453 Date : 05-Jun-2018 Feedback - Birmingham Quality · 2021. 1. 29. · H454 453E 3.15 P481 19.5...

Date : 05-Jun-2018

Feedback

Page 1

for Steroid Hormones

Distribution : 453

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© Data in UK NEQAS / Birmingham Quality reports is confidential. For this Scheme, the Organiser is Finlay MacKenzie Birmingham Quality is a UKAS accredited proficiency testing provider No. 7860. www.birminghamquality.org.uk

Published at 8:57 on Thursday 14 June 2018

Quality ManagerPathology LaboratoryBiochemistry DepartmentTownCountyPostcodeCountry

This Scheme is essentially web-based. We can alert you to information regarding the Scheme via email. The e-mail address (or addresses) we are currently using to contact your laboratory is shown below in red . If no e-mail address is displayed or the information shown is incorrect, please email us with an appropriate contact e-mail address as soon as possible, using the word 'feedback' in the title line. Based on the date information you have provided, the transit time from specimen dispatch [ ] to receipt [ ] was day(s), and the subsequent time to analysis [ ] in your laboratory was day(s). (Missing values indicate dates not provided. "0 days" represents same day). Any comments you made to us are shown below and have been acted upon where necessary Any specific comments applicable only to laboratory are shown below Any general comments applicable to all laboratories are shown below Please note that Free Testosterone now appears on our Schedule of Accreditation for ISO 17043 You have until the close of Distribution 454 (03/07/2018) to submit late results / request amendments to results for Distribution 453. Please enter any late results or requests to amend non-analytical errors for Distribution 453 on the web under the usual Results button ensuring the correct Distribution number has been selected. You should include your name and a valid reason. Amending results is at the discretion of the Director and is not an automatic entitlement. We are not accepting any further requests to amend results or to change methods for Distribution 452. Performance Surveillance and Performance Issues If you have a red banner for any analyte on the Performance Summary Icon (PSI) page, then you should log this in your Quality Management System. Birmingham Quality is here to help. If you are unsure as to why you have out-of-consensus problems or if you are having difficulties with your Root Cause Analysis, then please do contact us. It is the responsibility of the Participant to act on, investigate and hopefully resolve, all out-of-consensus performance. It is the responsibility of the Organiser to highlight in the regular report any out-of-consensus performance by the use of scores, symbols, graphs and ‘traffic lights’ etc. Likewise, for the non-numerical analytes, please check the Pie Charts and other graphical representations to see if you are out-of-consensus. Finlay MacKenzie Director, Birmingham Quality Report authorised on Wednesday 13 June 2018 by: Finlay MacKenzie Scheme Organiser

Birmingham Quality is a UKAS accredited proficiency testing provider No. 7860. Please see http://www.ukas.com for full details of the accreditation status of our services

Birmingham Quality is proud to offer EQA services that adhere to the Code of Practice and have the badge of quality of UK NEQAS

of 60

Date : 05-Jun-2018

Performance Summary Icons (click graph for details)

Page 2


Distribution : 453

Laboratory :




B s

core

C score

Cortisol

P-ABCPENR (DASH1)

0 5 10 15 20 25

-30

-20

-10

0

10

20

30

B s

core

C score

Urinary Free Cortisol

P-ABCPENR (DASH1)

0 25 50 75 100

-25

0

25

50

75

100

B s

core

C score

17OH-Progesterone

P-ABCPENR (DASH1)

0 20 40 60 80

-60

-40

-20

0

20

40

60

B s

core

C score

Progesterone

P-ABCPENR (DASH1)

0 5 10 15 20 25

-25-20-15-10-505

10152025

B s

core

C score

Oestradiol [E2]

P-ABCPENR (DASH1)

0 10 20 30 40

-40

-30

-20

-10

0

10

20

30

40

B s

core

C score

Oestradiol [high-level]

P-ABCPENR (DASH1)

0 10 20 30 40

-40

-30

-20

-10

0

10

20

30

40

B s

core

C score

Testosterone [female]

P-ABCPENR (DASH1)

0 20 40 60 80

-40

-20

0

20

40

60

80

B s

core

C score

Testosterone [male]

P-ABCPENR (DASH1)

0 5 10 15 20 25

-30

-20

-10

0

10

20

30

B s

core

C score

Free Testosterone

P-ABCPENR (DASH1)

0 5 10 15 20 25 30

-30

-20

-10

0

10

20

30

B s

core

C score

SHBG

P-ABCPENR (DASH1)

0 5 10 15 20

-30

-20

-10

0

10

20

30

B s

core

C score

Androstenedione

P-ABCPENR (DASH1)

0 20 40 60 80 100 120 140

-40

-20

0

20

40

60

80

100

120

140

B s

core

C score

DHA sulphate

P-ABCPENR (DASH1)

0 5 10 15 20 25 30

-40

-30

-20

-10

0

10

20

30

40

B s

core

C score

Aldosterone

P-ABCPENR (DASH1)

0 10 20 30 40 50 60

-20

-10

0

10

20

30

40

50

60

of 60

Date : 05-Jun-2018

Participation summary

Page 3


Distribution : 453

Laboratory :




All our time periods are 'rolling' to give you current information. You may wish to keep you own log of Calendar Year or Financial Year time points if you require 'year-end' statements for your own internal use. Any analytes with out of consensus performance will be highlighted in red and can be clicked for further details.

17OH-Progesterone

You have no performance data for:

You have out of consensus performance for:

DHA sulphateFree TestosteroneYou have in consensus performance for:

Testosterone [male]SHBGAndrostenedione

Cortisol


Analytical Performance over the last 6 months (rolling time window of 6 distributions)

None

Oestradiol [high-level] Urinary Free Cortisol

Aldosterone Progesterone Oestradiol [E2]

This scheme cycle is notionally every four weeks. Analytically, we assess you over a six month time window (6 Distributions). For return rates, late and amended results we assess you over a twelve month period (12 distributions).

Satisfactory0 distributions accepted from the last 12

ParticipationSatisfactoryLate ReturnsSatisfactory

0 distributions from the last 1212 distributions out of a possible 12

Amendments

Rating Affected Distributions Distributions

Participation and Return Rates

You can judge, in association with your IQC and other QA measures, if your current performance is a blip or part of a trend.

