~ .n: ~~.-or' - fTOPiOnjl CoA is Cafbo\j\o.ted ro m e.ihLf I malotJ(:11 CaA L:) \' s ~.

-,sc>me(i 2c..d to s IJ._ CCiV1j1 C6 A ---::, 3 \uCo Sc, b.j :J lu CDVle 6j~l')ea/:S_ The is omei'cv')e 11 ec.ds 1),'/ 8,1-- V," r 812 J > EXcycf;ol"1 of fYOr,'onak.J) rne.r&1 WlC(lolJa1e.- I'f) U(/Y)e....

Q: .EXPlqill Wy:- v'et7Cha,'1] FA tJe.IJCY3illeo3!ucose-JJ bnof'ma ,,'Iit/) /11 J3. o~; Jati~t1

I

1. A hYJorm,/; fif/) 0 r Col!}; f:t1t:. .shcJttJ~* Caf(]; t;l1ede(.- (;ellS' lecJr ID j!JCemia@ C P T n de Fic;enf!-=-= Ms ltJeaKfless.J (Yl.J'ijLab,.nem,.o. 0 (Ylj69labi'/}VYlq

dV(.t1j e. '(aCiSc..

tre.a1rnelJi:. 50111ePTl A cPTlL deFic"efl9 aye rYf.aft:)b:;:-d) A vOid Fosht7j \ ,," Ao I t hd ~yy\.c,J .. U(Y\ CMd\ '\Q I\CSft" cr,'ol') of Id~ CnQ,"1') rr4 -3 s o W .o(al U(/I,f";Y\.-{;,.....".. ~ Cilv-d.iOfYljorp "b J /As WCtaI1e.. def( c ,et\C'1 ; _ + -\. ~nine5~ ;- I .ver: d...s-e(.ll)e..J. . -:::.J ~ t C)e. mc:u"J : - frc.~(\/:1n~

C) 01V1e.l d isc>,d.e(s: \(Ql1s1o~e. d~roe;1~ t Loss i(\ u("ine. ~- K.cAn:; ~"~ew:le...- .COfYlpl,'c.abOYl5 o~ GH'I),"J,'V!L de.{'OCvlj ; -I~f.f FCI,)uy"e./ I,Ver frdbletY7s.l G:,rnQ of slAdJendf!lJ}v

2. t1Cd;vMChQ""ACl CoA Och 0(0 ~1IA1.7~ fa HeAD' dtfiC,- 'dCclJfYllAlaho(\ of Y'V\(.J,ufY] Chaill rA ~ tox...c ..~'j C hi \ d(er'l c()(Y1plu,"r1s 0 F .:~~o.sJ-."~ ~f>dJ/:Jcemiq If'J of) 't(')Cda\:tOV'\ -'5> ~ 3\v..(pn~jC/l'1~'5. . . u..~CArg ~ ~ ~

~e(oX is ()ma 1 0i;Jett :0'" 0 t tA >,\~ .~e", ~(~~~G.~boJ.~'"l ~Gm. d ",,-H4' peIbji50mQI F'A o')(,.:Ia+;o" d'(fS Fro"" r oi..eJa!;oV'l ;11 3 ",seeds :-CDAds Of) Vc~ Io~ c.ha;", t"A ~ 20 c

V!:.JJ

0{ - Ot.,JatiOf\ of EA,!)er.:- pa1t\.w'1 F'0' oX;daj;ofl dF h,a/lcJ,ed charr: FA I:'. plyfO/}iC ar..)s,tc.;- HiC(05o!Y1&') 0 F the.. bra ill

f3 0( (02- [oJ

IR.-~U7.-tt\ LOC\-\ < \ I f\ ~\-\'1.. ~ \-\-~\ Cool-\

C \-\j O~\ ~at\".c. d~CQ'~H~.Iqtl""" \ l \c \.\.3 0I P(d't'\C~' Ffr . ''".i. ' ,( kc1'6 P 1'1~~' fAL ,66'f-,datioY\' ~ ACICA'c'J '[3' "dt~ . n:J 0 ) 61'~ a ic(\

pfopl e(l~\ LoA "'7 G tu LOS e.,

Re f oSU(1'\l.s d; .s(..~e.. :-C6,.se. :_ Def;c;e~Cj of 0( ~d(o~~IWllso ("lIed 1'~+OIl"G"c.:J 01\'.1"",

BroWIl adipoSe t,&sue..f SfeGa\ -Spc- or ad;?ose.. tiss.ue.-;f ,VUt1 ctiOYl : - He.Q+ 3~ L( phos pho fa,,1e./k.e.."r]~ a F Ac p@ s \-\0 t Cj s+e it'\< 0 ~ Keto oCjL sun~Q/.)e.

