apply? . . .

a Rebate not due yeti . .

b Exception to rebate? . .

c No rebate due? . .

If "Yes" to line 2c, provide in Part VI the date the rebatecomputation was performed .

3 Is the bond issue a variable rate issue? . X

4a Has the organization or the governmental issuer enteredinto a qualified hedge with respect to the bond issue?

X

b Name of provider. . . . . . . . . GOLDMAN SACHS

c Term of hedge . 3000 %

d Was the hedge superintegrated? X

e Was the hedge terminated? . X


Schedule K (Form 990) 2015 Page 3

Arbitrage (Continued)

A B c D


5a Were gross proceeds invested in a guaranteed investment Xcontract (GIC)7

b Name of provider . . . . . . . . . .

C Term ofGIC . . . . . . . . .

d Was the regulatory safe harbor for establishing the fair marketvalue of the GIC satisfied? .

6 Were any gross proceeds invested beyond an available temporary Xperiod?

7 Has the organization established written procedures to monitor Xthe requirements of section 1487

Procedures To Undertake Corrective Action


Has the organization established written procedures to ensurethat violations of federal tax requirements are timely identified Xand corrected through the voluntary closing agreement program ifself-remediation is not available under applicable regulations?

Supplemental information . Provide additional information for responses to questions on Schedule K (see instructions).



SCHEDULE 0 Supplemental Information to Form 990 or 990-EZOMB No 1545-0047

(Form 990 or 2015990- EZ )Complete to provide information for responses to specific questions on

Form 990 or 990-EZ or to provide any additional information.► Attach to Form 990 or 990-EZ. Open to Public

Department of the ► Information about Schedule 0 (Form 990 or 990-EZ ) and its instructions is at InspectionTreasury www.irs.gov/f orm990.Internal RevenueService

Name of the organizationHoward Hughes Medical Institute

Employer identification number

59-0735717

Return

Reference

Explanation

Form 990, (C) HIGHLIGHTS FROM HHMI RESEARCH LABORATORIES (FISCAL YEAR 2016) 1) Study Examines Scale of Gene Mutations in

Part III, Line Human Neurons Christopher Walsh, Boston Children's Hospital https //www hhmi org/new s/study-examines-scale-gene-

4a Program mutations-human-neurons A single neuron in a normal adult brain likely has more than a thousand genetic mutations that are notService present in the cells that surround it, according to research from HHMI scientists The majority of these mutations appear to arise

Description while genes are in active use, after brain development is complete 2) High-Speed Microscope Images Entire Living Organisms at

(continued) High Resolution Philipp Keller, Janelia Research Campus https //www hhmi org/new s/seeing-big-picture A microscope developed

at HHMI's Janelia Research Campus is giving scientists a clearer, more comprehensive view of biological processes as theyunfold in living animals The microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with

enough resolution in all three dimensions that each cell appears as a distinct structure What's more, it does so at speeds fast

enough to watch cells move as a developing embryo takes shape and to monitor brain activity as it flashes through neuronalcircuits 3) Researchers Identify New Factors that Guide Organization of Rant Roots Philip Benfey, Duke University

https //www hhm org/news/researchers-identify-new-factors-guide-organization-plant-roots As the root of a growing plant

pushes its way through soil, its cells have a lot of organizing to do New cells must take on the appropriate identities andpositions to form distinct layers of tissue that give the root its structure, protect it from the environment, and ensure that it can

properly transport materials to and from the rest of the plant HHMI scientists have identified a set of proteins that plays a

surprisingly broad role in guiding this tissue formation The factors, known as the BIRDS, help a root maintain its organization as itgrows, guiding several distinct steps in the development of two interior layers of tissue 4) New Studies Advance Understanding

of CRISPR Gene Editing Jennifer Doudna, University of California, Berkeley Robert Tian, HHMI https //www hhm org/news/new-

studies-advance-understanding-cnspr-gene-editing CRISPR/Cas9, a defense system that bacteria use to protect againstinvading genetic elements, was adapted by scientists in 2012 as tool to edit genomes in the lab The new technology has been

adopted enthusiastically by the research community because of its ability to cleave target sequences of DNA with remarkable

precision and efficiency After directly watching individual Cas9 enzymes explore DNA inside living cells, HHMI scientists reportthat they have a better understanding of how Cas9 speeds through this task, testing out potential targets but quickly moving on

from those that are not an exact match 5) Mutations Before Birth Might Disrupt Heart and Nervous System Development Christine

Seidman, Brigham and Women's Hospital Richard Lifton, Yale University https //www hhmi org/news/mutations-birth-might-disrupt-heart-and-nervous-system-development A team of scientists has determined why some children who are born with

heart defects also often have developmental disabilities such as problems with speech or muscle coordination The research

suggests that these children accrue mutations very early in development that damage genes crucial for heart and brainformation About one percent of new borns suffer from congenital heart disease, in which structural flaws in the organ, such as

misshapen valves or abnormal connections between major vessels, disrupt blood circulation With surgery or less invasive

procedures, doctors can now correct defects that would have killed many of these children 30 years ago 6) Made in the Shade

How Rants Can Beat the Competition Joanne Chory, The Salk Institute for Biological Studies https //www hhm org/news/made-shade-how-plants-can-beat-competition HHMI research has uncovered a molecular mechanism that enables plants to detect

w hen they are in the shade of other plants and adapt by speeding up their growth The scientists found that light-sensing and

DNA-binding proteins team up to sw itch on a unique set of genes that cause a plant to grow 7) Breakable Genes May PromoteDisease and Brain Cell Diversity Frederick Alt, Boston Children's Hospital https //www hhmi org/news/breakable-genes-may-

promote-disease-and-brain-cell-diversity HHMI researchers have identified 27 genes in brain stem cells that are prone to a type

of DNA damage The fragility of those genes could explain why they are often mutated or deleted in cancers andneuropsychiatric disorders such as schizophrenia But their tendency to break could also benefit the brain by providing a way to

produce a greater diversity of neurons 8) New Studies Examine How Mice Respond to a Predator's Scent Linda Buck, Fred

Hutchinson Cancer Research Center https //www hhmi org/news/new-studies-examine-how-mice-respond-predator-s-scentWhen the tw itching pink nose of a mouse detects danger, the animal has to act fast Fortunately, a predator rapidly triggers the

release of stress hormones in the mouse and prompts behaviors that reduce the risk of it becoming the predator's latest snack

