42nd AnnuAl PSYCHOPHARMACOLOGYmedia-ns.mghcpd.org.s3.amazonaws.com/psychopharm2018/2018... ·...

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42nd AnnuAl PSYCHOPHARMACOLOGY

Jerrold F. Rosenbaum, MDPsychiatrist-in-Chief Massachusetts General Hospital Stanley Cobb Professor of Psychiatry Harvard Medical School

Course DireCtors:

ThursdAy-sundAy, OcTOber 18-21, 2018Westin Copley Place • 10 Huntington Ave., Boston, MA

Maurizio Fava, MDDirector, Division of Clinical Research of the MGH Research Institute Executive Vice Chair, Department of Psychiatry Executive Director, Clinical Trials Network & Institute (CTNI) Massachusetts General Hospital Associate Dean for Clinical & Translational Research Slater Family Professor of Psychiatry Harvard Medical School

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42nd AnnuAl PsychOPhArmAcOlOgyThursday–sunday • OcTOber 18-21, 2018

WesTin cOpley place • 10 hunTingTOn ave., bOsTOn, Ma

WELCOMEOn behalf of the entire Massachusetts General Hospital Department of Psychiatry, we are proud to welcome you to the 42nd Annual Psychopharmacology Conference.

Over the years this event has educated thousands of professionals on the latest advances in mental health.During each session, we ask our faculty to share their experience in both clinical research and patient care. This unique perspective as clinician-researchers helps mold standards of care in mental health. They review the latest data from clinical trials and new studies. They also highlight effective pharmacologic and behavioral interventions for an array of mental health conditions. Specific sessions cover anxiety, ADHD, depression, bipolar disorder, eating disorders, OCD, psychosis, PTSD, substance use, and much more.

We encourage you to ask questions during panel discussions. Take advantage of curbside consultations to discuss cases face-to-face. Network and share ideas with colleagues who join us from across the United States and around the world.

Thank you for joining us in Boston this year..

Jerrold F. Rosenbaum, MD Maurizio Fava, MD

TARGET AUDIENCEThe target audience for this event is Psychiatrists, Psychologists, General and Family Practice Physicians, Psychiatric Nurses, Physician Assistants, Nurse Practitioners and Social Workers.

COMPLIMENTARY BREAKFAST AND COFFEE BREAKSComplimentary breakfast and coffee breaks will be available to course participants. Please note that lunch and dinner will be on your own.

EVALUATION FORMS/CME/CEU CERTIFICATES Every participant needs to complete the activity evaluation online to claim CME/CEU credits for this course. Please refer to the Evaluation and CME Information document in this syllabus for more information. We strongly encourage you to complete the evaluation, even if you do not require a certificate. Your comments are important to us as we plan future programs. The link to claim credit is as follows: www.mghcme.org/psychopharmQUESTIONSOpportunity for questions will be provided at the end of each module during the panel discussion. Please write your questions on the index cards provided. Cards will be collected during the last 15 minutes of the lecture prior to the start of the panel discussion. Experience has shown that this method is preferable to that of spontaneous questions.

COPYRIGHTThe course materials and PowerPoint presentations are copyright protected by Massachusetts General Hospital, Department of Psychiatry, Division of Postgraduate Education, the faculty members and the appropriate authors. Videotaping and audiotaping are not allowed. Thank you for your cooperation.

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CELLULAR TELEPHONES & PAGERSDuring the lectures, we ask that you turn your cell phones and pagers to vibrate or off. We also ask that you do not talk on your cell phones inside the meeting room. Thank you for your cooperation.

CONTACT INFORMATIONFor questions or comments, please contact MGH Psychiatry Academy member services at 866-644-7792 or [email protected].

LEARNING OBJECTIVESAt the end of this educational activity, participants should be able to:

Identify rational, evidence-based pharmacologic and non-pharmacologic therapies for patients with unipolar, bipolar, treatment-resistant, and post-partum depression. Assess obstacles to maintenance of long-term recovery and the liability issues associated with psychopharmacology. Discuss diagnostic and evidenced-based treatment strategies for pediatric onset mood disorders. Compare the neurobiology and evidence-based treatment approaches to addiction, anxiety, schizophrenia, and mood

disorders. Review the course and treatment of psychiatric disorders during pregnancy and menopause. Recognize psychosocial issues and evidence-based treatment modalities for eating and sleep disorders. Analyze drug interactions and the pharmacotherapy of adult ADHD and geriatric disorders.

ACCREDITATION This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of McLean Hospital and Massachusetts General Hospital. McLean Hospital is accredited by the ACCME to provide continuing medical education for physicians.

McLean Hospital designates this live activity for a maximum of 29.50 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

PSYCHOLOGISTSThe Massachusetts General Hospital Department of Psychiatry is approved by the American Psychological Association to sponsor continuing education (CE) for psychologists. The Massachusetts General Hospital Department of Psychiatry maintains responsibility for this program and its content. This offering meets the criteria for 29.50 Continuing Education (CE) credits for psychologists.

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REGISTERED NURSESThis program meets the requirements of the Massachusetts Board of Registration in Nursing (244 CMR 5.00) for 29.50 contact hours of nursing continuing education credit. Advance practice nurses, please note: Educational activities which meet the requirements of the ACCME (such as this activity) count towards 50% of the nursing requirement for ANCC accreditation.

SOCIAL WORKERSThe Collaborative of NASW, Boston College, and Simmons College Schools of Social Work authorizes social work continuing education credits for courses, workshops, and educational programs that meet the criteria outlined in 258 CMR of the Massachusetts Board of Registration of Social Workers.

This program has been approved for 24.50 Social Work Continuing Education hours for relicensure, in accordance with 258 CMR. Collaborative of NASW and the Boston College and Simmons Schools of Social Work Authorization Number D80039-2.

