8 aterosclerose e balanco redox

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Transcript of 8 aterosclerose e balanco redox

  • 1. Aterosclerose Coronariana e o Papel do Balano Redox. Prof. Mrio IBqM - UFRJ

2. Joseph L. Goldstein e Michael S. Brown1973-81 : Definio do modelo de transporte de lipdeos por lipoprotenas.Caracterizao dos receptores heptico e extrahepticos de LDL, VLDL eQuilomicron. 3. Locais de Extravasamento de Superoxido na Mitocondrida 4. Fukumura et al. Nature Reviews Cancer 6, 521534 (July 2006) | doi:10.1038/nrc1910 5. Table 1. Human plasma antioxidants.Antioxidant Concentration (M) Mechanism of actionWater-soluble antioxidantAscorbic acid 35 - 85 Scavenger of lipid peroxyl radical; regenerationof a-tocopherol by one-electronreduction;prevents copper binding to LDLUric acid 130 - 450 Scavenger of oxygen radical; metal chelationAlbumin 430 - 680 Major plasma protein with one high affinitycopper binding site; inhibitor of ceruloplasminoxidative activityTransferrin 26 - 48 Plasma protein with iron binding abilityLipophilic antioxidantsa-Tocopherol 15 - 45Scavenger of lipid peroxyl radicalUbiquinol-10 0.4 - 1Scavenger of lipid peroxyl radical; regenerationof a-tocopherolb-Carotenoids 0.19-1.58 Scavenger of singlet oxygen and peroxylradical (at low oxygen tension)