6-Aloe Dental Guide

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    Entrenet Nutritionals

    Aloe Oral Gel

    Dental Guide

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    INDEX

    SECTION 1 INTRODUCTION

    SECTION 2 ENTRENET ALOE INFORMATION

    SECTION 3 ALOE VERA DENTAL RESEARCH

    SECTION 4 DENTAL APPLICATIONS

    SECTION 5 COMPANY INFORMATION

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    Entrenet Nutritionals continues to expand its line of healthcare professional products. Themost recent addition is our state of the art Aloe Oral & Topical Gels. Aloe Vera has

    quickly become recognized for its healing potential both internally and externally. As youwill learn from recent articles such as the one found in General Dentistry/May-June 1999,

    Aloe Vera has now entered into the field of dentistry.

    The benefits of Aloe Vera have been confirmed by research in medical schools,independent laboratories, and by a large number of clinical cases. Aloe Vera gel

    anesthetizes tissue, is bactericidal, is virucidal, is fungicidal, is hemostatic, is anantipyretic, is an anti-inflammatory, is antipruretic, is a capillary dilator, is an enhancer of

    normal cell proliferation and epithelialization, and is a tissue moisturizer.

    Entrenet Aloe Vera products are currently recognized as the most scientifically advancedand research documented in the healthcare industry. This dental guide will provide you

    with Aloe Vera research, dental research, and dental applications. Entrenet is proud toserve the dental industry. You will be provided with the highest quality product and

    service available.

    I. General DescriptionA. Location: Dry regions of Northern MexicoB. Plant Characteristics:

    Tough, fleshy, spear-like or triangular leaves rising in a rosette configuration; as

    many as 30 leaves per plant, saw-like leaf margins; leaf is filled with gel from acentral, clear mucilaginous pulp; plant grows from 1.5 to 4 feet high. Of the 200

    plus species of Aloe Vera, four have nutritional value, and Aloe Barbadensis Milleris the most common.

    II. Entrenet Aloe XL Qualifications Exceeds all standards set by the International Aloe & Science Council.

    Boasts the IASC certification label and information on products. Created using the Active Aloe process. Active Aloe guarantees that our product

    contains biologically active aloe. Active Aloe maintains a 50,000-100,000 polysaccharide molecular weight. This

    molecular weight relates to a 75% Immune Recovery. Combined with the IASC & Aloe Corp, Entrenet Aloe consistently ranks as the

    most scientifically advanced aloe in the market to date.

    III. Chemical CompositionA. Active Compounds (Currently 250 identifiable elements)

    Anthraquinones (aloin, barboloin, aloe-emodin): cathartics.

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    Saccharides (acetylated mannose): antiviral and immunopotentiating action. Prostaglandins and fatty acids (gamma-linoleic acidprostaglandin 1 series):

    favorable effects on inflammation, allergy, platelet aggregation, wound healing. Others: enzymes, amino acids, vitamins, minerals.

    B.

    Other compounds

    Cholesterol, triglycerides, steroids, uric acid, lignins, beta-sitosterol, glibberellin,

    salicylic acid.

    IV. PharmacologyAntibacterial and antifungal

    69% extract: bactericidal against Pseudomonas a., Klebsiella p., Serratia m.,

    Citrobacter, Enterobacter c., Strep. Pyogenes and Agalactiae. 77% extract: bactericidal against Staph. A. 80% for E. coli, 90% for Strep f. and

    Candida a. Inhibition of growth: Mycobacterium 5., Trichophyton, and Bacillus subtilis.

    Antiviral: acemannan

    Direct antiviral activity against HIV1 by inhibiting glycosylation of

    glycoproteins. Acts synergistically with AZT or acyclovir by inhibiting the replication of HIV

    and HSV1.Also effective against feline leukemia, influenza, measles.

    Immune enhancement: acemannan

    Enhancement of macrophage activity, release of immune system potentiators,

    T-cell function, interferon production.Possible activity in sarcomas and spontaneous tumors.

    Anti-allergy and anti-inflammatory: glycoproteins and anthraquinones

    Block generation of thromboxanes and bradykinin.

    Inhibit and break down bradykinin.

    Wound Healing

    Vitamin C, E and Zinc. Stimulate fibroblast and connective tissue formation, promoting wound repair.

    Stimulate repair process and epidermal growth. Stimulate cell division three-fold.

    V. Clinical Application Specific to Inflammation and Wound Healing

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    Aloe Vera has anti-inflammatory components such as amino acids, vitamin C,

    aspirin-like compounds, and mannose which can normalize the acute vascularresponse. Aloe Vera can block the polymorphonuclear leucocyte response, but

    does not reduce connective tissue formation.

    Aloe Vera inhibits acute inflammation but unlike steroids it stimulates fibroblastgrowth to improve wound healing. Aloe Vera contains amino acids such as phenylalanine and tryptophane, which

    have anti-inflammatory activity.Aloe Vera can block prostaglandin synthesis.

