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31764

PHARMACEUTICALS HAVING DOTTED ACTIVE INGREDIENTS

AND A METHOD AND APPARATUS FOR THE

PREPARATION THEREOF

Gunther Voss, Peter Gruber, Diessen, Federal Republic Of Germany assigned to Boehringer Ingelheim G m b H

w 1 9

A method for the preparation of pharma- ceuticals which comprises using a piezoelectric dosing system to dot liquid, dissolved or suspen- ded active substance onto a pharmaceutical car- rier.

4479942

TETRAHYDROFURNAN- CARBOXYLIC ACID

DERIVATIVES, PROCESSESOR PREPARATION THEREOF AND

PHARMACEUTICAL COMPOSITIONS THEREOF

Michio Yamashita, Tadaaki Komori , Junji Hosoda, Yoshio Kawai, Itsuo Uchida, Masanobu Kohsaka, Hiroshi Imanaka, Kazuo Sakane, Hiroyuki Setoi, Tsutomu Teraji, Takarazuka, Japan assigned to Fujisawa Pharmaceutical Co Ltd

H H

R3 N ~ N

N ~ . - - / R I

This invention relates to tetrahydrofuran- carboxylic acid derivatives, of antimicrobial ac- tivity, of the formula: See Patent for Chemical Structure wherein R1 is amino or a protected amino group, R2 is amino or acylamino and R3 is carboxy or a protected carboxy group or a pharmaceutically acceptable salt thereof.

4479943

3-DEMETHOXYISTAMYCIN B, THE 2"-N-FORMIMIDOYL

DERIVATIVE THEREOF AND PHARMACEUTICAL

COMPOSITION CONTAINING SAME

Hamao Umezawa, Shinichi Kondo, Daishiro Ikeda, Tokyo, Japan assigned to Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

6' O)

H3CN~ I~, ~ , . .~ O H2N..~ !

3' H2 N \ O ~ 3

I|3CN I COCH2NUR

As new compounds are provided 3- demethoxyistamycin B and 3-demethoxy-2"-N- formimidoylistamycin B which each is useful as