Other CE Licenses: Other Providers can claim a Participation Certificate upon successful completion of this course. Participation Certificates will specify the title, location, type of activity, date of activity, and number of AMA PRA Category 1 Credits™ associated with the activity. Providers should check with their regulatory agencies to determine ways in which AMA PRA Category 1 Credits™ may or may not fulfill continuing education requirements. Providers should also consider saving copies of brochures, agenda, and other supporting documents.

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THURSDAY, OCTOBER 18, 2018

4:00 – 8:00PM Law and Psychiatry THIS IS A TICKETED EVENT, DINNER SERVED Ronald Schouten, MD, JD, Matthew P. Lahaie, MD, JD, Marilyn Price, MD

4:00 – 8:00PM Psychosomatic Medicine THIS IS A TICKETED EVENT, DINNER SERVED Theodore A. Stern, MD, Christopher M. Celano, MD, Nicholas Kontos, MD,

Felicia A. Smith, MD

4:00 – 8:00PM Eating Disorders THIS IS A TICKETED EVENT, DINNER SERVED Kamryn T. Eddy, PhD, Elizabeth Lawson, MD, Franziska Plessow, PhD,

Lazaro Zayas, MD

FRIDAY, OCTOBER 19, 2018

7:00 – 8:00AM Registration & Continental Breakfast

8:00 – 8:15AM Welcome Maurizio Fava, MD

8:15 – 8:30AM Introduction and Overview Jerrold F. Rosenbaum, MD

MODULE TOPIC – MOOD DISORDERS

8:30 – 9:15AM Bipolar Depression Andrew A. Nierenberg, MD

9:15 – 10:00AM Bipolar Long-Term Management Roy H. Perlis, MD, MSc

10:00 – 10:15AM Coffee Break

10:15 – 11:00AM Treatment Resistant Depression Maurizio Fava, MD

11:00 – 12:00PM Panel Discussion Moderator: Jerrold F. Rosenbaum, MD Panelists: Andrew A. Nierenberg, MD, Roy H. Perlis, MD, MSc, Maurizio Fava, MD

12:00 – 1:00PM Lunch (on your own)

MODULE TOPIC – ANXIETY/OCD

1:00 – 1:45PM OCD Michael A. Jenike, MD

PROGRAM AGENDA

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1:45 – 2:30PM PTSD Kerry J. Ressler, MD, PhD

2:30 – 3:15PM Anxiety Disorders and Treatments Naomi M. Simon, MD, MSc

3:15 – 3:30PM Coffee Break

3:30 – 4:10PM Obsessive-Compulsive Related Disorders Lisa M. Zakhary, MD, PhD

4:10 – 4:40PM CBT for OCD Sabine Wilhelm, PhD

4:40 – 5:30PM Panel Discussion Moderator: Michael A. Jenike, MD Panelists: Kerry J. Ressler, MD, PhD, Naomi M. Simon, MD, MSc, Lisa M. Zakhary, MD, PhD, Sabine Wilhelm, PhD

5:30 – 6:30PM Dinner (on your own)

6:30 – 7:30PM Friday Evening Seminars (please pick two): 7:30 – 8:30PM Seminars begin at 6:30PM and repeat at 7:30PM.

Natural Medications for Psychiatric Disorders David Mischoulon, MD, PhD (Independence A-B, 4th Floor)

Suicide Theodore A. Stern, MD (St. George A, 3rd Floor)

The Neurobiology of Addiction Jodi Gilman, PhD (St. George B, 3rd Floor)

Psychopharmacology of Sleep Disorders John W. Winkelman, MD, PhD (America Ballroom, 4th Floor)

The Neurobiology of Mood and Psychotic Disorders Daphne J. Holt, MD, PhD (St. George C, 3rd Floor)

Cognitive-Behavioral Therapy to Augment Psychopharmacological Therapy Michael W. Otto, PhD (St. George D, 3rd Floor)

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SATURDAY, OCTOBER 20, 2018

7:00 – 8:00AM Continental Breakfast

8:00 – 8:15AM Welcoming Remarks David H. Rubin, MD

MODULE TOPIC – PSYCHOSIS

8:15 – 9:00AM First-Episode Psychosis and Schizophrenia Oliver Freudenreich, MD, FAPM

9:00 – 9:45AM Rapid Treatments for Psychiatric Disorders Cristina Cusin, MD


10:00 – 10:45AM Management of Side-Effects of Antipsychotics Oliver Freudenreich, MD, FAPM

10:45 – 11:45AM Panel Discussion Moderator: David H. Rubin, MD Panelists: Oliver Freudenreich, MD, FAPM, Cristina Cusin, MD


MODULE TOPIC – NEW THERAPIES: WHAT IS ON THE HORIZON?

1:00 – 1:45PM Stimulation and/or Surgical Approaches to Psychiatric Illness Darin D. Dougherty, MD, MMSc

1:45 – 2:30PM New Treatments for Schizophrenia Oliver Freudenreich, MD, FAPM


2:45 – 3:30PM New Treatments for Mood Disorders Michael E. Henry, MD

3:30 – 4:15PM What is New in Addiction? John F. Kelly, PhD

4:15 – 5:15PM Panel Discussion Moderator: Michael E. Henry, MD Panelists: Oliver Freudenreich, MD, FAPM, John F. Kelly, PhD

5:15 – 6:30PM Dinner (on your own)

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6:30 – 7:30PM Saturday Evening Seminars (please pick one): Seminars begin at 6:30PM and do not repeat.