HHMI scientists have identified a brain area that is critical to this instinctive fear response, helping explain how the braintranslates danger signals detected by the nose into a physiological response The research offers clues to the larger puzzle of

how animals, including humans, perceive and respond to fear 9) Command and Control System Monitors Food Intake of Flies

Leslie Vosshall, The Rockefeller University https //www hhm org/news/conrrs/conymnd-and-control-systerri-monitors-food-intake-f liesWorking in fruit flies, HHMI scientists have discovered a command center in the brain that controls how much insects eat and

how quickly they consume their food To make the decision, neurons in the command center integrate information about an

animal's internal state of satiety with taste cues detected just moments after food is swallowed These neurons simultaneouslymonitor how hungry the fly is and w hat the fly is ingesting Rapid feedback from the cells helps ensure that the insects consume

appropriate amounts of nourishing foods 10) Learning How the Brain Recovers from Disruptions Karel Svoboda and Shaul

Druckmann, Janelia Research Campus https //www hhmi org/news/learning-how-brain-recovers-disruptions Scientists atHHMI's Janelia Research Campus have found that the brain is organized into modules that work together to maintain critical

functions, even in the face of disturbances This structural organization may explain how neurons that store short-term

memories can recover from significant disruptions-for example, enabling a quarterback to remember a planned play despite the

distractions he encounters before he throws the football This organizational motif is likely to underlie other essential circuitrywithin the brain as well 11) The Genetic History of Ice Age Europe David Reich, Harvard University

https //www hhm org/news/genetic-history-ice-age-europe Analyses of ancient DNA from prehistoric humans paint a picture of

dramatic population change in Europe from 45,000 to 7,000 years ago The new genetic data reveal two big changes inprehistoric human populations that are closely linked to the end of the last Ice Age around 19,000 years ago As the ice sheet

retreated, Europe was repopulated by prehistoric humans from southwest Europe (e g , Spain) Then, in a second event about

14,000 years ago, populations from the southeast (e g , Turkey, Greece) spread into Europe, displacing the first group ofhumans 12) Staying a Step Ahead of Cancer Kevan Shokat, University of California, San Francisco

https //www hhm org/news/staying-step-ahead-cancer HHMI scientists have designed a potential cancer therapy that uses a

unique strategy to block mTOR, a molecule that helps drive the growth of many tumors In animal experiments, the drug reducesthe size of tumors that are resistant to earlier-generation cancer drugs called mTOR inhibitors 13) Molecule Required for Pain

Also Helps Regulate Body Weight Scott Sternson, Janelia Research Campus https //www hhmi org/new s/molecule-required-

pain-also-helps-regulate-body-w eight A molecule best known for its involvement in pain perception also plays an important rolein regulating body weight, according to new research in mice by scientists at HHMI's Janelia Research Campus The molecule,

called Nav1 7, enables some neurons to efficiently integrate information they receive over time When weight-regulating neurons

lose this ability, mice become either over- or underweight

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Reference

Explanation

Form 990, (C) Educational Media HHMI's Educational Media Group is comprised of Biolnteractive and Tangled Bank Studios Biolnteractive, aPart III, Line resource for AP biology and college-level introductory biology teachers, has been in existence for more than 15 years and

4b Program receives 2 5 million unique visitors per year through its w ebsite The Educational Media Group produces science education

Service resources including interactive multimedia materials, scientific animations, videos, in-class activities, the annual Holiday LecturesDescription on Science, as well as award-winning, broadcast-quality short films The products are then made available to educators online,

(continued) through the Biolnteractive org website and YouTube channel, and at workshops and conventions The 2015 Holiday Lectures on

Science featured speakers, Robert M Pringle and Corina ETarnita both from Princeton University, who discussed the "Patternsand Processes in Ecology " The speakers delivered their lectures live to an audience of about 150 high school students from the

Washington, DC area They described their efforts to understand patterns and processes that organize and regulate natural

ecosystems Their lectures were also made available online and will be supplemented by a variety of educational resources,including two "Scientist at Work" videos showing Silliman and Power conducting their research in salt marshes and rivers,

respectively This year, HHMI's Educational Media Group has continued to expand its efforts in translating its educational

materials into Spanish and conducting professional development workshops for teachers in Latin American countries incollaboration with the Instituto de Neurociencia Biomedica (BNI), Universidad de Chile, and the Tecnologico de Monterrey, Mexico

The Spanish resources are currently available on the Biolnteractive website and on Loligo, a new Spanish-language science

education w ebsite produced by BNI HHMI's Educational Media Group also expanded its efforts into citizen science This year thegroup launched an educational addition to WildCam Gorongosa, its popular citizen science project that invites participants to

identify animals in photos taken by motion-activated trail cameras at Gorongosa National Park (GNP) The new educational tool,

called WildCam Lab, allows educators to create virtual classrooms in which students can ask questions and test hypothesesusing data from the trail camera project Students can select subsets of photos according to different criteria, dow nload and

sort through data, and share their work with other student HHMI's Educational Media Group has also started planning a second

citizen science project based in Darien National Park in Panama Finally, HHMI's Educational Media Group will be launching anexciting new app, called BiomeView er, in which users can explore the climate, vegetation, and wildlife of biomes across the

globe BiomeView er builds on the success of the popular EarthView er app which has been dow nloaded over 1 8 million times

(D) Tangled Bank Studios Tangled Bank Studios, LLC, HHMI's documentary film production unit, is dedicated to the creation of

original science documentaries for broadcast, theatrical, and digital distribution As an extension of HHMI's longstanding scienceeducation mission, the company aims to produce programs that capture compelling stories of discovery across all branches of

scientific inquiry, with particular focus on the life sciences Tangled Bank Studios won its first Emmy award, honoring the 2014

three-part PBS series Your Inner Fish The show won in the Outstanding Graphic Design & Art Direction category in the 37thNews & Documentary Emmy Awards competition Your Inner Fish was a 2014 television series based on the best-selling book

by leading paleontologist and evolutionary biologist Neil Shubin, a professor at the University of Chicago In taking viewers on a

cutting-edge, scientific adventure, Your Inner Fish reveals a startling truth hidden within the human body is a history of life onEarth Tangled Bank Studios has also produced Mass Extinction-Life at the Brink (Smithsonian Channel 2014) and Vaccines-

