3RD ANNUAL SYMPOSIUM

Clinical & Pharmaceutical Solutions through Analysis

MEETING PROGRAM

Where Technology and Solutions MeetWhere Discovery Meets the Clinic

Milestone Development Services

March 13 - 15, 2017University of Florida

Clinical & Translational Sciences Institute

WELCOME2017

March 13, 2017

Dear Colleagues:

On behalf of the organizing committee, our sponsors, and the University of Florida, it is our pleasure to welcome you to the 3rd Annual Metabolomics Symposium on Clinical and Pharmaceutical Solutions through Analysis (CPSA Metabolomics 2017). Our meeting promises to be timely with regard to unique analytical perspectives in the field and feature lively discussions, memorable interactions, and the sharing of real-world experiences.

The goal of CPSA Metabolomics is to provide timely, in-depth reviews of innovative technology and emerging practices in the clinic through open discussion of industry related issues and needs. Our aim is to feature scientific leaders within diversified symposia and sponsored events specially designed to be highly interactive where professionals can openly share their experiences and visions in a collegial setting – where technology and solutions meet!

We are delighted to feature, Dr. Irwin Kurland of the Albert Einstein College of Medicine, as our plenary speaker. His lecture “Metabolic Phenotyping: From Model Organisms to Man” will provide insight into his premier research and his novel stable isotope based flux phenotyping methodology on a mass spectrometry platform.

The symposia sessions provide a wonderful opportunity to interact with industry leaders as well as openly share experiences – from the laboratory to the clinic. Specific issues and needs from previous CPSA annual meetings in the USA, China and Brazil will continue at CPSA Metabolomics and feature: 1) clinical applications and workflows; 2) crossover technologies and methods derived from proteomics; 3) biomarker discovery; 4) informatics and multiple/patterned data sets; 5) preferred analytical platforms; 6) sample preparation and chemistries; and 7) novel multianalyte quantitation approaches.

Our annual meeting will once again feature poster sessions, an interactive sponsors exhibition, and a graduate student workshop that highlights experiences and lessons learned by our distinguished Mentors – what they wish they would have known when they were students! Pre-conference events – CPSA OPEN and CPSA 5K – along with our Workshop and Metabolomics Lecture Series will help set the stage for our annual meeting.

We are in the midst of a most challenging time in healthcare. Please help lead the way by actively participating, freely interacting, and sharing ideas during the event and afterwards. Creativity and imagination have been key ingredients to making CPSA meetings – here in Gainesville and all over the world – a memorable experience. In this way, a genuine passion for the analytical sciences can lead to personal growth as well as opportunities to significantly impact the field through participation and leadership.

Finally, special thanks go to the sponsors of CPSA Metabolomics. In particular, we wish to thank Bruker Daltonics, McKinley Scientific, New Objective, SCIEX, Thermo Fisher Scientific, Waters Corporation, and the University of Florida for giving this meeting life. Thank you! All CPSA sponsors share the passion and commitment for both innovative technologies and relationships.

Enjoy the meeting – a celebration of the sciences – and of course, where technology and solutions meet!

Sincerely,

Mike S. Lee, Ph.D.CPSA Founder

Timothy J. Garrett, Ph.D.CPSA Metabolomics Program Chair

©2017 Waters Corporation. Waters, Vion and the Science of What’s Possible are registered trademarks of Waters Corporation.

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SPONSORSThank You!

The CPSA Metabolomics Symposium is made possible by the broad-based support of industry sponsors. The passion for the analytical sciences and the accelerated discovery and development of pharmaceuticals is shared by each sponsor. As a result, the event is dedicated to promoting awareness and understanding of the issues and needs associated with research and development in the hopes of inspiring significant advances in the field.

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Where Technology and Solutions Meet. Where Discovery Meets the Clinic. March 13 - 15, 2017

PROGRAM CHAIR

Timothy GarrettUniversity of Florida

Aiko BarschBruker Daltonics

Bradley AckermannEli Lilly & Company

Andrey BondarenkoInfoClinika

Alex BukoHuman Metabolome Technologies America

Jose Castro-PerezWaters Corporation

Donald ChaceMedolac Laboratories

Paul CorcoranMcKinley Scientific

Gabriele CrucianiUniversity of Perugia

Leigh DarbeeMcKinley Scientific

Susmita DattaUniversity of Florida

Emily EhrenfeldNew Objective

Teresa FanUniversity of Kentucky

Steve FanninBruker Daltonics

Todd GillespieEli Lilly & Co.

