5 PMTCT - hst.org.za Health Barometers/5 (Section A) PMTCT.pdf · Antenatal 1st visit before 20...
Transcript of 5 PMTCT - hst.org.za Health Barometers/5 (Section A) PMTCT.pdf · Antenatal 1st visit before 20...
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Section A: PMTCT
5 PMTCTMathilda Ntloana, Ahmad Haeri Mazanderani and Gayle Sherman
This chapter presents three core national indicators used to assess the progress and performance of key services in the prevention of mother-to-child transmission (PMTCT) programme. Data are from the District Health Information Software (DHIS).
5.1 Antenatal 1st visit before 20 weeks rateThe antenatal 1st visit before 20 weeks rate measures the number of women who have a booking visit (first visit) before they are 20 weeks (about half way) into their pregnancy as a proportion of all antenatal 1st visits. The numerator is the number of antenatal 1st visits before 20 weeks and the denominator is the total number of antenatal 1st visits. The National Department of Health’s (NDoH) Annual Performance Plan (APP) 2016/17–2018/19 set a national target of 62.0% for antenatal 1st visit before 20 weeks rate.a With its latest strategic plan, the NDoH aims to achieve an antenatal 1st visit before 20 weeks rate of 66.0% by 2018/19.
Antenatal care (ANC) is a public health strategy that provides pregnantb women with an opportunity to receive critical interventions to improve the health of mother and baby, and to reduce poor pregnancy outcomes and maternal and child mortality. Antenatal care attendance is associated with an increased chance of receiving skilled birth attendance. Early ANC booking increases the likelihood of HIV-positive women being started on antiretroviral treatment (ART) earlier, thus preventing intrauterine and intrapartum transmission of HIV from mother to infant. Improved early ANC booking before 20 weeks in South Africa will help to further reduce the risk of mother-to-child transmission of HIV (MTCT) to below the current rate of 1.2% and will improve the progress towards the new global target of elimination of MTCT.c
National and provincial overview
In 2016/17, the antenatal 1st visit before 20 weeks rate in South Africa was 65.2%. This is 3.2 percentage points above the target of 62% for this year. Table 1 shows the gradual increase of 4 percentage points compared with 2015/16. Figure 1 shows that the provincial antenatal 1st visit before 20 weeks rates for 2016/17 ranged from 58.4% in Gauteng (GP) to 71.7% in Mpumalanga (MP). All provinces except Gauteng met the national target of 62%.
Table 1: Provincial and national averages for antenatal 1st visit before 20 weeks rate, 2009/10–2016/17
2009/10%
2010/11%
2011/12%
2012/13%
2013/14%
2014/15%
2015/16%
2016/17%
Eastern Cape 28.9 31.7 33.6 39.6 43.3 48.8 59.7 63.8Free State 43.7 45.2 47.1 53.5 56.8 58.6 62.9 65.8Gauteng 25.2 30.6 34.6 37.8 43.7 48.4 54.9 58.4KwaZulu-Natal 34.6 36.9 41.0 46.4 56.2 57.3 64.8 70.2Limpopo 42.9 41.6 41.3 42.0 45.8 50.7 60.7 65.7Mpumalanga 33.0 36.0 37.5 42.2 49.0 56.6 65.9 71.7Northern Cape 45.1 47.2 52.3 58.2 56.4 60.1 62.4 64.7North West 37.2 39.6 42.3 44.1 50.6 54.3 60.7 63.7Western Cape 48.5 62.0 48.1 52.3 56.5 61.6 67.7 69.6SA 34.5 37.6 40.2 44.0 50.0 53.9 61.2 65.2
a National Department of Health. Annual Performance Plan, 2016/17 – 2018/19. National Department of Health. Pretoria. 2016.
b World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. Geneva: World Health Organization. 2016. ISBN-13: 978–92–4–154991–2.
c National Department of Health. Last Mile Plan for Elimination of MTCT in South Africa. National Department of Health. Pretoria. 2016.
