THE FUNCTION OF GENITAL ORGAN:

1.REPRODUCTION

2.SEXUAL ACTIVITY

THE FUNCTION OF GENITAL ORGAN:

1.REPRODUCTION

2.SEXUAL ACTIVITY

FASE PUBERTAS PRIA

SEXUAL DEVELOPMENT

1.CHROMOSOMAL SEX2.GONADAL SEX3.GENITAL SEX4.HORMONAL SEX5.PSYCHOLOGICAL SEX

THE FUNCTION OF TESTIS

1.SPERMATOGENESIS

• SPERMATOSITOGENESIS (PROLIFERASI)

• MEIOSIS (SPERMATOSIT I AND II)

• SPERMIOGENESIS (SPERMATID SPERMATOZOA)

• SPERMIATION ( PEMATANGAN)

2.STEROIDOGENESIS (ANDROGEN PRODUCTION )

SPERM ANALYSIS• CONCENTRATION

=>20 MILLION/ML

• MOTILITY >50%

• NORMAL MORPHOLOGY

>30%

DEFINITIONA CHEMICAL WHICH IS PRODUCTED BY CELL OR CELL GROUP IN BODY SOLUTION AND GIVE PHYSIOLOGIC EFFECT ON CELL REGULATION

THE FUNCTIONIS A CONTROL SYSTEM OF INTEGRATION

NERVE SYSTEM

ORGAN

ENDOCRINE SYSTEM

GROWTH AND DEVELOPMENTREPRODUCTION

INTERNAL ENVIRONMENTENERGY

THE FUNCTION OF HORMON

1. LEYDIG CELL (INTERSTIAL CELLS OF LEYDIG), IN INTERSTITIAL TISSUE OF TESTIS

2. SUPRARENALIS GLAND ( THE UPPER OF KIDNEY).

THE ANDROGEN PRODUCTION

HORMON

1.ANDROGEN (TESTOSTERON)

2.ESTROGEN

Hormone

Receptor

Effector

2nd Messengers Cytoplasm

Protein Kinases

mRNA

NucleusGene

P

H

HReceptor Cytoplasm

mRNA

NucleusGeneHRE

H H

A B

P

ANDROGEN (TESTOSTERON)

• DEVELOPMENT AND MAINTENANCE REPRODUCTIVE TISSUE • MALE CHARACTERISTIC• SEXUAL DRIVE

1.THE CONCENTRATION OF STEROID2.INTERACTION BETWEEN RECEPTOR AND PROTEIN3.THE RECEPTOR ACTION IN GENOMIC STATE

SOME FACTORSINFLUENCE ANDROGEN

FUNCTION ON CELL TARGET

BIOSYNTESE IN LEYDIG CELLSCHOLESTEROL SINTESE FROM GLUCOSE AND FATTY ACID MITOCHONDRIA BREAK THE CHAIN OF KOLESTEROL TO PRODUCES PREGNENOLONEPREGNENOLONE ENTER TO RETICULUM ENDOPLASMA. THIS PROCESS IS HELP BY CYTOCHROM AND ENZYM REACTION WHICH PRODUCE BY TESTOSTERON.

BIOSYNTESE OF ANDROGEN IN TESTIS

LEYDIG CELLS BLOOD OTHER TISSUEACETATE

CHOLESTEROL CHOLESTEROL

PREGNENOLONE PROGESTERONE

17 OH-PREGNENOLONE 17 OH-PREGNENOLONE ESTRONE ESTRONE

ANDROSTENEDIONE ANDROSTENEDIONE ANDROSTENEDIONE ANDROSTENEDIONE

TESTOSTERONE TESTOSTERONE TESTOSTERONE

ESTRADIOL ESTRADIOL

BIOSYNTESE ANDROGEN IN SEL LEYDIG

CONCENTRATION OF PLASMA ANDROGEN AND PRODUCTION

STEROID [PLASMA] (NG/DL) PRODUCTION (NG/DAY) TESTOSTERONE MALE 700 7000FEMALE 40 300ANDROSTENEDIONEMALE 100 2500 FEMALE

170 3500DHTMALE 30 300

FEMLE 20 60

TESTOSTERON SECRETION TO SPERMATC VENA, IS BOUNDED BY PROTEIN PLASMA (HIGH AFINITY: TEBG = TESTOSTERONE-ESTRADIOL BINDING GLOBULIN WHICH PRODUCED IN LIVER

TESTOSTERONE TRANSPOR •2% FREE T •30% TEBG•68 % IN ALBUMIN AND PLASMA PROTEIN

T

DHT SPECIAL RECEPTOR IN SOME AREA:

EPITEL GERMINAL EPIDIDIMISDUCTUS DEFERENS VESICA SEMINALIS

PROSTATEHAIR FOLLICEL SEBACEA GL

TRANSFORMATION 5-REDUKTASE

THE PHASES OF MALE PUBERTY

THE PHASES OF SEXUAL ACTIVITY

EXCITEMENT

PLATEAU

ORGASMIC

RESOLUTION

GOOD MORNING EVERYBODY

EJACULATION

CYCLE OF MENSTRUATION

1.PROLIFERATION2.SECRETION3.MENSTRUATION

Rp. 2,3 MILJARD/KGRp. 2,3 MILJARD/KG

BERAPA HARGA TUBUH ANDA/KG?

DR. MOROVITZDR. MOROVITZ

INCREASE THE PRODUCTION OF MILK TO IMPROVE PHYSICAL

HEALTH AND FITNESS

TQ AND SEE YOU NEXT TIME

SEE YOU NEXT TIME