Erik HansenNew Objective

Faith HaysShimadzu

David HeywoodWaters Corporation

Rick HigashiUniversity of Kentucky

Gene InmanEli Lilly & Co. (Retired)

John JaniszewskiPfizer

Qin JiBristol Myers Squibb

Richard KibbeyYale University

Steve KlohrBristol-Myers Squibb

Alla KlossGenzyme

Irwin KurlandAlbert Einstein College of Medicine

Ken LewisOpAns

Yutai LiMerck

Gustavo MaegawaUniversity of Florida

Tom MetzPacific Northwest Research Labs

Nicole MatzPRA Health Sciences

Eric MilgramPepsiCo

Alisha Mitchell-RobertsUniversity of Florida

Shane NeedhamAlturas Analytics

Fred RegnierPurdue University

Michelle ReidUniversity of Florida

Nalini SadagopanAgilent Technologies

Jim ShenBristol-Myers Squibb

Petia ShipkovaBristol-Myers Squibb

David SwinneyInstitute for Rare and Neglected Diseases

Jeremiah TiptonBioTech & OMICx Solutions

Baljit UbhiSCIEX

Gary ValaskovicNew Objective

2017 ORGANIZING COMMITTEE

SYMPOSIA & SESSIONS

Roy VazSanofi

Sihe WangCleveland Clinic

Naidong WengJanssen Pharmaceuticals

Eric YangGlaxoSmithKline

Nathan YatesUniversity of Pittsburgh

Richard YostUniversity of Florida

Ismael ZamoraMolecular Discovery

LOGISTICS & MANAGEMENT

Communications & Media

Carla Marshall-WaggettNew Objective

Martin SteelMcKinley Scientific

Management & Correspondence

Mike LeeMilestone Development Services

EVENTSSunday March 12

4:00 PM - 6:00 PM CPSA 5K CPSA Charitable Foundation

Meet & Start at Where Technology and Relationship Meet the RoadUF Hilton and Conference Center Join us for the CPSA 5K! Walk, run or bike the scenic course through the beautiful UF campus.

Organizers: Timothy Garrett, University of Florida; Nicole Matz, PRA Health Sciences; Michelle Reid, University of Florida; Martin Steel, McKinley Scientific; Shane Needham, Alturas Analytics;

Together We Can Go Farther!

9:00 AM CPSA OPEN GOLF EVENT CPSA Charitable Foundation

Mark Bostick Golf Course Organizers: Paul Corcoran, McKinley Scientific and University of Florida Steve Fannin, Bruker Daltonics

10:00 AM REGISTRATION

3rd Floor Lobby

1:00 PM - 4:00 PM PRE-CONFERENCE WORKSHOP

Don Chace, Medolac Laboratories, and Mike Lee, Milestone Development Services

5:00 PM - 7:00 PM RECEPTION & METABOLOMICS LECTURE SERIES

Hosted by Waters Corporation

� Opening RemarksTimothy Garrett, University of Florida and Mike Lee, Milestone Development Services

� Welcome and IntroductionSuraj Dhungana, Waters Corporation

� Applications of Metabolomics for Clinical and Translational ResearchAmrita Cheema, Georgetown University

WORKSHOP & RECEPTION

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Where Technology and Solutions Meet. Where Discovery Meets the Clinic.

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By collaborating with the scientific community, we’ve developed pioneering Thermo Scientific™ Orbitrap™ MS solutions combined with the most comprehensive breadth of chromatographic separations to detect and resolve chemically diverse compounds in the metabolome. These industry-leading solutions deliver the most precise, accurate, and confident metabolite profiles and identifications more quickly so you can go beyond the limit of what was ever thought possible.

Find out more at thermofisher.com/metabolomics

© 2017 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. AD90245-EN0217S

Harness the power of metabolomics to gain in-depth biological insights and advance scientific research

Learn more at booth #1 and be sure to attend our lunch seminar on Tuesday, March 14th from 11:30 a.m. to 1:30 p.m.

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Identify and quantify large numbers of Routine Metabolomics with the X500R

metabolites on a routine basis—fast.

Visit the SCIEX booth to learn how to simplify your metabolomics workfl ow. Measure, process, characterize and translate your research into biological knowledge fast.

