PATENT ABSTRACTS 183

4628027

V I T R O D I A G N O S T I C M E T H O D S U S I N G M O N O C L O N A L A N T I B O D I E S A G A I N S T

C O N N E C T I V E T I S S U E P R O T E I N S

Steffen Gay assigned to Molecular Engineering Associates Ltd; The Board of Trustees of the Universtiy of Alaba

Collagen profiles of human body tissues and fluids, i.e., the types of distinct connective tissue proteins present, their distribution in human body tissues and fluids, and the concentration ratios among distinct types, are subject to change during certain pathological conditions and during therapeutic regimens for the treatmefit of such conditions. These changes in collagen pro- files can be detected by immunohistological, immunocytological and immunoserological techniques. In vitro diagnostic methods em- ploying monoclonal antibodies specific for con- nective tissue proteins are provided which can be used for monitoring the results of therapeutic measures taken against inflammatory diseases, fibrotic diseases and cancer and for detecting or following the pathogenesis of such diseases.

4628032

M O N O C L O N A L A N T I B O D Y S P E C I F I C F O R A M A M M A R Y

T U M O R C Y T O P L A S M I C A N T I G E N

Christine A White, Renato Dulbecco, William Allen assigned to The Salk Institute for Bio- logical Studies

An hybridoma cell line and the monoclonal anti- body produced thereby are provided. The mono- clonal antibody is specific for antigen found almost exclusively in the cytoplasm of human mammary tumor cells. The antibody is useful in diagnosing mammary tumors.

4628045

I M M U N O T H E R A P E U T I C A N T I A L L E R G I C P O L Y P E P T I D E

A G E N T S W H I C H B I N D T O B A S O P H I L I M M U N O G L O B I N F C

R E C E P T O R S

Gary Hahn assigned to Immunetech Pharma- ceuticals

mune complex binding to immunoglobulin Fc receptors is disclosed.

4631191

M E T H O D S A N D C O M P O S I T I O N S U S E F U L IN P R E V E N T I N G

E Q U I N E I N F L U E N Z A

Beverly Dale, Barbar Cordell assigned to Bio- technology Research Partners Ltd

Recombinant vaccines for immunizing horses against equine influenza virus (EIV) are dis- closed. The DNA sequences encoding the hemagluttinin (HA) and neuraminidase (NA) glycoproteins from the two strains of EIV cur- rently infective in horses are used to construct vaccinia carried vaccines, to design synthetic peptides for primer and booster administration. and to permit recombinant synthesis of HA and/or NA protein based vaccines. These DNA sequences also provide probes useful for pre- paring similar vaccines from fresh isolates of new strains generated by genetic drift.

4631259

T R A N S P O S O N IN C L O N I N G D N A

Don B Clewell, Mary Gawron-Burke assigned to Board of Regents of The University of Michigan

Processes and new genetic materials are pro- vided for cloning specific DNA fragments by using a unique conjugative transposon designated Tn916. The transposon is used to first target specific genes by insertional inactivation. A restriction fragment containing the inserted transposon is then inserted into a plasmid vector and transformed into Escherichia coli or other suitable host by selection for the transposon encoded tetracycline (Tc) resistance. The trans- formants so produced are then grown in the abs- ence of tetracycline conditions under which Tn916 excises from the chimeric plasmid thus restoring the integrity of the DNA into which the transposon was originally inserted. This process provides a new and useful way of producing new life forms that are useful for making desired pro- ducts having established utility.

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O R A L V A C C I N E F O R I M M U N I Z A T I O N A G A I N S T

E N T E R I C D I S E A S E

A peptide having the amino acid sequence Asp- Samuel B Formal, Louis Baron, Dennis J Ser-Glu-Pro-Arg and capable of blocking im- Kopecko assigned to The United States of