91. Cell Reproduction Notebook Check (stamped) 92. Karyotype Lab (graded) 93. Intro to Genetics...
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Transcript of 91. Cell Reproduction Notebook Check (stamped) 92. Karyotype Lab (graded) 93. Intro to Genetics...
•91. Cell Reproduction Notebook Check (stamped)•92. Karyotype Lab (graded)•93. Intro to Genetics Reading Guide (stamped)•94. Genetics Notes•95. Punnett Squares•96. More Punnett Square Practice•97. Exceptions to Mendel’s Rules•98. Oompah Loompa’s (stamped?)•99. Progress Report #6 (stamped)•100. POP QUIZ!•101. Pedigrees (a & b)•102. Ugly Baby Lab•103. Genetic Disorders (stamped)•104. Genetic Technology (a. notes & b. activity sheet)•105. Progress Report #7 (stamped)•106. Biotechnology Review•107. Genetics Practice•108. Genetics Notebook Check – starts on 3/31/11
• 3/31 & 4/4 Genetics Unit TEST and Notebook Checks!• 4/1 Teacher Workday!• Castle Learning Practice/Extra
Credit closes on 3/30 at midnight!
IMPORTANT DATES!
a medical procedure used to diagnose chromosomal disorders in a developing fetus. A small amount of amniotic fluid, which contains fetal
tissues, is extracted from the amniotic sac surrounding a
developing fetus, and the DNA is examined.
AMNIOCENTESIS
GENETICS #94• Gregor Mendel = father of heredity–Mid 1800s–Studied garden pea plants (because they
could produce purebred individuals)–Studied how traits were passed from one
generation to the next
–Mendel came up with several important concepts
1. Parents pass on genes2. For each trait, an organism has 2 genes (1
allele from Mom and 1 from Dad)3. Alleles can be dominant and recessive• Tall plants could equal TT or Tt, short = tt•Genotype = genetic make-up for trait (TT)• Phenotype = physical look of trait (tall)
Law of Dominance• If organisms contain two identical
alleles for a trait, it shows that trait.Curly hair = HHStraight hair = hh
• If organisms contain two different alleles for a trait, it shows the dominant trait.Curly hair = Hh
HOMOZYGOUS ALLELES
HETEROZYGOUS ALLELES
Punnett SquaresUsed to
predict the possible
combinations of dominant
and recessive alleles in the
offspring.Genotypic ratio = 1 RR : 2 Rr : 1 rrPhenotypic ratio = 3 pink : 1 yellow
• Dad = XY, some sperm have X, some have Y• Mom = XX, all eggs
have X because that’s all Mom has to donate• Who determines
gender of baby – Mom or Dad?
Determining Gender!
Law of Independent Assortment
The genes for traits found on different chromosomes separate independently
when gametes are made.
Test CrossA deliberate
genetic cross with a homozygous
recessive individual that can be used to
determine whether an organism is
homozygous or heterozygous dominant for a
trait.
?
Phenotype is a mix of geneticsand environment
MostlyEnvironment Mix
MostlyGenetic
Language Height Blood typeReligion Weight Eye color
Intelligence
Nature vs. Nurture Debate
1. Green pea plant (GG) X Green pea plant (Gg)2. Tall plant (TT) X short plant (tt)3. Two tall plants (Tt)4. Two white flowers (white = recessive)5. Homozygous red flower X white flower6. Homozygous dominant brown mouse X
heterozygous brown mouse (tan = recessive)7. Heterozygous white rabbit X black rabbit.8. Two heterozygous white rabbits. (black = rec)9. How would you figure out if a purple plant
(dominant) is heterozygous vs. homozygous?
#96 More Punnett Square Practice(make Punnett Squares & describe offspring using genotypic and phenotypic ratios)
Sometimes genetics isn’t always as simple as Mendel’s
Law of Dominance
Exceptions to Mendel’s Rules
#97
• Heterozygote is a BLEND of the 2 homozygotes• RR = red flowers• rr = white flowers• Rr = PINK flowers• Cross two pink flowers.• Genotypic ratio 1:2:1• Phenotypic ratio
Incomplete Dominance
1 red: 2 pink: 1 white
Codominance• Heterozygote show BOTH traits• BB = black cows• WW = white cows• BW = black & white• BB X WW• All BW offspring• Genotypic ratio = 0:4:0• Phenotypic ratio = 0:4:0
Multiple Alleles• Traits that have more than two
alleles.• Blood types –
3 allelesA and B are co-dominantO is recessive to A and B
4 phenotypes1)Type A
blood contains “A” proteinsgenotype: AA or AO
2) Type Bblood contains “B” proteins (genotype: BB or BO)
3)Type ABblood contains both proteins genotype: AB
4) Type Oneither protein present in bloodGenotype: OO
• AB is an example of ________________.