One Single Integrated Interface!The SCIEX OS Software Platform puts MS control, data processing and reporting at your fi ngertips. The guided workfl ow allows for minimal MS expertise and gets you to biological insights fast

Libraries Enable Higher Confi dence in Metabolite Identifi cationGet to actionable results quickly with user-friendly processing software and a validated biologically relevant metabolite library that can be expanded with other validated libraries

Routine and RobustAutomated and integrated mass calibration allows enhanced stability while new diagnostic and tuning tools allow for more uptime.

Maximize your Lab’s Effi ciencyThe X500R QTOF, with N-TOF technology has a compact TOF tube and a foot print of 25 cubic-feet, it occupies less lab space than any other HRMS on the market today

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Maximize your Lab’s Effi ciency

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AB Sciex is doing business as SCIEX. © 2017 AB Sciex. For research use only. Not for use in diagnostic procedures. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license.

02/2017 RUO-MKT-07-5081-A

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March 13 - 15, 2017

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PROGRAMTuesday March 14

7:30 AM – 8:30 AM REGISTRATION & WAKE-UP COFFEE

8:30 AM – 8:45 AM WELCOME & OPENING REMARKS - DISEASE IS THE ENEMY!

Welcome

Mike Lee, Milestone Development Services

Objectives, Format, and Opening Remarks

Timothy Garrett, University of Florida

8:45 AM - 9:30 AM PLENARY LECTURE

Metabolic Phenotyping: From Model Organisms to Man

Irwin Kurland, Einstein College of Medicine

9:45 AM - 11:15 AM SYMPOSIUM SESSION

Biomarker Stability/Sample Integrity

Discussion Leader: Alla Kloss, Genzyme

� One Chapter From a Manual on How to Ruin a Metabolomics StudyAlla Kloss, Sanofi

� Biomarkers for Human Plasma Sample Quality using an IROA-Labeled Universal Internal StandardCasey Chamberlain, University of Florida

� Examining Heat Treatment for Stabilization of the Lipidome Jeremy Koelmel, University of Florida

Gain deeper biological insight into complex samples

Benefit from combined NMR and MS solutions

Improve your productivity by dedicated Metabolomics workflows

Understand the structure and interactions of molecules

Innovation with IntegrityMass Spectrometry

For research use only. Not for use in diagnostic procedures

For more information, visit www.bruker.com or email ms.sales.bdal@bruker.com

Bruker Is the Smart Solution For All Your Metabolomics Challenges

www.cpsa-analytics.com

2017

Chris JohnsonPittsburgh Pirates

Plenary Speaker

Nathan A. YatesUniversity of Pittsburgh

Program Chair

Make plans now to attend CPSA Analytics 2017! This annual meeting is destined to become the premier industry-led event dedicated to promoting awareness of issues

and needs in collaborative data processing and dissemination

Where Technology and Personalized Healthcare Meet

May 17 - 18, 2017Hosted by The University of Pittsburgh

2nd Annual Analytics Symposium onClinical & Pharmaceutical Solutions through Analysis

CPSA Analytics 2018

Symposia • Roundtables • Workshops • Events

PROGRAMWednesday March 15

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PROGRAMTuesday March 14

7:30 AM - 8:30 AM REGISTRATION & WAKE-UP COFFEE

8:30 AM - 10:00 AM SYMPOSIUM SESSION

Investigating Homeostasis: Technologies and Methodologies for Drug Discovery

Discussion Leader: John Janiszewski, Pfizer

� Using Metabolism To Support Drug Discovery: From Target Identification To Biomarker Validation David Pirman, Agios

� Leveraging MIMOSA-Based Fluxomics To Unravel The Mechanism Of Action of Lead Matter In Early Drug Discovery Darren Dumlao, Pfizer

� Fluxing Around: Creating Computational Infrastructure for Metabolic Labeling Experiments Abhishek Jha, Elucidata

10:15 AM - 11:45 AM SYMPOSIUM SESSION

Multi-Omic Integration in the Clinical Sciences

Discussion Leader: Irwin Kurland, Albert Einstein College of Medicine

� Propionate Induces an Apparent Conflict Between Fluxomic and Metabolomic Measures in the Perfused Mouse HeartMatthew Merritt, University of Florida

� The Age Of Multi-Omics Has Arrived - Accelerating Integrated Perspectives In BiologyDevin Drew, Thermo Fisher Scientific

� OneOmics™: Integrate Multi-Omics Data Seamlessly in the CloudMatthew Skaley, SCIEX