Antenatal 1st visit before 20 weeks rate by province, 2016/17
Percentage [Source: DHIS]
GP
NW
EC
NC
LP
FS
WC
KZN
MP
20 40 60 80
63.8
69.6
65.8
70.2
71.7
65.7
63.7
58.4
64.7
SA: 65.2
Target: 62
ProvincesECFSGPKZNLPMPNCNWWC
73
Section A: PMTCT
Figure 1: Antenatal 1st visit before 20 weeks rate by province, 2016/17
District overview
At district level, the antenatal 1st visit before 20 weeks rate ranged widely, from 45.4% in Alfred Nzo (Eastern Cape (EC)) to 79.1% in Eden (Western Cape (WC)). It is encouraging that 82.7% of districts (43 out of 52) achieved the national target (Figure 2).
In 2016/17, antenatal 1st visit before 20 weeks rate increased in all districts except Overberg (WC), which had a decline of 0.7 percentage points from the previous year. Only one district increased the rate by more than 10 percentage points, namely Amajuba (KwaZulu-Natal (KZN)) (11.7 percentage points) followed by uThukela (KZN) with 9.7 percentage points.
Antenatal 1st visit before 20 weeks rate by district, 2016/17
Percentage [Source: DHIS]
A Nzo: DC44Johannesburg: JHB
Ekurhuleni: EKUTshwane: TSH
JT Gaetsewe: DC45Joe Gqabi: DC14
Bojanala: DC37Capricorn: DC35
G Sibande: DC30Buffalo City: BUF
RS Mompati: DC39ZF Mgcawu: DC8Mangaung: MANWaterberg: DC36
Sekhukhune: DC47Lejweleputswa: DC18
Fezile Dabi: DC20N Mandela Bay: NMA
NM Molema: DC38Frances Baard: DC9
T Mofutsanyana: DC19Cape Town: CPT
West Rand: DC48OR Tambo: DC15
eThekwini: ETHSedibeng: DC42Vhembe: DC34
Nkangala: DC31King Cetshwayo: DC28
Pixley ka Seme: DC7C Hani: DC13Mopani: DC33
Ugu: DC21Amajuba: DC25
Dr K Kaunda: DC40uThukela: DC23
S Baartman: DC10uMgungundlovu: DC22
Amathole: DC12Zululand: DC26
Harry Gwala: DC43iLembe: DC29
uMkhanyakude: DC27West Coast: DC1
Central Karoo: DC5uMzinyathi: DC24
Cape Winelands: DC2Namakwa: DC6Xhariep: DC16
Ehlanzeni: DC32Overberg: DC3
Eden: DC4
20 40 60 80
62.5
66.1
73.1
71.0
71.5
69.9
59.8
67.1
76.5
65.4
66.1
74.5
65.5
70.1
71.2
71.0
74.4
70.2
71.7
72.5
69.6
72.3
78.0
61.1
68.3
77.8
70.1
67.9
60.6
64.3
60.5
65.7
62.8
79.1
70.7
67.6
72.3
45.4
59.3
65.2
66.1
73.3
75.0
69.9
63.0
65.8
57.9
67.6
55.8
63.7
65.6
58.8
SA: 65.2
Target: 62
ProvincesECFSGPKZNLPMPNCNWWC
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Section A: PMTCT
Figure 2: Antenatal 1st visit before 20 weeks rate by district, 2016/17
ANC 1st visit <20 w rate
FY 2010 FY 2011 FY 2012 FY 2013 FY 2014 FY 2015 FY 2016 FY 2017Financial year
Per
cent
age
30
40
50
60
70
66.668.4
61.9
31.731.2
38.237.9
38.9
Indicator value by SEQ (weighted average of data by district quintile)SEQ
SEQ 1 (most deprived)
SEQ 2 (deprived)
SEQ 3
SEQ 4 (well off)
SEQ 5 (least deprived)
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Section A: PMTCT
Map 1 shows the geographical distribution of antenatal 1st visit before 20 weeks rate by district and sub-district for 2016/17.
Map 1: Antenatal 1st visit before 20 weeks rate by sub-district, 2016/17
Figure 3 shows a steady increase in antenatal 1st visit before 20 weeks rate for all socio-economic quintiles (SEQs) between 2009/10 and 2016/17. The rates in 2016/17 ranged from 61.9% (SEQ5) to 68.4% (SEQ3). Up until 2014/15 SEQ1 (most deprived) consistently had the lowest coverage, however, since 2015/16 SEQ5 had the lowest coverage.
