65401176 Pathophysiology of BREAST CANCER
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Pathophysiology of BREAST CANCER Predisposing factor Gender M<F Genetic/Hereditary Precipitating factor Life style Sexual practice Virus Environmental Chemical Physical Damage/Change in genetic material [DNA] Response with carcinogen Cell death = Cell replace Hyperplasia Recurrent injury ↓ metaplasia BREAST ↓ Lump ↓ Tail of Spence ↓ Orange peel dumpling ↓ Nipple inversion Prolonged injury ↓ Mutation ↓ Loss of P53 Loss of apoptysis ↓ Dysplasia ↓ anaplasia Decreased T-CELL ↓ Neoplasia ↓ “Promotion” CANCER Absorb Surrounding Nutrients Cachexia Wasting syndrome Anorexia Weight loss Weakness Fat loss Lipolysis Hypothalamus Cell starvation 1cm growth ↓ Angio genesis growth factor Hypoxia ↓ Lactic acid ↓ Pain Anoxia ↓ Cell Death Inflammation → kinis → PAIN Pyrogen → Recurrent fever
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pathophysiology of breast cancer
Transcript of 65401176 Pathophysiology of BREAST CANCER
Pathophysiology of BREAST CANCER
Predisposing factor Gender M<F Genetic/Hereditary
Precipitating factor Life style Sexual practice Virus Environmental Chemical Physical
Damage/Change in genetic material [DNA]
Response with carcinogen
Cell death = Cell replace
Hyperplasia
Recurrent injury ↓
metaplasia
BREAST ↓
Lump ↓
Tail of Spence ↓
Orange peel dumpling
↓ Nipple inversion
Prolonged injury ↓
Mutation ↓
Loss of P53
Loss of apoptysis ↓
Dysplasia ↓
anaplasia
Decreased T-CELL ↓
Neoplasia ↓
“Promotion” CANCER
Absorb Surrounding Nutrients
Cachexia
Wasting syndrome
Anorexia
Weight loss
Weakness
Fat loss
Lipolysis
Hypothalamus
Cell starvation
1cm growth ↓
Angio genesis growth factor
Hypoxia ↓
Lactic acid ↓
Pain
Anoxia ↓
Cell Death
Inflammation → kinis → PAIN
Pyrogen → Recurrent fever
