6BI05_01_que_20130121

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Write your name hereSurname Other names

Centre Number

Candidate Number

Edexcel GCE

BiologyAdvanced Unit 5: Energy, Exercise and CoordinationMonday 21 January 2013 Morning Time: 1 hour 45 minutesPaper Reference

6BI05/01Total Marks

You must have: A copy of the scientific article modified from New Scientist articles (enclosed)

InstructionsUse black ink or ball-point pen. Fill in the boxes at the top of this page with your name, centre number and candidate number. Answer all questions. Answer the questions in the spaces provided there may be more space than you need.

InformationThe total mark for this paper is 90. The marks for each question are shown in brackets use this as a guide as to how much time to spend on each question. Questions labelled with an asterisk (*) are ones where the quality of your written communication will be assessed you should take particular care with your spelling, punctuation and grammar, as well as the clarity of expression, on these questions. Candidates may use a calculator.

AdviceRead each question carefully before you start to answer it. Keep an eye on the time. Try to answer every question. Check your answers if you have time at the end. Turn over

P39881A2013 Pearson Education Ltd.

*P39881A0128*

1/1/1/1/1/

Answer ALL questions. Some questions must be answered with a cross in a box . If you change your mind about an answer, put a line through the box and then mark your new answer with a cross . 1 (a) The graph below shows the changes in potential difference across the membrane of a neurone after stimulation. +50 Potential difference / mV +30 +10 10 30 50 70 90 A E 0 1 2 Time / ms F 3 4 (1)................................................... . . . . . . . . . . .

C

B

D

(i) Using the information in the graph, state the maximum change in potential difference across the membrane of this neurone during depolarisation.

mV

(ii) The table below describes three of the stages shown in the graph. Place a cross in the box ( ) below the letter that correctly links the description to one of the labels on the graph above. (3) Description Stage when the concentration of positive ions is greatest inside the axon Stage when hyperpolarisation first occurs Stage showing the resting potential A B C D E F

2

*P39881A0228*

*(b) When a nerve impulse reaches a synapse, calcium ions enter the neurone through the pre-synaptic membrane. This causes a neurotransmitter, such as acetylcholine, to be released. Describe and explain the sequence of events that occurs at the synapse, after a neurotransmitter has been released. (5). . . . . . . . . . . . .................................... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ........... ............................................................................................................................... .. . . . . . . . . . . . . . . . . . . . .

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(Total for Question 1 = 9 marks)

*P39881A0328*

3

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BLANK PAGE

4

*P39881A0428*

2 Respiration is a vital process in living organisms. All organisms carry out glycolysis. The Krebs cycle also occurs in some organisms. (a) The diagram below shows some of the stages in glycolysis, using the hexose sugar glucose. Glucose Molecule R Molecule S Phosphorylated glucose

Phosphorylated 3 carbon compound

Phosphorylated 3 carbon compound

Name the molecules R and S shown in the diagram. (2) Molecule R . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Molecule S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

*P39881A0528*

5

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(b) The diagram below shows some of the stages in the Krebs cycle. Acetyl CoA

4 carbon compound

6 carbon compound

1 molecule T 6H

5 carbon compound

2H 1 molecule T

(i) Name molecule T and use the information in the Krebs cycle diagram to give a reason for your answer. (2). . . . . . . . . . . . .................................... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ........... ............................................................................................................................... .. . . . . . . . . . . . . . . . . . . . .

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