Calling the Shots (PBS/NOVA 2014) New films released this year In a new one-hour documentary, WGBH Boston's NOVA team

partnered with HHMI's Tangled Bank Studios and Holt Productions to develop, Can Alzheimer's Be Stopped' The film premiered inApril 2016 on PBS Despite the urgent need for treatment, dozens of drug trials to tackle Alzheimer's disease have failed Less

than one percent of Alzheimer's drugs tested have been approved, and none of them can stop the disease Can Alzheimer's Be

Stopped? takes view ers behind the scenes of drug trials to reveal how they are designed, w hat makes them so challenging,and why researchers are encouraged in their quest for an effective treatment Spillover - Zika, Ebola & Beyond premiered on

PBS in August 2016 Throughout the last few decades, diseases that spill over from animals to humans have been on the rise

What's behind their increase, and can we do anything to combat these dangerous foes' The film follows scientists as theyinvestigate the rise of spillover viruses like Zika, Ebola and Nipah, and learn what science can do to anticipate and prevent

epidemics around the world (E) eLife - Open Access Journal HHMI, together with the Wellcome Trust and the Max Planck

Society, continues to support a top tier scientific journal called eLife The online journal follows an open access model and isdirected by practicing scientists eLife Sciences Publications, Ltd , is an independent non-profit entity governed by a separate

board of directors eLife began publishing research articles in late 2012 and is publishing articles online on a regular basis

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Reference

Explanation

Form 990, 14) Extensive Variation Revealed in 1001 Genomes and Epigenomes of Arabidopsis Joseph Ecker, The Salk Institute forPart III, Line Biological Studies https //www hhmi org/news/extensive-variation-revealed-1001-genomes-and-epigenomes-arabidopsis An

4a Program international team of scientists has sequenced the w hole genomes and epigenomes of more than 1,000 Arabidopsis thaliana

Service plants, sampled from geographically diverse locations The collection of 1,001 genomes and 1,001 epigenomes not onlyDescription illuminates new aspects of the plant's evolutionary history, but also provides a comprehensive, species-w ide picture of the

(continued- interaction between genetic and epigenetic variation in this important model plant 15) Large Protein Nanocages Could Improve

1) Drug Design and Delivery David Baker, University of Washington https //www hhmi org/news/large-protein-nanocages-could-irrprove-drug-design-and-delivery Using novel computational and biochemical approaches, scientists have accurately designed

and built from scratch 10 large protein icosahedra -- polyhedra with 20 faces -- similar to viral capsids that carry viral DNA The

designed structures are made of two different engineered proteins, present in 60 copies each, which self-assemble intoicosahedra They have a wide variety of potential applications, from targeted drug delivery to the development of more effective

vaccines, the researchers say 16) Gene Tweak Leads to Differences in Drosophila Courtship Songs David Stern, Janelia

Research Campus https //www hhm org/news/love-me-do-gene-tweak-leads-differences-drosophila-courtship-songs

Pinpointing the precise relationship between genes and behavior has been notoriously tricky for biologists Janelia Research

Campus scientists have devised new strategies to drill down into this link Using new technologies, a group of Janelia scientists

has identified a gene that causes male Drosophila to produce different courtship songs - one sings a high note, the other strikesa low note The researchers hope the findings and methodology will serve as a roadmap for biologists, allowing them to

determine other genetic roots of behavior (D) Honors and Awards Received by HHMI Scientists (Fiscal Year 2016) FJledge

Shares Lasker Award The Albert and Mary Lasker Foundation selected HHMI investigator Stephen Elledge of Brigham andWomen's Hospital and Evelyn Witkin of Rutgers University as recipients of the 2015 Albert Lasker Basic Medical Research

Award The Lasker Awards -- considered among the most respected science prizes in the world -- honor visionaries w hose

insight and perseverance have led to dramatic advances that w ill prevent disease and prolong life Elledge and Witkin werehonored for discoveries concerning the DNA-damage response -- a fundamental mechanism that protects the genomes of all

living organisms Doudna Receives Canada's Gairdner Award for Research on CRISPRThe Gairdner Foundation announced that

HHMI Investigator Jennifer Doudna of the University of California, Berkeley is a recipient of the prestigious 2016 Canada Gairdner

International Award in recognition of her contributions to medical science The awards, which are presented annually, recognizescientists responsible for some of the w orld's most significant medical discoveries Doudna, who became an HHMI investigator in

1997, was honored for development of CRISPR-Cas9 as a genome-editing tool for eukaryotic cells HHMI Scientists Elected to

The Royal Society HHMI investigators Mark Davis and Jennifer Doudna have been elected to foreign membership in the RoyalSociety in recognition of their exceptional contributions to science Fellows and foreign members are elected for contributions to

fundamental research as well as for leading scientific and technological progress in industry and research establishments This

year, 50 fellows and 10 foreign members were elected Deisseroth and Hobbs Awarded Breakthrough Prizes The BreakthroughPrize Foundation selected HHMI investigators Karl Deisseroth of Stanford University and Helen Hobbs of the University of Texas

Southwestern Medical Center as recipients of the Breakthrough Prizes in Life Sciences The prizes honor transformative

advances toward understanding living systems and extending human life Deisseroth was honored for the development andimplementation of optogenetics - the programming of neurons to express light-activated ion channels and pumps, so that their

electrical activity can be controlled by light Hobbs was recognized for the discovery of human genetic variants that after the

levels and distribution of cholesterol and other lipids, inspiring new approaches to the prevention of cardiovascular and liverdisease The Breakthrough Prizes recognize pioneering work in physics and genetics, cosmology, and neurology and

mathematics Each prize carries an award of $3 million Zoghbi Awarded Shaw Prize The Shaw Prize Foundation in Hong Kong

announced that Huda Zoghbi, a Howard Hughes Medical Institute investigator at Baylor College of Medicine, and Adrian Bird ofthe University of Edinburgh w ill share the $1 2 million award for their discovery of the genes and proteins involved in the

developmental disorder Rett syndrome The Shaw Prize consists of three annual awards in astronomy, life science and

medicine, and mathematical sciences These international awards honor individuals who have achieved distinguishedbreakthroughs in academic and scientific research The awards are dedicated to furthering societal progress, enhancing quality

of life, and enriching humanity's spiritual civilization Five HHMI Researchers Elected to National Academy of Medicine Five HHMI

researchers have been elected to the National Academy of Medicine (NAM) The HHMI scientists are among 70 new NAMmembers and 10 international members elected today Established originally as the Institute of Medicine in 1970 by the National