You are not registered for:

Testosterone [male] DHA sulphate

Out of consensus for at least one specimen for:

You have no specimen %bias etc. for:In consensus for all specimens for: Free Testosterone

Analytical Performance for specimens from distribution 453 only

Oestradiol [high-level] Aldosterone

SHBG 17OH-Progesterone Progesterone

Oestradiol [E2]

None

Urinary Free Cortisol Androstenedione Cortisol


None

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Date : 05-Jun-2018

Distribution Summary

Page 4


Distribution : 453

Laboratory :




%biasBResult A score C scorePool CB scoreTargetSpecimen ASpecimen

-2.4

374

453E

FT439

453D

17.9

84

453B

+4.6

40.7

170

184

+8.5

281

Free Testosterone

FT432

453A

273

Progesterone

453D

C546

18.7

9262

P480

E523

+13.6

11413

134

258

(nmol/L)

5.10

1.20

25.3

Date : 05-Jun-2018

Distribution Summary

Page 5


Distribution : 453

Laboratory :




%biasBResult A score C scorePool CB scoreTargetSpecimen ASpecimen

1.9A407

D326

(umol/L)

48

4.2

+61.8

-13.3

453C

198

297

-13.349

3.0

1.7

+1.3

207.9

(pmol/L)

453E +44.0

L103732

G396

523

26.1

56.9

453E

4.8

453A

L104

+35.1

27.9

9.1

453B

A409

>30.0+6.9

9.2D335

Androstenedione

3.3

453A

L094

973

A411

G391

D324

453D1.3

+32.0

251

2.4

2.2

D327

D328

453C

DHA sulphate

2.2

2.46 +10.5-2.3

(nmol/L) 56.5SHBG

+32.8

30.8

(nmol/L)

+62.1215

14.4

G360 -4.8

14.2453B

453B

453C

1.8

124

4.5

453D

A410

+0.9

59.5

453B +39.4

-19.4

453A

51.9

453D

53

453A

Aldosterone+143.3

-8.8

+38.2453C

116

15.3

481

G416

1.4 +0.7A408

45

If your laboratory is outside of the acceptable limits of performance for any its rolling time-window scores (A, B or C scores), this will be indicated by a red traffic light symbol. It is the responsibility of the laboratory to undertake an internal investigation to establish the underlying cause and put in place corrective and preventive action. Please do not wait to receive a formal notification of performance from the Scheme Organiser or the National Quality Assurance Advisory Panel (NQAAP) before logging the non-conformity and, where necessary, acting upon the data contained in your report. A green traffic light merely reflects that your laboratory is performing as well as the state-of-the-art allows; it does not necessarily mean that your assay / laboratory performance is good enough clinically. . The 'A-Score' is not available for Free Testosterone. Once we have accumulated more data points we will be able to calculate concentration-dependent degree of difficulty factors and put them in the same ‘currency’ as the A scores in other Schemes.

You have until the close of Distribution 454 (03/07/2018) to submit late results / request amendments to results for Distribution 453. Please enter any late results or requests to amend non-analytical errors for Distribution 453 on the web under the usual Results button ensuring the correct Distribution number has been selected. You should include your name and a valid reason. Amending results is at the discretion of the Director and is not an automatic entitlement. We are not accepting any further requests to amend results or to change methods for Distribution 452.

Distribution 454 will be dispatched on 12/06/2018 . Results are due back in Birmingham by, notionally, 23:59 on 03/07/2018. Where your results appear as "XPL", it is because you did not report a numerical value for that analyte, but you did provide an explanation as to why a result was not reported.

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Date : 05-Jun-2018

Method Summary

Page 6


Distribution : 453

Laboratory :




arrow median

Units Method

A score

Your Submethod

A scoremedian

A scoreYour Method All labwith trend

pmol/LBeckman Access/Dxi

94

nmol/L

DiaSorin Liaison

Urinary Free Cortisol

Beckman Access/Dxi

74

pmol/L

67

Beckman Access/Dxi

116

218

pmol/L

127

53

Beckman Access/Dxi

323

Oestradiol [high-level] 147

212

78

Tandem Mass Spectrometry

126

Beckman Access/Dxi [2SF]

nmol/L

DHA sulphate

Androstenedione

220

72

nmol/L

SHBG

nmol/L

128

251

umol/L

nmol/L

Progesterone

44

nmol/L

124

Aldosterone

59

Beckman Access/Dxi

56

Cortisol

60Oestradiol [E2] 256

187

273


160


Free Testosterone

45

Beckman Access/Dxi

84

76

171

149

17OH-Progesterone

74nmol/L

69

nmol/L

nmol/L

194

Siemens Immulite 2000/2500 [X]

Beckman Access/Dxi

121

216


Testosterone [male]

117

Our method update service is web-based and is accessed online via the 'edit' button on the 'Results and Reports page'. You can select from a dropdown of methods or select the default option from the major manufacturer’s products*. *If you are not using the system according to the manufacturer's instructions, please select the in-house category within your system's method principle.

A s

core

Graphic Equalizer Plot of A scoresAll laboratories

P-BWATSCR2CO

RT

UF

C

17P

PR

OG E2

E2H

I

FT

ES

MT

ES

FR

EE

T

SH

BG

AN

DR

DH

AS

ALD

O

0

50

100

150

200

250

300

A s

core

Method Graphic Equalizer Plot of A scoresfor your methods

P-BWATSCM2CO

RT

UF

C

17P

PR

OG E2

E2H

I

FT

ES

MT

ES

FR

EE

T

SH

BG

AN

DR

DH

AS

ALD

O

0

50

100

150

200

250

300

of 60

Date : 05-Jun-2018

Cumulative Summary

Page 7


Distribution : 453

Laboratory :




B s

core

C score

Cortisol B score is -8.3 and C score is 12.9Your method is Beckman Access/Dxi

P-ABCPENR (ABCPENR)

0 5 10 15 20 25

-30

-20

-10

0

10

20

30

Your labYour methodOverall (n=254)Your method (n=22)

B s

core

C score

Urinary Free Cortisol B score is +62.0 and C score is 76.7Your method is Siemens Immulite 2000/2500 [X]

P-ABCPENR (ABCPENR)

0 25 50 75 100

-25

0

25

50

75

100


B s

core

C score

17OH-Progesterone B score is -4.9 and C score is 17.9Your method is Tandem Mass Spectrometry

P-ABCPENR (ABCPENR)

0 20 40 60 80

-60

-40

-20

0

20

40

60


B s

core

C score

Progesterone B score is -1.7 and C score is 15.5Your method is Beckman Access/Dxi

P-ABCPENR (ABCPENR)

0 5 10 15 20 25

-25-20-15-10

-505

10152025


B s

core

C score

Oestradiol [E2] B score is +51.2 and C score is 48.5Your method is Beckman Access/Dxi

P-ABCPENR (ABCPENR)

0 10 20 30 40

-40

-30

-20

-10

0

10

20

30

40


B s

core

C score

Oestradiol [high-level] B score is +19.3 and C score is 14.7Your method is Beckman Access/Dxi

P-ABCPENR (ABCPENR)

0 10 20 30 40

-40

-30

-20

-10

0

10

20

30

40


B s

core

C score

Testosterone [female] B score is +58.6 and C score is 65.4Your method is Beckman Access/Dxi

P-ABCPENR (ABCPENR)

0 20 40 60 80

-40

-20

0

20

40

60

80


B s

core

C score

Testosterone [male] B score is -14.3 and C score is 8.3Your method is Beckman Access/Dxi

P-ABCPENR (ABCPENR)

0 5 10 15 20 25

-30

-20

-10

0

10

20

30


B s

core

C score

Free Testosterone B score is -6.8 and C score is 14.3Your method is Beckman Access/Dxi [2SF]

P-ABCPENR (ABCPENR)

0 5 10 15 20 25 30

-30

-20

-10

0

10

20

30


B s

core

C score

SHBG B score is -8.8 and C score is 4.8Your method is Beckman Access/Dxi

P-ABCPENR (ABCPENR)

0 5 10 15 20

-30

-20

-10

0

10

20

30


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Date : 05-Jun-2018

Cumulative Summary

Page 8


Distribution : 453

Laboratory :




B s

core

C score

Androstenedione B score is +0.7 and C score is 15.3Your method is Tandem Mass Spectrometry

P-ABCPENR (ABCPENR)

0 20 40 60 80 100 120 140

-40

-20

0

20

40

60

80

100

120

140


B s

core

C score

DHA sulphate B score is +10.5 and C score is 4.2Your method is Tandem Mass Spectrometry

P-ABCPENR (ABCPENR)

0 5 10 15 20 25 30

-40

-30

-20

-10

0

10

20

30

40


B s

core

C score

Aldosterone B score is +61.8 and C score is 56.9Your method is DiaSorin Liaison

P-ABCPENR (ABCPENR)

0 10 20 30 40 50 60

-20

-10

0

10

20

30

40

50

60


of 60

Date : 05-Jun-2018

Analyte : Cortisol (nmol/L)

Page 9


Distribution : 453

Laboratory :




C546453B

C522

PoolSpec.

