Vol. 266, No. 34 The Journal of December 5. 1991

Biological Chemistry Copyright 0 1991 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St., Baltimore, MD 21202 U S A .

CONTENTS*

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22807

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22847

MINIREVIEW von Willebrand factor.

J. Evan Sadler

COMMUNICATIONS Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy.

Mika Nagaike, Shigeaki Hirao, Hisao Tajima, Sumihare Noji, Shigehiko Taniguchi, Kunio Matsumoto, and Toshikazu Nakamura

Marker exchange of the structural genes for nitric oxide reductase blocks the denitrification pathway of Pseudomonas stutxeri at nitric oxide.

Cornelia Braun and Walter G. Zumft

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

Joan M. Heuel, Kimberly A. White, and Michael A . Marletta

U small nuclear ribonucleoprotein requirements for nematode cis- and trans-splicing in vitro.

Gregory J . Hannon, Patricia A . Maroney, and Timothy W . Nilsen

Multiple cis-acting elements are required for RNA po- lymerase I11 transcription of the gene encoding H1 RNA, the RNA component of human RNase P.

Gretchen Hannon, Sidney Altman, and Timothy W . Nilsen Gregory J . Hannon, Alison Chubb, Patricia A . Maroney,

Ribosome-independent GTPase activity of translation initiation factor IF2 and of its G-domain.

L. Pon, and Claudio 0. Gualerzi Manuela Seuerini, Roberto Spurio, Anna La Teana, Cynthia

A synthetic peptide mimic of plasma apolipoprotein E that binds the LDL receptor.

Cheryl A. Dyer and Linda K. Curtiss

ARTICLES Structure of oligosaccharides on Saccharomyces SUC2

paatoris. invertase secreted by the methylotrophic yeast Pichia

Robert B. Trimble, Paul H . Atkinson, Juerg F. Tschopp, R. Reid Townsend, and Frank Maley

A novel glycosylation phenotype expressed by Lec23, a Chinese hamster ovary mutant deficient in a-gluco- sidase I.

Manas K. Ray, Jing Yang, Subha Sundaram, and Pamela Stanley

Histidine tRNA guanylyltransferase from Saccharo- myces cereuisiae. I. Purification and physical proper- ties.

Suchira Pande, Dieter Jahn, and Dieter Sol1

Histidine tRNA guanylyltransferase from Saccharo- myces cereuisiae. 11. Catalytic mechanism.

Dieter Jahn and Suchira Pande

Quantitative analysis of molecular species of diacyl- glycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells.

Amiya K. HaIra Chunghee Lee, Stephen K. Fisher, Bernard W. Agranof/, and

Identification of the pheophytin-QA-Fe domain of the reducing side of the photosystem I1 as the Cu(I1)-inhib- itory binding site. ~

Immaculada Yruela, Guillermo Montoya, Pablo J . Alonso, and Rafael Picorel

22851

22858

22866

22872

22878

22887

22893

22899

22905

22912

22919

22926

22932

22939

Activation of the proteinase B precursor of the yeast Saccharomyces cereuisiae by autocatalysis and by an internal sequence.

Vicki L. Nebes and Elizabeth W. Jones

The effects of p-hydroxymercuribenzoic acid modifi- cation and heat treatment on the CuA reduction poten- tial of cytochrome c oxidase.

Zhuyin Li, Randy W. Larsen, Lian-ping Pan, and Sunney I. Chan

Transforming growth factor-81 inhibits scavenger receptor activity in THP- 1 human macrophages.

Lori A. Bottalico, Ruth E. Wager, Luis B. Agellon, Richard K. Assoian, and Ira Tabas

muscarinic atrial K+ channels. Mechanism of fluoride activation of G protein-gated

Atsuko Yatani and Arthur M. Brown

Identification of novel factors which bind specifically to the core promoter of the immunoglobulin heavy chain gene.

Jeffrey D. Paruin and Phillip A. Sharp

The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet @-cells in the isolated perfused rat pancreas.

Amal Ghosh, Peter Ronner, Erlinda Cheong, Parwaiz Khalid, and Franz M. Matschinsky

Metalloenzymes in DNA repair. Escherichia coli endo- nuclease IV and Saccharomyces cereuisiae Apnl.

Joshua D. Leuin, Robert Shapiro, and Bruce Demple

Drosophila laminin A chain sequence, interspecies comparison, and domain structure of a major carboxyl portion.

Katherine Garrison, Albert J . MacKrell, and John H. Fessler

Dietary sucrose enhances processing of mRNA-S14 nu- clear precursor.

Lynn A. Burmeister and Cary N . Mariash

Drug action of thapsigargin on the Ca'+ pump protein of sarcoplasmic reticulum.

Yoshiyuki Kijima, Eunice Ogunbunmi, and Sidney Fleischer

Inhibitory control of prolactin and Pit-1 gene pro- moters by dopamine. Dual signaling pathways required for D2 receptor-regulated expression of the prolactin gene.

C. Sundmark Harry P. Elsholtz, April M. Leu, Paul R. Albert, and Valdine

Allene oxide and aldehyde biosynthesis in starfish oo- cytes.

E. Boeglin, Wen-Chao Song, and Laurent Meijer Alan R. Brash, Molly A . Hughes, Dan J . Hawkins, William

Quantitation of acyl-CoA and acylcarnitine esters ac- cumulated during abnormal mitochondrial fatty acid oxidation.

Rajinder Singh Kler, Sandra Jackson, Kim Bartlett, Laur- ence A . Bindo//, Simon Eaton, Morteza Pourfarzam, Frank E. Frerman, Stephen I . Goodman, Nicholas J. Watmough, and Doughs M. Turnbull

brane heparan sulfate proteoglycan, reveals extensive The complete sequence of perlecan, a basement mem-

similarity with laminin A chain, low density lipopro- tein-receptor, and the neural cell adhesion molecule.

Douglas M . Noonan, Anna Fulle, Piera Valente, Silla Cui, Elizabeth Horigan, Makoto Sasaki, Yoshihiko Yamada, and John R. Hassell

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1991) J. Bid. Chem. 266, 12797-12807, and reprints may be obtained from the editorial office.

111 ...

LV

22948

22954

22960

22968

22975

22983

22991

22998

23003

23010

23016

23022

23027

2.3033

GATA-binding transcription factors in mast cells reg- ulate the promoter of the mast cell carboxypeptidase A gene.

Leonard I . Zon, Michael F. Gurish, Richard L. Stevens, Cheri Mather, Dale S. Reynolds, K. Frank Austen, and Stuart H. Orkin

ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii.

Yuhua Zhang, Elliott M. Ross, and William J . Snell

Conformational requirement for lysine hydroxylation in collagen. Structural studies on synthetic peptide sub- strates of lysyl hydroxylase.