Violence Risk Assessment in Clinical Practice Ronald Schouten, MD, JD, Lieutenant Frederick Cabral (Independence A-B, 4th Floor)

Geriatrics Feyza E. Marouf, MD (America Ballroom, 4th Floor)

Traumatic Brain Injury: A Neuropsychiatric Perspective Kaloyan S. Tanev, MD (St. George A-B, 3rd Floor)

Illuminating the Black Box: Antidepressants, Youth and Suicide David H. Rubin, MD (Great Republic, 7th Floor)

PMDD and Depression During the Menopausal Transition: New Insights Laura Petrillo, MD (Empire, 7th Floor)

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SUNDAY, OCTOBER 21, 2018

7:00 – 7:45AM Continental Breakfast

7:45- 8:00AM Welcoming Remarks David H. Rubin, MD

MODULE TOPIC – ADDICTION

8:00 – 8:45AM Tobacco and Cocaine A. Eden Evins, MD, MPH

8:45 – 9:30AM Alcohol and Opiates John A. Renner, MD

9:30 – 10:00AM Panel Discussion Moderator: David H. Rubin, MD Panelists: A. Eden Evins, MD, MPH, John A. Renner, MD


MODULE TOPIC – WOMEN’S HEALTH

10:15 – 11:00AM Course and Treatment of Mood and Anxiety Disorders During Pregnancy Lee S. Cohen, MD

11:00 – 11:45AM Postpartum Mood Disorders Marlene P. Freeman, MD

11:45 – 12:15PM Panel Discussion Moderator: David H. Rubin, MD Panelists: Lee S. Cohen, MD, Marlene P. Freeman, MD


MODULE TOPIC – ACROSS THE LIFESPAN

1:15 – 2:00PM Pediatric Bipolar Disorder and Mood Disorders Janet Wozniak, MD

2:00 – 2:45PM ADHD Joseph Biederman, MD


3:00 – 3:45PM Drug Interactions Jonathan E. Alpert, MD, PhD

3:45 – 4:15PM Panel Discussion Moderator: Joseph Biederman, MD Panelists: Jonathan E. Alpert, MD, Janet Wozniak, MD

4:15PM Adjourn

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FACULTY

Jane Pimental, MPHManaging DirectorMassachusetts General Hospital Psychiatry Academy

David H. Rubin, MD (Reviewer)Director, Child and Adolescent Psychiatry Residency TrainingMassachusetts General Hospital and McLean HospitalDirector, Postgraduate Medical Education, Department of PsychiatryExecutive Director, Massachusetts General Hospital Psychiatry AcademyMassachusetts General Hospital

Susan Sprich, PhD (Psychologist Reviewer)Director, Postgraduate Psychology EducationDirector, Cognitive Behavioral Therapy ProgramMassachusetts General HospitalAssistant Professor of PsychologyHarvard Medical School

Maurizio Fava, MD (Course Director)Director, Division of Clinical Research of the MGH Research InstituteExecutive Vice Chair, Department of PsychiatryExecutive Director, Clinical Trials Network & Institute (CTNI)Associate Dean for Clinical & Translational Research Massachusetts General HospitalSlater Family Professor of PsychiatryHarvard Medical School

Jerrold F. Rosenbaum, MD (Course Director)Psychiatrist-in-Chief Massachusetts General HospitalStanley Cobb Professor of Psychiatry Harvard Medical School

PLANNERS & COURSE DIRECTORS

SPEAKERSJonathan E. Alpert, MD, PhD

Dorothy and Marty Silverman University Professor and ChairDepartment of Psychiatry and Behavioral ScienceProfessor of Psychiatry, Neuroscience and PediatricsPsychiatrist-in-ChiefMontefiore Medical CenterAlbert Einstein College of Medicine

Joseph Biederman, MDChief, Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD Director, Bressler Program for Autism Spectrum Disorder Massachusetts General Hospital Professor of Psychiatry Harvard Medical School

Lieutenant Frederick Cabral Cambridge Police DepartmentFamily & Social Justice Unit

Christopher M. Celano, MDAssociate Director, Cardiac Psychiatry Research ProgramAssistant PsychiatristMassachusetts General HospitalAssistant Professor of PsychiatryHarvard Medical School

Lee S. Cohen, MDDirector, Ammon-Pinizzotto Center for Women’s Mental HealthPerinatal and Reproductive Psychiatry Clinical Research ProgramMassachusetts General HospitalEdmund and Carroll Carpenter Professor of Psychiatry Harvard Medical School

Cristina Cusin, MDStaff Psychiatrist, Depression Clinical and Research ProgramMassachusetts General HospitalAssistant Professor Harvard Medical School

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Darin D. Dougherty, MD MMScDirector, Division of NeurotherapeuticsDepartment of PsychiatryMassachusetts General HospitalAssociate Professor of PsychiatryHarvard Medical School

Kamryn T. Eddy, PhDCo-Director, Eating Disorders Clinical and Research ProgramMassachusetts General HospitalAssociate Professor of Psychology (Psychiatry)Harvard Medical School

A. Eden Evins, MD, MPHDirector, Center for Addiction MedicineMassachusetts General HospitalWilliam Cox Family Professor of Psychiatry in the Field of Addiction MedicineHarvard Medical School

Maurizio Fava, MD (Course Director)Director, Division of Clinical Research of the MGH Research InstituteExecutive Vice Chair, Department of PsychiatryExecutive Director, Clinical Trials Network & Institute (CTNI)Associate Dean for Clinical & Translational Research Massachusetts General HospitalSlater Family Professor of PsychiatryHarvard Medical School

Marlene P. Freeman, MDAssociate Director, Perinatal and Reproductive PsychiatryClinical Research Program, Massachusetts General HospitalAssociate Professor of Psychiatry, Harvard Medical School

Oliver Freudenreich, MD, FAPMCo-Director, MGH Schizophrenia Clinical and Research ProgramMassachusetts General HospitalAssociate Professor of PsychiatryHarvard Medical School

Jodi Gilman, PhDAssociate Professor, Harvard Medical SchoolCenter for Addiction MedicineMassachusetts General Hospital

Michael E. Henry, MDMedical Director, Bipolar Clinic and Research ProgramDirector, Somatic TherapyMassachusetts General Hospital

Daphne J. Holt, MD, PhDCo-director, Schizophrenia Clinical and Research ProgramMassachusetts General HospitalAssociate Professor, Harvard Medical School

Michael A. Jenike, MDFounder, OCD Clinic, Massachusetts General HospitalFounder, Massachusetts General Hospital/ McLean Hospital OCD InstituteProfessor of Psychiatry, Harvard Medical School