Pool C520:Pool C521, ratio 1:2453E453D

Pooled male serum

Pool description / Treatments / Additions

Pooled male serumNormal serum [M]

C491 Normal serum [M]

C573453A

453C

C572 12.9

The B limit is +/-

Your B score is

The A limit is15.0

121

20.0

Your A score is-8.3

The C limit is

200

Your C score is

All methods Beckman Access/Dxi

Specimen : 453A

400 500 600 700 800Cortisol (nmol/L)

0

10

20

30

40

50

60

70

no. of la

bora

tories

67134

Roche Cobas/Modular

602

Gen II

22

Meann

517

3.8

Beckman Access/Dxi

42

984.4

624

5.9

8.817

28

Siemens ADVIA Centaur 8.2

Abbott Architect

13

109

540

62724

255

32Siemens Immulite 2000/2500

SD

10.8


53 3.1

553

65

CV(%)

55

6.413

658

46

All methods [ALTM] 658

Your method mean

(Tandem Mass Spectrometry)Standard Uncertainty

Accuracy Index

479

%bias

517

Your result

277

Beckman Access/Dxi

-27.2

16

Your specimen:

Target

Specimen : 453B

130 160 190 220 250Cortisol (nmol/L)

0

20

40

60

80

100

no. of la

bora

tories

20434

Roche Cobas/Modular

169

Gen II

22

Meann

190

3.6

Beckman Access/Dxi

13

983.9

157

11.1

6.86

6


Abbott Architect

13

109

non-numeric results

158

1586

254


SD

12.5


52

1

3.9

203

21

CV(%)

17

8.113

163

13


Your method mean


Accuracy Index

170

%bias

190

Your result

49

Beckman Access/Dxi

+4.6Your specimen:

5

Target

Specimen : 453C

100 120 140 160 180Cortisol (nmol/L)

0

20

40

60

80

100

no. of la

bora

tories

15934

Roche Cobas/Modular

145

Gen II

22

Meann

141

3.5

Beckman Access/Dxi

12

984.0

142

8.9

8.76

6


Abbott Architect

13

109

non-numeric results

139

1435

254


SD

7.4


52

1

4.2

154

11

CV(%)

15

8.213

143

12


Your method mean


Accuracy Index

123

%bias

141

Your result

145

Beckman Access/Dxi

-14.1Your specimen:

4

Target

Specimen : 453D

200 240 280 320 360Cortisol (nmol/L)

0

20

40

60

80

100

no. of la

bora

tories

32434

Roche Cobas/Modular

281

Gen II

22

Meann

277

3.7

Beckman Access/Dxi

25

984.2

273

7.1

9.110

11


Abbott Architect

13

109

265

27410

255


SD

8.9


53 3.7

296

25

CV(%)

20

8.913

281

25


Your method mean


Accuracy Index

256

%bias

277

Your result

104

Beckman Access/Dxi

-8.9Your specimen:

9

Target

Specimen : 453E

220 280 340 400 460Cortisol (nmol/L)

0

10

20

30

40

50

60

70

no. of la

bora

tories

36534

Roche Cobas/Modular

344

Gen II

22

Meann

293

3.8

Beckman Access/Dxi

29

984.3

364

7.0

9.610

16


Abbott Architect

13

109

302

36514

255


SD

11.3


53 3.3

329

39

CV(%)

28

7.713

374

28


Your method mean


Accuracy Index

258

%bias

293

Your result

371

Beckman Access/Dxi

-31.1Your specimen:

11

Target

of 60

Pool

(exclusion)

[Type]

Distribution 448

05-Dec-2017

result target %bias

Distribution 449

23-Jan-2018

result target %bias

Distribution 450

27-Feb-2018

result target %bias

Distribution 451

27-Mar-2018

result target %bias

Distribution 452

01-May-2018

result target %bias

Distribution 453

05-Jun-2018

result target %bias

60 59 +1.7C551 [F,V]103 116 -10.9C552 [F,V]

123 143 -14.1C546 [M,R,V]161 145 +11.0 145 148 -1.9C526 [M,R,V]

149 161 -7.5C561 [F,V]170 163 +4.6C573 [M,V]

146 182 -19.7C553 [F,V]160 186 -14.0C569 [F,V]187 194 -3.8C567 [F,V]

206 225 -8.3C562 [F,V]221 234 -5.7C499 [M,V]

275 250 +9.8C527 [M,R,V]266 257 +3.6C571 [M,V]

213 262 -18.7C555 [F,V]282 275 +2.4C563 [M,V]

256 281 -8.9C491 [M,V]261 293 -11.0C570 [F,V]

267 295 -9.3C564 [M,V]256 302 -15.2C568 [F,V]

312 339 -8.1C534 [M,V]263 340 -22.5C565 [F,V]

346 349 -1.0C528 [M,R,V]239 350 -31.8C516 [F,V]318 366 -13.2C519 [M,V]

258 374 -31.1C522 [F,V]296 386 -23.4C554 [F,V]

599 561 +6.7C529 [M,R,V]479 658 -27.2C572 [M,V]

1050 947 +10.9C530 [M,R,V]

MethodmeanA scoreB scoreC score

SF1+7.5

126-8.313.2

SF1-9.0

135-9.612.4

SF1-8.1

122-8.511.4

SF1-14.2

135-9.812.0

SF1-12.1

120-8.511.6

SF1-15.3

121-8.312.9

F female only poolM male only poolR RecoveryV no preservative

Date : 05-Jun-2018


Page 10


Distribution : 453

Laboratory :




A s

core

Cortisol Median and IQRs of A scores

P-BWABCAT

AB

13

SF

1

BO

5

CO

10

DC

11

MS

2

0

50

100

150

200

250

300

All

Meth

od

B s

core

Median and IQRs of B score

P-BWABCBR

AB

13

SF

1

BO

5

CO

10

DC

11

MS

2

-30

-20

-10

0

10

20

30

All

Meth

od

B s

core

C score


P-ABCPENR

0 5 10 15 20 25

-30

-20

-10

0

10

20

30


C s

core

Median and IQRs of C score

P-BWABCCR

AB

13

SF

1

BO

5

CO

10

DC

11

MS

2

0

5

10

15

20

25

All

Meth

od

of 60

Date : 05-Jun-2018


Page 11


Distribution : 453

Laboratory :