!ne. 2- Y1Ionome(s o.{~ Gt't\o.c~d h

Rc.qUi(c:me-nt Fo( f'A ~tr1hesl.s :-- C1> Ac

~ I Lj rJA D P 1"-:;' [05f.he'CjlcJ-e.A ~ Achve. .foY.M ~~,r~W\"\""''' l'"s\.tl.-v Ph05>p~o0tat~C:\ : ,V\~c...h'~ ~e{'yY1. ..' . .' ~ 8' fh"sp~&;(tjI~l::ioYl oc.CurS b-::1 AMP K;Y\w')e. W i'::. "'ctil/q-teJ bJ AHP/< l ~ 0~ et\ (\Clc~to.Te, -l0 tC(M Ct \ .rat~- Ci t{aTe.. paS5f!1) to Sto.sa L- ~ TP ei \raf.e.- 1(1./x.. ({-:h(YIIAI~tcJ 'bJ /I1Suh",1I bfCC(ts (,rv'l"41e.

JlHa QI ( ". \ L, Ce.1l"e.(tc.d ,,\,0 '(Y\at(4t-c.. ~ , .tg14tc OH.J u e se 0 ". oa l'OV\ ~ t AlP 1

~ t tJAOH r t :1-56 cd ...tI~ DHc: t t I -l- -r~A

~ So ,va ~ IS "'at oX~d;L

d) .!r15uL'v1 s1il'Yl",IQJeo l-H~P ~ t NADPH-rHte) J{} 5u 1,'1/ \,\ ACe Ijl CoA Cofbr:!t IwJe (I l(e1 et?Z. a t FA !;t/f1J1t4lJ If

NA 0 \-----t------------ ,Iv'AD

~;VADH ..H1-t-----------~ NAD H-tll

Rc\Qt .C)~ be..h4J.f.c..'\ !:)\SACoH O~icJClho.,.-\ ~A tr1ftvu..J~,C(c>SorY\QL SyS~e:M fo(' FA e.\ e.f!')Q\lor"\

if TJi,.~ y.sjem 1. ..en?j me, (le-,pmJIble.... rfd' elat1j~f;oV1 0 F f4 FI'OfYi eto fo C i'(, rtl~ s~m:lll( cc> Sto~6Lc. ~5te.,.,j~ ;-

- ~o.c~ Cjdc. e..\~--'C4llo ~~\C6A 1,12. CQl'bli/l5 uS"'!.J

l1etabaliSM or unsato(ated FA'-!''iYi7fie/.J;$ or UStA :-

,q- syt11he.oi.5 0 r MofJQenoic FA :- W -, ~ Wy UlJsa-J"yu/ ed rA a (c-0, I-I~o

E )("mp)&.l :-

PqlrYJit'C. "16c." ~~ JCSQtur(M):J JttJ4/urcv'J

.J. yYl fd ( f Q (J CL CJ r P()FA; -

--------

\'\etabolism 0 r (onj!(J41eJ lipiJS ( rh6Sph, I,'pial ~ Gfy(,/;p"d) ~ol Grnj"'juted \ipidS iY\C'\lde...S rhos phlljljCef/dv.J /) .s phtl1jcl,plJ..s rh~srho.9\yc~(;d6J ~-. C:(::A----'-----:-L------' . " fA -

fl,(me.d of ph"spha-l;di( awd .' \;'LO\.o..CY,L:.!}loyGero/3fCa 'flj I)j a ted 10 o..t'\oihcr 3 rOLl p '. oih e(" t'\"H.VVl b erS I'" c lu j e :-

@ rhos phafiJj l se ('ifle. ~hosphatlttl Ch6lone {tJ~(i lh;tJ/lf'A r f'~ fA { rA

-LwLser:ne. (f!J- cho'.'(}e..

fh6sphat"djL ethanol/un,'ne Cl C(rh,lt'lI~ G!) rh4!>sphahc!:1ll116s;t"L.. ~AS FA ~Af FA

l@- e~tl~I~n1i()e.. L@-l-floS,'toL

@ SPh,'YljO)" P i 0\ s :-t

CuntQ;(} S Ph't1j 05"11 e. C(J71j~afeJ.e. fA to ro(rYI Ccycunid I thy I'(,}C /lAcle :-@ s rhit10jOIJclill (1) u'f'ebros;de.5

\~- cno\:IlE:.. \~ ~J\&Co.fC or !3aloc:-l~.sc..