John F. Kelly, PhDFounder and Director, Recovery Research InstituteProgram Director, Addiction Recovery Management Service (ARMS)Associate Director, Center for Addiction MedicineMassachusetts General HospitalElizabeth R. Spallin Associate Professor of Psychiatry in Addiction MedicineHarvard Medical School

Nicholas Kontos, MD Director, Fellowship in Consultation-Liaison PsychiatryMassachusetts General Hospital Assistant Professor of PsychiatryHarvard Medical School

Matthew Lahaie, MD, JDMedical Director, Maine Office of Child and Family ServicesMaine Department of Health and Human Services, MGH VisitingMedical Director, Massachusetts General Hospital Children and the Law ProgramStaff Psychiatrist, Massachusetts General Hospital Law & Psychiatry ServiceAssistant in Psychiatry, Massachusetts General HospitalInstructor in Psychiatry, Harvard Medical School

Elizabeth A. Lawson, MD, MMScDirector, Interdisciplinary Oxytocin Research Program Physician, Neuroendocrine Clinical Center, Neuroendocrine Unit Massachusetts General Hospital Associate Professor of MedicineHarvard Medical School

Feyza E. Marouf, MDProgram Director, Partners HealthCare Geriatric Psychiatry FellowshipAssistant Psychiatrist, Massachusetts General HospitalInstructor in Psychiatry, Harvard Medical School

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David Mischoulon, MD, PhDDirector, Depression Clinical and Research ProgramMassachusetts General HospitalProfessor of Psychiatry, Harvard Medical School

Andrew A. Nierenberg, MDThomas P. Hackett, MD, Endowed Chair in Psychiatry at MGHDirector, Dauten Family Center for Bipolar Treatment InnovationDirector, Training and Education, MGH Research InstituteMassachusetts General HospitalProfessor of Psychiatry, Harvard Medical School

Michael W. Otto, PhDProfessor, Department of Psychological and Brain SciencesBoston University

Roy H. Perlis, MD, MScDirector, Center for Quantitative HealthDivision of Clinical Research and Center for Genomic MedicineMassachusetts General HospitalProfessor of PsychiatryHarvard Medical School

Laura F. Petrillo, MD Director of Training, The Ammon-Pinizzotto Center for Women’s Mental HealthMassachusetts General HospitalInstructor, PsychiatryHarvard Medical School

Franziska Plessow, PhDInstructor in Medicine, Harvard Medical SchoolInstructor in Investigation, Neuroendocrine UnitMassachusetts General Hospital

Marilyn Price, MDAssistant ProfessorDepartment of Psychiatry Harvard Medical School

John A. Renner, MDAssociate Chief of Psychiatry, Boston VA Healthcare SystemConsultant, Department of Psychiatry, Massachusetts General HospitalProfessor of Psychiatry, Boston University School of MedicinePast-President, American Academy of Addiction Psychiatry

Kerry J. Ressler, MD, PhDChief Scientific OfficerJames and Patricia Poitras Chair in PsychiatryChief, Division of Depression & Anxiety DisordersMcLean HospitalProfessor of Psychiatry, Harvard Medical School

Jerrold F. Rosenbaum, MD (Course Director)Psychiatrist-in-Chief, Massachusetts General HospitalStanley Cobb Professor of Psychiatry, Harvard Medical School

David H. Rubin, MD Director, Child and Adolescent Psychiatry Residency TrainingMassachusetts General Hospital and McLean HospitalDirector, Postgraduate Medical Education, Department of PsychiatryExecutive Director, Massachusetts General Hospital Psychiatry AcademyMassachusetts General Hospital

Ronald Schouten, MD, JDDirector, Law & Psychiatry Service Massachusetts General Hospital Associate Professor of Psychiatry Harvard Medical School

Naomi M. Simon, MD, MScProfessor, Department of Psychiatry, Director, Anxiety and Complicated Grief ProgramSenior Advisor, Steven A. Cohen Military Family ClinicNew York University Langone HealthDirector, Center for Anxiety and Traumatic Stress DisordersDirector, Complicated Grief ProgramMassachusetts General Hospital

Felicia A. Smith, MD Associate Chief of Psychiatry, Division of Psychiatry and Medicine Chief of the Avery D. Weissman, MD Consultation Psychiatry Service Massachusetts General Hospital Assistant Professor of Psychiatry Harvard Medical School

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Theodore A. Stern, MDChief Emeritus, Avery D. Weisman Psychiatry Consultation ServiceDirector, Thomas P. Hackett Center for Scholarship in Psychosomatic MedicineDirector, Office for Clinical CareersMassachusetts General HospitalNed H. Cassem Professor of Psychiatry in the field of Psychosomatic Medicine/ConsultationHarvard Medical SchoolEditor-in-Chief, Psychosomatics

Kaloyan S. Tanev, MDDirector of Clinical Neuropsychiatry ResearchMedical Director, Home Base Program Outpatient ClinicMassachusetts General HospitalAssistant Professor of Psychiatry Harvard Medical School

Sabine Wilhelm, PhDChief of Psychology, Massachusetts General HospitalDirector, Obsessive-Compulsive and Related Disorders ProgramMassachusetts General Hospital and Harvard Medical SchoolProfessor of Psychology, Harvard Medical School

John W. Winkelman, MD, PhDChief, Sleep Disorders Clinical Research ProgramDepartments of Psychiatry and NeurologyMassachusetts General HospitalProfessor of PsychiatryHarvard Medical School

Janet Wozniak, MDChair, Quality and Safety, Department of PsychiatryDirector, Child and Adolescent Psychiatry Outpatient ServiceDirector, Pediatric Bipolar Disorder Clinical and Research ProgramMassachusetts General HospitalAssociate Professor of Psychiatry, Harvard Medical School

Lisa M. Zakhary, MD, PhDCo-Director of Psychopharmacology, OCD and Related Disorders ProgramDirector of Psychopharmacology, Excoriation Clinic and Research UnitMassachusetts General Hospital