Ping Jiang and Vettai S. Ananthanarayanan

Modulation of renal epithelial cell growth by glucosyl-

sine, and diacylglycerol. ceramide. Association with protein kinase C, sphingo-

diyoun, Thomas P. Thomas, Dorothy Wu, Florence S. Barcelon, James A. Shayman, Gayatri D. Deshmukh, Shahryar Mah-

and Norman S. Radin

outer segments of bovine retinal rods by Na-Ca-K ex- Regulation of free cytosolic Ca'+ concentration in the

change measured with fluo-3.1. Efficiency of transport and interactions between cations.

Paul P. M. Schnetkamp, Xue-Bin Li, Debesh K. Bum, and Robert T . Szerencsei

the outer segments of bovine retinal rods by Na-Ca-K Regulation of intracellular free Ca'+ concentration in

exchange measured with fluo-3. 11. Thermodynamic competence of transmembrane Na+ and K+ gradients and inactivation of Na+-dependent Ca'+ extrusion.

Robert T . Szerencsei Paul P. M. Schnetkamp, Debesh K. Basu, Xue-Bin Li, and

Disulfide bonding controls the processing of retroviral envelope glycoproteins.

David Kabat Brian C. Gliniak, Susan L. Kozak, Richard T. Jones, and

Arginine 197 of lac repressor contributes significant energy to inducer binding. Confirmation of homology to periplasmic sugar binding proteins.

Ronit 0. Spotts, Artemis E. Chakerian, and Kathleen S. Matthews

Reconstitution and properties of homologous and chi- meric HIV-1.HIV-2 ~ 6 6 . ~ 5 1 reverse transcriptase.

Kathryn J. Howard, Karl B. Frank, lain S. Sim, and Stuart F. J . Le Grice

thionine synthase by various forms of cobalamin. Mechanism of conversion of human apo- to holome-

J . Fred Kolhouse, Carolyn Utley, Sally P. Stabler, and Robert H. Allen

thrombomodulin. Two distinct structural changes are The active site of thrombin is altered upon binding to

detected by fluorescence, but only one correlates with protein C activation.

Jia Ye, Naomi L. Esmon, Charles T. Esmon, and Arthur E. Johnson

The effect of carbohydrate on the structure and stabil- ity of erythropoietin.

Linda Owers Narhi, Tsutomu Arakawa, Kenneth H . Aoki, Rebecca Elmore, Michael F. Rohde, Thomas Boone, and Thomas W. Strickland

Molecular cloning and characterization of prolactin- like protein C complementary deoxyribonucleic acid.

Szpirer, Goran Leuan, Simon C. M. Kwok, and Michael J . Santanu Deb, Katherine F. Roby, Teresa N . Faria, Claude

Soares

Involvement of the distal histidine in the low affinity exhibited by Hb Chico (Lys""" 4 Thr) and its isolated @ chains.

Max Perutz, Giulio Fermi, and Daniel T.-B. Shih Celia Bonaventura, Robert Cashon, Joseph Bonauentura,

23041

23048

23053

23060

23068

23074

23083

23091

23097

23103

23112

23120

23128

23135

Progesterone-regulated cyclic modulation of mem- brane metalloendopeptidase (enkephalinase) in human endometrium.

M. Linette Casey, Jesse W. Smith, Kimihiro Nagai, Louis B. Hersh, and Paul C. MacDonald

plasminogen activator inhibitor gene responsive to Identification of regulatory sequences in the type 1

transforming growth factor @. eld, and David J . Loskutoff

Mark R. Keeton, Scott A. Curriden, Anton-Jan van Zonneu-

Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleo- tide-binding protein activator of cholera toxin.

Su-Chen Tsai, Randy S. Haun, Mikako Tsuchiya, Joel Moss, and Martha Vaughan

Extracellular domain-IgG fusion proteins for three hu- man natriuretic peptide receptors. Hormone pharma- cology and application to solid phase screening of syn- thetic peptide antisera.

Brian D. Bennett, Gregory L. Bennett, Roderick V .

David G. Lowe Vitangcol, Jill R. S. Jewett, John Burnier, William Henzel, and

Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro- Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis.

Malini Rajagopalan, John L. Neidigh, and Donald A. Mc- Clam

Hormonal activation of gene transcription in ras-trans- formed NIH3T3 cells overexpressing RIIa and RIIB subunits of the CAMP-dependent protein kinase.

Stanley McKnight Anne D. Otten, Lise A. Parenteau, Stein Dfiskeland, and G.

Gene structure of mammalian acetylcholinesterase. Al- ternative exons dictate tissue-specific expression.

and Palmer Taylor Ying Li, Shelley Camp, Tara L. Rachinsky, Damon Getman,

A ribosomal calmodulin-binding protein from Dictyos- telium.

and Rupert Mutzel Jurgen Sonnemann, Annette Bauerle, Thomas Winckler,

Role of disulfide bonds in biologic activity of human interleukin-6.

Fowlkes John N . Snouwaert, Frank W. G. Leebeek, and Dana M.

Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orien- talis.

Bradford W . Gibson, Dazhi Tang, Robert Mandrell, Michele Kelly, and Eliot R. Spindel

Effects of gene mutations in lipoprotein and hepatic lipases as interpreted by a molecular model of the pan- creatic triglyceride lipase.

Zygmunt S. Derewenda and Christian Cambillau

Copper K-extended x-ray absorption fine structure studies of oxidized and reduced dopamine @-hydroxyl- ase. Confirmation of a sulfur ligand to copper(1) in the reduced enzyme.

Ninian J. Blackburn, Samar S. Hasnain, Trudie M. Pettin- gill, and Richard W . Strange

Structure-activity relationships of interleukin-6 deter- mined using chemically synthesized analogs. Critical

pling of neutrophil chemotaxis, exocytosis, and recep- role of NH,-terminal residues and evidence for uncou-

tor binding activities.

and Bernhard Moser Ian Clark-Lewis, Christoph Schumacher, Marco Baggiolini,

An active serine is involved in covalent substrate amino

synthetase. acid binding at each reaction center of gramicidin S

Wilhelm Schlumbohm, Torsten Stein, Christian Ullrich, Joachim Vater, Michael Krause, Mohamed A. Marahiel, Volker Kruft, and Brigitte Wzttmann-Llebold

Baltimore, MD 21202, U.S.A. Volume 267 for 1992: United States, $670; other countries, $820. Single copy: United States, $23.00; other countries, $27.00. Special subscription rates are The Journal of Bioloprcal Chemistry (ISSN 0021-9258) is published three times per month by the American Society for Biochemistry and Molecular Biology, Inc., 428 East Preston Street,

available to members, graduate students, and postdoctoral fellows for personal use only. Qualifying forms are available from the ASBMB Office,,9650 Rockville Pike, Bethesda, MD 20814. Second class ostage paid at Baltimore. MD 21202, U.S.A. and at additional mailing offices. Send address changes to The Journal of Rrologrcal C h e m x t v at 428 East Preston Street, Baltimore, ME 21202, I1.S.A.

V

23142

23147

23152

23157

23163

23169

23175

23185

23191

23197

23204

23215

23226

23233

23240

Phorbol ester induces manganese-superoxide dismu- tase in tumor necrosis factor-resistant cells.

