9-Circulatory Systems in Animals Part 2

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    Lymphatic System

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    The exchange of substances between the blood

    and the interstitial fluid that bathes the cells takes

    place across the thin walls of the capillaries.

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    As blood proceeds along the capillary:1. Blood pressure drops

    2. The capillary becomes hypertonic compared to thesurrounding tissue fluids

    3. The resulting osmotic gradient pulls water into the capillary byosmosis near the venule end.

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    About 85% of the fluid that leaves the

    blood at the arterial end of the capillary

    bed re-enters from the interstitial fluid at

    the venous end.

    The remaining 15% is eventually returned

    to the blood by the vessels of the

    lymphatic system.

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    Fluid enters this system by diffusing into tiny lymphcapillaries intermingled among capillaries of thecardiovascular system.

    Once inside the lymphatic system, the fluid is called

    lymph, with a composition similar to the interstitial fluid. Eventually the lymphatic system drains into the

    circulatory system near the subclavian veins.

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    Lymph vessels, like

    veins, have valves thatprevent the backflow offluid toward thecapillaries.

    Rhythmic contraction ofthe vessel walls helpdraw fluid into lymphaticcapillaries.

    Also like veins, lymph

    vessels depend mainly onthe movement of skeletalmuscle to squeeze fluidtoward the heart.

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    Along a lymph vessels are organs called lymph

    nodes. Inside a lymph node is a honeycomb of

    connective tissue with spaces filled withleukocytes (WBC) called lymphocytes and

    macrophages Lymphocytes and macrophages are

    specialized for attacking viruses and bacteria.

    When the body is fighting an infection, thesecells multiply, and the lymph nodes becomeswollen.

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    In addition to

    defending against

    infection and

    maintaining thevolume and protein

    concentration of the

    blood, the lymphatic

    system transports fatsfrom the digestive

    tract to the circulatory

    system.

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    Blood

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    Figure 42.14 The composition of mammalian blood

    99%

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    Figure 42.14x Blood smear

    erythrocyte

    platelet

    leukocytes

    Fi 42 1 Diff i i f bl d ll

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    Figure 42.15 Differentiation of blood cells

    Macrophages

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    Erythrocytes

    Biconcave in shape due to absence of

    nucleus

    Absence of nucleuslifespan of 120

    days

    Dead erythrocytes recycled by spleen and

    liver into bilirubinbile

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    Erythrocytes

    Hemoglobin is the protein

    attached to the

    erythrocyte

    Hemoglobin has 4

    polypeptide chains

    (quaternary structure)

    Each polypeptide chain

    has a heme (iron) group

    that binds O2

    Therefore one erythrocyte

    carries 8 oxygen atoms

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    Regulation of Erythrocytes

    1) + Low blood O2

    2) + erythropoietin

    3) + erythrocytes

    4) + High blood O2

    5) - erythropoietin

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    Blood Clotting

    Platelets initiate

    clotting at site of tear

    in blood vessel wall

    Fibrin is produced toseal any leaks in the

    blood clot

    Platelets + Fibrin +

    Pus = Scab

    Fig re 42 16 Blood clot

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    Figure 42.16x Blood clot

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    Mechanism of Blood Clotting