Lazaro V. Zayas, MDStaff psychiatrist, Child, Adolescent, & Adult PsychiatryAttending Psychiatrist, Eating Disorders Clinical and Research ProgramMassachusetts General Hospital Instructor in Psychiatry, Part-TimeHarvard Medical School

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FACULTY DISCLOSURE STATEMENTS

FACULTY DISCLOSURE STATEMENTS In accord with the disclosure policy of McLean Hospital as well as guidelines set forth by the Accreditation Council on Continuing Medical Education, all people in control of educational content, including speakers, course directors, planners, and reviewers, have been asked to disclose all relevant financial relationships with commercial interests of both themselves and their spouses/partners over the past 12 months, as defined below:

Commercial InterestThe ACCME defines a “commercial interest” as any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients. The ACCME does not consider providers of clinical service directly to patients to be commercial interests. For more information, visit www.accme.org.

Financial relationshipsFinancial relationships are those relationships in which the individual benefits by receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest, excluding diversified mutual funds), or other financial benefit. Financial benefits are usually associated with roles such as employment, management position, independent contractor (including contracted research), consulting, speaking and teaching, membership on advisory committees or review panels, board membership, and other activities from which remuneration is received, or expected. ACCME considers relationships of the person involved in the CME activity to include financial relationships of a spouse or partner.

Relevant financial relationships ACCME focuses on financial relationships with commercial interests in the 12-month period preceding the time that the individual is being asked to assume a role controlling content of the CME activity. ACCME has not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship. The ACCME defines “relevant’ financial relationships” as financial relationships in any amount occurring within the past 12 months that create a conflict of interest.

Conflict of InterestCircumstances create a conflict of interest when an individual has an opportunity to affect CME content about products or services of a commercial interest with which he/she has a financial relationship.

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The following planners, speakers, and content reviewers, on behalf of themselves and their spouse or partner, have reported financial relationships with an entity producing, marketing, re-selling, or distributing health care goods or services (relevant to the content of this activity) consumed by, or used on, patients:

NAME COMPANY RELATIONSHIPJonathan E. Alpert, MD, PhD American Society of Clinical Psychopharmacology, American

Psychiatric Association, LIJ/Zucker-Hillside, Nevada Psychiatric Association, New York University, North Shore Medical Center, Primedia, Psicofarma, Reed Medical Education, University of Louisville, Xian-Janssen

Honoraria (Speaker)

Belvoir Publishing, Marcel Dekker, Institut la Conference Hippocrate

Royalties

Consulting Medical Associates, Luye Pharmaceuticals, PamLab LLC, Pharmavite

Consultant Fees

Abbott Labs, Alkermes, Aspect Medical Systems, Astra-Zeneca, Bristol-Myers Squibb, Cephalon, Eli Lilly & Co., Forest Pharmaceuticals, GlaxoSmithKline, J&J Pharmaceuticals, Lichtswer Pharma, Lorex Pharmaceuticals, NARSAD, NIH, Novartis, Organon, Otsuka, PamLab LLC, PCORI, Pharmavite, Roche Laboratories, Solvay Pharma, Sanofi/Synthelabo, Wyeth-Ayerst Laboratories

Research Support

Joseph Biederman, MD Headspace Inc., Lundbeck AS, Neurocentria Inc., Pfizer Pharmaceuticals, Roche TCRC Inc., Shire Pharmaceuticals Inc., Sunovion Pharmaceuticals Inc., PamLab

Research Support, (Researcher)

Aevi Genomics, Akili, Guidepoint, Ironshore, Medgenics, Piper Jaffray

Consultant Fees (Consultant)

Alcobra, Shire, Akili Scientific Advisory BoardAvekshan LLC Financial Interest reviewed and

are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies.

Christopher Celano, MD Sunovion Pharmaceuticals Honorarium (Lecture on a topic unrelated to this lecture)

Lee S. Cohen, PhD Alkermes Biopharmaceuticals; Forest/Actavis Pharmaceuticals; Otsuka Pharmaceuticals; Sunovion Pharmaceuticals, Inc.; Teva Pharmaceuticals

Research Support National Pregnancy Registry for Atypical Antipsychotics

Brain & Behavior Research Foundation; JayMac Pharmaceuticals; National Institute on Aging; National Institutes of Health; SAGE Therapeutics

Other research support

Alkermes Biopharmaceuticals; Praxis Precision Medicines, Inc. Advisory/Consulting (through MGH Clinical Trials Network Initiative)

Cristina Cusin, MD Janssen Advisory Board – One TimeBoehringer Lecture FeeTakeda Advisory Board – One TimePCT/US15/56192; 070919.00032 Acyliccucurbit[N]uril type molecular containers to treat intoxication and substance abuse

Royalty/Patent

Darin D. Dougherty, MD, MMSc Medtronic, LivaNova Research GrantKamryn T. Eddy, PhD Cambridge University Press Future royalties, book; Advance

(Author)Park Nicollet Clinic, Minnesota Speaker Fee (Training in CBT

for ARFID)

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NAME COMPANY RELATIONSHIPA. Eden Evins, MD, MPH Alkermes Inc Advisory Board (Consulting

Fee)Ethismos Consultant (No Fee)Karuna Inc. Leader Data Safety Monitoring

Board (Consulting Fee)Brain Solutions, LLC Research Support (Salary to

MGH)Maurizio Fava, MD Abbott Laboratories; Acadia Pharmaceuticals; Alkermes, Inc.;