Junichi Fujii and Naoyuki Taniguchi

Activation of a phosphatidylcholine-specific phospho- lipase C by colony stimulating factor 1 receptor re- quires tyrosine phosphorylation and a guanine nucleo- tide-binding protein.

Goutam Ghosh Choudhury, Victor L. Syluia, and Alan Y. Sakaguchi

human neutrophils. Dependence on changes in cytosolic fMet-Leu-Phe-induced activation of phospholipase D in

burst activation. free Ca2+ concentration and relation with respiratory

G. C. Roger Kessek, Dirk Roos, and Arthur J . Verhoeven

Localization of chromatophore proteins of Rhodo-

chromatophores with phosphatidylglycerol liposomes bacter sphaeroides. I. Rapid Ca'+-induced fusion of

for proteinase delivery to the luminal membrane sur- face.

Rolf Theiler and Robert A. Niederman

Localization of chromatophore proteins of Rhodobacter sphaeroides. 11. Topography of cytochrome c1 and the Rieske iron-sulfur protein as determined by proteolytic digestion of the outer and luminal membrane surfaces.

Transcriptional regulation of cytochrome d in nitro- gen-fixing Azotobacter vinelandii. Evidence that up- regulation during Nz fixation is independent of nifA but dependent on ntrA.

Farhad Moshiri, Eric G. Smith, Joseph P. Taormino, and Robert J. Maier

Functional analysis of T-cell mutants defective in the biosynthesis of glycosylphosphatidylinositol anchor. Relative importance of glycosylphospha- tidylinositol anchor versus N-linked glycosylation in T-cell activation.

Lawrence J . Thomas, Rita DeCasperi, Eiji Sugiyama, Hui- Ming Chang, Pamela J . Beck, Peter Orlean, Masaharu Urak- aze, Tetsu Kamitani, Joseph F. Sambrook, Christopher D. Warren, and Edward T. H. Yeh

The poly-N-acetyllactosamines attached to lysosomal membrane glycoproteins are increased by the pro- longed association with the Golgi complex.

Wei-Chun Wang, Ni Lee, Daisuke Aoki, Michiko N. Fukuda, and Minoru Fukuda

Molecular properties of global suppressors of temper- ature-sensitive folding mutations in P22 tailspike en- dorhamnosidase.

Rolf Theiler and Robert A. Niederman

Sang Chul Lee, Hyeyeong Koh, and Myeong-Hee Y u

The carboxyl-terminal tripeptide Ala-Lys-Ile is essen- tial for targeting Candida tropicalis trifunctional en- zyme to yeast peroxisomes.

Rachubcnskl John,D. Ai tchison, W. Wayne Murray, and Richard A.

The cyclophilin multigene family of peptidyl-prolyl iso- merases. Characterization of three separate human iso- forms.

Derk J. Bergsma, Catherine Eder, Mitchell Gross, Hans Kersten, Daniel Syluester, Edward Appelbaum, Donna Cusi- mano, George P. Liui, Megan M. McLaughlin, Karla Kasyan, Terence G. Porter, Carol Siluerman, Damien Dunnington, An-

Brandt, and Mark A. Levy nalisa Hand, William P. Prichett, Mary J. Bossard, Martin

Epitope mapping of four monoclonal antibodies recog- nizing the hexose core domain of Salmonella liDoDolv- saccharide.

Lindberg

" - J o h n M . C. Luk, Siu M. Lind, R. S. W. Tsang, and Alf A.

Molecular basis of thyroid hormone regulation of mye- lin basic protein gene expression in rodent brain.

Jacob Robbins, and Vera M. Nikodem Antonella Farsetti, Tomoaki Mitsuhashi, Beatrice Desvergne,

The bovine mannose 6-phosphate/insulin-like growth

binding sites to domains 1-3 and 7-1 1 of the extracy- factor 11 receptor. Localization of mannose 6-phosphate

toplasmic region.

Kornfeld Bethany Wes t lund , Nancy M. Dahms, and S tuar t

Requirements for primer synthesis by bacteriophage T 7 63-kDa gene 4 protein. Roles of template sequence and T7 56-kDa gene 4 protein.

Lynn V. Mendelman and Charles C. Richardson

23251

23257

23261

23268

23274

23282

23288

23296

23306

23315

23323

23329

23334

23341

23347

23354

23365

Stimulation of endothelin- 1 gene expression by insulin in endothelial cells.

F. Jauier Oliuer, Guadalupe de la Rubia, Edward P. Feener, M u - E n Lee, Mary R. Loeken, Teruo Shiba, Thomas Querter- mous, and George L. King

Synthesis and characterization of 5-azido-UDP-glucu- ronic acid. A new photoaffinity probe for UDP-glucu- ronic acid-utilizing proteins.

Lester, Alan D. Elbein, and Anna Radominska Richard R. Drake, Piotr Zimniak, Body E. Holey, Roger

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

Donald A. Young M. Kerry O'Banion, Henry B. Sadowski, Virginia Winn, and

Concerted modulation of al(X1) and a2(V) collagen mRNAs in bovine vascular smooth muscle cells.

Sonenshein Karen E. Brown, Roger Lawrence, and Gail E.

Differential expression of small chondroitin/dermatan sulfate proteoglycans, PG-Ibiglycan and PG-II/de- corin, by vascular smooth muscle and endothelial cells in culture.

Wight, and Linda J. Sandell Hannu T. Jiiruelainen, Michael G. Kinsella, Thomas N.

Purification of the transforming growth factor-8 (TGF- 8) binding proteoglycan hetaglycan.

Massague Janet L. Andres, Lars Ronnstrand, Sela Cheifetz, and Joan

Transcriptional regulation of the small nuclear ribo-

ing sequences with homology to genes encoding ribo- nucleoprotein E protein gene. Identification of cis-act-

soma1 proteins. Michael P. Fautsch and Eric D. Wieben

Vitamin D receptor interaction with specific DNA. As- sociation as a 1,25-dihydroxyvitamin Ds-modulated heterodimer.

Teruki Sone, Sandra Kerner, and J . Wesley Pike

Multiple origins of the human glycophorin St" gene. Identification of hot spots for independent unequal ho- mologous recombinations.

Cheng-Hun Huang and Olga 0. Blumenfeld

Distal cis-acting promoter sequences mediate glucocor- ticoid stimulation of cardiac atrial natriuretic factor gene transcription.

J. Schmidt, Jacques Drouin, and Mona Nemer Stefania Argentin, Yu Lin Sun, Isabelle Lihrmann, Thomas

Integrin all,,& (platelet GPIIb-IIIa) recognizes multiple sites in fibronectin.

Ron D. Bowditch, Carol E. Halloran, Shin-ichi Aota, Masa-

H. Ginsberg nobu Obara, Edward F. Plow, Kenneth M. Yamada, and Mark

Characterization of Escherichia coli SecA protein bind- ing to a site on its mRNA involved in autoregulation.