Figure 3: Trends in average district values by socio-economic quintile for Antenatal 1st visit before 20 weeks rate, 2009/10‒2016/17
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Section A: PMTCT
Key Findings ✦ In 2016/17, South Africa exceeded the national target for antenatal 1st visit before 20 weeks rate for the second year
in a row. The majority of provinces and districts met the national target.
✦ These improvements could be attributed to focused interventions by the NDoH to improve early ANC booking rates through:
• Implementation of the 90-90-90 strategiesd
• The announcement of the Last Mile Planc
• The launch of ward-based community outreach teams in 2011
• Implementation of the 2015 PMTCT National Consolidated Guidelines
• Annual PMTCT stock-take workshops.
Recommendations ✦ Variations in district performance continue to exist within the same province. This implies that some districts have
the potential to improve more than others; it also indicates the need to address important health system barriers preventing women from accessing ANC and PMTCT services early.
5.2 Antenatal client initiated on ART rateThe antenatal client initiated on ART rate measures antenatal clients on ART as a proportion of the total number of antenatal clients who are HIV positive and not previously on ART. The numerator is the number of ANC clients initiated on ART, and the denominator is the total number of ANC clients eligible for ART. The national policy changed numerous times between 2008 and 2015 resulting in changes in eligibility criteria for ART initiation, hence changes in estimates for this indicator over this time period.
The 2014/15 move to option B+e and the introduction of 90-90-90b in 2016 have ensured a high coverage of ART to pregnant women accessing ANC services. Option B+ provides for life-long maternal triple antiretroviral therapy (combination ART) regardless of maternal CD4 count and WHO staging. Provision of ART to HIV-positive ANC clients reduces the chance of PMTCT of HIV during pregnancy, intra- and postpartum and while breastfeeding. The other goals of ART treatment are to suppress the patient’s viral load to an undetectable level and to improve immunological status, with the CD4 cell count rising and remaining above the baseline. The 90-90-90 strategy further emphasises these goals by focusing on initiation rates, retention in care and viral load suppression rates.
According to the latest South African ART guidelines,f all HIV-positive pregnant women should receive ART with appropriate counselling during their first ANC visit regardless of gestational age, CD4 count and/or WHO staging.
National and provincial overview
In 2016/17, the ANC client initiated on ART rate in South Africa was 95.1% and 0.1 percentage points above the national target of 95% for this year (Table 2). Three provinces (Eastern Cape, KwaZulu-Natal and Mpumalanga) had a slight decline in ANC client initiated on ART rate from 2015/16 to 2016/17. The provinces with the largest percentage improvement from 2015/16 to 2016/17 are Free State (FS) (8.5% increase), North West (NW) (10.4% increase) and Western Cape (17.2% increase).
d UNAIDS. 90-90-90. An ambitious treatment target to help end the AIDS epidemic. 2014. Available from: http://www.unaids.org/sites/default/files/media_asset/90-90-90_en_0.pdf [Assessed 15 August 2017].
e Interagency Task Team on the Prevention and Treatment of HIV Infection in Pregnant Women, Mothers and Children. Option B+ countries and PMTCT regimen. 2015.
f National Department of Health. National Consolidated Guidelines for the Prevention of Mother-to-child Transmission of HIV (PMTCT) and the Management of HIV in Children, Adolescents and Adults. National Department of Health. Pretoria. April 2015.