American Cyanamid;Aspect Medical Systems; AstraZeneca; Avanir Pharmaceuticals; AXSOME Therapeutics; Biohaven; BioResearch; BrainCells Inc.; Bristol-Myers Squibb; CeNeRx BioPharma; Cephalon; Cerecor; Clarus Funds; Clintara, LLC; Covance; Covidien; Eli Lilly and Company;EnVivo Pharmaceuticals, Inc.; Euthymics Bioscience, Inc.; Forest Pharmaceuticals, Inc.; FORUM Pharmaceuticals; Ganeden Biotech, Inc.; GlaxoSmithKline; Harvard Clinical Research Institute; Hoffman-LaRoche; Icon Clinical Research; i3 Innovus/Ingenix; Janssen R&D, LLC; Jed Foundation; Johnson & Johnson Pharmaceutical Research & Development; Lichtwer Pharma GmbH; Lorex Pharmaceuticals; Lundbeck Inc.; Marinus Pharmaceuticals; MedAvante; Methylation Sciences Inc; National Alliance for Research on Schizophrenia & Depression (NARSAD); National Center for Complementary and Alternative Medicine (NCCAM);National Coordinating Center for Integrated Medicine (NiiCM); National Institute of Drug Abuse (NIDA); National Institute of Mental Health (NIMH); Neuralstem, Inc.; NeuroRx; Novartis AG; Organon Pharmaceuticals; Otsuka Pharmaceutical Development, Inc.; PamLab, LLC.; Pfizer Inc.; Pharmacia-Upjohn; Pharmaceutical Research Associates., Inc.; Pharmavite® LLC; PharmoRx Therapeutics; Photothera; Reckitt Benckiser; Roche Pharmaceuticals; RCT Logic, LLC (formerly Clinical Trials Solutions, LLC); Sanofi-Aventis US LLC; Shire; Solvay Pharmaceuticals, Inc.; Stanley Medical Research Institute (SMRI); Synthelabo; Taisho Pharmaceuticals; Takeda Pharmaceuticals; Tal Medical; VistaGen; Wyeth-Ayerst Laboratories

Research Support

Adamed, Co; Advanced Meeting Partners; American Psychiatric Association; American Society of Clinical Psychopharmacology; AstraZeneca; Belvoir Media Group; Boehringer Ingelheim GmbH; Bristol-Myers Squibb; Cephalon, Inc.; CME Institute/Physicians Postgraduate Press, Inc.; Eli Lilly and Company; Forest Pharmaceuticals, Inc.; GlaxoSmithKline; Imedex, LLC; MGH Psychiatry Academy/Primedia; MGH Psychiatry Academy/Reed Elsevier; Novartis AG; Organon Pharmaceuticals; Pfizer Inc.; PharmaStar; United BioSource,Corp.; Wyeth-Ayerst Laboratories.

Speaking & Publishing

Compellis; PsyBrain, Inc. Equity Holdings

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NAME COMPANY RELATIONSHIPPatents for Sequential Parallel Comparison Design (SPCD), licensed by MGH to Pharmaceutical Product Development, LLC (PPD) (US_7840419, US_7647235, US_7983936, US_8145504, US_8145505); and patent application for a combination of Ketamine plus Scopolamine in Major Depressive Disorder (MDD), licensed by MGH to Biohaven. Patents for pharmacogenomics of Depression Treatment with Folate (US_9546401, US_9540691).

Royalties, Patents

for the MGH Cognitive & Physical Functioning Questionnaire (CPFQ), Sexual Functioning Inventory (SFI), Antidepressant Treatment Response Questionnaire (ATRQ), Discontinuation-Emergent Signs & Symptoms (DESS), Symptoms of Depression Questionnaire (SDQ), and SAFER; Lippincott, Williams & Wilkins; Wolkers Kluwer; World Scientific Publishing Co. Pte.Ltd.

Copyrights

Abbott Laboratories; Acadia; Affectis Pharmaceuticals AG; Alkermes, Inc.; Amarin Pharma Inc.; Aspect Medical Systems; AstraZeneca; Auspex Pharmaceuticals; Avanir Pharmaceuticals; AXSOME Therapeutics; Bayer AG; Best Practice Project Management, Inc.; Biogen; BioMarin Pharmaceuticals, Inc.; Biovail Corporation; Boehringer Ingelheim; Boston Pharmaceuticals; BrainCells Inc; Bristol-Myers Squibb; CeNeRx BioPharma; Cephalon, Inc.; Cerecor; CNS Response, Inc.; Compellis Pharmaceuticals; Cypress Pharmaceutical, Inc.; DiagnoSearch Life Sciences (P) Ltd.; Dinippon Sumitomo Pharma Co. Inc.; Dov Pharmaceuticals, Inc.; Edgemont Pharmaceuticals, Inc.; Eisai Inc.; Eli Lilly and Company; EnVivo Pharmaceuticals, Inc.; ePharmaSolutions; EPIX Pharmaceuticals, Inc.; Euthymics Bioscience, Inc.; Fabre-Kramer Pharmaceuticals, Inc.; Forest Pharmaceuticals, Inc.; Forum Pharmaceuticals; GenOmind, LLC; GlaxoSmithKline; Grunenthal GmbH; Indivior; i3 Innovus/Ingenis; Intracellular; Janssen Pharmaceutica; Jazz Pharmaceuticals, Inc.; Johnson & Johnson Pharmaceutical Research & Development, LLC; Knoll Pharmaceuticals Corp.; Labopharm Inc.; Lorex Pharmaceuticals; Lundbeck Inc.; Marinus Pharmaceuticals; MedAvante, Inc.; Merck & Co., Inc.; MSI Methylation Sciences, Inc.; Naurex, Inc.; Navitor Pharmaceuticals, Inc.; Nestle Health Sciences; Neuralstem, Inc.; Neuronetics, Inc.; NextWave Pharmaceuticals; Novartis AG; Nutrition 21; Orexigen Therapeutics, Inc.; Organon Pharmaceuticals; Osmotica; Otsuka Pharmaceuticals; Pamlab, LLC.; Pfizer Inc.; PharmaStar; Pharmavite® LLC.; PharmoRx Therapeutics; Praxis Precision Medicines; Precision Human Biolaboratory; Prexa Pharmaceuticals, Inc.; PPD; Purdue Pharma; Puretech Ventures; PsychoGenics; Psylin Neurosciences, Inc.; RCT Logic, LLC ( formerly Clinical Trials Solutions, LLC); Relmada Therapeutics, Inc.; Rexahn Pharmaceuticals, Inc.; Ridge Diagnostics, Inc.; Roche; Sanofi-Aventis US LLC.; Sepracor Inc.; Servier Laboratories; Schering-Plough Corporation; Shenox Pharmaceuticals; Solvay Pharmaceuticals, Inc.; Somaxon Pharmaceuticals, Inc.; Somerset Pharmaceuticals, Inc.; Sunovion Pharmaceuticals; Supernus Pharmaceuticals, Inc.; Synthelabo; Taisho Pharmaceuticals; Takeda Pharmaceutical Company Limited; Tal Medical, Inc.; Tetragenex; Teva Pharmaceuticals; TransForm Pharmaceuticals, Inc.; Transcept Pharmaceuticals, Inc.; Usona Institute,Inc.; Vanda Pharmaceuticals, Inc.; Versant Venture Management, LLC; VistaGen

