3Protein Information Resource, Georgetown University, … · 2013-11-12 · ‘Manual curation of...
Transcript of 3Protein Information Resource, Georgetown University, … · 2013-11-12 · ‘Manual curation of...
‘Manual curation of Drosophila
melanogaster in UniProtKB’
Elena Cibrián Uhalte1 and UniProt Consortium1,2,3
1EMBL-European Bioinformatics Institute, Cambridge, UK
2SIB Swiss Institute of Bioinformatics, Geneva, Switzerland
3Protein Information Resource, Georgetown University, Washington DC & University of Delaware, USA
Email: [email protected] URL: www.uniprot.org
Funding
UniProt is funded by the European Molecular Biology Laboratory, National Institutes of Health, European Union, Swiss Federal Government, British Heart Foundation and National Science
Foundation.
Drosophila melanogaster in UniProtKB
Drosophila melanogaster manually curated entry
Drosophila melanogaster is a priority model organism for UniProt Knowledgebase
(UniProtKB) manual curation. The Drosophila protein annotation program
focuses on the manual curation of characterised Drosophila melanogaster proteins
with experimental data from the scientific literature. UniProtKB provides a complete
non-redundant proteome for Drosophila melanogaster based on the translation of
the Drosophila melanogaster completely sequenced genome, which currently
comprises 19,721 entries and which can be downloaded from the UniProt website.
All Drosophila melanogaster entries are cross-referenced with FlyBase with which
UniProtKB keeps close contact in order to ensure data consistency between both
databases. In addition to melanogaster, 11 other Drosophila species are currently
present in UniProtKB as complete proteome sets.
Database cross-references
Annotation of biological information
All Drosophila melanogaster
entries are cross-referenced
with FlyBase
Manually curated
FlyBase gene symbol
Synonyms captured
from literature
Current ORF symbol
Manual
Referenced
annotation
Function
References:
Protein sequence features
Drosophila melanogaster
complete proteome
Keywords and Gene Ontology annotation Drosophila complete
proteome available
on UniProt website
Gene Ontology (GO) terms are assigned
manually based on experimental data from
the literature and also added based on
automatic methods. In addition, GO terms
are imported from other GO consortium
members
Nucleotide sequence
Manual annotation protocol