U UCS>Sut to I'-PiJ ~ s,,1 f4 t.-J s Q) G",,:;'ias;Je-,

WAG cI- s.' r.re.' .)JfA CompleX C Ho~ " ~ ,.... ()(:' P~,,~ f\-lc. ::\['1

CoAsHJ

'__ 1, ,.i

ser'l'1e p,,'W':r"!:Il.t ("",f)'s fe("w')c-

pLP

CatQ b61ism O~ Sph;f) '0 liP; ds :-;,QC C\A( bj s?e CA fe'L \js(>$ csma I er-tzdrnv:>

1. \'Y\ p6 ( tC\r1(, 0 ~ pho s phe I; Pie! -1 G \yCoI; I;) dUhosphD\;pid :- AlphEc..

I

t,/, ',\,/. (.JJ:HI(if'm4/.h(!) in -ffi~ Mefabcs I:SWl "f PL oy .5' reo fl'pi'd ~.. ,

- CDResp;'fat6fJ distress ~nd(om~ ~-C d ('.."C" , ( r \ r I I ,'''' orema1 o(~ ,'t\ fc-H}to.u.S~ :; er i le., ~ 0 '" u~ Sv( rOC1"rnS ., I'- Le (ijh ,'" I Sphi" Cj6m 'le);1) ra-h'o ..1_

- is a";; ,'t\d(x 0 f lu~ m,dcJf,lj_ ratio 2: 1 Cl rno(~ il'\diCaf.eo lliat ,v~s are ty)qlul7e..

@ Multiple sc\~(CS\S:-. ChGl((A(4ef:""l.ed ~- De.Mj 1:r)ofio(} 0 f 1t~ne (IIto ()f LJhr14. Wla t16\. -? beCo mea 5,' m;}", /0 'J,

\'Y\ cdi e("- t phosphoj,'PlJs .s sph'"r:J"l'i'iJs ir1 Whit~matier- CS r:- t phosrh6 \t'pnl ~ !'jG

(JJ 5ph";j6/ipid05i.5 :..( I IJ u- t bre.~ 5ph/r}q~kp,'(jCo.\AS' :_ Dc r..e'(\~ 0 :JS(J.J(Jm~ e.1l'" tn J

1 (h lpd.s it1 tiSSUe/.)EFF~ct:. AC(vrnular,on Or Sf J'1lj1> EX"mpltll :. GCl~chc(""5 diS(AI.)c- I\ f

i~'

co"",sCoAI .CH., ~CH, Co .....sCoA

2 A(~1yl (ofl

''-~---- .:.. 111 J,; b;f,'oY) ()F TeA (jcJ~@ Jt1h'-bifion o~ aCeGJ CoA Ca{bCl)j14l.)c..~ J,l1q}o'21JCoA---'l

Q c.ti v tl" of\ cl F c PT. i ~ V-af1sf~rf t ~Cj I C04 10 m,' roe hOf1c1~"o --?I't p o~; Ja t..0 y'\ .

@ t 3IlA("sc.. ol.,-dqf,'ol'l ~ stiMlAlaf,'cll of 51(,\col1~~cn~IJ' !~o..Jj" to .!-i c>~cdoaCe.1ate.

;l7of f3(Qi'() C(A() o.CComrnoJate.. Ke.tone.. boJieo o1.'c\o..hOV\LJh'~'r1 5-6 cJ~ ~

Frt>rYl Sta(l}aT"oVl a.,. SO Ke.+o;eneSI) (lefi'.v;eA1i '" prefaYaM:JsTep pe (ftJOyud by Me-I/t/;t..r

Cotnp/e.-re.- oK; d~t,oVl0 F FAKe.+o1Y5i5

Det. :- O..iJat;oY) of /(etor)e. b6dieos,t~~-Mitochond(;q ef -e..X~{'ah~ratic.Ci~cJe/.) t\l.4.c' To p,eoen:i 1

CoA Cft,iflspeYMC- {l "IhiopnoTaI)e.. "s~~;- .