Advisory Board/Consultant

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NAME COMPANY RELATIONSHIPMarlene P. Freeman, MD JayMac, Sage Investigator Initiated Trials

(Research)Otsuka, Alkermes Advisory BoardJanssen (Johnson& Johnson) Independent Data Safety and

Monitoring CommitteeGOED newsletter Medical EditingTeva, Alkermes, Inc., Otsuka America Pharmaceutical, Inc., Forest/Actavis, Sunovion Pharmaceuticals, Inc.

Dr. Freeman is an employee of Massachusetts General Hospital, and works with the MGH National Pregnancy Registry [Current Registry Sponsors

Acadia, NIMH Research Funding: As an employee of MGH, Dr. Freeman works with the MGH CTNI)

Oliver Freudenreich, MD, FAPM

Alkermes, Novartis, Janssen, Neurocrine Consultant (Advisory Board)Avanir, Otsuka, Saladax, Janssen Research grant (PI)Neurocrine Honoraria (CME talk)Global Medical Education Honoraria (CME speaker and

content developer)Wolters-Kluwer Royalties (content developer)UpToDate Royalties, honoraria (content

developer and editor)Michael E. Henry, MD Hoffman LaRoche Salary (Spouse/Family Member)Elizabeth Lawson, MD Oxytocin Therapeutics, Inc. Consultant, Scientific Advisory

Board David Mischoulon, MD, PhD Nordic Naturals Principal Investigator

Pharmavite LLC, and Gnosis USA, Inc. Consultant (Unpaid)Blackmores Speaker Honoraria (paid

through Western Sydney University for Grand Rounds)

Lippincott Williams & Wilkins Book Royalties (Editor of published book)

Andrew A. Nierenberg, MD Alkermes Scientific Advisory Board CMEology, Sunovion, Takeda/Lundbeck CME PresentationUp-to-date, APSARD HonorariaAlfasigma, NIH, Brain and Behavior Research Foundation, Marriott foundation, PCORI, FitBit, Cogito, Janssen

Grant Support

Belvior Editorial boardNaurex Teva, shire, Pfizer, Jazz Pharmaceuticals, Supernus, Neurocrine, Neuronetics, NeuroRx, Sage Pharmaceuticals, Janssen

Consultation

Psychiatric Annals Editor-in-ChiefAssurex Scientific Advisory BoardOtsuka Digital Medicine National

Steering CommitteeWiley Publishing Associate Editor for Depression

and Anxiety

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NAME COMPANY RELATIONSHIPMichael Otto, PhD Big Health Speaker Fee (talks on

empirically-supported psychological treatments)

Oxford University Press, Routledge Book RoyaltiesNIMH, NIDA Grant Support

Roy H. Perlis, MD, MSc Psy Therapeutics Equity (Scientific Advisor)Genomind Consultant Fee (Scientific

Advisor)RID Ventures Consultant Fee (Scientific

Advisor)Outermost Therapeutics Equity (Founder)

John A. Renner, MD Johnson & Johnson, General Electric Stock HolderAmerican Psychiatric Association Publishing Royalties (Book Editor)

Kerry J. Ressler, MD, PhD Biogen, Pfizer, Alkermes ConsultantResilience Therapeutics Consulting Fee (Founding

Member)NIMH, HHMI, NARSAD, Burroughs Wellcome Foundation Research Funding

Jerrold F. Rosenbaum, MD Psy Therapeutics Founder (Ownership Interest) Naomi M. Simon, MD, MSc G1 Therapeutics Spousal Equity

Axovant pharmaceuticals, Praxis, Springworks ConsultantPCORI, Department of Defense, Highland Street Foundation, NIH

Research Grant

Susan Sprich, PhD (Psychologist Reviewer)

Oxford University Press Royalties, for co-authoring treatment manual and client workbook,

Springer Royalties for editing bookTheodore A. Stern, MD Academy of Consultation-Liaison Psychiatry Editor of Psychosomatics

(Salary)Elsevier Grants/Royalties (Editor,

textbooks on Psychiatry)MCE Conferences Lecturer Honoraria

Sabine Wilhelm, PhD Guilford Publications, New Harbinger Publications, Oxford University Press, and Springer.

Royalties

Elsevier Publications Consulting feeNational Institute of Mental Health Honorarium (Grant Reviewer)Brattleboro Retreat, the International Obsessive Compulsive Disorder Foundation, Concordia University and the Tourette Association of America

Honorarium (Speaker)

Association for Behavioral and Cognitive Therapies Travel ReimbursementAmerican Insurance Trust Professional liability program

longevity rewardTelefonica Alpha, Inc. Salary Support (PI on Funded

Study)John W. Winkelman, MD, PhD Advance Medical, FlexPharma, UpToDate Consultant/Honoraria

NIMH 1R01MH095792, Luitpold, RLS Foundation, UCB Research Grants

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NAME COMPANY RELATIONSHIPJanet Wozniak, MD UptoDate Royalties (Spouse)

Advance Medical, FlexPharma, Merck, Otsuka and Gerson Lehman Group

Consultation Fees (Spouse)

RLS Foundation Research Support (Spouse)PCORI Research Support

All other individuals including course directors, planners, reviewers, faculty, staff, etc., who are in a position to control the content of this educational activity have, on behalf of themselves and their spouse or partner, reported no financial relationships related to the content of this activity.