Academy of Sciences, the National Academy of Medicine addresses critical issues in health, science, medicine, and related

policy and inspires positive actions across sectors The new members are HHMI investigators, Michael Green, University of

Massachusetts School of Medicine, Nikola Pavletich, Memorial Sloan Kettering Cancer Center, Alexander Rudensky, MemorialSloan Kettering Cancer Center, Jean-Laurent Casanova, The Rockefeller University, and HHMI Senior International Research

Scholar, Nahum Sonenberg, McGill University HHMI Scientists Hected to National Academy of Sciences Heven Howard Hughes

Medical Institute scientists were elected to membership in the National Academy of Sciences They are among 84 new membersand 21 foreign associates from 15 countries elected in recognition of their distinguished and continuing achievements in original

research The National Academy of Sciences is a private organization of scientists and engineers dedicated to the furtherance

of science and its use for the general welfare The scientists are Joseph DeRisi, University of California, San Francisco,Raymond Deshaies, California Institute of Technology, Nathaniel Heintz, The Rockefeller University, Hopi Hoekstra, Harvard

University, Kenneth Murphy, Washington University in St Louis, Krishna Niyogi, University of California, Berkeley, David Sabatini,

Whitehead Institute for Biomedical Research, Amita Sehgal, University of Pennsylvania, Geraldine Seydoux, The Johns HopkinsUniversity, Michael Summers, University of Maryland, Baltimore County, Bonnie Bartel, Rice University


Form 990, Part VI, The Howard Hughes Medical Institute's Form 990 is initially prepared by its Tax Compliance Department, in coordination

Line 11 b Review of with other HHMI departments as needed The draft return is reviewed by senior management of HHMI and by attorneysform 990 by in HHMI's Office of the General Counsel Following these reviews and the resolution of any questions that have been

governing body raised, the draft return is reviewed by HHMI's outside tax preparer Finally, a copy of the return is provided to the

members of HHMI's Board of Trustees so that they have an opportunity to review and comment on the return before itis filed

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Reference

Explanation

Form 990, In addition to HHMI's code of conduct, which addresses conflicts of interest and applies to all HHMI employees, officers,Part VI, Line Trustees, and advisors, HHMI has specific conflict of interest policies for different categories of personnel Under the HHMI

12c Conflict policies that apply to Trustees, officers, and key employees, these individuals must disclose annually interests that could give

of interest rise to conflicts of interest, and must certify annually their compliance w ith the conflict of interest policy that applies to thempolicy Annual disclosures and certifications are reviewed by HHMI's Office of the General Counsel, and by other HHMI managers as

needed The conflict of interest policy covering HHMI's Trustees also requires each Trustee to disclose to the other Trustees

any actual or apparent conflict of interest with respect to a proposed HHMI transaction If the other Trustees decide that thereis only the appearance of a conflict of interest, and that it could not reasonably be considered to affect the independent,

unbiased judgment of the disclosing Trustee with respect to the transaction at issue, no further action is required to address

the apparent conflict In all other cases, including all actual conflicts of interest, the disclosing Trustee is not permitted toparticipate in the deliberation or decision regarding the transaction under consideration, and must leave the room during the

deliberation and vote The conflict of interest policies covering HHMI's officers and key employees require each covered

individual to obtain supervisory approval up to the level of HHMI's President before entering into an affiliation with or acquiringan interest of 1% or more in any entity that is or may become a recipient of HHMI funds HHMI's President, in consultation with

HHMI's General Counsel, may permit the affiliation or interest if it would not interfere w ith the covered individual's performance

of his or her HHMI responsibilities, would not create the appearance of a conflict of interest, and would be consistent withsound business judgment HHMI's President may set conditions on approval, for example that there be no remuneration to the

covered individual Proposed affiliations and interests of 1 % or more of HHMI's President are subject to the approval of the

Chairman of the Trustees

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Reference

Explanation

Form 990, Part The compensation for HHMI's President, other officers, and key employees is set using the following procedures EveryVI, Line 15a other year, the Audit and Compensation Committee of HHMI's Board of Trustees engages one or more independent

Process to compensation consultants to conduct a study of comparable market data The study includes data for HHMI's President,

establish other officers, and key employees The independent compensation consultants also provide an opinion regarding thecompensation of reasonableness of the compensation arrangements for the positions included in the study The study includes comparable

top management market data for all components of compensation for each person covered by the study, including base salary, incentive

official compensation (if any), and benefits The Committee relies on the market data and opinion provided by the compensationconsultant in making recommendations to the Board of Trustees regarding compensation for HHMI's President, other officers

and key employees The decision is made by independent Trustees Any Trustee who has a conflict of interest with respect

to a specific officer or key employee must recuse himself or herself from the decision on that person's compensation, andleave the meeting room during the debate and voting on it In the alternate years w hen a study is not done, the Audit and

Compensation Committee confirms with the independent compensation consultants that the range of any proposed merit

increases for HHMI employees, including senior management, is reasonable compared with generally prevailingcompensation increases in the market over the past year The Committee relies on this advice in recommending

compensation for HHMI's President, other officers and key employees, and the Board of Trustees relies on this advice in

making compensation decisions Recusal procedures are the same as in the years when a study is done In each year,minutes of the discussions and decisions regarding compensation are prepared after each meeting and are submitted for

approval at the next meeting Approved minutes are kept in HHMI's records All minutes include the date of the meeting,

identify those Trustees who attended and voted on the compensation arrangements, and note any recusals of Trusteeswith a conflict of interest The comparability studies and opinions relied on at the meeting are referenced in the minutes, and

copies of these materials are also kept in HHMI's records HHMI's Board of Trustees followed this process in August 2015 in

determining compensation for the following positions for fiscal year 2016 President, Vice Presidents, and ManagingDirectors - Investments

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Reference

Explanation

Form 990, Part The compensation for HHMI's President, other officers, and key employees is set using the following procedures EveryVI, Line 15b other year, the Audit and Compensation Committee of HHMI's Board of Trustees engages one or more independent

Process to compensation consultants to conduct a study of comparable market data The study includes data for HHMI's President, other

establish officers, and key employees The independent compensation consultants also provide an opinion regarding thecompensation of reasonableness of the compensation arrangements for the positions included in the study The study includes comparable

other employees market data for all components of compensation for each person covered by the study, including base salary, incentive

compensation (if any), and benefits The Committee relies on the market data and opinion provided by the compensationconsultant in making recommendations to the Board of Trustees regarding compensation for HHMI's President, other officers

and key employees The decision is made by independent Trustees Any Trustee who has a conflict of interest with respect

to a specific officer or key employee must recuse himself or herself from the decision on that person's compensation, andleave the meeting room during the debate and voting on it In the alternate years w hen a study is not done, the Audit and

