7147621 Human Physiology

8/12/2019 7147621 Human Physiology

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HUMAN PHYSIOLOGYAnita Ocampo-So, MD, FPSP, DPBA, MHA

Professor


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GOALS

1 !o "n#erstan# t$e importantf"nctions of t$e %ario"s or&an

s'stems( !o ac)"ire t$e a*i+it' to pro*+em

so+%in& an# critica+ t$in in&

!o #iscern t$e %a+"e of +a*orator'e)"ipment an# proce#"res as#ia&nostic ai#s


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GOALS

1 !o #e%e+op t$e attit"#e an# $a*itessentia+ to t$e practice of

me#icine an# contin"in& me#ica+e#"cationi Sensiti%it' to co++ea&"es, societ',

an# patientii Sensiti%it' to #ifferenceiii Sensiti%it' to responsi*i+it' to .M/i% Inte&rit'


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PHYSIOLOGY

P$'sio+o&' state# *roa#+' an#simp+' is t$e st"#' of $o0

+i%in& or&anisms 0orIt #ea+s 0it$ t$e f"nctions of+i%in& *ein&s an# t$e

Inte&ration on $o0 t$e #ifferentor&an s'stems 0or to&et$er toaccomp+is$ comp+e tas s


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PHYSIOLOGY

.+a"#e Bernar#2After carr'in& o"t an ana+'sis

of p$enomena, 0e m"sta+0a's reconstr"ct o"rp$'sio+o&ica+ s'nt$esis so asto see t$e 3oint action of a++ t$eparts 0e $a%e iso+ate# 4


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PHYSIOLOGY an# LIF/

P$'sio+o&' #ea+s 0it$ t$ef"nctions of +i%in& t$in&s t$"s

it #ea+s 0it$ +ife itse+f Life is t$e interp+a' of t$eor&anism to its en%ironment

It e p+ains t$e p$'sica+ an#c$emica+ factors t$at areresponsi*+e for t$e ori&in,

#e%e+opment an# pro&ression of


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A!!5IBU!/S OF !H/ HUMANBODY

1 Or&ani6ation( Irrita*i+it'

.ontracti+it'7 N"trition8 5espiration9 / cretion: Meta*o+ism an# Gro0t$;

5epro#"ction


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HUMAN BODY

1 So+i# component.e++

!iss"es - master tiss"es- %e&etati%e tiss"es

Or&ans

S'stems( Li)"i# component

( Ma3or f+"i# compartments


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FLUID .OMPA5!M/N!S

Interna+/n%ironment

P+asma < LISF < 11L

(= of !BF1= of !BF

(;LVolume17LPO 7 - Anions.+ -

> ? , M&??CationsNa ? , .a ??@; mOsm=LOsmolarit

y @; mOsm=L

: 8-: 7 pH: 7-: 78

I.F/.F


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HOM/OS!ASIS

!$e maintenance of t$e *o#'in a stse of re+ati%e constanc'

in t$e interna+ en%ironmentCONTROL SYSTEM < 0or s on

1 .e++"+ar +e%e+( Or&anisma+ +e%e+

!$ro"&$o"t t$e entire *o#'


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.HA5A.!/5IS!I.S

5ef+e in nat"reOperates on a fee#*acmec$anism, most+' - C rare+'

?Amp+ification or GainOsci++ation < #ri%in&, 0a in&,#ampe#


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./LL an# its FUN.!IONS

.e++s, +i e t$e $"man *o#'$as

1 Di%ision of +a*or( Specia+i6ation

M"t"a+ interaction7 .entra+i6e# contro+

.e++ < *asic +i%in& "nit of t$e

*o#'


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P5O!OPLASM

!$e #ifferent s"*stances t$atma e "p t$e ce++ It is

compose# of ( ater

/+ectro+'tes7 Proteins8 Lipi#s9 .ar*o$'#rates

< principa+ f+"i# me#i"m

- Ma3or cations an#anions- Ne t to 0ater, most

a*"n#ant

- ( t'pesa Str"ct"ra+

-P$osp$o+ipi#s an# c$o+estero+

- !ri&+'ceri#es an# nat"ra+ fats- Litt+e str"ct"ra+

f"nction


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PHYSI.AL S!5U.!U5/ of t$e./LL

.ontains $i&$+' or&ani6e#p$'sica+ str"ct"res ca++e#Or&ane++es

.o%ere# 0it$ a mem*rane

are t$e n"c+e"s, en#op+asmicretic"+"m, mitoc$on#ria,+'sosomes, an# Go+&i

apparat"s


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./LL M/MB5AN/

It en%e+opes t$e ce++It is compose# most+' of

Proteins < 88ELipi#s < 7(EP$osp$o+ipi#s < (8E.$o+estero+ < 1 EOt$er Lipi#s < 7E

.ar*o$'#rates < E


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./LL M/MB5AN/1 Lipi# Mem*rane

- Basic str"ct"re is a *i+a'er* P$osp$o+ipi# part

1 H'#rop$i+ic part- ater so+"*+e- .onsists of t$e $ea# &ro"p

- P$osp$ate portion( H'#rop$o*ic part

- Fat so+"*+e- .onsists of t$e ( c$ain &ro"p- Fatt' ac'+ portion


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./LL M/MB5AN/

P$osp$o+ipi# Bi+a'erPrimari+' responsi*+e for t$epassi%e permea*i+it' propertiesof t$e mem*rane.$o+ine containin&

+ecit$in p$osp$ati#'+c$o+ineSp$in&om'e+in

Aminop$osp$o+ipi#sP$osp$ati#'+serineP$osp$ati#'+et$ano+amine


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./LL M/MB5AN/

Ot$ersP$osp$ati#'+&+'cero+

P$osp$ati#'+inosito+car#io+ipin

.$o+estero+

G+'co+ipi#s


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LIPID BILAY/5

Feat"resIt is f+"i# an# not so+i# so portions oft$e mem*rane can f+o0 +itera++' from

one point to anot$erS"*stances #isso+%e# or f+oatin& in t$e+ipi# *i+a'er #iff"se to a++ areas of t$ece++ mem*raneLipi# so+"*+e s"*stances easi+' crosst$e +ipi# *i+a'er

ater so+"*+e s"*stances #o not#isso+%e in t$e +ipi# *i+a'erC t$e' crosst$e mem*rane t$ro"&$ 0ater-fi++e#c$anne+s, pores, or carriers


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( M/MB5AN/ P5O!/INS

Most+' G+'coproteinsFi*ronectin < inte&rins

( t'pes of Proteins( Inte&ra+ proteins

Perip$era+ proteins


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M/MB5AN/ P5O!/INS

F"nctions( Anc$or

P"mps7 .arriers8 Ion c$anne+s9 5eceptors: /n6'mes; Anti*o#' processin&


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M/MB5AN/.A5BOHYD5A!/S

!$e' are referre# to as t$e ce++G+'coca+'

In com*ination 0it$ +ipi#s

7147621 Human Physiology

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