1

Gen II

Beckman Access/Dxi

13

Roche Cobas/Modular

All methods [ALTM]

n

109

1

3

Tandem Mass SpectrometrySiemens Immulite 2000/2500

13

4

2

34

1

non-numeric results

Not stated, please specify

98

OCD (J&J) VITROS

Siemens ADVIA Centaur

Tosoh AIA

53

255

DiaSource4

Randox Evolution

22

Gen I

Abbott Architect

24624

10.8

627

SDMean

977

792

8.8

658

28 4.4

553

625

517

622

540 17

569

5.9

490

6.4

65

671

CV(%)

453A

32

3.146

8.23.8

42

55

602

6157

12.5

158

SDMean

217

182

6.8

163

6 3.9

203

154

190

283

158 6

170

11.1

156

8.1

21

204

CV(%)

453B

22

3.913

8.53.6

13

17

169

5142

7.4

143

SDMean

202

183

8.7

143

6 4.0

154

142

141

177

139 6

140

8.9

115

8.2

11

159

CV(%)

453C

14

4.212

9.23.5

12

15

145

10273

8.9

274

SDMean

389

348

9.1

281

11 4.2

296

271

277

349

265 10

274

7.1

244

8.9

25

324

CV(%)

453D

21

3.725

6.23.7

25

20

281

14364

11.3

365

SDMean

483

429

9.6

374

16 4.3

329

363

293

371

302 10

343

7.0

293

7.7

39

365

CV(%)

453E

23

3.328

7.83.8

29

28

344

Randox Evolution


51

13

Gen I

All methods

CO10

n

4

37

1103

12Tandem Mass SpectrometryDC11

AB13

MS2

254

SF1RX4

101

Roche Cobas/Modular BO5

Beckman Access/Dxi

Siemens Immulite 2000/2500

Gen II

22Abbott Architect

52

108

211

Interquartile rangeMedian

240

41

125

53

186 245

97

269117

53

97

32100

82

47

41

A score

32

42

87151

110102

91113

31

214

74

-1.6

+1.1

+19.5


+21.1

-3.0

-5.8

+2.4

+17.2 +22.5

-0.2

+22.9-8.5

-1.3

-8.8

-4.2+6.0

-10.1

-0.2

-2.6

B score

-4.2

-6.5

-4.2+11.9

-7.1-10.1

-0.9+8.5

-3.4

+17.9

-3.1

4.2

9.6

6.6


20.2

3.4

11.6

4.8

6.1 7.3

11.1

20.510.6

4.5

6.1

2.710.0

5.5

4.3

3.4

C score

2.8

3.6

10.213.7

6.99.6

10.711.5

3.0

19.4

5.7

of 60

Date : 05-Jun-2018

Cortisol (nmol/L)

Page 12


Distribution : 453

Laboratory :




Specim

en A

ccura

cy Index

Distribution

Specimen Accuracy Indexfor each specimen in time-window

P-ABCATS (ABC1)

448 449 450 451 452 453

0

50

100

150

200

250

300

A s

core

Distribution

A score by distributionYour current A score is 121

P-ABCAT (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

50

100

150

200

250

300

All

Meth

od

Specim

en %

bia

s

Distribution

Specimen %biasfor each specimen in time-window

P-ABCBRS (ABC1)

448 449 450 451 452 453

-30

-20

-10

0

10

20

30

B s

core

Distribution

B score by distributionYour current B score is -8.3

P-ABCBR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

-30

-20

-10

0

10

20

30

All

Meth

od

Diffe

rence (

nm

ol/L)

Concentration (nmol/L)

Difference (result - target)for each specimen in time-window

P-BA1FS1A (ABC1)

0 200 400 600 800 1000

-100-80-60-40-20

020406080

100

C s

core

Distribution

C score by distributionYour current C score is 12.9

P-ABCCR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

5

10

15

20

25

All

Meth

od

Specim

en %

bia

s



P-BA1FS1P (ABC1)

0 200 400 600 800 1000

-30

-20

-10

0

10

20

30

B s

core

C score


P-ABCPENR (ABC1)

0 5 10 15 20 25

-30

-20

-10

0

10

20

30


Specim

en A

ccura

cy Index



P-YSTMOD (ABC1)

0 200 400 600 800 1000

0

50

100

150

200

250

300 ALTMMLTM

CV

%


Cortisol Between-laboratory agreementBeckman Access/Dxi

P-PROFILE (ABC1)

0 200 400 600 800 1000

0

5

10

15

20

25

of 60

Date : 05-Jun-2018

Analyte : Urinary Free Cortisol (nmol/L)

Page 13


Distribution : 453

Laboratory :




U428453B

PoolSpec.

453D

Normal urine [M]


Pool U463 [M] + 200 nmol/L CortisolPool U421 [M] + 138 nmol/L CortisolNormal paediatric urineU453

U464453A

453C

U463 76.7

The B limit is +/-

Your B score is

The A limit is20.0

323

20.0

+62.0Your A score is

The C limit is

200

Your C score is

All methods Siemens Immulite 2000/2500 [X]

Specimen : 453A

0 33 66 99 132Urinary Free Cortisol (nmol/L)

0

10

20

30

40

no. of la

bora

tories

Abbott Architect

60

48

11.9

3

Mean


n

116

46

Roche Cobas/Modular [X]53

4

80

SD

43.8

18

3

4 7.7

21

CV(%)

36Siemens Immulite 2000/2500 [X]


Your method mean


Accuracy Index

72

%bias

60

Your result

500


+101.7Your specimen:

1

Target

Specimen : 453B


0

5

10

15

20

25

30

no. of la

bora

tories

Abbott Architect

271

249

7.0

3

Mean


n

264

46


17

80

SD

9.8

18

3

10 3.8

24

CV(%)



Your method mean


Accuracy Index

312

%bias

271

Your result

203


+29.6Your specimen:

3

Target

Specimen : 453C


0

5

10

15

20

25

30

no. of la

bora

tories

Abbott Architect

234

199

11.9

3

Mean


n

310

46


22

80

SD

16.0

18

3

11 5.4

32

CV(%)



Your method mean


Accuracy Index

284

%bias

234

Your result

389


+54.6Your specimen:

4

Target

Specimen : 453D


0

5

10

15

20

25

30

no. of la

bora

tories

Abbott Architect

103

84

11.0

3

Mean


n

330

46


7

80

SD

36.9

18

3

5 5.4

31

CV(%)



Your method mean


Accuracy Index

133

%bias

103

Your result

500


+101.1Your specimen:

1

Target

of 60

Pool

(exclusion)

[Type]

Distribution 448

05-Dec-2017

result target %bias

Distribution 449

23-Jan-2018

result target %bias

Distribution 450

27-Feb-2018

result target %bias

Distribution 451

27-Mar-2018

result target %bias

Distribution 452

01-May-2018

result target %bias

Distribution 453

05-Jun-2018

result target %bias

(

Date : 05-Jun-2018

Analyte : Urinary Free Cortisol (nmol/L)

Page 15


Distribution : 453

Laboratory :




18


80

Roche Cobas/Modular [X]Siemens Immulite 2000/2500 [X]

46

All methods [ALTM]

3

n

3

Abbott Architect 4

43.8

SD

453A

Mean

3660

21

CV(%)

7.7

11.9

116

4

53

48

10

9.8

SD

453B

Mean

241271

24

CV(%)

3.8

7.0

264

17

252

249

11

16.0

SD

453C

Mean

184234

32

CV(%)

5.4

11.9

310

22

204

199

5

36.9

SD

453D

Mean

66103

31

CV(%)