12:00 PM - 2:00 PM LUNCH: VENDOR SPOTLIGHT & POSTER REVIEW

Sponsored by Bruker Daltonics

A Multi-Omics Study Elucidates an Increase in Pio-Production EfficiencyGary Kruppa, Bruker

Lunch served in lobby as you mix and mingle with our vendors and poster authors

11:30 AM – 1:30 PM LUNCH: VENDOR SPOTLIGHT & POSTER REVIEW

Sponsored by Thermo Fisher Scientific

� Removing the Data Processing Bottleneck: Move Efficiently from Data to Structure to Pathway with NEW Thermo Scientific™ Compound Discoverer™ 2.0Amanda Souza, Thermo Fisher Scientific

� Profiling of Organic Acids in Mouse Muscle Using Ion Chromatography/MSChristopher Petucci, Sanford Burnham Presby Medical Discovery Institute

� Using Proteometabolomics to Examine Mechanisms of Drug Resistance in Multiple MyelomaJohn Koomen, H. Lee Moffitt Cancer Center and Research Institute

Lunch served in lobby. Join the session, mix and mingle with our vendors and poster authors

1:45 PM - 3:00 PM SYMPOSIUM SESSION

Personalized Metabolism

Discussion Leaders: Don Chace, Medolac Laboratories and Emily Ehrenfeld, New Objective

� Using Proteometabolomics to Examine Mechanisms of Drug Resistance in Multiple Myeloma John Koomen, H. Lee Moffitt Cancer Center and Research Institute

� Translational Metabolomics in Biopharma Michael Reily, Bristol-Myers Squibb

� Metabolomics in the Clinic: Discriminating Between Research/Development and Application/Service Don Chace, Medolac Laboratories

3:30 PM - 5:00 PM SYMPOSIUM SESSION

Clinical Applications of Metabolomics and It’s Role on Diagnosis and Therapeutic Response and Monitoring

Discussion Leader: Gustavo Maegawa, University of Florida

� Use of Ion Chromatography/Mass Spectrometry for Targeted Metabolite Profiling of Polar Organic AcidsChris Petucci, Sanford-Burnham Medical Research Institute

� Routine Discovery Metabolomics Workflows on X500R QTOF SystemMatthew Skaley, SCIEX

6:00 PM SPONSORED SOCIAL EVENT

McKethan Stadium Sponsored by McKinley Scientific & New Objective

First pitch: 6:30 pm Play Ball! Gators vs. Florida State SeminolesMcKethan Stadium on the University of Florida campus vs.

PROGRAMWednesday March 15

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Where Technology and Solutions Meet. Where Discovery Meets the Clinic.

215 PM - 3:45 PM SYMPOSIUM SESSION

Customers Meet Vendors

Discussion Leader: Alla Kloss, Genzyme

Customer PanelDarren Dumlao, PfizerHarvey Lieberman, SanofiDavid Pirman, Agios Pharmaceuticals

Vendor PanelRalf Bogumil, BiocratesSuraj Dhungana, Waters CorporationFaith Hays, Shimadzu Scientific InstrumentsKen Jones, SCIEXGary Kruppa, BrukerChristine Miller, Agilent TechnologiesMatthew Skaley, SCIEXAmanda Souza, Thermo Fisher Scientific

4:00 PM - 5:00 PM GRADUATE STUDENT SESSION

Catalyzing Curiosity: Bridging Passion and Discovery

Curiosity is perceived to be an innate quality and essential characteristic of any scientist. The ideas, which flow from imagination into high-impact research, are seemingly natural; graduate school, and specifically doctoral education, is the ideal environment to cultivate this creativity and intuition. Let’s examine the relationships between initial questions, unexpected developments, and the growth of new curiosity-driven chemistry.

Mentors: Don Chace, Medolac Laboratories; Paul Corcoran, McKinley Scientific; Gabriele Cruciani, University of Perugia; Steve Fannin, Bruker; Todd Gillespie, Eli Lilly & Co.; Faith Hays, Shimadzu; David Heywood, Waters; Eugene Inman, Eli Lilly and Co. (Ret); John Janiszewski, Pfizer; Alla Kloss, Genzyme; Yutai Li, Merck; Carla Marshall-Waggett, New Objective; Nalini Sadagopan, Agilent Technologies; Martin Steel, McKinley Scientific; Jeremiah Tipton, BioTech & OMICs Solutions; Baljit Ubhi, SCIEX; Roy Vaz, Sanofi; Richard Yost, University of Florida

5:15 PM CLOSING REMARKS

Timothy Garrett, University of Florida

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