#I f3 ydl'''!J hu!Jrllfe.. 15 (d1J(/~('led it. .;1Ce-fo aw&d~ t:J /Z(.(/CYJ,aJ Jf3hyJr~!Jbt.l!JyPte.DH 1fjen o.{efo~(.e-fa1c.l5 Cutlv(rrtd to 2..m~lcc:J"" a(~t:tlc.ofl

tJAD f/ADHtHTC 1-\3 C \46 H c l-h, Coo J.I _-:::\~-:;--:--~~_Lf_~ 11p ~Jfd& bf.llj YIIn: D H ) c:.."~LO c. ~h..Co 0 Hpl1jJ(IXy blJ!Jfti'fG. ACe +0 D Ce1at ./ 0

~C6nJifions o.SS'cCiatcd e. 1 Kete'lencoiS -8 .[, kcftJys/s ("

1.:

..1- De.hydt'bje.()a.:;;''------;---!...---.::::L~4-__ ~>1- De. ~d YO c.holv.>tc:(oL-Ljv~( .0 jt1t0:t/:r1L lUVP-vncle( 5K,"()LiVe~ ~ I,\id~e~~

::tc,oL-,. CE. i5 Dbtait1eJ ~ fJ1~ '(lct;OI1 of LeAT J: \h(... Y\CI.~" Lipoprofe.il\ (Af:)i/lc1 cho leotefol '-5 LOLJ franSp6rts

chol.u.>te{oL ry-. rn Lille,-z.1-6 l'::"'sIJ!/.) II Barl cho\0teroL.. ~ \-\DL .I::(~(\5fO(tSOC""c>\~1~(oL V("e.M ti S.$lA-L'.) tb Liv'UL ( !\cl/e.rS j I Y--'/ ~-

(])LDL @ HoL (> VLDL-

- 'l".

'. ~Yfch~/eote(oleP1it3;- ~3]i 0< f :- t P\0-0W1C\ ch618Jierol Mo(e..ihan 240 ~I d L-Causeo:- Do HtJ ~3D 20 2 H N

Q) QieJ f7iCh ifl cno , S(fJ ~ Cr,o/e.J1eroL@ Q;Q beteo Md\', flA.s d"e 1""6 :-

0.') 'I L;p(j!15~5~ l' FA ~ 1f3 oXiJaJ.-dYJ..---'7' l' aCt!!JI C6f-Jb') l' fA ---'> l' TA G ~ l' VLDL.c..') ..\, CAC+,'V;!j or L;pOfytJ1eit1 hpa/.Je. ~tch.,j\omiC(OYl.5

@ Q(i~ }\"()j Co rfe A '5 yY\ -o-1F(o-teir')emia 11(5J Qbsrfv\ctiVe. 3Q\l(\dice.. IId",e to t e:t.c.(etio(\ of c.h4Ieote(ol Al.)bilc. S&Sll }j),poi&(oIdi5fYl U due. -to ~ bile salts to(mai;"", ,.@ 1)yper lipOp(ofeit1erYJia (I ype. n .. IY. e phV(?.5;5 \' vn K noWI1 rY\t;challi$/YI

.!!1Po cl1o(~te('olemio :-Der. :... .l. plasma cholv.>reroL J.Ss thall )20-'!:3IJLCo"'s~: ... PHOL1

CD fr'o Icmjed FC\5tj~fh\lsFh.lir:~

cl . 1

t_.~t..

~ fif6 I,po p(t1-/eifJ :-De (. >- 7he.. p(r;feil1 pa(f of apo 1if0r(6te.it75'Yff/J ;~ iYlt:J..-al pMe'll 'Call'.f: be- 5Cf

\jtljd(o'Y5i5 or rnaiOfe c~,lomjc,o(J bj~(6tei(l i"paIJe I' ./ LpL pfeoelJt /11 tI1~Va,.1CuI(Jre,ndo1~J;uyY) of h d(6 ~Si5 o~ TAG Ccr'lte:r1t 0 F c~lomiCl"() i(Jib;-

/ z G \y Cero 1 : -~ pta KUI by I; Vel" fYJa;'?Y ,(ail+a;rt 3iyUY-O /(.>lA/)< J anVi _ FfA :_ vpta Kef) b-! eX trohepahc.. -t\ SS lA/) or, Cay'r/c.~.'". J J. b t: m 01./ lit/er .