Katherine M. Dolan and Donald B. Oliuer

The Drosophila RBP-J. gene encodes the binding pro- tein for the immunoglobulin J. recombination signal sequence.

Takahisa Furukawa, Masashi Kawaichi, Norisada Matsun- ami, Haruko Ryo, Yasuyoshi Nishida, and Tasuku Honjo

tiation factor 4A in maize root tips. Hypoxia enhances phosphorylation of eukaryotic ini-

Cecelia Webster, Rebecca L. Gaut, Karen S. Browning, Joanne M. Rauel, and Justin K. M . Roberts

Cloning and characterization of a testis-specific thy- mosin Bl0 cDNA. Expression in post-meiotic male germ cells.

Sheng-Cui Lin and Marcelle Morrison-Bogorad

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. ["H]acetylcholine mustard iden- tifies residues in the cation-binding subsite.

Liu Jonathan B. Cohen, Shannan D. Sharp, and W u Schyong

Mapping and molecular modeling of a recognition do- main for lysosomal enzyme targeting.

Stuart Kornfeld Thomas J. Baranski, Gerald Koelsch, Jean A. Hartsuck, and

VI

23373 Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COLlAl) de- velop a phenotype resembling a lethal form of osteogen- esis imperfecta.

Jaspal S. Khillan, Anne S. Olsen, Sirpa Kontusaari, Boris Sokolou, and Darwin J . Prockop

23380 Structure of the murine erythropoietin receptor com- plex. Characterization of the erythropoietin cross- linked proteins.

Patrick Mayeux, Catherine Lacombe, Nicole Casadeuall, Stany Chretien, Isabelle Dusanter, and Syluie Gisselbrecht

23386 Isolation and functional properties of an arginine-se- lective endoprotease from rat intestinal mucosa. A pu- tative prosomatostatin convertase.

Julie Bourdais, Adrian R. Pierotti, Hamadi Boussetta, Nicole Barre, Ginette Deuilliers, and Paul Cohen

23392 Lack of coupling of D-2 receptors to adenylate cyclase in GH-3 cells exposed to epidermal growth factor. Pos- sible role of a differential exmession of G; urotein subtypes.

Toso, Nadia Gabellini, Sandra Sigala, and PierFranco Spano

”

Cristina Missale, Flora Boroni, Laura Castelletti, Roberto Dal

23399 Binding of elastin to Staphylococcus aureus.

William C. Parks, Joel Rosenbloom, William R. Abrams, and Pyong Woo Park, Dauid D. Roberts, Leonard E. Grosso,

Robert P. Mecham

23407 In vivo restriction. Sequence and structure of endonu- clease 11-dependent cleavage sites in bacteriophage T4 DNA.

Margareta Krabbe and Karin Carlson

23416 The hepatitis B virus S promoter comprises a CCAAT motif and two initiation regions.

Dao-Xiu Zhou and T. S. Benedict Yen

23422 Characterization and molecular cloning of a proenzyme form of a ribosome-inactivating protein from maize. Novel mechanism of proenzyme activation by proteo- lytic removal of a 2.8-kilodalton internal peptide seg- ment.

Terence A. Walsh, Alice E . Morgan, and Timothy D. Hey

23428 Chronic ethanol exposure increases levels of protein kinase C 6 and c and protein kinase C-mediated phos- phorylation in cultured neural cells.

rich Robert 0. Messing, Pamela J . Petersen, and Curtis J. Hen-

23433 Primary structure of bovine endothelin ETB receptor and identification of signal peptidase and metal pro- teinase cleavage sites.

Suzuki, Teizo Ito, Hiromi Hagiwara, and Shigehisa Hirose Yasuyoshi Saito, Takeshi Mizuno, Makoto Itakura, Yohko

23438 Characterization of trypsin-sensitive factor(s) required

Maria I . Colombo, Susana Gonzalo, Peggy Weidman, and for endosome-endosome fusion.

Philip Stahl

23446 Type I1 collagen mRNA containing an alternatively

chondrogenesis. spliced exon predominates in the chick limb prior to

Hyun-Duck Nah and William B. Upholt

23453 Dimerization of internalized epidermal growth factor receptors.

Alexander Sorkin and Graham Carpenter

23461

23467

23471

23477

23483

23490

23499

23505

23510

23515

23516

23516

Structure of the polyglutamyl side chain posttransla- tionally added to a-tubulin.

Jean-Claude Prome Virginie Redeker, Jean-Pierre Le Caer, Jean Rossier, and

Ligand-induced internalization and increased cell cal- cium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.

J . Walsh, Alan Wells, H. Steuen Wiley, Gordon N . Gill, and Chia-Ping Chang, Joseph P. Y. Kao, Cheri S. Lazar, Brenda

Michael G. Rosenfeld

Protein kinase activity required for an early step in interferon-a signaling.

Daniel S. Kessler and Dauid E. Levy

Stromelysin expression regulates collagenase activa- tion in human fibroblasts. Dissociable control of two metalloproteinases by interferon-y.

Elaine N . Unemori, Matthew J . Bair, Eugene A. Bauer, and Edward P. Amento

Molecular cloning and sequencing of a gene from al- kaliphilic Bacillus firmus OF4 that functionally com- plements an Escherichia coli strain carrying a deletion in the nhaA Na+/H+ antiporter gene.

D. Mack luey, Arthur A. Guffanti, Jonah S. Bossewitch, Etana Padan, and T e r v A . Krulwich

Evidence for extracellular orientation of the chicken Transverse tubule Mgz+-ATPase of skeletal muscle.

and rabbit enzymes.

Study of the endoproteolytic cleavage of platelet gly- coprotein IIb using oligonucleotide-mediated mutagen- ems.

mer Poncz, and Joel S. Bennett Michael A . Kolodziej, Gaston Vilaire, Daniel Gander, Morti-

Regulation of integrin-type cell adhesion receptors by cytokhes.

Thromboxane Az synthase. Modification during “sui- cide” inactivation.

Ana Saborido, Gloria Moro, and Alicia Megias

Pia Santala and Jyrki Heino

Dauid A. Jones and F. A . Fitzpatrick

ADDITIONS AND CORRECTIONS A novel family of progesterone-induced, retinol-bind- ing proteins from uterine secretions of the pig. Vol. 265

Araghi, and R. Michael Roberts. Subsequent work done by the Janet Clawitter, William E. Trout, Michael G. Burke, Sam

following authors: Melody Stallings-Mann, William E. Trout, and R. Michael Roberts Pancreatic f i cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble. Vol. 266 (1991) 21257- 21264.

Stephan Christgau, Helen Schierbeck, Henk-Jan Aanstoot, Lissi Aagaard, Kathi Begley, Hans Kofod, Kim Hejnaes, and Steinunn Baekkeskou A surface antigen of Giardia lamblia with a glycosyl- phosphatidylinositol anchor. Vol. 266 (1991) 21318- 21325.

Siddhartha Das, Alexis Traynor-Kaplan, Dauid 5’. Reiner, Tze-Chiang Meng, and Frances D. Gilltn

(1990) 3248-3255.