Polygenic Inheritance• Several genes are inherited
from each parent for 1 trait.• Many possible phenotypes.• Examples: skin color, eye color,
height, weightABC, ABc, AbC, aBC = dark
abc, abC, Abc, aBc = light
ABC ABc AbC Abc aBC aBc abC abc
ABC 66 5 5 4 5 4 4 3ABc 5 4 4 3 4 3 3 2AbC 5 4 4 3 4 3 3 2Abc 4 3 3 2 3 2 2 1aBC 5 4 4 3 4 3 3 2aBc 4 3 3 2 3 2 2 1abC 4 3 3 2 3 2 2 1abc 3 2 2 1 2 1 1 0
• Located on X chromosome• Females are only carriers• Mostly males are affected• Colorblindness, hemophilia, baldness• XBXB = normal female• XBXb = carrier female• XbXb = colorblind female• XBY = normal male• XbY = colorblind male• Cross a carrier female with a normal male.
Explain the possible offspring.
Sex-Linked Traits
Human Genome - identifying the 30,000+ genes in human DNA and the order of the bases A, C, T, and G.• Discovering new ways to diagnose, treat &
prevent genetic disorders• Trying to identify the location of all genes on
chromosomes• To sequence DNA, scientists use restriction
enzymes and gel electrophoresis
GENETIC TECHNOLOGY #104A
Applications of Biotechnology1. DNA fingerprints –Analyzing the sequences of DNA to
determine similarities or differences between different samples of DNA
2. Restriction enzymes–Cut fragments of DNA so that scientists
can place them on gel electrophoresis–Steps of gel electrophoresis:
1. Blood/cell sample is isolated2. Extract DNA3. Cut DNA using restriction enzymes4. Place fragments on gel5. Fragments separated by electrical
current6. DNA bands can be matched/compared
Steps of Gel Electrophoresis
3. Transgenic organisms–Have DNA from another species inserted
into their own DNA–Restriction enzymes cut plasmid DNA
(circular, not chromosomal) and foreign DNA–“Stick” them together – makes recombinant
DNA4. Amniocentesis (see karyotype lab)5. Cloning - making genetically identical
organisms–4 steps: (see page 333)
Genetics Review
Gel electrophoresis video
WHAT ARE THESE THINGS??
1. Refers to an individual’s observable traits.2. Which of the following describes a phenotype?
a. Gg b. homozygous c. dimples d. heterozygous
3. What term describes an organism in which two alleles for a trait are different?
4. Crossing a purebred, purple-flowered plant with a purebred, white-flowered plant can be symbolized by which of the following genotype crosses?a. Ff X ff b. FF X ff c. Ff X Ff d. FF X FF
5. Two pea plants are crossed, TT X tt. Make a Punnett Square. Write the genotypic ratio.
6. AB blood is a result of what type of inheritance?7. Know how to determine genotypic & phenotypic ratios…8. Know how to analyze pedigrees…
9. White short-horned cattle and Black Angus cattle have been crossed to produce offspring with superior beef and rapid growth qualities. The process of choosing organisms with the most desirable traits for mating is…
10. Non-disjunction involving the X chromosome occurs during oogenesis and produces XX eggs and 0 eggs. If normal Y sperm fertilize the eggs, which genotypes are possible?a. XX &XY b. XXY &YO c. XYY & X0 d. XYY & X0
11. Huntington’s disease is what type of disease?12. What is the job of a restriction enzyme?13. A male with IAIB blood has a wife with O blood. What are the
possible blood types of any children they may have?14. Scientists have cloned sheep, but not yet a human. Why not, do
you think?15. What is a transgenic organism?
a) Individual showing the trait being tracked
b) Malec) Generation #d) Offspring with birth
order left to righte) Femalef) Marriage/matingg) Sex undetermined
I, II, III, IV
151617181920
21
Words To Know1. Pleiotropy2. Codominance3. Incomplete dominance4. Polygenic Inheritance5. Homozygous vs.
heterozygous6. Plasmid7. Alleles8. Replication,
Transcription & Translation
9. Recombinant DNA
10. Karyotype11. Cloning12. Test cross13. Sex-linked vs. autosomal14. mRNA vs. tRNA15. Synapsis16. Crossing Over17. Non-disjunction18. Diploid vs. haploid19. DNA fingerprint20. Trisomy