-albui1'1/YJ For uptaKe ~ ynela 0 15 JForrna/-;~n of C~\6mic("on n(..ma/)G1n~~ :-f A f-fer ~droh5;5 "% TAG .I a po A..-3 ~p6c, ore. 1'yons Fefred to HOL ~

fhL n.e.rnoil1,'5 part,c J~ ale Called C!510fY1lCrQ?1 [kma/JIJ/) s:r ih.e- ne.mq;')"(lJ ,-;46 is r(Cl115 f'~('recJ +0 HOL ,'Y) e.xchCl~e .e, ch~kofetO/.eS1ets/ 1i1'5 is eata lyZu/ ~ c hot~te~1 01er~("a(lsfer FY'"l?fe,'n (CE T P]'dISO Co.\\ed aPo D .

fQ1-.e.. O~ Cb'OmiC'O(\ n.(.mOY1~t1t :-tf c.~JoyY};C(C>(\ [1e.rnal'la(}Js q(e uptc.Ketl ~ihe.. \;v'er thto~A 5 peCj-'c

~pO neCepfoY"5-r .:J:11 Liver fj:,1Z- di r(ererd urnfdl1erJiS are.. J:yclt'd!JZbs,'s bj\ "po f~()I;1~40Co

G \y(e(~1FfA

1 i5c~lc mi C{ot) n(n1a1!4J.r/;

j,,,2 :..---.';! .

'" .: .. ~'\ ,"

Mei"boli5M or VLDLsytJ /{,I/.J;S :.. f3 y Jht5(s of mature VLQL tJ \i~f(dfe;i'l iipaoe. :-TAG CoY1fe()t or VL DL is ~J(()jzd ~ LpL iAt6 :

- G \yCeroL ;- u pttAKerl bJ !iv'e-L IJ ecmfalYJ j \y~ K.'na!.Jclt- f rA : - upta Ke.Tl by e. X r~ he. fa ric. t-' s sve->

Fo(mah'Of\ or v LDL {1(.YY\af\Qfl fs \ 1.OL ) :-IoL u \(\te(YY\eJiat~ d.e.(\st:1 \ipopro+eifls Q{{ Form;J after t1;~o.choYl or LPL 011V L DL 0 (e leaDe.. or ope> c. bo,c.K To HDLConVe{si6Y\ of 1DL to LDL :- Bj

CD .furffie.r IJd("~.s\.S or ,AG- ~e \~ oe. t a po E bo.c K +0 \-\oL +

"t ;;Jlso I'f\G ,'s r{~(\5 fefl"ed re l-\DLifl e'l.ch'~Je.. choloo/v.L -'-Cf.iV\ \'5 is Co.talj"z.

7"'" t~ 1OL-f:Ffl (; lyGtl'o/ ~

it;: - -

I.-/; i

~, chVfo rYli ClOfl VLDLsyll Tl1es;.s i Y1 t~sf;"lJe..- LiWFUll c.h~t1 t{CtI1SP()(jj die.fa~ J,p,.Js to I,'ver t(O(}5p"rL TAG from l,Ver 1';, eX'r~--.- J.. other bSSUfl.)

"" e. pa \i c. -\'iSStA eJ.);

Corvtposihon avc B'1$~ opDA a?6 B1.o0(tJMul'lt Fbftn) \-\o.i() \~ TA& __ ~Qi{j~ lA G ~ S~YYle. chO\eI.)terll LIn C,{Cv.\Qhor'l 1\c.~\J,(e -apo C. ~ 2>t'o E ~C~v;{c. C?>fo c. -\ 0\,0 ~~ \-\qtv{e. Fo{m) fvot't\ c.;(Cu\a hr11 \-\OL. ~(o(Y\ C;rCu\a tj~ \-\OL

c'

HYclrrSiS By IipOprO fe,iy') IiPal.)e. BY IieDp\ d\;sCOif;P~~\HDL -to srherolda1. HDL)~, ...~~--

----------------~

D\5COh~li\t HDL1--Ch,\~110- \,h,sph.\;pid oul.( \~jcn.--

, - choJ~te{ol~t0 '.---../ tc \-\.5dfOf'h6bi'C. Co{~ I>

Sphe(6idttL. \-\DL

r- .' " r\e.~o.be, l;5~('j 0 r- pl()S ma Vr

(:34"i, g, \" '-'\-r: ~ lI. 11 c: ./ I 1.1 f:l. Cl 1". f.:p r t: . p -~'~' " !F I YI e r0tyll,'a n,! ~ rw .....'S6"'-1~/~.frhtJJDu.~ 1,:. d~reci> ;,,...~