Vol. 266, No. 34 The Journal of Biological Chemistry December 5, 1991

CONTENTS Arranged by Subject Categories

22771

22807

22818

22926

22968

23175

23185

23215

922781

022803

22837

22851

22866

22872

MINIREVIEW von Willebrand factor.

J. Evan Sadler

CARBOHYDRATES, LIPIDS, AND OTHER NATURALPRODUCTS

Structure of oligosaccharides on Saccharomyces SUC2 invertase secreted by the methylotrophic yeast Pichia pastoris.

Reid Townsend, and Frank Maley

"

Robert B. Trimble, Paul H. Atkinson, Juerg F. Tschopp, R.

A novel glycosylation phenotype expressed by Lec23,

sidase I. a Chinese hamster ovary mutant deficient in a-gluco-

Manas K. Ray, Jing Yang, Subha Sundaram, and Pamela Stanley

Allene oxide and aldehyde biosynthesis in starfish oo- cytes.

Alan R. Brash, Molly A. Hughes, Dan J. Hawkins, William E. Boeglin, Wen-Chao Song, and Laurent Meijer

Modulation of renal epithelial cell growth by glucosyl- ceramide. Association with protein kinase C, sphingo- sine, and diacylglycerol.

diyoun, Thomas P. Thomas, Dorothy Wu, Florence S. Barcelon, James A. Shayman, Gayatri D. Deshmukh, Shahryar Mah-

and Norman S. Radin

biosynthesis of glycosylphosphatidylinositol Functional analysis of T-cell mutants defective in the

anchor. Relative importance of glycosylphospha- tidylinositol anchor versus N-linked glycosylation in T-cell activation.

Ming Chang, Pamela J. Beck, Peter Orlean, Masaharu Urak- Lawrence J. Thomas, Rita DeGasperi, Eiji Sugiyama, Hui-

aze, Tetsu Kamitani, Joseph F. Sambrook, Christopher D. Warren, and Edward T. H . Yeh

The poly-N-acetyllactosamines attached to lysosomal membrane glycoproteins are increased by the pro- longed association with the Golgi complex.

Wei-Chun Wang, Ni Lee, Daisuke Aoki, Michiko N. Fukuda, and Minoru Fukuda

Epitope mapping of four monoclonal antibodies recog- nizing the hexose core domain of Salmonella lipopoly- saccharide.

Lindberg

~~ ~

John M. C. Luk, Siu M. Lind, R. S. W. Tsang, and Alf A .

CELL BIOLOGY AND METABOLISM Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy.

Noji, Shigehiko Taniguchi, Kunio Matsumoto, and Toshikazu Mika Nagaike, Shigeaki Hirao, Hisao Tajima, Sumihare

Nakamura

that binds the LDL receptor. A synthetic peptide mimic of plasma apolipoprotein E

Cheryl A. Dyer and Linda K. Curtiss

Quantitative analysis of molecular species of diacyl- glycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells.

Amiya K. Hajra Chunghee Lee, Stephen K. Fisher, Bernard W . Agranoff, and

Activation of the proteinase B precursor of the yeast Saccharomyces cerevisiae by autocatalysis and by an internal sequence.

Vicki L. Nebes and Elizabeth W. Jones

Transforming growth factor-81 inhibits scavenger receptor activity in THP-1 human macrophages.

K. Assoian, and Ira Tabas Lori A . Bottalico, Ruth E. Wager, Luis B. Agellon, Richard

Mechanism of fluoride activation of G protein-gated muscarinic atrial K+ channels.

Atsuko Yatani and Arthur M. Brown

22932 Quantitation of acyl-CoA and acylcarnitine esters ac- cumulated during abnormal mitochondrial fatty acid oxidation.

ence A. Bindoff, Simon Eaton, Morteza Pourfarzam, Frank E. Rajinder Singh Kler, Sandra Jackson, Kim Bartlett, Laur-

Frerman, Stephen I. Goodman, Nicholas J. Watmough, and Douglass M. Turnbull

22954 ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii.

Yuhua Zhang, Elliott M. Ross, and William J. Snell

22991 Disulfide bonding controls the processing of retroviral

Brian C. Gliniak, Susan L. Kozak, Richard T. Jones, and envelope glycoproteins.

Dauid Kabat

23041 Progesterone-regulated cyclic modulation of mem- brane metalloendopeptidase (enkephalinase) in human endometrium.

M . Linette Casey, Jesse W. Smith, Kimihiro Nagai, Louis B. Hersh, and Paul C. MacDonald

23068 Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro- Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis.

Malini Rajagopalan, John L. Neidigh, and Donald A. Mc- Clain

23147 Activation of a phosphatidylcholine-specific phospho- lipase C by colony stimulating factor 1 receptor re- quires tyrosine phosphorylation and a guanine nucleo- tide-binding protein.

Sakaguchi Goutam Ghosh Choudhury, Victor L. Syluia, and Alan Y.

23152 fMet-Leu-Phe-induced activation of phospholipase D in human neutrophils. Dependence on changes in cytosolic

burst activation. free Ca2+ concentration and relation with respiratory

G. C. Roger Kessels, Dirk Roos, and Arthur J. Verhoeuen

23197 The carboxyl-terminal tripeptide Ala-Lys-Ile is essen- tial for targeting Candida tropicalis trifunctional en- zyme to yeast peroxisomes.

Rachubinski John D. Aitchison, W. Wayne Murray, and Richard A.

23233 The bovine mannose 6-phosphate/insulin-like growth factor I1 receptor. Localization of mannose 6-phosphate binding sites to domains 1-3 and 7-1 1 of the extracy- toplasmic region.

Bethany Westlund, Nancy M. Dahms, and Stuart Kornfeld

23274 Differential expression of small chondroitin/dermatan

corin, by vascular smooth muscle and endothelial cells sulfate proteoglycans, PG-Ihiglycan and PG-II/de-

in culture.

Wight, and Linda J . Sandell Hannu T. Jurueluinen, Michael G. Kinsella, Thomas N.

23296 Vitamin D receptor interaction with specific DNA. As- sociation as a 1,25-dihydroxyvitamin D3-modulated heterodimer.

Teruki Sone, Sandra Kerner, and J. Wesley Pike

23380 Structure of the murine erythropoietin receptor com- plex. Characterization of the erythropoietin cross- linked proteins.

Stany Chretien, Isabelle Dusanter, and Syluie Gisselbrecht Patrick Mayeux, Catherine Lacombe, Nicole Casadeuall,

23392 Lack of coupling of D-2 receptors to adenylate cyclase in GH-3 cells exposed to epidermal growth factor. Pos- sible role of a differential exmession of G; Drotein subtypes.

Toso, Nadia Gabellini, Sandra Sigala, and PierFranco Spano

. -

Cristina Missale, Flora Boroni, Laura Castelletti, Roberto Dal

23399 Binding of elastin to Staphylococcus aureus. Pyong Woo Park, Dauid D. Roberts, Leonard E. Grosso,

Robert P. Mecham William C. Parks, Joel Rosenbloom, William R. Abrams, and

Indicates a Communication

vii

Vlll ...