5.4

11.0

330

7

92

84

Immunotech RIA

MS2

16


All methods

48

n

DC1133

AB13

81

IB1IT1


Roche Cobas/Modular [X] BO8

IBL Elisa

3

3Abbott Architect

63

233

212


293

44

493

196 268

296487

453

225

28

222

407 370

38

235480

A score

281

72

+5.3

+32.6

+27.8


+64.2

+0.1

+885.0

+25.1 +44.9

+64.5+522.9

+238.9

+31.0

-4.1

+30.0

+216.4 +143.6

-1.0

+33.0+439.1

B score

+54.8

+8.1

8.2

46.3

44.9


96.6

5.8

1390.4

42.0 60.8

97.2605.8

251.2

46.0

4.4

43.6

123.6 100.6

5.4

47.0491.9

C score

81.7

10.4

of 60

Date : 05-Jun-2018

Urinary Free Cortisol (nmol/L)

Page 16


Distribution : 453

Laboratory :




Specim

en A

ccura

cy Index

Distribution


P-ABCATS (ABC1)

448 449 450 451 452 453

0

50

100

150

200

250

300

A s

core

Distribution


P-ABCAT (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

50

100

150

200

250

300

All

Meth

od

Specim

en %

bia

s

Distribution


P-ABCBRS (ABC1)

448 449 450 451 452 453

-25

0

25

50

75

100

B s

core

Distribution

B score by distributionYour current B score is +62.0

P-ABCBR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

-25

0

25

50

75

100

All

Gro

up

Meth

od

Diffe

rence (

nm

ol/L)



P-BA1FS1A (ABC1)

0 200 400 600 800 1000

-100-80-60-40-20

020406080

100

C s

core

Distribution


P-ABCCR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

25

50

75

100

All

Gro

up

Meth

od

Specim

en %

bia

s



P-BA1FS1P (ABC1)

0 200 400 600 800 1000

-25

0

25

50

75

100

B s

core

C score

Urinary Free Cortisol B score is +62.0 and C score is 76.7Your method is Siemens Immulite 2000/2500 [X]

P-ABCPENR (ABC1)

0 25 50 75 100

-25

0

25

50

75

100


Specim

en A

ccura

cy Index



P-YSTMOD (ABC1)

0 200 400 600 800 1000

0

50

100

150

200

250

300 ALTMMLTM

CV

%


Urinary Free Cortisol Between-laboratory agreementSiemens Immulite 2000/2500 [X]

P-PROFILE (ABC1)

0 200 400 600 800 1000

0

10

20

30

40

50

of 60

Date : 05-Jun-2018

Analyte : 17OH-Progesterone (nmol/L)

Page 17


Distribution : 453

Laboratory :




H456453B

H459

PoolSpec.

Pool H454 + 25.5 nmol/L 17OHP + 50 nmol/L 11-Deoxycorticosterone453E453D

Normal serum [F]


Pool H454 + 5 nmol/L 11-DeoxycorticosteronePool H454 + 50 nmol/L 11-DeoxycorticosteronePool H454 + 25.5 nmol/L 17OHP + 5 nmol/L 11-DeoxycorticosteroneH458

H455453A

453C

H454 17.9

The B limit is +/-

Your B score is

The A limit is15.0

67

20.0

-4.9Your A score is

The C limit is

200

Your C score is

All methods Tandem Mass Spectrometry

Specimen : 453A

0.0 0.9 1.8 2.7 3.617OH-Progesterone (nmol/L)

0

5

10

15

20

25

30

no. of la

bora

tories

CIS Coated Tube

1.87

1.43

21.8

0.68

Mean


n

22.9

39

2.971.05

non-numeric results0.26

61

4

SD

38.9

3

3DiaSource 7

0.56

CV(%)

1.21IBL Elisa

All methods [ALTM] 1.21

Your method mean


Accuracy Index

1.3

%bias

1.21

Your result

36


+7.8Your specimen:

0.06

Target

Specimen : 453B


0

5

10

15

20

no. of la

bora

tories

CIS Coated Tube

1.66

1.38

18.8

0.47

Mean


n

17.8

40

2.641.03


62

3

SD

35.4

3

3DiaSource 7

0.49

CV(%)

1.20IBL Elisa


Your method mean


Accuracy Index

1.4

%bias

1.20

Your result

78


+16.7Your specimen:

0.05

Target

Specimen : 453C


0

5

10

15

20

25

30

no. of la

bora

tories

CIS Coated Tube

1.72

1.53

35.2

0.43

Mean


n

15.7

37

2.731.14


59

6

SD

46.6

3

3DiaSource 7

0.71

CV(%)

1.29IBL Elisa


Your method mean


Accuracy Index

1.4

%bias

1.29

Your result

40


+8.5Your specimen:

0.10

Target

Specimen : 453D

8 16 24 32 4017OH-Progesterone (nmol/L)

0

5

10

15

20

no. of la

bora

tories

CIS Coated Tube

14.5

23.3

10.6

1.7

Mean


n

7.4

44

22.613.3

2.7

66

SD

20.1

3

3DiaSource 7

4.7

CV(%)

25.2IBL Elisa


Your method mean


Accuracy Index

28.6

%bias

25.2

Your result

76


+13.6Your specimen:

0.54

Target

Specimen : 453E

8 16 24 32 4017OH-Progesterone (nmol/L)

0

5

10

15

20

no. of la

bora

tories

CIS Coated Tube

14.7

23.5

11.0

1.6

Mean


n

7.7

44

21.013.6

2.8

66

SD

20.9

3

3DiaSource 7

4.9

CV(%)

25.3IBL Elisa


Your method mean


Accuracy Index

31.7

%bias

25.3

Your result

140


+25.2Your specimen:

0.56

Target

of 60

Pool

(exclusion)

[Type]

Distribution 448

05-Dec-2017

result target %bias

Distribution 449

23-Jan-2018

result target %bias

Distribution 450

27-Feb-2018

result target %bias

Distribution 451

27-Mar-2018

result target %bias

Distribution 452

01-May-2018

result target %bias

Distribution 453

05-Jun-2018

result target %bias

0.5 0.39 +29.6H451 [F,V]0.5 0.46 +9.4H449 [F,V]0.5 0.50 -0.3H452 [F,V]

0.2 0.52 -61.5H445 [F,V]0.5 0.70 -28.8H444 [F,V]

1.4 1.20 +16.7H455 [F,V]1.3 1.21 +7.8H454 [F,V]1.4 1.29 +8.5H456 [F,V]

1.5 1.50 -0.3H450 [F,V]1.4 1.83 -23.5H447 [M,V]

2.2 2.34 -5.8H453 [M,V]2.0 2.59 -22.8H446 [M,V]

2.2 3.08 -28.6H423 [F,V]2.8 3.57 -21.7 3.8 3.57 +6.3H404 [F,V]

4.6 4.77 -3.6H405 [F,V]4.3 5.41 -20.5H448 [F,V]

5.8 7.2 -19.6 6.9 7.1 -3.0H406 [F,V]7.8 8.4 -7.3H407 [F,V]

9.5 11.4 -16.9 10.1 9.8 +3.4H408 [F,R]11.6 12.2 -5.1 15.5 12.7 +22.3H409 [F,V]14.4 15.9 -9.2H411 17.3 17.9 -3.4 17.8 18.7 -4.7H410