Antenatal client initiated on ART rate by province, 2016/17
Percentage [Source: DHIS]
WC
EC
FS
GP
MP
NC
LP
NW
KZN
20 40 60 80 100
93.3
90.8
94.2
97.2
94.9
95.2
95.9
94.8
95.1
SA: 95.1
Target: 95.5
ProvincesECFSGPKZNLPMPNCNWWC
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Section A: PMTCT
Table 2: Provincial and national averages for antenatal client initiated on ART rate, 2013/14‒2016/17
2013/14%
2014/15%
2015/16%
2016/17%
Eastern Cape 79.0 91.7 93.9 93.3Free State 80.8 88.7 86.8 94.2Gauteng 63.1 87.4 92.4 94.8KwaZulu-Natal 85.4 95.2 97.6 97.2Limpopo 78.6 92.9 92.8 95.2Mpumalanga 74.2 92.9 95.6 94.9Northern Cape 80.3 89.8 92.2 95.1North West 79.2 90.2 86.9 95.9Western Cape 68.5 82.8 77.5 90.8SA 76.3 91.2 93.0 95.1
Figure 4 shows that the provincial antenatal client initiated on ART rates for 2016/17 ranged from 90.8% in the Western Cape to 97.2% in KwaZulu-Natal. Only four provinces reached the nation target (95%) during 2016/17, namely KwaZulu-Natal, North West, Limpopo (LP) and Northern Cape (NC).
Figure 4: Antenatal client initiated on ART rate by province, 2016/17
District overview
At district level, the antenatal client initiated on ART rate ranged widely, from 35.4% in Central Karoo (WC) to 101.6% in uThukela (KZN) (Figure 5). The rates above 100% could be the result of underestimation of the denominator, or could have resulted from client migration between sub-districts, districts and provinces. It was noted that only 53.8% of districts (28 out of 52) achieved the national target (Figure 6).
In 2016/17, antenatal client initiated on ART rate decreased from 2015/16 in 16 districts, Central Karoo (WC), Ugu (KZN), Gert Sibande (MP) and West Rand (GP) declined by more than 5 percentage points (10.9, 9.1, 6.2 and 5.4 points respectively) (Figure 7). Three districts increased coverage by more than 10 percentage points, namely NM Molema (NW) (17.3), Cape Town (WC) (16.6) and Fezile Dabi (FS) (15.6).
Antenatal client initiated on ART rate by district, 2016/17
Percentage [Source: DHIS]
Central Karoo: DC5Eden: DC4
Cape Winelands: DC2G Sibande: DC30
Overberg: DC3OR Tambo: DC15
Ugu: DC21S Baartman: DC10
West Coast: DC1A Nzo: DC44
Ekurhuleni: EKUSekhukhune: DC47
Fezile Dabi: DC20NM Molema: DC38
Pixley ka Seme: DC7T Mofutsanyana: DC19
Harry Gwala: DC43C Hani: DC13
Waterberg: DC36Amajuba: DC25
uMgungundlovu: DC22ZF Mgcawu: DC8
Frances Baard: DC9Mangaung: MAN
Johannesburg: JHBMopani: DC33
Cape Town: CPTLejweleputswa: DC18
Tshwane: TSHRS Mompati: DC39
Joe Gqabi: DC14Dr K Kaunda: DC40
Nkangala: DC31N Mandela Bay: NMA
Vhembe: DC34JT Gaetsewe: DC45
Amathole: DC12eThekwini: ETHBojanala: DC37
iLembe: DC29Capricorn: DC35Buffalo City: BUF
West Rand: DC48Sedibeng: DC42
King Cetshwayo: DC28Ehlanzeni: DC32
uMkhanyakude: DC27Xhariep: DC16
uMzinyathi: DC24Namakwa: DC6Zululand: DC26uThukela: DC23
20 40 60 80 100
98.4
95.9
91.2 90.2
96.8
93.3
96.3
89.1
99.6
95.9
92.8
79.7
92.0
89.2
94.4
101.6
99.7
94.0
101.2
99.6
98.6
98.2
85.1 83.4
96.4
99.2
95.8
96.6
98.3
93.4
97.4
92.1
96.1
73.3
96.4
98.6
93.0
91.2
96.7
91.7
98.5
35.4
100.0
92.5
94.4 94.7
91.2
97.4
95.5 94.8
96.5
96.1
SA: 95.1
Target: 95.5
ProvincesECFSGPKZNLPMPNCNWWC
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Section A: PMTCT
Figure 5: Antenatal client initiated on ART rate by district, 2016/17
ANC initiate ART rate
FY 2011 FY 2012 FY 2013 FY 2014 FY 2015 FY 2016 FY 2017Financial year
Per
cent
age
60
70
80
90
100
110 110.2
83.7
94.7
62.4
107.3
96.4
94.6
75.8
Indicator value by SEQ (weighted average of data by district quintile)SEQ
SEQ 1 (most deprived)
SEQ 2 (deprived)
SEQ 3
SEQ 4 (well off)
SEQ 5 (least deprived)
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Section A: PMTCT
Map 2 shows the geographical distribution of antenatal client initiated on ART rate by district and sub-district.
