New Patents ix

4956007 4956352

NITRAMINODIARYL SULFOXIDE DERIVATIVES, PROCESS FOR

THEIR PREPARATION AND PHARMACEUTICAL AND

PESTICIDAL COMPOSITIONS CONTAINING THEM

TRICYCLO COMPOUNDS, A PROCESS FOR THEIR PRODUCTION AND A PHARMACEUTICAL

COMPOSITION CONTAINING THE SAME

Janos Kreidl, Peter Turcsanyi, StefkoBela, nee Brill Judit Meszaros, Erika Bogsch, Budapest, Hungary assigned to Richter Gedeon Vegyeszeti Gyor Rt

Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka, Ibaraki, Japan assigned to Fujisawa Pharmaceutical Co Ltd

The invention relates to a new process for the preparation of nitraminodiaryl sulfoxide derivatives of the formula (I), See Patent for Chemical Structure (I) wherein R and RI represent hydrogen or alkyl having from 1 to 6 carbon atoms, and R2 is hydrogen, halogen, alkyl having from I to 6 carbon atoms, alkoxy having from ! to 6 carbon atoms, or phenyl or thiophenyl both optionally substituted by one or more identical or different halogen(s) and/or nitro group(s). The compounds of formula (I) are pharmaceutically active, and are particularly useful in the veterinary therapy as anthelmintics. In addition they show pesticidal, particularly ac- aricidal, fungicidal and herbicidal properties. The invention relates also to pharmaceutical and pesticidal compositions containing as active in- gredient compounds of formula (I). The com- pounds of formula (I), in which the substituents are as defined, with the proviso that if R2 is hydrogen and the substituent -N(R,RI) is in para-position related to the sulfoxide group, R and RI are other than hydrogen or methyl, are n e w .

4956351

ANTIVIRAL PHARMACEUTICAL COMPOSITIONS CONTAINING

CYCLODEXTRINS

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: See Patent for Chemical Structure (I) to a process for their production, to a pharmaceutical composi- tion containing the same and to a use thereof.

4956366

SUBSTITUTED THIENOIMIDAZOLE

DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF,

PHARMACEUTICAL COMPOSITIONS CONTAINING

THEM, AND THE USE THEREOF AS INHIBITORS OF GASTRIC

ACID SECRETION, AS GASTROPROTECTIVES AND AS

MEDICAMENTS FOR INTESTINAL INFLAMMATIONS

Hildegard Nimmesgern, Klaus Weidmann, Hans-Jochen Lang, Robert Rippel, Andreas W Herling, Frankfurt am Main, Federal Republic Of Germany assigned to Hoechst Aktiengesel- lschaft

Jean Mesens, Koenraad J L M Andries, Wechel- derzande, Belgium assigned to Janssen Pharma- ceutica N V frame-543

An antiviral composition for adminisitration to a mammal, in particular, intranasally, for the treatment of the common cold by control of common rhinoviruses. The composition is an in- clusion complex of a cyclodextrin, e.g. an alpha-, beta- or gamma-cyciodextrin or derivatives thereof and an antiviral agent.

Substituted thienoimidazole derivatives, a pro- cess for the preparation thereof, pharmaceutical compositions containing them, and the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for in- testinal inflammations The invention relates to compounds of the formula See Patent for Chem- ical Structure (I) in which A represents See Pa, tent for Chemical Structure (a) SRI orR2 (b) R2SR1 (c) T denotes -S-, -SO- or -SO2-, R1 to Rl0, X, Y and Z have the meanings indicated in