    Aloe Vera contains bradykinase, which breaks down into bradykinin, avasodilator, and at the same time stimulates the angiotensin, a potent

    vasoconstrictor. Aloe Vera can act as a modulator of both immune and inflammatory reactions.

    VI. Toxicity Allergic Reactions: generalized eczematous and popular dermatitis (from topical

    application).

    VII. Dosage Oral Gel: apply liberally. Juice: 2-4 ounces per day for general usage. May increase up to one liter per day

    depending upon condition.

    References:

    Danhof, Ivan E., Ph. D., M.D. Aloe Leaf Handling and Constituent Variability. AloeToday. Autumn/Winter. 1991, pp. 12-15

    Davis, RH, et al. Anti-inflammatory and wound healing activity of a growth substance in

    Aloe Vera. Journal of the American Podiatric Medical Association. 84(2): 77-81, 1994Feb.

    Davis, RH, et al. Aloe Vera, hydrocortisone, and sterol influence on wound tensile

    strength and anti-inflammation. Journal of the American Podiatric Medical Association.84(12): 614-21, 1994 Dec.

    Karaca, K., et al. Nitric Oxide production by chicken macrophages activate by

    Acemannan, a complex carbohydrate extracted from Aloe Vera. International Journal ofImmunopharmacology. 17 (3): 183-8, 1995 March

    IASC (International Aloe and Science Council) research and information. Website and

    information maintained by MultiMark Communication. Research dates between June1996-August 1999. Unlimited resources.

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    H.R. McDaniel, R.H. Carpenter, D.V.M., and B.H. McAnalley, Ph.D. Identification ofGigantic Circulation Monocytic Cell in Warm-Blooded Animals. Abstract of Papers and

    Poster. ASCP Scientific Assembly. American Society of Clinical Pathologist. NewOrleans, 1987. p. 118

    H. Saito, T. Ishiguro, G. Imanishi, I. Suzuki.Pharmacological Studies on Plant Lectins.Aloctin-A. Inhibitory Effect of Aloctin-A on Experimental Models of Inflammation in

    Rats. Journal of Pharmacology. Japan. Vol 32., pp. 139-142

    Dental Applications

    1. Apply Aloe Oral Gel directly to the sites of periodontal surgery.

    2. Apply Aloe Oral Gel to the gum tissues when they have been traumatized or

    scratched by toothbrush-dentifrice abrasion, sharp foods, dental floss and toothpick

    injuries.

    3. Apply Aloe Oral Gel to extraction sites. (Dry sockets do not develop when Aloe

    Oral Gel is applied).

    4. Apply Aloe Oral Gel to herpetic viral lesions, aphthous ulcers, cankar sores and

    cracks occurring at the corner of lips. Gum abscesses are soothed by applications as

    well.

    5. Apply Aloe Oral Gel to Lichen Planus and Benign Pemphigus. Aloe Oral Gel can

    provide relief to gum problems associated with AIDS and Leukemia. Migratory

    glossititis, geographic tongue and Burning Mouth Syndrome are improved.

    6. Apply Aloe Oral Gel to denture patients with sore ridges and ill fitting dentures.

    Partials can benefit from a reduction in funguses and bacterial contamination, as

    well as reduced inflammation.

    7. Aloe Oral Gel can be used around dental implants to control inflammation from

    bacteria contamination.

    8. Aloe Oral Gel can also be used to help a wide variety of oral disorders which

    include: Candidiasis, Desquamative Gingivitis, Vesiculobullous disease, acute

    Monocytic Leukemia, hematological disorders and nutritional problems all respond

    well.

    **Apply Entrenet Aloe Oral Gel liberally throughout the day. You may saturate

    gauze with Aloe Oral Gel to keep in contact with affected area for an extended

    period of time. Aloe Oral Gel is completely non-toxic and will not contradict any

    pharmaceutical medications.**

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    Entrenet Nutritionals Company Bio

    Entrenet was founded in May 1998 by Judy Hannan and Tracy Belcastro, both of whom

    reside in Pittsburgh, PA.

    Entrenet has quickly forged its name as one of the leading professional nutritionalsuppliers in the country, with more than 20,000 business associates. Entrenet is well

    known for its superiority in the field of Aloe Vera and associated nutritionalsupplements. Entrenets large healthcare professional clientele is based on the fact of

    outstanding merit in the field of medical nutritional support data and clinical studies.Most recently, our Activin Grape Seed antioxidant was presented at the American

    Association of Cancer Research. Medical reports released indicate Activins ability toreduce breast, lung and stomach cancer cells by as much as 48%. Entrenets Aloe

    dominance is scientifically supported by its representation as a member of theInternational Aloe Science Council. Research has also supported the fact that Entrenets

    Active Aloe process creates an aloe with a 75% immune recovery rate. This is nearlythree times the strength of our closest competitor.

    Entrenet provides independent assays on every one of its products.

    Whichever products you choose from Entrenet Nutritionals for your practice, you can be

    assured that you are receiving the most potent nutritional supplements that our industryhas to offer.