Healthcare Products

4686098

E N C A P S U L A T E D M O U S E C E L L S T R A N S F O R M E D W I T H A V I A N

R E T R O V I R U S - B O V I N E G R O W T H H O R M O N E D N A , A N D A

M E T H O D O F A D M I N I S T E R I N G B G H IN V I V O

John J Kopchick, Frederick C Leung, Thomas J Livelli, Richard H Malavarca assigned to Merck & Co Inc

Recombinant DNA constructs having an avian retroviral long terminal repeat (LTR) ligated to the bovine growth hormone gene, were co- transformed into a mammalian cell (mouse) cul- ture in order to obtain a stable cell culture secreting large amounts of bovine growth hor- mone. The transformed mouse cells were encap- sulated in hollow fibers and implanted into animals, thereby producing circulating bovine growth hormone.

4686101

V A C C I N E A G A I N S T V A R I C E L L A - Z O S T E R V I R U S

Ronald Ellis, Robert Lowe, Paul Keller, Andrew J Davison assigned to Merck & Co Inc

A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral pro- teins has been identified by DNA sequence analysis. This gene can hybrid select messenger RNA which encodes and expresses a protein which reacts with human canvalescent zoster sera and with polyclonal monospecific antisera which neutralize viral infectivity. These proteins are useful for the preparation of a vaccine for VZV,

4686102

M U L T I V A L E N T P N E U M O C O C C A L V A C C I N E A N D

P R E P A R A T I O N T H E R E O F

Mary Ritchey, Francis Cano, Hara Gerald 0£3, James D English, Wenlii Lin assigned to American Cyanamid Company

A multivalent pneumococcal vaccine consisting of immunogenic amounts of purified pneu- mococcal capsular polysaccharide (substantially absent £37 C + 38 +0 polysaccharide) of pneu- mococcal types (Danish designation) 1,2, 3,4, 5, 6B, 7F, 8, 9N, 9V, 10A, I lA, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F and 33F, and from none to one or both of 6A and 25, and combina- tions thereof and methods of purifying pneumococcal capsular polysaccharide types 3, 5, 9V, 10A, l lA, 15B, 17F, 19A, 22F and 33F.

101

4686180

O N C O - F E T A L S P E C I F I C M O N O C L O N A L A N T I B O D I E S , M E T H O D S O F P R E P A R A T I O N

A N D U S E

Joseph H Coggin, William J Payne assigned to South Alabama Medical Science Foundation

A process of preparing a hybridoma secreting oncofetal-specific monoclonal antibodies, which comprises: (a) immunizing an animal with ira-