7/28/2019 6 Diseases

1/2

Rubeola Rubella Anthrax Brucella Tetanus Rabies

Pathology Fever, maculopapular

rash, cough & coryza or

conjunctivitis

Complications

1- Diarrhea2- Respiratory

inflammations

3- Otitis media4-

Vitamin Adeficiency

5- Encephalitis6- Subacute

sclerosing

panencephalitis

Same +

lymphadenopathy

Complications

1- Encephalitis2- TCP3- Arthritis4- Congenital

rubella syd

Cutaneous:

localized itch,

painless papule

turns vesicular &

enlarges, ulcerates,

blackens & forms

eschar.

GI: shock & death.

Inhalational: likeinfluenza, + N&V,

severe resp

distress,

diaphoresis,

cyanosis & shock.

Hgic meningitis if H.

spread

Fever > 3days, profuse

night sweating, fatigue,

myalgia & arthralgia

Complications:

1- Chronic ostitis,osteoperiostitis,

late cold abscess.

2- Endocarditis.3-

Epidydimo-orchitis.

4- Granulomatousrenal & hepatic

diseases.

5- Hypersplenism.6- Meningitis & enc.

Generalized spasms,

risus sardonicus,

trismus.

Death of unknown

cause 3-28 day old

CFR = 90% in neonatal

CFR = 30-90% in adults

Acute fatal

encephalomyelitis

Headache, fever,

malaise

Paralysis & hydrophobia

CFR = 100%

Confirmation Virus isolation & Ab

detection

same Isolation, antigen,

culture, radio

Isolation, serum titre >

1:160, 4 fold increase titreover 2 weeks

Clinical

Normal ability to suck 3days, loss of it after

that, convulsions

Clinical

Place Endemic in many WW endemic Agricultural areas WW, areas where reservoir

exists

WW WW

Time Any esp. winter Winter & spring -------- Variable acc. When

reservoir gives birth

Summer Any

Person Any age mainly children

Malnutrition

Children & young adults Wool sorters, drum

makers, travelers

General, more in adult

males acc. occupation

All All especially exposed to

animals & lab workers

IP 10 days for symptoms 18 days 1-7 days 1-3 weeks, may reach 7 m 4-21 days, 2 days in

neonatal

4 days to 1 year

MOT Droplet, direct contact,contamination & air

Same + transplacental Contact, D & Ind Contact, common vehicle,vector, air borne in labs

Injury Contact with saliva orlab

Susceptibility General General General General, full protection

after recovery

General General

Period of com 4 days before & 4 days

after, highly infectious

7 days before & 4 after

rash, congenital =

months

??? NO NO NO

7/28/2019 6 Diseases

2/2

Vaccine Live attenuated, mono

or MMR, single dose

SC, MMR is given in 2

doses

Same

CI in pregnancy

Cell free vaccine

0,2,4 weeks,

6,12,18 months,

annual booster

--------- Tetanus toxoid

DPT (2,4,6,18m, 4prim,

booster/10years)

Any one at risk at any

age

On injury

Human cell diploid

vaccine (0,3,7,14,28

days) + booster 90 days

Antirabies serum (horse

antiserum-rabies IG)

Prevention Basic respiratory,

vaccine,

immunoglobulin (for

immunocompromised)

Basic respiratory,

immunization

Vaccination,

education, sterilize

animal products,

deep bury, properventilation,

disinfection & dust

control

Eradication, pasteurization,

education of both public &

exposed persons

TT

Health education

Licensing midwives

Postexposure: cleaning,

antiseptic, no suture,

half dose of IG on injury,

penicillin, immunizationPreexposure: vaccine +

booster/2years

Avoid import of dogs

from infected areas

Control (cases) Report, isolate,

disinfect, no Rx

Report, isolate, no Rx Notify, treat,

disinfect

Report, Ix source,

disinfection of animal

discharge, treat

Report, isolate ( for

patients sake), treat

Report, isolate (for

patients sake),

supportive &

disinfection

Control

(contacts)

Surveillance, vaccine or

IG for unimmunized

Surveillance, IG for

pregnant only

Ix for exposure Nothing NOthing Gloves & gowns