Compensation Committee confirms with the independent compensation consultants that the range of any proposed merit

increases for HHMI employees, including senior management, is reasonable compared with generally prevailingcompensation increases in the market over the past year The Committee relies on this advice in recommending

compensation for HHMI's President, other officers and key employees, and the Board of Trustees relies on this advice in

making compensation decisions Recusal procedures are the same as in the years w hen a study is done In each year,minutes of the discussions and decisions regarding compensation are prepared after each meeting and are submitted for

approval at the next meeting Approved minutes are kept in HHMI's records All minutes include the date of the meeting,

identify those Trustees who attended and voted on the compensation arrangements, and note any recusals of Trustees witha conflict of interest The comparability studies and opinions relied on at the meeting are referenced in the minutes, and

copies of these materials are also kept in HHMI's records HHMI's Board of Trustees followed this process in August 2015 in

determining compensation for the following positions for fiscal year 2016 President, Vice Presidents, and ManagingDirectors - Investments


Form 990, Part V1, Line HHMI's practice has been to make a copy of its charter and by-laws available on request HHMI's code of conduct,

19 Required documents which addresses conflicts of interest, is available to the public on the HHMI w ebsite A dow nloadable copy ofavailable to the public HHMI's most recent audited financial statements is also available to the public on the website In addition, HHMI

publishes "Year in Review" that provides a summary of each year's activity, expenditures, and financial

performance


Form 990 , Part VIII, Line Miscellaneous - Total Revenue 313443, Related or Exempt Function Revenue , Unrelated Business Revenue

11d Other Miscellaneous Revenue Excluded from Tax Under Sections 512 , 513, or 514 313443 , Innovation Dissemination - Total RevenueRevenue 117362, Related or Exempt Function Revenue , Unrelated Business Revenue , Revenue Excluded from Tax Under

Sections 512 , 513, or 514 117362,

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Reference

Explanation

Schedule A, List of hospital affiliations for e-filing Hospital, City, State, Zip Code- B&W Hospital, Boston, MA, 02115/ Children's Hosp, Boston,Part I, Line 4 MA, 02115/ Children's Hosp, Cincinnati, OH, 45229/ Dana-Farber, Boston, MA, 02115/ Fred Hutch, Seattle, WA, 98109/ JHopkins

List of Hosp, Baltimore, MD, 21205/ Mass Gen Hosp, Boston, MA, 02129/ MSKCC, New York, NY, 10021/ Nat'l Jewish, Denver, CO,

Hospital 80206/ St Jude, Memphis, TN, 38105/ Duke-Duke Hosp, Durham, NC, 27706/ NYU-NYU Hosps, New York, NY, 10016/ OHSU-Affiliations OHSU Hosp, Portland, OR, 97239/ Rockefeller-Hosp, New York, NY,10021/ Penn State Univ-Hosp, University Park, PA 16802/

Stanford-Hosp, Palo Alto, CA, 94305/ UCLA-Med Ctr, Los Angeles, CA, 90095/ UCSD-Med Ctr, San Diego, CA, 92093/ UCSF-

UCSF Hosps, San Francisco, CA, 94143/ Ulowa-Ulowa Hosps, Iowa City, IA, 52242/ UMass-Med Ctr, Worcester, MA, 01605/UMich-UMich Hosp, Ann Arbor, MI, 48109/ UPenn-UPenn Hosp, Philadelphia, PA, 19104/ UT-Austin-UT Hosp, Austin, TX, 78712/

UTSW-UTSW Hosps, Dallas, TX, 75390/ UUtah-UUtah Hosps, Salt Lake City, UT, 84112/ UWash-Med Ctr, Seattle, WA, 98195/

ADARC-aff hosp, New York, NY, 10016/ AECOM-affil hosps, New York, NY, 10461/ Baylor-aff hosps, Houston, TX, 77030/BU-aff hosp, Boston, MA, 02126/ Brandeis-aff hsps, Waltham, MA, 02254/ CalTech-aff hosps, Pasadena, CA, 91125/ Carnegie-

aff hsps, Baltimore, MD, 21210/ CSHL-affil hosps, Cold Spring Harbor, NY, 11724/ CSU-affil hosp, Fort Collins, CO, 80521/

Columbia-aff hsps, New York, NY, 10027/ Cornell-aff hosps, New York, NY, 14853/ Harvard-aff hosps, Cambridge, MA, 02138/Indiana-affil hosp, Bloomington, IN, 47405/ TJL-affil hosps, Bar Harbor, ME, 04609/ JHU-affil hosps, Baltimore, MD, 21218/

MichSU-affil hosps, Lansing, MI, 48824/ MIT-affil hosps, Boston, MA, 02139/ NWU-affil hosps, Evanston, IL, 60208/ Princeton-aff

hosps, Princeton, NJ, 08544/ Rutgers-affil hosp, Piscataway, NJ, 08854/ Salk-affil hosps La Jolla, CA, 92093/ Scripps-affilhosps, La Jolla, CA 92037/ Stow ers-aff hosps, Kansas City, MO, 64110/ SUNY-affil hosps, Stony Brook, NY,1 1794/ Texas

A&M-aff hsp, College Station, TX, 77843/ Tufts-aff hosps, Boston, MA, 02111/ UCB-affil hosps, Berkeley, CA, 94720/ UCDavis-

affil hsps, Davis, CA, 95616/ UCR-affil hosps, Riversde, CA, 92521/ UCSC-aff hosps, Santa Cruz, CA, 95064/ UChi-affil hosp,Chicago, IL, 60637/ UColo-aff hosp, Boulder, CO, 80309/ UColo-aff hosp, Denver, CO, 80217/ Uillinois-aff hsp, Urbana, IL,

61801/ UMD-affil hosp, Baltimore, MD, 21201/ UMN-affil hosp, Minneapolis, MN 55414/ UNC-affil hosps, Chapel Hill, NC, 27599/

UOregon-aff hsp, Eugene, OR,97403/ UWisc-affil hosps, Madison, WI, 53706/ WashU-aff hosp, St Louis, MO, 63130/ YaleU-affilhosp, New Haven, CT, 06520/


Schedule A, Part I, Line 4 The Institute is a medical research organization for its taxable year ended August 31, 2016 , as its expenditures of $

MRO Qualification 791,795,075 on a cash basis for the year ended August 31 , 2015 exceeded the MRO requirement of $727,119,083(3 5% of the HHMI endow ment)

l efile GRAPHIC print - DO NOT PROCESS I As Filed Data - I DLN: 93493109008027

SCHEDULER Related Organizations and Unrelated PartnershipsOMB No 1545-0047

(Form 990)► 2Complete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.