23428

23438

23453

23467

23499

23505

23515

*22789

22960

23010

23083

23135

23365

23386

23422

23477

Chronic ethanol exposure increases levels of protein kinase C d and t and protein kinase C-mediated phos- phorylation in cultured neural cells.

Robert 0. Messing, Pamela J. Petersen, and Curtis J. Hen- rich

Characterization of trypsin-sensitive factor@) required for endosome-endosome fusion.

Maria I. Colombo, Susana Gonzalo, Peggy Weidman, and Philip Stahl

Dimerization of internalized eeidermal growth factor - receptors.

Alexander Sorkin and Graham Carpenter

Ligand-induced internalization and increased cell cal- cium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.

J . Walsh, Alan Wells, H. Steuen Wiley, Gordon N. Gill, and Chia-Ping Chang, Joseph P. Y. Kao, Cheri S. Lazar, Brenda

Michael G. Rosenfeld

coprotein IIb using oligonucleotide-mediated mutagen- Study of the endoproteolytic cleavage of platelet gly-

ems.

mer Poncz, and Joel S. Bennett Michael A. Kolodziej, Gaston Vilaire, Daniel Gander, Morti-

Regulation of integrin-type cell adhesion receptors by cytokines.

Pia Santala and Jyrki Heino

A novel famils of Droeesterone-induced. retinol-bind- ing proteins fiom Gerrne secretions of the pig. Vol. 265

Araghi, and R. Michael Roberts. Subsequent work done by the Janet Clawitter, William E. Trout, Michael G. Burke, Sam

following authors: Melody Stallings-Mann, William E. Trout, and R. Michael Roberts

(1990) 3248-3255.

ENZYMOLOGY Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

Joan M. Heuel, Kimberly A. White, and Mtchael A. Marletta

Conformational requirement for lysine hydroxylation in collagen. Structural studies on synthetic peptide sub- strates of lysyl hydroxylase.

Ping Jiang and Vettai S. Ananthanarayanan

Mechanism of conversion of human apo- to holome- thionine synthase by various forms of cobalamin.

J . Fred Kolhouse, Carolyn Utley, Sally P. Stabler, and Robert H. Allen

Gene structure of mammalian acetylcholinesterase. Al- ternative exons dictate tissue-specific expression.

Ying Li, Shelley Camp, Tara L. Rachinsky, Damon Getman, and Palmer Taylor

An active serine is involved in covalent substrate amino acid binding at each reaction center of gramicidin S synthetase.

Joachim Vater, Michael Krause, Mohamed A. Marahiel, Volker Wilhelm Schlumbohm, Torsten Stein, Christian Ullrich,

Kruft, and Brigitte Wittmann-Liebold

Mapping and molecular modeling of a recognition do- main for lysosomal enzyme targeting.

Thomas J . Baranski, Gerald Koelsch, Jean A. Hartsuck, and Stuart Kornfeld

Isolation and functional properties of an arginine-se- lective endoprotease from rat intestinal mucosa. A pu- tative prosomatostatin convertase.

Barre, Ginette Deuilliers, and Paul Cohen Julie Bourdais, Adrian R. Pierotti, Hamadi Boussetta, Nicole

Characterization and molecular cloning of a proenzyme form of a ribosome-inactivating protein from maize. Novel mechanism of proenzyme activation by proteo- lytic removal of a 2.8-kilodalton internal peptide seg- ment.

Terence A. Walsh, Alice E. Morgan, and Timothy D. Hey

Stromelysin expression regulates collagenase activa- tion in human fibroblasts. Dissociable control of two metalloproteinases by interferonyy.

Elaine N. Unemort, Matthew J . Batr, Eugene A. Bauer, and Edward P. Amento

23510

022785

22847

22887

22912

22975

22983

23157

23163

23169

23329

23483

23490

23516

=22792

Thromboxane AZ synthase. Modification during “sui- cide’’ inactivation. David A. Jones and F. A. Fitzpatrick

MEMBRANES AND BIOENERGETICS Marker exchange of the structural genes for nitric

Pseudomonas stutzeri at nitric oxide. oxide reductase blocks the denitrification pathway of

Cornelia Braun and Walter G. Zumft

Identification of the pheophytin-QA-Fe domain of the reducing side of the photosystem I1 as the Cu(I1)-inhib- itory binding site.

and Rafael Picorel Immaculada Yruela, Guillermo Montoya, Pablo J . Alonso,

The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet &cells in the isolated perfused rat pancreas.

Anal Ghosh, Peter Ronner, Erlinda Cheong, Parwaiz Khalid, and From M. Matschinsky

Drug action of thapsigargin on the CaZ+ pump protein of sarcoplasmic reticulum.

Yoshiyuki Kcima, Eunice Ogunbunmi, and Sidney Fleischer

Regulation of free cytosolic Ca2+ concentration in the outer segments of bovine retinal rods by Na-Ca-K ex- change measured with fluo-3. I. Efficiency of transport and interactions between cations.

Robert T. Szerencsei Paul P. M. Schnetkamp, Xue-Bin Li, Debesh K. Basu, and

Regulation of intracellular free Ca2+ concentration in the outer segments of bovine retinal rods by Na-Ca-K exchange measured with fluo-3. 11. Thermodynamic competence of transmembrane Na+ and K+ gradients and inactivation of Na+-dependent Ca2+ extrusion.

Paul P. M. Schnetkamp, Debesh K. Basu, Xue-Bin Li, and Robert T. Szerencsei

Localization of chromatophore proteins of Rhodo- bacter sphaeroides. I. Rapid Ca2+-induced fusion of chromatophores with phosphatidylglycerol liposomes for proteinase delivery to the luminal membrane sur- face.

Rolf Theiler and Robert A. Niederman

sphaeroides. 11. Topography of cytochrome CI and the Localization of chromatophore proteins of Rhodobacter

Rieske iron-sulfur protein as determined by proteolytic digestion of the outer and luminal membrane surfaces.

Rolf Theiler and Robert A. Niederman

Transcriptional regulation of cytochrome d in nitro- gen-fixing Arotobacter vinelandii. Evidence that up- regulation during Nz fixation is independent of nifA but dependent on ntrA.

Robert J . Maier Farhad Moshiri, Eric G. Smith, Joseph P. Taormino, and

Characterization of Escherichia coli SecA protein bind- ing to a site on its mRNA involved in autoregulation.

Katherine M. Dolan and Donald B. Oliver

Molecular cloning and sequencing of a gene from al- kaliphilic Bacillus firmus OF4 that functionally com- plements an Escherichia coli strain carrying a deletion in the nhaA Na+/H+ antiporter gene.