Map 2: Antenatal client initiated on ART rate by sub-district, 2016/17
Figure 6 illustrates that the antenatal client initiated on ART rate for all SEQs in 2016/17 is stabilising around the 95.1% mark, with rates ranging from 94.6% (SEQ3) to 96.4% (SEQ2).
Figure 6: Trends in average district values by socio-economic quintile for antenatal client initiated on ART rate, 2009/10–2016/17
Infant PCR test positive around 10 weeks rate by province, 2016/17
Percentage [Source: DHIS]
GP
MP
NC
EC
NW
FS
LP
KZN
WC
1 2 3 4 5
1.6
0.8
1.3
1.0
1.7
1.2
1.5
1.7
1.7
SA: 1.3
Target: 1.4 ProvincesECFSGPKZNLPMPNCNWWC
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Section A: PMTCT
Key Findings ✦ The national target for antenatal client initiated on ART rate of 95% for 2016/17 was achieved nationally.
✦ Only four provinces and 28 districts reached the national target.
✦ It is encouraging to note that there is no notable difference in the uptake of ART across the socio-economic quintiles, which can be interpreted as an achievement in the provision of equitable care.
Recommendations ✦ Districts that have consistently performed below the target require further investigation with regards to data
quality.
5.3 Infant PCR test positive around 10 weeks rateIn June 2015, South Africa introduced routine HIV polymerase chain reaction (PCR) testing at birth for all HIV-exposed neonates, and repeat testing at 10 weeks of age for infants who tested HIV negative at birth. Infants who test HIV PCR positive are recommended to have a second HIV PCR test to confirm their status.
The data elements are ‘infant PCR test around 10 weeks’ (denominator) and ‘infant PCR test positive around 10 weeks’ (numerator) and were included in the NIDS (National Indicator Data Set) from April 2016. The 10 weeks testing data elements and indicators were introduced as a replacement for the 6 weeks testing data elements and indicators. These programmatic changes have resulted in new challenges to accurately capture testing within defined age ranges and to de-duplicate repeat tests performed for individual patients. As South Africa has yet to implement a unique health identification system, DHIS and National Health Laboratory Services (NHLS) data are currently unable to accurately determine testing coverage and mother-to-child transmission rates at 10 weeks of age within the early infant diagnosis (EID) programme.
The infant PCR test positive around 10 weeks rate measures infants tested PCR positive for follow-up test as a proportion of infants PCR tested around 10 weeks.
Although the DHIS indicator ‘HIV PCR positivity at around 10 weeks of age’ excludes confirmatory positive results from infants who have already screened HIV positive at a particular facility, confirmatory results of infants who engage testing services at other facilities may be included. Similarly, confirmatory positive results of infants who have tested HIV-PCR positive prior to 6 weeks of age may be counted. Hence, the current inability to accurately de-duplicate positive results may also account for the positivity rate at around 10 weeks of age likely being an over estimation of intra-partum/ early postnatal transmission rates.
National and provincial overview
In 2016/17, the infant PCR test positive around 10 weeks rate in South Africa was 1.3% and below the national target of 1.4% (Figure 7). Five of the nine provinces have infant PCR positivity rates (at around 10 weeks) higher than the national target, namely Gauteng (1.7%), Mpumalanga (1.7%), Northern Cape (1.7%), Eastern Cape (1.6%) and North West (1.5%). Western Cape has the lowest PCR positivity rate at 10 weeks with 0.8%.