Department of the Treasury ► Attach to Form 990. ► Information about Schedule R (Form 990) and its instructions is at www.irs.aov/form990 . Ope n to Public

Internal Revenue Service Inspection


59-0735717

Identification of Disregarded Entities Complete if the organization answered "Yes" on Form 990, Part IV, line 33.

(a)Name, address, and EIN (if applicable) of disregarded entity

(b)Primary activity

(c)Legal domicile (stateor foreign country)

(d)Total income

(e)End-of-year assets

(f)Direct controlling

entity


RiCUM Identification of Related Tax-Exempt Organizations Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had onenr mnra ralatari tax-pyamnt nrnani7atinnc rliirinn tha tay vaar

(a)Name, address, and EIN of related organization

(b)Primary activity

(c)Legal domicile (stateor foreign country)

(d )Exempt Code section

( e)Public charity status

(if section 501(c)(3))

(f)Direct controlling

entity

(g)Section 512(b)(13) controlled

entity?

Yes No

For Paperwork Reduction Act Notice , see the Instructions for Form 990 . Cat No 50135Y Schedule R (Form 990) 2015

Schedule R (Form 990) 2015 Page 2

Identification of Related Organizations Taxable as a Partnership Complete if the organization answered "Yes" on Form 990, Part IV, line 34because it had one or more related organizations treated as a partnership during the tax year.

(a)Name, address, and EIN of

related organization

(b)Primary activity

(C)Legal

domicile(state orforeigncountry)

(d )Direct

controllingentity

( e)Predominant

income(related,unrelated,

excluded fromtax under

sections 512-514)

(f)Share of

total income

(g)Share of

end-of-yearassets

(h)Disproprtionateallocations?

(i)Code V-UBI

amount in box20 of

Schedule K-1(Form 1065)

(1)General ormanagingpartner?

(k)Percentageownership

Yes No Yes No


Identification of Related Organizations Taxable as a Corporation or Trust Complete if the organization answered "Yes" on Form 990, Part IV, line34 because it had one or more related organizations treated as a corporation or trust during the tax year.

(a)Name, address, and EIN of

related organization

(b)Primary activity

(c)Legal

domicile(state or foreign

country)

(d )Direct controlling

entity

( e)Type of entity

(C corp, Scorp,

or trust)

(f)Share of total

income

(g)Share of end-

of-yearassets

(h)Percentageownership

(1)Section 512(b)(13)

controlledentity?

Yes No


Schedule R (Form 990) 2015


Transactions With Related Organizations Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.

Note . Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule

1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?

a Receipt of (i) interest, (ii)annuities, (iii)royalties, or(iv)rent from a controlled entity .

b Gift, grant, or capital contribution to related organization(s) . . . . . .

c Gift, grant, or capital contribution from related organization(s) .

d Loans or loan guarantees to or for related organization(s)

e Loans or loan guarantees by related organization(s)

f Dividends from related organization(s)

g Sale of assets to related organization(s) . .

h Purchase of assets from related organization(s) . .

i Exchange of assets with related organization(s) . .

j Lease of facilities, equipment, or other assets to related organization(s)

k Lease of facilities, equipment, or other assets from related organization(s) . . . . .

I Performance of services or membership or fundraising solicitations for related organization(s)

m Performance of services or membership or fundraising solicitations by related organization(s)

n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s)

o Sharing of paid employees with related organization(s) . . . . . . . . . .

p Reimbursement paid to related organization(s) for expenses

q Reimbursement paid by related organization(s) for expenses

r Other transfer of cash or property to related organization(s) .

s Other transfer of cash or property from related organization(s)

Page 3

No

!s

No

No

No

No

No

No

No

No

No

lm No

In No

10 No

Sp No

Sq No

Sr No

is Yes

2 If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds

(a)Name of related organization

(b)Transactiontype (a-s)

(c)Amount involved

(d)Method of determining amount involved




Unrelated Organizations Taxable as a Partnership Complete if the organization answered "Yes" on Form 990, Part IV, line 37.

Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or grossrevenue) that was not a related organization See instructions regarding exclusion for certain investment partnerships

(a)Name, address, and EIN of entity

(b)Primary activity

(c)Legal

domicile(state orforeigncountry)

(d)Predominant

income(related,unrelated,

excluded fromtax under

sections 512-

(e)Are all partners

section501(c)(3)

organizations?

(f)Share of

totalincome

(9)Share of

end-of-yearassets

(h )Disproprtionateallocations?

(1)Code V-UBIamount inbox 20

of ScheduleK-1

(Form 1065)

(])General ormanagingpartner?

(k)Percentageownership

514)Yes No Yes No Yes No




Provide additional information for responses to questions on Schedule R (see instructions

I Return Reference Explanation


Additional Data



EIN: 59-0735717


Form 990, Schedule R, Part I - Identification of Disregarded Entities(c)

(a) (b) Legal Domicile (d) (e) (f)Name, address, and EIN (if applicable) of disregarded entity Primary Activity (State Total income End-of-year assets Direct Controlling

or Foreign EntityCountry)

(1) HHMI II LLC INVESTMENT DE 7,482,899 515,652,860 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(1) HHMI IV LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(2) HHMI V LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(3) HHMI XII LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(4) HHMI XVI LLC INVESTMENT DE -7,196,998 369,516,766 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(5) SPRUGOS INVESTMENTS II LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(6) SPRUGOS INVESTMENTS V LLC INVESTMENT DE 8,776,795 61,472,990 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(7) SPRUGOS INVESTMENTS VII LLC INVESTMENT DE 28,076,355 229,778,026 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(8) SPRUGOS INVESTMENTS VIII LLC INVESTMENT DE 33,383,422 218,197,977 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(9) SPRUGOS INVESTMENTS X LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(10) SPRUGOS INVESTMENTS XI LLC INVESTMENT DE 22,917,767 70,480,415 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(11) SPRUGOS INVESTMENTS XII LLC INVESTMENT DE 8,943 108,933 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(12) SPRUGOS INVESTMENTS XIII LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(13) PRIVATE EQUITY HOLDING LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(14) PRIVATE EQUITY HOLDING-AHEAD LLC INVESTMENT DE 394 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(15) PRIVATE EQUITY HOLDING-ALEXA LLC INVESTMENT DE -2,593 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(16) PRIVATE EQUITY HOLDING-CS CAPITAL LLC INVESTMENT DE -467,856 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(17) PRIVATE EQUITY HOLDING-EUROCASTLE LLC INVESTMENT DE -360,168 2,635,439 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(18) PRIVATE EQUITY HOLDING-FAVRILLE LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(19) PRIVATE EQUITY HOLDING-KAP LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

