4800078

PATENT ABSTRACTS

I M M U N O T H E R A P E U T I C M E T H O D O F T R E A T I N G

R E S P I R A T O R Y D I S E A S E BY I N T R A N A S A L A D M I N I S T R A T I O N

O F I G B

Gregor Prince, Rober Chanock, Val Hemming assigned to The United States of America as represented by the Secretary of the Department of Health and Human Services

A new immunotherapeutic method of treating lower respiratory tract infection caused by respiratory syncytial virus (RSV) is disclosed. The method employs topical application of RSV antibodies into the lower respiratory tract. The new treatment modality is more effective and rapid than the conventional therapy.

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M E T H O D O F I N D U C I N G T H E D I F F E R E N T I A T I O N O F

M A L I G N A N T C E L L S W I T H S E C O S T E R O L

Hector F DeLuca, Heinrich Schnoes, Wan F Lau assigned to Wisconsin Alumni Research Foundation

The invention provides a method for inducing the differentiation of malignant cells utilizing certain seco-sterol compounds, such as the dif- ferentiation of leukemia cells to normal macro- phages and thereby affords a method for treating leukemic disorders.

4801450

H I G H T I T E R P S E U D O M O N A S I M M U N E S E R U M G L O B U L I N

Michael Collins, Robert Roby assigned to Miles Laboratories Inc

Normal plasma from donors who have not been vaccinated with a P seudomonas vaccine or had a Pseudomonas infection can be screened for higher than normal titers of naturally occurring antibody to four or, preferably, two of seven Fisher Immunotypes of Pseudomonas. Those plasmas with higher titers of such antibody can be pooled and fractionated to give hyperimmune

299

serum globulin having high titers of antibody against all seven Fisher Immunotypes. The pro- duct may be treated to render it intravenously in- jectable and the so-prepared material is effective in treating patients with Pseudomonas infection. Also disclosed is a novel antibody preparation including minimum titers of the seven Fisher lmmunotypes.

4801687

M O N O C L O N A L A N T I B O D Y P U R I F I C A T I O N P R O C E S S U S I N G

P R O T E I N A

That T Ngo assigned to Bioprobe International Inc

Immunoglobins are purified by adsorption upon an immobilized protein A adsorbent using a buf- fer having a pH of 7.5 to 10 and containing a combination of monovalent cations and poly- basic anions in a concentration of about 0.6M to 1.75M.

4801690

N O V E L L E C T I N S D E R I V E D F R O M B A C T E R I A L P I L I

Charles C Brinton, Mark Hanson assigned to Bactex Inc

A lectin derived from the pili of piliated or- ganisms, said lectin being non-covalently bi- ndable to the pilus rod protein of said pili and separable therefrom by the action of aqueous sodium dodecyl sulfate, possessing a single bi- nding site for binding to mammalian erythrocyte ghosts.

4806M7

I N T E R F E R O N C O M B I N A T I O N S

Paul J Leibowitz assigned to Schering Corpora- tion

There are disclosed compositions and methods for treating tumors and viruses in humans by ad- ministering a combination of gamma interferon and delta-4 alpha-2 (Bgl ll-l)/(Bgl II) alpha-I hybrid interferon, preferably by injection.