28.6 25.2 +13.6H458 [F,V]31.7 25.3 +25.2H459 [F,V]

41.6 49.0 -15.1H396 [F,V]


MS2-20.4

63-12.6

7.0

MS2-31.4

74-14.9

8.7

MS2+6.5

74-13.310.6

MS2-5.7

70-12.511.6

MS2+4.9

64-9.713.8

MS2+14.4

67-4.917.9

F female only poolM male only poolR RecoveryV no preservative

Date : 05-Jun-2018


Page 18


Distribution : 453

Laboratory :




A s

core

17OH-Progesterone Median and IQRs of A scores

P-BWABCAT

DE

1

IB1

MS

2

0

50

100

150

200

250

300

All

Meth

od

B s

core


P-BWABCBR

DE

1

IB1

MS

2

-60

-40

-20

0

20

40

60

All

Meth

od

B s

core

C score


P-ABCPENR

0 20 40 60 80

-60

-40

-20

0

20

40

60


C s

core


P-BWABCCR

DE

1

IB1

MS

2

0

20

40

60

80

All

Meth

od

of 60

Date : 05-Jun-2018


Page 19


Distribution : 453

Laboratory :




3


66

DiaSourceIBL Elisa

44

All methods [ALTM]

6

7

n

non-numeric results

3

CIS Coated Tube

38.9

SDMean

1.21

453A

1.870.68

0.56

CV(%)

2.97

21.8

22.9

0.26

1.05

1.43 35.4

SDMean

1.20

453B

1.660.47

0.49

CV(%)

2.64

18.8

17.8

0.23

1.03

1.38 46.6

SDMean

1.29

453C

1.720.43

0.71

CV(%)

2.73

35.2

15.7

0.45

1.14

1.53 20.1

SDMean

25.2

453D

14.51.7

4.7

CV(%)

22.6

10.6

7.4

2.7

13.3

23.3 20.9

SDMean

25.3

453E

14.71.6

4.9

CV(%)

21.0

11.0

7.7

2.8

13.6

23.5

IBL Elisa

4

All methods

n

465

CI3

70

DE1IB1

Tandem Mass Spectrometry MS2

DiaSource 7CIS Coated Tube 156

175

A score

Interquartile range

56

Median

17437

308

46

176

183299 294

75143

171

74

-20.6

+13.7

B score

Interquartile range

0.0

Median

-8.6-4.9

+84.4

-7.7

-16.7

+4.8+79.3 +74.6

+7.6-14.2

-18.1

+1.0

28.8

41.4

C score

Interquartile range

9.3

Median

46.26.8

110.2

8.1

40.5

57.3107.3 97.4

16.532.4

34.5

17.3

of 60

Date : 05-Jun-2018

17OH-Progesterone (nmol/L)

Page 20


Distribution : 453

Laboratory :




Specim

en A

ccura

cy Index

Distribution


P-ABCATS (ABC1)

448 449 450 451 452 453

0

50

100

150

200

250

300

A s

core

Distribution


P-ABCAT (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

50

100

150

200

250

300

All

Meth

od

Specim

en %

bia

s

Distribution


P-ABCBRS (ABC1)

448 449 450 451 452 453

-60

-40

-20

0

20

40

60

B s

core

Distribution


P-ABCBR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

-60

-40

-20

0

20

40

60

All

Meth

od

Diffe

rence (

nm

ol/L)



P-BA1FS1A (ABC1)

0 20 40 60 80 100 120

-20

-15

-10

-5

0

5

10

15

20

C s

core

Distribution


P-ABCCR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

20

40

60

80

All

Meth

od

Specim

en %

bia

s



P-BA1FS1P (ABC1)

0 20 40 60 80 100 120

-60

-40

-20

0

20

40

60

B s

core

C score


P-ABCPENR (ABC1)

0 20 40 60 80

-60

-40

-20

0

20

40

60


Specim

en A

ccura

cy Index



P-YSTMOD (ABC1)

0 20 40 60 80 100 120

0

50

100

150

200

250

300 ALTMMLTM

CV

%


17OH-Progesterone Between-laboratory agreementTandem Mass Spectrometry

P-PROFILE (ABC1)

0 20 40 60 80 100 120

0

10

20

30

40

50

of 60

Date : 05-Jun-2018

Analyte : Progesterone (nmol/L)

Page 21


Distribution : 453

Laboratory :




P481453B

P483

PoolSpec.

Normal serum [F]453E453D

Pool 487:Pool 488, ratio 3:1


Normal serum [F]Normal serum [F]Normal serum [F]P482

P480453A

453C

P493 15.5

The B limit is +/-

Your B score is

The A limit is15.0

84

15.0

-1.7Your A score is

The C limit is

200

Your C score is


Specimen : 453A

14 18 22 26 30Progesterone (nmol/L)

0

20

40

60

80

no. of la

bora

tories

1.123.7

Beckman Access/Dxi Alt Calib

23.1

20.9

21

Meann

18.1

Roche Cobas/Modular

Beckman Access/Dxi

6.9

Randox Evolution43


7.41.2

OCD (J&J) VITROS

104Siemens ADVIA Centaur

Abbott Architect

18.0

3

23.3

22.6

23.5

238

7.137

SD

8.5

7

54 5.2

1.7

2.0

CV(%)

4.524.1

1.2

1.3


Your method mean

(ALTM)Standard Uncertainty

Accuracy Index

19.5

%bias

18.1

Your result

171

Beckman Access/Dxi

-15.7Your specimen:

0.2

Target

Specimen : 453B


0

20

40

60

80

100

120

no. of la

bora

tories

0.611.7


11.7

12.5

21

Meann

10.0

Roche Cobas/Modular

Beckman Access/Dxi

2.4

Randox Evolution43


8.50.7

OCD (J&J) VITROS


Abbott Architect

10.3

3

12.1

12.6

11.2

238

9.337

SD

7.7

7

54 5.5

1.1

0.9

CV(%)

5.311.9

0.3

0.8


Your method mean


Accuracy Index

12.0

%bias

10.0

Your result

22

Beckman Access/Dxi

+2.9Your specimen:

0.1

Target

Specimen : 453C


0

20

40

60

80

no. of la

bora

tories

0.819.5


19.4

23.6

21

Meann

17.9

Roche Cobas/Modular

Beckman Access/Dxi

9.2

Randox Evolution43


9.61.0

OCD (J&J) VITROS


Abbott Architect

16.7

3

20.2

22.9

17.8

238

9.037

SD

7.0

7

54 4.9

1.7

1.4

CV(%)

4.018.6

1.5

1.7


Your method mean


Accuracy Index

21.9

%bias

17.9

Your result

129

Beckman Access/Dxi

+13.1Your specimen:

0.1

Target

Specimen : 453D


0

10

20

30

40

50

60

70

no. of la

bora

tories

0.924.3


23.7

23.4

21

Meann

20.3

Roche Cobas/Modular

Beckman Access/Dxi

4.1

Randox Evolution43


11.31.1

OCD (J&J) VITROS


Abbott Architect

19.4

3

24.8

24.4

21.4

238

7.837

SD

7.8

7

54 4.4

1.8

1.9

CV(%)

3.822.6

0.8

2.3


Your method mean


Accuracy Index

23.4

%bias

20.3

Your result

15

Beckman Access/Dxi

-1.3Your specimen:

0.2

Target

Specimen : 453E


0

10

20

30

40

50

60

70

no. of la

bora

tories

1.642.5


41.7

39.0

21

Meann

34.6

Roche Cobas/Modular

Beckman Access/Dxi

10.1

Randox Evolution43


9.81.9

OCD (J&J) VITROS


Abbott Architect

32.5

3

42.6

42.2

44.5

238

6.737

SD

7.0

7

54 4.5

2.8

2.9

CV(%)

3.842.3

3.3

3.4


Your method mean


Accuracy Index

40.7

%bias

34.6

Your result

25

Beckman Access/Dxi

-2.4Your specimen:

0.2

Target

of 60

Pool

(exclusion)

[Type]

Distribution 448

05-Dec-2017

result target %bias

Distribution 449

23-Jan-2018

result target %bias

Distribution 450

27-Feb-2018

result target %bias

Distribution 451

27-Mar-2018

result target %bias

Distribution 452

01-May-2018

result target %bias

Distribution 453

05-Jun-2018

result target %bias

(0.8)(P510) [F,V](0.7)(P509) [F,V]

(1.1)(P504) [F,V](0.9)(P503) [F,V]

(1.1)(P507) [F,V]1.4 1.2 +16.5P511 [V]

2.0 2.1 -3.9P502 [F,V]4.9 3.9 +25.2P508 [F,V]

5.4 4.0 +36.1P479 [F,V]9.9 8.7 +14.3P465 [F,V]

12.0 11.7 +2.9P480 [F,V]10.5 15.1 -30.6P489 [F,R,V]12.7 15.3 -17.0 15.6 15.5 +0.4P468 [F,V]

21.9 19.4 +13.1P481 [F,V]21.2 20.1 +5.4P467 [F,V]

19.8 22.9 -13.4P512 [F,V]21.2 22.9 -7.5P462 [F,V]

19.5 23.1 -15.7P493 [F,V]23.4 23.7 -1.3P482 [F,V]

24.8 26.8 -7.4P513 [F,V]22.2 29.0 -23.4P490 [F,R,V]

27.8 29.8 -6.7P514 [F,V]27.3 30.8 -11.3P466 [F,V]

31.0 32.4 -4.3P515 [F,V]34.9 35.3 -1.0P516 [F,V]

40.7 41.7 -2.4P483 [F,V]69.2 64.7 +6.9P506 [F,V]

100.5 86.3 +16.5P505 [F,V]59.4 86.3 -31.1P492 [F,R,V]


SF1-22.7

82-10.0

9.2

SF1+6.5

66-7.88.2

SF1+20.9

64-4.713.2

SF1-6.6

72-6.39.1

SF1+9.7

78-3.214.0

SF1-0.7

84-1.715.5

F female only poolR RecoveryV no preservative

Date : 05-Jun-2018


Page 22


Distribution : 453

Laboratory :




A s

core

Progesterone Median and IQRs of A scores

P-BWABCAT

AB

13

SF

1

BO

5

CO

10

DC

11

0

50

100

150

200

250

300

All

Meth

od

B s

core


P-BWABCBR

AB

13

SF

1

BO

5

CO

10

DC

11

-25-20-15-10

-505

10152025

All

Meth

od

B s

core

C score


P-ABCPENR

0 5 10 15 20 25

-25-20-15-10

-505

10152025


C s

core


P-BWABCCR

AB

13

SF

1

BO

5

CO

10

DC

11

0

5

10

15

20

25

All M

eth

od

of 60

Date : 05-Jun-2018


Page 23


Distribution : 453

Laboratory :




OCD (J&J) VITROS

Beckman Access/Dxi


All methods [ALTM]

n

37104

Randox Evolution

54

238

Beckman Access/Dxi Alt Calib4

7

3Roche Cobas/Modular

21


3

Abbott Architect

1.218.0

8.5

4.5

SDMean

22.6

7.1

7.4

1.124.1

20.9

18.1

23.7

23.3 1.2

23.5

1.7

2.0

453A

CV(%)

5.21.3

6.9

23.1

0.310.3

7.7

5.3

SDMean

12.6

9.3

8.5

0.611.9

12.5

10.0

11.7

12.1 0.7

11.2

1.1

0.9

453B

CV(%)

5.50.8

2.4

11.7

1.516.7

7.0

4.0

SDMean

22.9

9.0

9.6

0.818.6

23.6

17.9

19.5

20.2 1.0

17.8

1.7

1.4

453C

CV(%)

4.91.7

9.2

19.4

0.819.4

7.8

3.8

SDMean

24.4

7.8

11.3

0.922.6

23.4

20.3

24.3

24.8 1.1

21.4

1.8

1.9

453D

CV(%)

4.42.3

4.1

23.7

3.332.5

7.0

3.8

SDMean

42.2

6.7

9.8

1.642.3

39.0

34.6

42.5

42.6 1.9

44.5

2.8

2.9

453E

CV(%)

4.53.4

10.1

41.7


BO5

53


Randox Evolution

All methods

105

n

RX4

MS2


43

Tandem Mass SpectrometryDC11

37

AB13

7

240

SF1SF4

Roche Cobas/Modular

OCD (J&J) VITROS AM12

Beckman Access/Dxi

CO10

3

21

3

Abbott Architect

43

72

88


106

35

171

76

82 104

150

112149

134

39

2957

31

71

125

A score

117

32

14277

51126

14465

59

84

45

+2.6

+4.0

-2.0


+6.0

+1.0

-14.1

-5.0

-4.5 +3.1

-14.0

+8.7-17.1

+6.8

+3.1

-0.4+2.4

+1.4

-7.7

+4.7

B score

+1.7

-1.2

-16.6+5.9

+4.6-18.5

-15.9+4.4

-8.5

-3.6

+1.5

5.8

8.8

15.9


11.8

4.9

11.1

8.6

14.1 16.8

9.2

12.68.7

31.5

5.4

4.18.8

4.3

8.5

25.2

C score

19.4

4.6

6.611.9

6.76.9

7.210.7

8.0

11.6

6.1

of 60

Date : 05-Jun-2018

Progesterone (nmol/L)

Page 24


Distribution : 453

Laboratory :




Specim

en A

ccura

cy Index

Distribution


P-ABCATS (ABC1)

448 449 450 451 452 453

0

50

100

150

200

250

300

A s

core

Distribution


P-ABCAT (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

50

100

150

200

250

300

All

Meth

od

Specim

en %

bia

s

Distribution


P-ABCBRS (ABC1)

448 449 450 451 452 453

-25-20-15-10

-505

10152025

B s

core

Distribution


P-ABCBR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

-25-20-15-10

-505

10152025

All

Meth

od

Diffe

rence (

nm

ol/L)



P-BA1FS1A (ABC1)

0 10 20 30 40 50 60 70 80 90 100

-5-4-3-2-1012345

C s

core

Distribution


P-ABCCR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

5

10

15

20

25

All M

eth

od

Specim

en %

bia

s



P-BA1FS1P (ABC1)

0 10 20 30 40 50 60 70 80 90 100

-25-20-15-10

-505

10152025

B s

core

C score


P-ABCPENR (ABC1)

0 5 10 15 20 25

-25-20-15-10

-505

10152025


Specim

en A

ccura

cy Index



P-YSTMOD (ABC1)

0 10 20 30 40 50 60 70 80 90 100

0

50

100

150

200

250

300 ALTMMLTM

CV

%


Progesterone Between-laboratory agreementBeckman Access/Dxi

P-PROFILE (ABC1)

0 10 20 30 40 50 60 70 80 90 100

0

5

10

15

20

25

of 60

Date : 05-Jun-2018

Analyte : Oestradiol [E2] (pmol/L)

Page 25


Distribution : 453

Laboratory :




E522453B

E524

PoolSpec.