Form 990. Schedule R. Part I - Identification of Disregarded Entities(c)

(a) (b) Legal Domicile ( d) (e) (f)Name, address, and EIN (if applicable ) of disregarded entity Primary Activity (State Total income End - of-year assets Direct Controlling


(21) PRIVATE EQUITY HOLDING -ROYCE LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(1) PRIVATE EQUITY HOLDING - STORERETRO LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(2) PRIVATE EQUITY HOLDING - XENOPORT LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(3) HHMI FI I LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(4)JANELIA FARM HOLDING LLC INVESTMENT VA 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(5) SELDEN ISLAND HOLDING LLC INVESTMENT VA 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(6)HHMI I LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(7) HHMI III LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(8) HHMI VI LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(9) HHMI VII LLC INVESTMENT DE -787,782 107,909,665 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(10) HHMI VIII LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(11) HHMI IX LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(12) HHMI X LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(13) HHMI XI LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(14) HHMI XIII LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(15) HHMI XIV LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(16) HHMI XV LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(17) SPRUGOS INVESTMENTS LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

(18) SPRUGOS INVESTMENTS III LLC INVESTMENT DE 17,380,556 324,995,022 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(19) SPRUGOS INVESTMENTS IV LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE , MD 20815

Form 990. Schedule R. Part I - Identification of Disregarded Entities(c)

(a) (b) Legal Domicile ( d) (e) (f)Name, address, and EIN (if applicable) of disregarded entity Primary Activity (State Total income End-of-year assets Direct Controlling


(41) SPRUGOS INVESTMENTS VI LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(1) SPRUGOS INVESTMENTS IX LLC INVESTMENT DE 10,396,721 330,002,477 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(2)SPRUGOS-FRENCH LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(3) PRIVATE EQUITY HOLDING II LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(4) PRIVATE EQUITY HOLDING III LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(5) RELATIVE VALUE STRATEGIES LLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(6)PSGLLC INVESTMENT DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(7) HHMI-SA LLC RESEARCH DE 0 161,606 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(8)TANGLED BANK STUDIOS LLC FILM PROD DE 0 0 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 20815

(9) MISSING LINK PRODUCTIONS LLC FILM PROD DE 0 126 HHMI4000 JONES BRIDGE ROADCHEVY CHASE, MD 2081547-1329820

(10) LSV ADVANTAGE INTL III (CAYMAN) LTD INVESTMENT CJ -789,734 27,196,419 HHMI89 NEXUS WAY 2/F CANAMA BAYGRAND CAYMAN KY11205CJ98-0689621

(11) LSV ADVANTAGE INTL III-B (CAYMAN) LTD INVESTMENT CJ 17,713,772 97,058,358 HHMI89 NEXUS WAY 2/F CAMANA BAYGRAND CAYMAN KY11205CJ98-1087158

Form 990. Schedule R. Part III - Identification of Related Organizations Taxable as a Partnership

(c) (e) (h)0)

0)

(a) (b)Legal (d) Predominant (f) (g) Disproprtionate Code V-UBI amount

General(k)

Name address and EIN of Primary activityDomicile Direct income Share of total Share of end-of- allocations? in

orPercentage, ,

related organization(State Controlling (related, income year assets

Box 20 of ScheduleManaging

ownershipor Entity unrelated, Partner?

Foreign excluded fromK 1

(Form 1065)Country) tax under

sections512-514) Yes No Yes No

CERBERUS HH PARTNERS INVESTMENT CJ HHMI Excluded 9,709,626 142,748,880 No 0 No 95LP

190 ELGIN AVENUEGEORGETOWN KY19005CJ98-1102879

GEM NPL CO-INV FUND LP INVESTMENT IL HHMI Excluded 2,241 1,607,918 No -223,424 No 67

900 NORTH MICHIGANAVENUE SUITE 14SUITE 1450CHICAGO, IL 6061146-4232021

HHLF LP INVESTMENT NY HHMI Excluded 6,348,363 31,437,374 No 0 No 94

555 5TH AVENUE FL18NEW YORK, NY 1001746-2823996

LUMINUS CREDIT INVESTMENT NY HHMI Excluded 1,924,728 45,845,840 No 0 No 99 0/0OPPORTUNITIES PIE I LP

1700 BROADWAY 38THFLOORNEW YORK, NY 1001926-1963557

SOLUS OPPORTUNITIES INVESTMENT NY HHMI Excluded 7,354,072 61,023,991 No 0 No 98FUND 2 LP

410 PARK AVENUE 11THFLOORNEW YORK, NY 1002246-3541945

CVI HH INVESTMENTS LP INVESTMENT MN HHMI Excluded 3,175,407 289,352,589 No 0 No 100 0/0

9320 EXCELSIOR BLVDMS144-7-2HOPKINS, MN 5534390-1010136

ECHO STREET GOODCO INVESTMENT NY HHMI Excluded 2,364,778 105,905,868 No 0 No 100 0/0SELECT II LP

10 EAST 53RD STREET32ND FLOORNEW YORK, NY 1002247-4827277

GEM BVP CO-INV-A LP INVESTMENT IL HHMI Excluded 0 7,075,267 No 0 No 100 0/0

900 NORTH MICHIGANAVENUESUITE 1450CHICAGO, IL 6061147-2251559

HH HOLDCO CO- INVESTMENT NY HHMI Excluded 371,467 69,391,381 No 0 No 99 478INVESTMENT FUND LP

32 BROADWAY SUITE1201NEW YORK, NY 1000430-0864915

HH SG SECONDARY FUND INVESTMENT NY HHMI Excluded 1,490,738 15,847,917 No 0 No 94LP

825 THIRD AVENUE10TH FLOORNEW YORK, NY 1002247-3358493

TOURMALET MATAWIN INVESTMENT CJ HHMI Excluded 2,364,893 35,066,543 No 0 No 100 0/0OFFSHORE FUND VI-A LP

89 NEXUS WAY CA MA NABAYGRAND CAYMANKY19007Ci

HH ELLINGTON MASTER INVESTMENT CT HHMI Excluded 12,566,556 30,037,303 No 0 No 82FUND LTD

53 FOREST AVENUEOLD GREENWICH, CT0687098-1020904

Form 990. Schedule R. Part IV - Identification of Related Organizations Taxable as a Corporation or Trust