D. Mack Iuey, Arthur A. Guffanti, Jonah S. Bossewitch, Etana Padan, and Terry A. Krulwlch

Evidence for extracellular orientation of the chicken Transverse tubule Mg+-ATPase of skeletal muscle.

and rabbit enzymes. Ana Saborido, Gloria Mom, and Alicia Megias

A surface antigen of Giardia lamblia with a glycosyl- Dhosohatidvlinositol anchor. vol. 266 (1991) 21318- 213i5. “

Reiner, Tze-Chiang Meng, and Frances D. Gtllm Siddhartha Das, Alexis Traynor-Kaplan, David S.

NUCLEIC ACIDS, PROTEIN SYNTHESIS AND MOLECULAR GENETICS

U small nuclear ribonucleoprotein requirements for nematode cis- and trans-splicing in vitro.

Nilsen Gregory J . Hannon, Patricia A. Maroney, and Timothy W.

Indicates a Communication

ix

022796

022800

22826

22832

22878

22905

22919

22948

23003

23027

23048

23053

23074

23091

23142

23204

Multiple cis-acting elements are required for RNA PO- lymerase 111 transcription of the gene encoding €31 RNA, the RNA component of human RNase P.

Gregory J . Hannon, Alison Chubb, Patricia A. Maroney, Gretchen Hannon, Sidney Altman, and Timothy W . Nilsen

Ribosome-independent GTPase activity of translation initiation factor IF2 and of its G-domain.

Manuela Seuerini, Roberto Spurw, Anna La Team, Cynthia L. Pon, and Claudia 0. Guulerzi

Histidine tRNA guanylyltransferase from Saccharo- myces cerevisiae. I. Purification and physical proper- ties.

Suchira Pande, Dieter Jahn, and Dieter Sol1

Histidine tRNA guanylyltransferase from Saccharo- myces cereuisiae. 11. Catalytic mechanism.

Dieter Jahn and Suchira Pande

Identification of novel factors which bind specifically to the core promoter of the immunoglobulin heavy chain gene.

Jeffrey D. Paruin and Phillip A. Sharp

Dietary sucrose enhances processing of mRNA-S14 nu- clear precursor.

Lynn A. Burmeister and Cary N. Mariash

Inhibitory control of prolactin and Pit-1 gene pro- moters by dopamine. Dual signaling pathways required for D2 receptor-regulated expression of the prolactin gene.

Harry P. Elsholtz, April M. Lew, Paul R. Albert, and Valdine C. Sundmark

ulate the promoter of the mast cell carboxypeptidase A GATA-binding transcription factors in mast cells reg-

gene.

Mather, Dale S. Reynolds, K. Frank Austen, and Stuart H. Leonard I. Zon, Michael F. Gurish, Richard L. Stevens, Cheri

Orkin

Reconstitution and properties of homologous and chi- meric HIV-1.HIV-2 ~ 6 6 . ~ 5 1 reverse transcriptase.

Kathryn J. Howard, Karl B. Frank, Iain S. Sim, and Stuart F. J . Le Grice

like protein C complementary deoxyribonucleic acid. Molecular cloning and characterization of prolactin-

Santanu Deb, Katherine F. Roby, Teresa N. Faria, Claude Szpirer, Goran Leuan, Simon C. M. Kwok, and Michael J. Soares

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor 8.

Mark R. Keeton, Scott A. Curriden, Anton-Jan van Zonneu- eld, and David J . toskutof f

Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleo- tide-binding protein activator of cholera toxin.

and Martha Vaughan Su-Chen Tsai, Randy S. Haun, Mikako Tsuchiya, Joel Moss,

Hormonal activation of gene transcription in ras-trans- formed NIH3T3 cells overexpressing RIIa and RIIB subunits of the CAMP-dependent protein kinase.

Anne D. Otten, Lise A. Parenteau, Stein Dbskeland, and G. Stanley McKnight

A ribosomal calmodulin-binding protein from Dictyos- telium.

Jiirgen Sonnemann, Annette Bauerle, Thomas Winckler, and Rupert Mutzel

tase in tumor necrosis factor-resistant cells. Phorbol ester induces manganese-superoxide dismu-

Junichi Fujii and Naoyuki Taniguchi

The cyclophilin multigene family of peptidyl-prolyl iso- merases. Characterization of three separate human iso- forms.

Derk J . Bergsma, Catherine Eder, Mitchell Gross, Hans Kersten, Daniel Syluester, Edward Appelbaum, Donna Cusi- mano, George P. Liui, Megan M. McLaughlin, Karla Kasyan, Terence G. Porter, Carol Siluerman, Danien Dunnington, An-

Brandt, and Mark A. Levy nalisa Hand, William P. Prichett, Mary J . Bossard, Martin

23226

23240

23251

23261

23268

23288

23306

23315

23334

23341

23347

23373

23407

23416

23433

23446

23471

Molecular basis of thyroid hormone regulation of mye- lin basic protein gene expression in rodent brain.

Jacob Robbins, and Vera M. Nikodem Antonella Farsetti, Tomoaki Mitsuhashi, Beatrice Desuergne,

Requirements for primer synthesis by bacteriophage T7 63-kDa gene 4 protein. Roles of template sequence and T7 56-kDa gene 4 protein.

Lynn V. Mendelman and Charles C. Richardson

Stimulation of endothelin-1 gene expression by insulin in endothelial cells.

Mu-En Lee, Mary R. e e k e n , T e r w Shiba, Thomas Querter- F. Jauier Oliuer, Guudalupe de la Rubia, Edward P. Feener,

m o w , and George L. Kmg

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

M. Kerry O'Banion, Henry B. Sadowski, Virginia Winn, and Donald A. Young

Concerted modulation of al(X1) and a2(V) collagen mRNAs in bovine vascular smooth muscle cells.

Karen E. Brown, Roger Lawrence, and Gail E. Sonenshein

Transcriptional regulation of the small nuclear ribo- nucleoprotein E protein gene. Identification of cis-act- ing sequences with homology to genes encoding ribo- somal proteins.

Michael P. Fautsch and Eric D. Wieben

Multiple origins of the human glycophorin St" gene. Identification of hot spots for independent unequal ho- mologous recombinations.

Cheng-Han Huang and Olga 0. Blumenfeld

Distal cis-acting promoter sequences mediate glucocor- ticoid stimulation of cardiac atrial natriuretic factor gene transcription.

J. Schmidt, Jacques Drouin, and Mona Nemer Stefania Argentin, Yu L in Sun, Isabelle Lihrmann, Thomas

The Drosophila RBP-J, gene encodes the binding pro-

sequence. tein for the immunoglobulin J. recombination signal

Takahisa Furukawa, Masashi Kawaichi, Norisada Matsu- nami, Haruko Ryo, Yasuyoshi Nishida, and Tasuku Honjo

Hypoxia enhances phosphorylation of eukaryotic ini- tiation factor 4 A in maize root tips.

Cecelia Webster, Rebecca L. Gaut, Karen S. Browning, Joanne M. Rauel, and Justm K. M. Roberts

mosin Dl,, cDNA. Expression in post-meiotic male germ Cloning and characterization of a testis-specific thy-

cells. Sheng-Cai Lin and Marcelle Morrison-Bogorad

Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COLlAl) de- velop a phenotype resembling a lethal form of osteogen- esis imperfecta.

