82 PATENT ABSTRACTS

4757021

R E C O M B I N A N T P L A S M I D A N D M I C R O B I A L S T R A I N

T R A N S F O R M E D B Y S A I D P L A S M I D

Haruhide Kawabe, Kazumoto Hirabayashi, Hazime Horii, Hirofumi Arimura, Masayuki Nishida, Tadakazu Suyama, Osaka, Japan as- signed to Green Cross Corporation

produce the new interferons are described. The amino acid sequences of these hybrids include at least two different subsequences, one of which has substantial homology with a portion of a first class of interferon (e.g., HulFN- alpha) and the other which has substantial homology with a portion of a second class of interferon (e.g., HulFN- beta). Data indicates the interferon ac- tivity of alpha- beta hybrids may be substantially restricted to either cell growth regulatory activity or antiviral activity.

A recombinant plasmid wherein at least two DNA fragments containing a Baker gene and a Charlie geue of the yeast 2 mum circular plasmid are incorporated into a plasmid containing genes encoding a physiologically active substance is disclosed. Also, a strain transformed by the recombinant plasmid is disclosed.

4758507

P R O D U C T S D I S P L A Y I N G T H E A N T I G E N I C I T Y O F H E P A T I T I S B

V I R U S E A N T I G E N S A N D M E T H O D S O F P R O D U C I N G

T H O S E A N T I G E N S

4757141

A M I N O - D E R I V A T I Z E D P H O S P H I T E A N D P H O S P H A T E

L I N K I N G A G E N T S , P H O S P H O R A M I D I T E

P R E C U R S O R S , A N D U S E F U L C O N J U G A T E S T H E R E O F

Steven Fung, Sam L Woo, Lloyd M Smith as- signed to Applied Biosystems Incorporated

The compounds of the invention include novel linking agents comprising 2-substituted-3- protected- 1,3,2-oxazaphosphacycloalkanes and their phosphoramidite precursors. The com- pounds of the invention further include con- jugates of the above linking agents with oligonucleotides and polymer supports. The compounds of the present invention are useful for linking organic moieties, such as fluorescent or chromogenic dyes, to polymer supports and oligonucleotides, particularly single- and double-stranded DNA and RNA fragments.

4758428

MULTICLASS HYBRID INTERFERONS

David F Mark, Abla Creasey assigned to Cetus Corporation

New multiclass hybrid interferon polypeptides, their corresponding encoding recombinant DNA molecules and transformed hosts which

Kennet Murray, Patricia MacKay, Heidelberg, Federal Republic Of Germany assigned to Bio- gen N P

Polypeptides displaying the antigenicity of hepatitis B virus e antigens, DNA sequences coding for those polypeptides, antibodies to those polypeptides and methods of producing and using those polypeptides, antibodies and DNA sequences. The polypeptides and anti- bodies of this invention are characterized by their use in compositions and methods for detec- ting hepatitis B virus infective carriers and in evaluating the course of HBV-related active liver disease.

4758511

C D N A C L O N E S C O D I N G F O R P O L Y P E P T I D E S E X H I B I T I N G I G E

B I N D I N G F A C T O R A C T I V I T Y

Christine L Martens, Kevin W Moore, Kimishig Ishizaka, Thomas F Huff assigned to DNAX Research Institute of Molecular and Cellular Biology Inc; The Johns Hopkins Universi

Plasmid vectors are provided that carry comple- mentary DNA (eDNA) clones coding for poly- peptides exhibiting mammalian IgE binding factor activity. One of these clones contains an open reading frame consisting of 556 codons. The eDNA is derived from messenger RNA isolated from a rat/mouse T-cell hybridoma line. The eDNA was cloned by incorporation into a pcD plasmid vector. The plasmid vector also contains DNA segments from the SV40 virus,