(a) (b) (c) (d) (e) (f) (g) (h) (i)Name, address, and EIN of Primary activity Legal Direct Type of entity Share of total Share of end-of- Percentage Section

related organization domicile controlling (C corp, S income year ownership 512(b)(13)(state or foreign entity corp, assets controlled

country) or trust) entity?

Yes No

(1) HHMI REAL ESTATE INC INVESTMENT DE HHMI C Corporation 20,439 1,668,550 100 % Yes4000 JONES BRIDGE ROADCHEVY CHASE, MD 2081520-3967202

(1) INVESTMENT CJ HHMI C Corporation 4,608,493 26,622,556 51 % YesPLEASANT VALLEY INVESTMENTS LP99 QUEENS ROAD CENTRALUNIT 2112 21/F THE CENTERHONG KONGHK98-0586696

(2)HH ELLINGTON FUND LTD INVESTMENT CJ HHMI C Corporation 12,566,556 30,037,303 100 % YesWALKER HOUSE 87 MARY STREETGEORGETOWN,GR KY19005CJ

(3) SPRUGOS MAURITIUS I LTD INVESTMENT MP HHMI C Corporation 6,775,987 29,127,898 100 % Yes33 EDITH CAVELL STREETPORT LOUISMP

(4) HHMI CAYMAN I COMPANY INVESTMENT CJ HHMI C Corporation -24,913 311,021 100 % YesWALKER WALKER HOUSE MARYSTREETPO BOX 265GTGEORGETOWNCJ

CHALKSTREAM KOREA FUND INVESTMENT CJ HHMI C Corporation -5,000,309 44,624,449 100 % Yes(5) INTERNATIONAL LP27 Hospital RoadGeorge Town, Grand Cayman KY19008CJ98-1248058

(6) INVESTMENT CJ HHMI C Corporation 84,458 3,982,159 100 % YesLSV ADVANTAGE INTERNATIONALIII LTD89 NEXUS WAY 2/F CAMANA BAYGRAND CAYMAN KY11205CJ98-1300995

(7) INVESTMENT CJ HHMI C Corporation 2,420,501 14,462,081 100 % YesLSV ADVANTAGE INTERNATIONALIII-B LTD89 NEXUS WAY 2/F CAMANA BAYGRAND CAYMAN KY11205CJ98-1315328

(8) INVESTMENT CJ HHMI C Corporation 15,533,287 97,841,370 70 % YesCOASTLAND RELATIVE VALUE FUND

LTDWALKER HOUSE 87 MARY STREETGEORGE TOWN,GRAND CAYMANKY19005CJ

(9) INVESTMENT CJ HHMI C Corporation 43,289 9,887,435 58 % YesIRONSIDES PARTNERS SPECIALSITUATIONS OFFSHORE FUND LTDPO BOX 309 UGLAND HOUSEGRAND CAYMAN 11104CJ

(10) INVESTMENT EI HHMI C Corporation 21,718,331 168,665,556 100 % YesMARSHALL WACE MANAGEDACCOUNTS PLC-MW EUROPA FUND IIBEAUX LANE HOUSEMERCER STLOWERDUBLIN 2EI

NEWFOUNDLAND TERRANOVA INVESTMENT CJ HHMI C Corporation -11,854,539 111,953,942 82 % Yes(11)OFFSHORE FUND89 NEXUS WAY CAMANA BAYGRAND CAYMAN KY19007CJ

Form 990. Schedule R. Part V - Transactions With Related Organizations

(a)Name of related organization

(b)Transactiontype(a-s)

(c)Amount Involved

(d)

Method ofdetermining amountinvolved

(1) CERBERUS HH PARTNERS LP B 33,998,371 FMV

(1) CVI HH INVESTMENTS LP B 80,000,000 FMV

(2) ECHO STREET GOODCO SELECT II LP B 100,000,000 FMV

(3) GEM BVP CO-INV-A LP B 7,100,000 FMV

(4) HH HOLDCO CO-INVESTMENT FUND LP B 83,665,150 FMV

(5) HH SG SECONDARY FUND LP B 12,828,000 FMV

(6) SPRUGOS MAURITIUS I LTD B 46,025,593 FMV

(7) CHALKSTREAM KOREA FUND INTERNATIONAL LP B 25,000,000 FMV

(8) LSV ADVANTAGE INTERNATIONAL III LTD B 389,848 FMV

(9) LSV ADVANTAGE INTERNATIONAL III-B LTD B 3,043,059 FMV

(10) CERBERUS HH PARTNERS LP S 3,864,734 FMV

(11) GEM NPLCO -INV FUND LP S 4,351,644 FMV

(12) HHLF LP S 43,054,472 FMV

(13) SOLUS OPPORTUNITIES FUND 2 LP S 19,396,949 FMV

(14) CVI HH INVESTMENTS LP S 36,000,000 FMV

(15) HH HOLDCO CO-INVESTMENT FUND LP S 17,546,687 FMV

(16) HH SG SECONDARY FUND LP S 3,498,963 FMV

(17) SPRUGOS MAURITIUS I LTD S 90,596,188 FMV

(18) HH ELLINGTON FUND LTD S 172,500,000 FMV

(19) COASTLAND RELATIVE VALUE FUND LTD S 151,873,341 FMV

(20) TOURMALET MATAWIN OFFSHORE FUND VI-A LP B 4,000,000 FMV

(21) TOURMALET MATAWIN OFFSHORE FUND VI-A LP S 21,000,000 FMV

(22) MARSHALL WACE MANAGED ACCOUNTS PLC-MW EUROPA FUND II S 15,000,000 FMV

(23) IRONSIDES PARTNERS SPECIAL SITUATIONS OFFSHORE FUND LTD S 5,000,000 FMV

990 Return ofOrganization Exempt...

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