Jaspal S. Khillan, Anne S. Oken, Sirpa Kontusaari, Boris Sokolou, and Darwin J . Prockop

I n vivo restriction. Sequence and structure of endonu- clease 11-dependent cleavage sites in bacteriophage T4 DNA.

Margareta Krabbe and Karin Carkon

The hepatitis B virus S promoter comprises a CCAAT motif and two initiation regions.

Dao-Xiu Zhou and T. S. Benedict Yen

Primary structure of bovine endothelin ETe receptor

teinase cleavage sites. and identification of signal peptidase and metal pro-

Yasuyoshi Saito, Takeshi Mizuno, Makoto Itakura, Yohko Suzuki, Teizo Ito, Hiromi Hagiwara, and Shigehisa Hirose

Type I1 collagen mRNA containing an alternatively spliced exon predominates in the chick limb prior to chondrogenesis.

Hyun-Duck Nah and William B. Upholt

Protein kinase activity required for an early step in interferon-a signaling.

Daniel S. Kessler and David E. Levy

Indicates a Communication

X

22858

22893

22899

22939

22998

23016

23022

23033

23060

23097

PROTEIN CHEMISTRY AND STRUCTURE The effects of p-hydroxymercuribenzoic acid modifi- cation and heat treatment on the CuA reduction poten- tial of cytochrome c oxidase.

Sunney I. Chan Zhuyin Li, Randy W . Larsen, Lian-ping Pan, and

Metalloenzymes in DNA repair. Escherichia coli endo- nuclease IV and Saccharomyces cerevisiae Apnl.

Joshua D. Levin, Robert Shapiro, and Bruce Demple

Drosophila laminin A chain sequence, interspecies comparison, and domain structure of a major carboxyl portion.

Katherine Garrison, Albert J. MacKrell, and John H. Fessler

brane heparan sulfate proteoglycan, reveals extensive The complete sequence of perlecan, a basement mem-

similarity with laminin A chain, low density lipopro- tein-receptor, and the neural cell adhesion molecule.

Douglas M. Noonan, Anna Fulle, Piera Valente, Silla Cai,

John R. Hassell Elizabeth Horigan, Makoto Sasaki, Yoshihiko Yamada, and

Arginine 197 of lac repressor contributes significant energy to inducer binding. Confirmation of homology to periplasmic sugar binding proteins.

Ronit 0. Spotts, Artemis E. Chakerian, and Kathleen S. Matthews

thrombomodulin. Two distinct structural changes are The active site of thrombin is altered upon binding to

protein C activation. detected by fluorescence, but only one correlates with

Jia Ye, Naomi L. Esmon, Charles T. Esmon, and Arthur E. Johnson

The effect of carbohydrate on the structure and stabil- ity of erythropoietin.

Linda Owers Narhi, Tsutomu Arakawa, Kenneth H. Aoki, Rebecca Elmore, Michael F. Rohde, Thomas Boom, and Thomas W . Strickland

Involvement of the distal histidine in the low affinity exhibited by Hb Chico ( L y P - Thr) and its isolated f l chains.

Celia Bonaoentura, Robert Cashon, Joseph Bonaoentura, Man Perutz, Giulio Fermi, and Daniel T.-B. Shih

Extracellular domain-IgG fusion proteins for three hu- man natriuretic peptide receptors. Hormone pharma- cology and application to solid phase screening of syn- thetic peptide antisera.

Vitangcol, Jill R. S. Jewett, John Burnier, Willium Henzel, and Brian D. Bennett, Gregory L. Bennett, Roderick V.

Daoid G. Lowe

Role of disulfide bonds in biologic activity of human interleukin-6.

Fowlkes John N . Snouwaert, Frank W . G. Leebeek, and Dana M.

23103 Bombinin-like peptides with antimicrobial activity

talis. from skin secretlons of the Asian toad, Bombina orien-

Bradford W. Gibson, Dazhi Tang, Robert Mandrell, Michele Kelly, and Elmt R. Splndel

23112 Effects of gene mutations in lipoprotein and hepatic lipases as interpreted by a molecular model of the pan- creatic triglyceride li ase.

Zygmunt S. Derewen2 and Christian Cambillau

23120 Cop e r X-extended x-ray absorption fine structure stu&es of oxidized and reduced do amine &hydroxyl- ase. Confirmation of a sulfur ligan8 to copper(1) in the reduced enz me.

Ninian J. Jlackburn, Samar S. Hasnain, Trudie M. Pettin- gill, and Richard W . Strange

23128 Structure-activity relationshi 6 of interleukin-8 deter- mined using chemically s ntEesized analogs. Critical role of NHn-terminal residrues and evidence for uncou- pling of neutrophil chemotaxis, exocytosis, and recep- tor binding activities:

Ian Clark-Lewzs, Chrzstoph Schumacher, Marco Baggiolini, and Bernhard Moser

23191 Molecular properties of global suppressors of temper- ature-sensitive folding mutations in P22 tailspike en- dorhamnosidase.

Sang Chul Lee, Hyeyeong Koh, and Myeong-Hee Yu

23257 Synthesis and characterization of 5-azido-UDP-glucu- ronic acid. A new photoaffinity probe for UDP-glucu- ronic acid-utilizing roteins.

Lester, Alan D. Elbern, and Anna Radominska Richard R. Drake: Biotr Zimniak, Body E. Haley, Roger

23282 Purification of the transforming growth factor-b (TGF-

Janet L. Andres, $rs Ronnstrand, Sela Cheifetz, and Joan 8) binding proteo lycan betaglycan.

Massague

23323 Integrin (platelet GPIIb-IIIa) recognizes multiple sites in flbronectin.

Ron D. Bowditch, Carol E. Halloran, Shin-ichi Aota, Masa-

H. Ginsberg nobu Obara, Edward F. Plow, Kenneth M. Yamada, and Mark

23354 Structure of the agonist-bindin site of the nicotinic acetylcholine rece tor. [3H]acetyfcholine mustard iden- tifies residues in t t e cation-binding subsite.

Jonathan B. Cohen, Shannan D. Sharp, and W u Schyong Liu

23461 Structure of the polyglutamyl side chain posttransla-

Virginle Redeker, Jean-Pierre Le Caer, Jean Rosier, and tionally.added to a-tubulin.

Jean-Claude Prome

23516 Pancreatic 0 cells ex res8 two autoantigenic forms of flutamic acid decar&oxylase., a 65-kDa hydrophilic orm and a 64-kDa amphiphillc form whlch can be both

membrane-bound and soluble. Vol. 266 (1991) 21257- 21264.

Lissl Aagaard, Kathz Begley, Hans Kofod, Klm Hejnaes, and Stephan Christgau, Helen Schierbeck, Henk-Jan ,Aanstoot,

Steinunn Baekkeskov

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