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FACULTY NAME TOPIC DAY AND TIMEAndrew A. Nierenberg, MD Bipolar Disorder and

DepressionFriday, October 19, 9:15am – 10:15am

Naomi M. Simon, MD, MSc Anxiety and PTSD Friday, October 19, 3:15pm – 4:15pm

Oliver Freudenreich, MD, FAPM Psychosis Friday, October 19, 3:15pm – 4:15pm

Cristina Cusin, MD Rapid Treatments Saturday, October 20, 9:45am – 10:45am

John F. Kelly, PhD Addiction Saturday, October 20, 2:15pm – 3:15pm

John A. Renner, MD Addiction, Tobacco, and Cocaine

Sunday, October 21, 10:00am – 11:00am

Lee S. Cohen, MD Women’s Health Sunday, October 21, 1:15pm – 2:15pm

Joseph Biederman, MD ADHD Across the Life Span

Sunday, October 21, 2:45pm – 3:45pm

PSYCHOPHARMACOLOGY CURBSIDE CONSULTANTS SCHEDULE

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PLEASE NOTE THAT THIS IS NOT THE OFFICIAL PROGRAM EVALUATION

Psychopharmacology 2018

Use this page to take notes on the speakers for their presentations. Evaluat ions wi l l be avai lable for complet ion onl ine at

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�Rating scale��1 = Strongly Disagree, 2 = Disagree, 3 = Agree, 4 = Strongly Agree.

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Talk Time and Speaker Rating Notes ��

The quality of the following presentations met or exceeded my expectations:

THURSDAY, OCTOBER 18, 2018

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Three Steps to Claiming your CME Credit…

3: Click on the ‘Evaluation’ button. Once you have completed your evaluation, and attested to the number of sessions you attended, your certificate will be generated. You should claim only the credit commensurate with the extent of your participation in the activity. Complete the evaluation and claim your credit by: November 26, 2018.

1: Visit www.mghcme.org/psychopharm and click on the orange ‘Register’ button.

2: Enter your ‘Academy Login’ username and password then click the ‘Login’ button. If you have forgotten your password, please click the ‘Reset Your Password?’ button. Once logged in, select your certificate type.

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3 2 1

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How to Reset Your Password…

Please visit www.mghcme.org/reset and enter the email address that you used to set up your account, and then click Submit.

You will receive an email with instructions to reset your password. The email will also include your username. If you do not receive an email within a few minutes, please check your Spam/Junk Mail folder.

After resetting your password, enter your username and your new password to access and complete the evaluation and claim your credit.

MY USERNAME IS: __________________________________

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Quick-Service Restaurants in Close Proximity to Westin Copley

Ingredients Located on the lobby level of the Westin Copley Place. Ingredients offers hot breakfast sandwiches, pastries, gourmet sandwiches, signature salads, assorted dry snacks, as well as a coffee bar.

Hours: Mon-Fri 6:30am - 3:00 pm Sat-Sun 7:00 am - 3:00 pm Bar10 Located on the lobby level of the Westin Copley Place. Seasonally-inspired American cuisine with an emphasis on fresh, local ingredients.

Hours: Sun-Thu 11:30am - 12:30 am Fri-Sat 11:30 am - 1:00 am Eataly Boston Located in the Prudential Shopping Center; 10 minute walk. A vibrant Italian marketplace that features an array of cafes, counters, restaurants and a cooking school. Hours: Mon-Fri 7:00am - 11:00 pm Sat-Sun 9:00 am - 11:00 pm Au Bon Pain Located across the sky bridge in the Copley Place Mall. Au Bon Pain features a wide selection of sandwiches, breakfast pastries and bagels, fresh salads and savory soups.

Hours: Mon-Fri 6:00am - 9:00 pm Sat 7:00 am - 7:00 pm The Blue Glass Cafe Located one block from the Westin Copley Place in the John Hancock Building; 5 minute walk. The menu includes house-made sandwiches, soups, salads, sushi, fresh daily entrees, and Starbucks coffee bar. Hours: Daily Lunch, 11:00am – 4:00pm Wagamama Located in the Prudential Shopping Center; 10 minute walk. A place of positive eating for positive living. Asian food inspired by the flavors of Japan. Hours: Mon-Thurs 11:00am - 10:00pm Fri-Sat 11:00am - 11:00pm Sun 11:00am - 10:00pm

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Sweet Green Located in the Prudential Shopping Center; 10 minute walk. Hours: Daily, 10:30am – 10:00pm Dig Inn 557 Boylston; 5 minute walk

Hours: Mon- Sun 10:30am - 10:00pm B. Good 665 Boylston Street; 10 minute walk. Hours: Mon-Sat 7:00am - 10:00pm Sun 11:00am – 9:00pm The Salty Pig 130 Dartmouth Street; 5 minute walk

Hours: Sun-Wed 11:30am - 12:00am Thur-Sat 11:30am – 1:00am California Pizza Kitchen Located in the Prudential Shopping Center; 8 minute walk. Hours: Mon- Thu 11:00am - 10:00pm Fri-Sat 11:00am – 11:00pm Sun 11:00am – 10:00pm Dirty Water Dough 222 Newbury Street; 10 minute walk. Hours: Sun-Wed 11:00am - 10:00pm Thu 11:00am - 10:00pm Fri-Sat 11:00am – 11:00pm Luke’s Lobster Back Bay 75 Exeter Street; 10 minute walk

Hours: Sun-Wed 11:00am - 9:00pm Thu-Sat 11:00am – 10:00pm

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