Figure 7: Infant PCR test positive around 10 weeks rate by province, 2016/17
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Section A: PMTCT
District overview
At district level, the infant PCR test positive around 10 weeks rate ranged widely, from 4.0% in Gert Sibande (MP) to zero per cent in Overberg (WC). It is encouraging that 63.5% of districts (33 out of 52) achieved the national target (Figure 8).
Due to the EID programme being in transition between 2015/16 and the introduction of new data elements and indicators from 2016/17, the trends for infant PCR test positive around 10 weeks rate will only be determined in the next financial year (2017/18). Data collected to date suggests some challenges with the uptake of the 10 weeks testing which definitely has an influence on the positivity rate. Gert Sibande (MP) clearly has challenges that urgently need to be addressed. Rural districts (specifically Northern Cape districts) with low patient numbers tend to show fluctuating high and low positivity rates and should be considered within the context of actual number of infants tested and those that test positive.
Infant PCR test positive around 10 weeks rate by district, 2016/17
Percentage [Source: DHIS]
G Sibande: DC30Tshwane: TSH
S Baartman: DC10OR Tambo: DC15West Rand: DC48
Namakwa: DC6Joe Gqabi: DC14ZF Mgcawu: DC8
NM Molema: DC38Pixley ka Seme: DC7
Nkangala: DC31Waterberg: DC36
Eden: DC4RS Mompati: DC39
A Nzo: DC44T Mofutsanyana: DC19
Dr K Kaunda: DC40iLembe: DC29
Cape Winelands: DC2Central Karoo: DC5
Fezile Dabi: DC20Ugu: DC21
Lejweleputswa: DC18Johannesburg: JHB
Frances Baard: DC9Amathole: DC12Ekurhuleni: EKU
JT Gaetsewe: DC45Sedibeng: DC42
Sekhukhune: DC47Vhembe: DC34
Mangaung: MANBuffalo City: BUFCapricorn: DC35uThukela: DC23
King Cetshwayo: DC28uMkhanyakude: DC27
Amajuba: DC25Ehlanzeni: DC32
uMgungundlovu: DC22Zululand: DC26
C Hani: DC13eThekwini: ETHXhariep: DC16
Bojanala: DC37Harry Gwala: DC43
N Mandela Bay: NMAuMzinyathi: DC24
Mopani: DC33Cape Town: CPTWest Coast: DC1
Overberg: DC3
1 2 3 4 5
1.1
0.70.6
3.3
1.2
0.9
2.5
3.1
0.8
1.3
1.5
1.5
1.41.4
1.0
1.1
0.8
1.0
0.9
1.01.0
1.5
0.0
4.9
2.1
1.0
0.7
1.2
1.1
2.0
0.8
2.3
1.71.8
1.5
1.2
0.8
1.6
1.2
1.2
3.0
1.4
3.0
2.1
2.4
1.3
1.2
0.8
1.3
1.1
0.8
3.4
SA: 1.3
Target: 1.4
ProvincesECFSGPKZNLPMPNCNWWC
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Section A: PMTCT
Figure 8: Infant PCR test positive around 10 weeks rate by district, 2016/17
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Section A: PMTCT
Map 3 shows the geographical distribution of infant PCR test positive around 10 weeks rate by district and sub-district.
Map 3: Infant PCR test positive around 10 weeks rate by sub-district, 2016/17
Key Findings ✦ The new guidelines recommend confirmatory testing through a second HIV PCR, instead of a baseline HIV viral load
for infants who test positive. These programmatic changes have resulted in new challenges such as ensuring tests are accurately captured within the appropriate age ranges.
✦ The uptake of PCR tests around 10 weeks is still low and this needs to be improved especially in districts that show high positivity rates.
Recommendations ✦ The impact of the revised EID programme on ART uptake and infant mortality should be researched to inform
further programme improvements.
✦ Implementation of the Last Mile planc with specific focus on closing the gaps.
✦ Integration and collaboration between the NHLS, DHIS and TIER.Net is needed in order to get more accurate positivity rates.
✦ Reaching elimination becomes more challenging as treatment targets are approached. South Africa needs to explore cohort monitoring of the mother infant pair from ANC to ensure the infant remains HIV negative.
✦ Integration of maternal and child health services is important to ensure a continuum of care.