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Introducing Licaps Fusion TechnologyA new standard in drug delivery

www.capsugel.com

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Licaps Fusion Technology

Capsugels New Fusion technology:Setting New Standards or Liquid Encapsulation

High protection meets ast release

High protectionFor outstanding product integrity

with liquid ormulations

Fast releaseFaster drug release acilitates more

rapid therapeutic eect

Rapid and complete capsule shell disintegration

Licaps thin shell made without plasticizers

or preservatives, is ideal or drugs requiring ast

release

Licaps capsules provide an efcient andhighly eective means or delivering liquiddrug ormulations

Liquid ormulations can speed drug substance

absorption helping ensure a rapid achievemento therapeutic eects

New Licaps Fusion Technology is a majoradvancement in liquid-flled capsules

Two-piece body and cap hermetically sealed to

orm a leak-proo, perectly airtight, one-piece

capsule

The one-piece capsule cannot be opened

without visible damage

Potentially tamper-evident

Licaps shell matrix is highly impermeableto atmospheric moisture and oxygen

Provides a high level o protection rom

degradation o sensitive compounds

Competing in todays pharmaceutical market requires innovative drug delivery technologies that can accelerate the drug development process

and unlock new opportunities or lie cycle management. Capsugels new Licaps Fusion Technology utilizes a series o cutting-edge advancements in capsule flling,

sealing and fnal product inspection to ensure consistent product quality and a robust and reliable capsule seal.

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Marketing

ExceedyourexpectationswithLicaps

FusionTechnology

Deliverthehighprotectionandastreleaseyour

patientsandconsumersexpect

LicapsFusion Technologyoersmany uniqueand innovative

marketing opportunities

Licapscapsulesdeliverast-actingefcacy-akeyconsumerand patientexpectation1

Vegetable-basedcapsule option

-Protectsmoisturesensitivepharmaceutical actives

- Matches theculturalpreerences oimportantconsumer/patient groups

InnovativeLicaps designprovidessingleormulti-phase

dosageormoptions

Licapscapsule-in-capsule andpellets-in-capsule ormulationsenablehigh-perormance productswith avarietyoreleaseprofle

s

Multi-phase ormulationoptionskeepincompatible activesseparated

Single-doseormulation o two products orfxeddosecombination whichcan lead to

increased patientcompliance

Modifeddrug release profles canbeachieved throughuse omulti-phase

ormulations

Licapssingle andmulti-phaseormulation options createuniqueandclearly

dierentiatedproducts.

www.capsugel.com

(1)Capsugel study: innovation in delivery system in OTC.Consumer market researchconducted in Italy, France, and the UK (n=12

00each country).LH2, October 2009.

Pellets in Licaps Cap-in-capLicaps

Broad applications, wide-ranging benets

Single or multiphase ormulations orinnovative and versatile product oerings

3rd generation

Extended release

lineextensions

Innovation

Cap-in-cap

Licaps

New chemical entities Added-value generics OTC line extensions

High protection and innovative

solutions or challenging

compounds

Realize the potentialo drugs and overcomeproblematic ormulations

Create new and improved

products rom existing drugs

Dierentiate yourcompound with a uniquedosage orm

Satisy a range o patient/

consumer needs (e.g. aster-

absorption, high acceptability)*

Stimulate strongerpurchase intent amongconsumers than traditionaldosage orms*

Over-arching benets:

Rapid development or aster time to market

Established, robust and fexible manuacturing process

Cost and sustainability advantages

Pellets in Licaps

2nd generation

Dual action

*Capsugel study: innovation in delivery system in OTC. Consumer market research conducted in Italy, France, and the UK (n=1200 each country). LH2, October 2009.

Dosage orm attitude and usage study in the US, guidelines, NY, 2009 published in study o consumer preerences: solid oral dosage orms, Capsugel 2010

Pellets in Licaps and Cap-in-cap open up new market applications:

Multiple release proles To reach pharmacokinetic challenges

Novel combinations

Complex ormulations To improve patient compliance

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Cutting-edge hard capsule design

Leader in innovation with proprietaryFusion Technology

Well dened seal zoneenables 100 % usion

o cap and body

Fluid entry channel ensures

consistent and ecient capillary fow

o sealing fuid

Dual ring system provides

a double barrier between the capsule

contents and the seal zone

Licaps

: a new standardin liquid-lled encapsulation

Directed

fluid jet

Magnified

Magnified

Gentle heat

SprayingSealing fluid is sprayed onto jointbetween cap and bodyCapillary action rapidly draws fluidup between the cap and the body.Suction removes excess fluid.

WarmingBrief application of gentleheat melts and fusesthe moistened capsulein the seal zone

SettingCapsule sets and hardens at room temperature

The combination of moistureand gentle heating ensures fusionof the cap and body, therebyproviding a robust and highlyreliable seal.

Tamper-proof seal is achieved.

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2012CapsugelBelgiumN

V.

Allrightsreserved.

201209001

BornemBelgium

BostonMassachusetts Plormel

FranceMorristownNew Jersey

PueblaMexico Bangkok

Thailand

New DelhiIndia

GreenwoodSouth Carolina

Colmar / StrasbourgFrance

SuzhouChina

SagamiharaJapan

JakartaIndonesia

For more inormation contact us via: www.capsugel.com or call +33 3 89205725

Bornem, Belgium

Rijksweg 11

BE-2880 Bornem

T+32 3 8900511

F+32 3 8892622

Colmar, France

10, rue Timken

FR-68000 Colmar

T+33 3 89205709

F+33 3 89414811

Disclaimer : The inormation in this leafet is

not intended to be used as a claim. It is the

responsibility o the customers to check with the

current regulations in their respective countries.

Capsugel visionTo be the leading provider o innovative dosage

orms and solutions to healthcare customers

around world

Worldwide locationsWith multiple production and business acilities

worldwide, Capsugel oers unmatched reliability

o supply

www.capsugel.com