L () L ne.Gp~V"'s ----7- Jl~L I) L,---,,~; H'~ji;;;~l.cht:i -&;de.r'Ok.-Y-] ,f !;j~ ~pe m "FC\mil"al H7fetl;f~r({,Ie;l1emi8 ~ :' Due 1;;, c!ef~cf ;"'j

(l~;71P/1tI/}f feu.,fo{5 If afo (.f.'.~7?:>/5 "-7 1"' ch.:Jlor1'1;C(0;,1 ("ClYlOIir.1l1t:~ V L DL ruz.yY)~l/p/l7'i- ( 1() L)

f Tjl'~[Jl ., Fatn"/,'g/ Hl~ t~~S'/7y&iolern/a le:_ DIAt' 'GoVerproJrl.c.lidYJ of VLOL.,J IASUflY c< SSc>CIi::lkJ e Cc>(oliaY'f h.ea,r j;sePl'J'S,o'oes0' ~ !y~JI Df'-1. 'I

t Fa (YJ i /;.1 H7fC/Z- " IPha I..pof Tole/lit-M ill :- t 1-10L --7 be {le (ca I i6 he"! itl' Hc!.f'Clt.'(. l.'rl)c..~ :-1ea.dst. '}VLi~1 (e.P.(}':g,")Q/775 (JoL)~X~/I&(Y}4S

L ~ I ~ C t-\O ' If" CA \ ~ ;_ Ie.Ctd5 iD b)ocK ;"1tFiC. J~v~rS' ~qt\j diQy'rh~~~ V L 0 L -~ ~ c.d"\j \;\Ie/'L -'S.'\' f l6>0tni T,AGr

, ~ L0 L --~ ~ pl"-"JrYl.:>. c.h()les kra L: _., ~ '@ FAIW')','"I alpha \ ..~~-,~ ~DL -1> ~C!roc 11 ~J J.. LeL -,?f i.Ai::4-3J,LDL

li..Po YT6+el' V1 (6) ~ C_ r\D=. L'poptr1 C~) 'Lp(a)" is s\(n~\,,(""-tD LDL [t6TfY1ci I) L.\~L c;1tc--.cheJJ:; 0;-;0'::']~ (ec-ts:- ~Ptn fe.~ e p\.v;>m,'n6jCt1 t;DI--- bi.'\cl:'1 e p~tn"n:1el'1 ",cf,'vC( f",r_-: J. f",hr.r:jstS

- 50 t I\'Sk ,,("C lrI. D >5 )"'e.'-l(t o.ttC-l,c:.K. s ,9 \;fL1) j s t 'vl b106d :r. Cv-J(y:) () j;e'r !'",'ch ill t.UJr-S f;:tPjoC ...J '

Rol

e..-, r -,.....l/~\ . -r: -c;'-\. 9'n! 1,4iD '''- I. r j

c- IY)achvah'oY} of STeroid hufmDt10J ~y~ 1fiVJ/~..JS d.!J'f)dof/oYl cf~,m().: l- ~f'p/W?lndl 1'ft:; r;1J~//!s.

I -.!:ipotro jOj'C 1fo.ctOYS _ .Dep. :- 5u b5ra,~{l%; Ylee.dd Fef :J/l1h!/)/'.S o( plMma l'loprote.!'()5 so I e.s.s.e:/jft"cL

Foy mohd;7..u.tlO("\ o~ TAG Frot,,"1 LV0- tD -.xt{Gth~f'aLc.. h'S,SL.4t/.;!,lr1clu d!/.);.-

CDS.55e",tio,l amino o.C, ..J -7 F!5(' J/-;1ii0is of P(07.6rJS'(iJ C'-l/1stifve.t)ts o( -Pho5f'holiPids ~ E:sset1t,'al FA

, ~ l-r'1D5 it"J )) ch()l,/~e..(j) 'He.~1 dono(s :_ nc~ u,Y-(.c! FOi' me.th..'jl"tiQ.'1 of -e.i}.Ci.')ol,,'ffktJe. 1;.')chcl('i~_

O. ') S A M (( A c. 'hv~ )"}'1~. ff:. iOr] ,':1 e. 11bj G \y (,'t'JL- b~ta(('lL-C) He.t5' L vH r=-ei. J \'i~~1 Coba \o.m//j ( Vl'r 612..)

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