5 pediatric research

NACIONAL UNIVERSITY

PEDRO RUIZ GALLO

COLLEGE OF HUMAN MEDICINE

NACIONAL UNIVERSITY PEDRO RUIZ GALLO

COLLEGE OF HUMAN MEDICINE

SUBJECT:

INTEGRANTS:

Medical English

Calderon Baldera Karen Eliana Diaz Mino Marlon Werner Fernandez Ferreyra Ana Maria Sofia Niño Effio Brenda Stefanny Popuche Cabrera Pedro Luis Razuri Farro Juan Alessandro

TEAM NUMBER 5

PROFESSOR: Dr. Rosa Gonzales

GROUP WORK

Presents

Hematopoietic Stem Cell Pediatric Transplatation

Medical English

INTRODUCTIONstandard procedure

treatment of hematological diseases

in solid tumors

Reconstitution of hematopoiesis

of

treatment of multiple malignancies in children.

infusion


The infusion of hematopoietic progenitors cells from the patient in cases of secondary myelosuppression administration of high dose chemotherapy

AUTOLOGOUS OR AUTOLOGOUS TRANSPLANTATION

known as


This procedure is used for the treatment of some high-risk tumors in childhood:

Neuroblastoma

Medulloblastoma

Ewing sarcoma

Nephroblastoma


Its use as consolidation treatment in acute myeloid leukemia is discussed.

In the case of lymphoblastic leukemia, their use is more controversial.


UNRELATED DONORS (UNRELATED) RESTRICTED USE

SHOULD BE DISCUSSED ON THE BASIS OF INDIVIDUAL CASES


However… IN RECENT YEARS

The results obtained with unrelated donor

Is approaching those obtained with donor family


So the use of unrelated donors

is spreading and expanding indications.


Initially, hematopoietic progenitors were obtained from bone marrow

in a surgical procedure involving the direct puncture of the same


In the nineties saw the widespread use of hematopoietic progenitors derived from

peripheral blood

This procedure consisted in administering drugs able to raise the number of progenitors in the circulating blood, to be removed later by leukapheresis.


Such parents get faster hematopoietic recovery than those obtained from

bone marrow

although with higher

incidence of chronic GVHD.



Finally Pediatrics Unitsin

increasing

Use Progenitors Cells

from

Umbilical Cord Blood


These progenitors cells

have

A Slower Recovery of Hematopoetic Function

butLower Incidence of

Disease


In the futureuse

Two important proteins

Noggin Chordin

They have a better proliferation function

Many scientists say talk of a possible cure of pediatric cancer

Thank you so much!

5 pediatric research

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