Pool E520:Pool E521, ratio 1:3453E453D

Normal serum [F]


Stripped serumPool E520:Pool E521, ratio 3:1Pool E520:Pool E521, ratio 1:1E523

E521453A

453C

E520 48.5

The B limit is +/-

Your B score is

The A limit is15.0

256

20.0


The C limit is

200

Your C score is


Specimen : 453A

100 130 160 190 220Oestradiol [E2] (pmol/L)

0

10

20

30

40

50

no. of la

bora

tories

10.318

OCD (J&J) VITROS

162

163

19

Meann

170

33

Beckman Access/Dxi

16106 9.8

14

41.015

Roche Cobas/Modular179

5

Abbott Architect

12

4

160

138


240

Tandem Mass Spectrometry149

SD

12.9

151

48 9.4

24.7

21

CV(%)

Siemens Immulite 2000/2500 377.8

70


Your method mean


Accuracy Index

157

%bias

170

Your result

15

Beckman Access/Dxi

-3.2Your specimen:

2

Target

Specimen : 453B

0 32 64 96 128Oestradiol [E2] (pmol/L)

0

5

10

15

20

no. of la

bora

tories

Abbott Architect

Roche Cobas/Modular

39


8

Mean

22

n

36

170

28Beckman Access/Dxi

51

non-numeric results4

38.5

64

45

SD

53.0

23127.3

14 27.0

21

CV(%)

1146


Your method mean


Accuracy Index%bias

36

Your result

Beckman Access/Dxi

Your specimen:

3

Target

Pool

(exclusion)

[Type]

Distribution 448

05-Dec-2017

result target %bias

Distribution 449

23-Jan-2018

result target %bias

Distribution 450

27-Feb-2018

result target %bias

Distribution 451

27-Mar-2018

result target %bias

Distribution 452

01-May-2018

result target %bias

Distribution 453

05-Jun-2018

result target %bias

Date : 05-Jun-2018

Analyte : Oestradiol [E2] (pmol/L)

Page 27


Distribution : 453

Laboratory :




Randox Evolution

non-numeric results

Beckman Access/Dxi


All methods [ALTM]

170

n

533

Roche Cobas/Modular

48

240

OCD (J&J) VITROS3

14


19


4

Abbott Architect

24.7

12.9

179

SDMean

138

149

41.0

18 10.3

129

170

9.8

160

3712

15

163 16

21

453A

7.8

CV(%)

9.470

151

162

14

11

53.0

SD

38.5

Mean

127.3

453B

21

CV(%)

27.0

28

36 46

45

51

39

8.410

14.9

143

SDMean

10426.1

20 13.9

112

151

12.8

135

114

14

132 17

20

453C

CV(%)

10.239

134

10.08

20.8

104

SDMean

6639.3

16 15.7

86

108

18.7

113

77

14

101 19

21

453D

CV(%)

12.542

101

13.3

65

34.4

19

SDMean

37

40

44.7

27.768

6788

5

453E

16

19 28.6

23

CV(%)

18.530

68

Method development [MDV2]

BO5

46


Randox Evolution

All methods

108

n

RX4

MS2


43

Tandem Mass SpectrometryDC11

34

AB13

5

242

SF1MDV2

Roche Cobas/Modular

OCD (J&J) VITROS AM12

Beckman Access/Dxi

CO10

3

18

14

Abbott Architect

62

87

142


103

49

161

96

135 143

141

123126

124

51

3667

46

89

112

A score

103

46

112108

60103

13783

75

100

60

+1.0

+6.6

+17.2


+20.5

-3.6

+24.7

-13.6

+6.5 +18.1

+0.1

+21.9+12.4

-11.8

-1.8

-8.6+10.7

-3.3

-15.8

-15.9

B score

-21.0

-7.7

-19.1+20.4

+2.1+8.7

-14.5+15.7

-18.5

+13.7

-1.8

15.5

18.9

38.1


37.8

12.4

36.9

18.4

37.3 42.2

30.9

38.130.8

19.6

12.4

9.215.3

10.7

17.7

18.8

C score

16.7

11.4

14.620.8

14.423.9

16.417.4

16.5

34.3

14.6

of 60

Date : 05-Jun-2018

Oestradiol [E2] (pmol/L)

Page 28


Distribution : 453

Laboratory :




Specim

en A

ccura

cy Index

Distribution


P-ABCATS (ABC1)

448 449 450 451 452 453

0

50

100

150

200

250

300

A s

core

Distribution


P-ABCAT (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

50

100

150

200

250

300

All

Meth

od

Specim

en %

bia

s

Distribution


P-ABCBRS (ABC1)

448 449 450 451 452 453

-40

-30

-20

-10

0

10

20

30

40

B s

core

Distribution

B score by distributionYour current B score is +51.2

P-ABCBR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

-40

-30

-20

-10

0

10

20

30

40

All

Meth

od

Diffe

rence (

pm

ol/L)

Concentration (pmol/L)


P-BA1FS1A (ABC1)

0 200 400 600 800 1000 1200 1400

-100-80-60-40-20

020406080

100

C s

core

Distribution


P-ABCCR (ABC1)

442 443 444 445 446 447 448 449 450 451 452 453

0

10

20

30

40

All

Meth

od

Specim

en %

bia

s



P-BA1FS1P (ABC1)

0 200 400 600 800 1000 1200 1400

-40

-30

-20

-10

0

10

20

30

40

B s

core

C score

Oestradiol [E2] B score is +51.2 and C score is 48.5Your method is Beckman Access/Dxi

P-ABCPENR (ABC1)

0 10 20 30 40

-40

-30

-20

-10

0

10

20

30

40


Specim

en A

ccura

cy Index



P-YSTMOD (ABC1)

0 200 400 600 800 1000 1200 1400

0

50

100

150

200

250

300 ALTMMLTM

CV

%


Oestradiol [E2] Between-laboratory agreementBeckman Access/Dxi

P-PROFILE (ABC1)

0 200 400 600 800 1000 1200 1400

0

10

20

30

40

50

of 60

Date : 05-Jun-2018

Analyte : Oestradiol [high-level] (pmol/L)

Page 29


Distribution : 453

Laboratory :




HE219453B

PoolSpec.

453D

Pool HE199 [F] + 8352 pmol/L Oestradiol


Pooled pregnancy serumNormal serum [F]Normal serum [F]HE220

HE210453A

453C

HE198 14.7

The B limit is +/-

Your B score is

The A limit is15.0

216

15.0


The C limit is

200

Your C score is


Spe

453 Date : 05-Jun-2018 Feedback - Birmingham Quality · 2021. 1. 29. · H454 453E 3.15 P481 19.5...

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Transcript of 453 Date : 05-Jun-2018 Feedback - Birmingham Quality · 2021. 1. 29. · H454 453E 3.15 P481 19.5...