化学33 - inpit.go.jp · iii ブラッドアクセス 抗血液凝固薬注入器 血流ポンプ...

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平成17年度 特許流通支援チャート 化学33 血液浄化材料 2006年3月 独立行政法人 工業所有権情報・研修館

Transcript of 化学33 - inpit.go.jp · iii ブラッドアクセス 抗血液凝固薬注入器 血流ポンプ...

i

1920

96

2003 24

8 1 110

2004 10%

4

1993 1 2003 12

1,553 899 58%

500 32% 22 1%

132 9%

1997 150

60

ii

41

30%

()

()

20 1,553 66%1,028

384 12

303 80%

3%

41%

30%

13%

4%

7%

2%

iii

(899)(500)

(22)

(132)

(899)(500)

(22)

(132)

(899)(500)

(22)

(132)

1993 2003 12

1,553

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iv

98

97

9594

01

0203

00 99

9693

0

50

100

150

200

0 20 40 60 80 100

1997

150 60

93 94 00

93 94 95 96 97 98 99 00 01 0203

0

10

20

30

40

50

60

70

80

90

100

v

56

25

54

66

2

38

51

40

43

25

43

11

6

6

78

10

7

44

58

8

14

66

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14

2

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4

42

2

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18

7

6

33

3

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5

4

35

4

2

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30

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3

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4

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6

1

86

68

6

7

14

1

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30

2

5

3

3

1

1

1

56

95

4

35

3

01 03 50

97 00 50

93 96 50

50

19931200312

0103

vi

1671925()[10]

2133556()[15]

04-208856 3117575 06-296686() () (;

[17] [18] )[16]

1771033 05-054373 11-309355(()) (()) ()

[29] [45] [11]1925313 62-041738

() ()[10] [10]

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[13]3076080 08-009668

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[11]

3097149()[31]

1723513 2131936() (())

[11] [21]

61-232860()[12]

1837949()

[10]02-211229 2135744 11-332980() (()) ()[12] [10] [12]

02-135130()[11]

1575364()[13]

1189979()[12]

1202225()[12]

13 3 6 1 1 1 175 73 100 10 12 12

344

112

225

6136

110

670

(;)

333

352

10 25

vii

230

169

108

75

58

4

4

3

9899

0102 30

56.4

63.5

52.6

63.3

47.3 45.242.3

46.1

37.9

48.3

63.2

17.8

13.5

20.4

11.4

21.8

16.8

12.5

21.6

28.7

31.0

19.43.1

6.1

3.6 1.3 10.0

6.5

4.2

3.0

12.1

5.5

10.322.116.2

23.4 24.1 18.2

30.3

38.7

26.3

17.2

13.8

4.5

0.6 0.7 0.0 0.0 2.7 1.3 2.4 3.0 4.01.4 2.6

0%

20%

40%

60%

80%

100%

93 94 95 96 97 98 99 00 01 02 03

viii

2005 7

230

27

IPC

3281364

01.07.24

B01D69/08

[ 6 ]

3330420

93.04.19

B01J20/26

19931200312

3

11

8

15

12

13

5

13

2

1 8

6

11

14

2

6

4

8

4

4

1

12

1

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14

13

1

3

3

4

3

1

2

1

1

3

1

1

1

1

1

2

1

3

1

ix

19931200312

7

2

2

17

15

12

2

9

2

1

1

2

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7

7

3

13

1

4

1

4

2

1

2

1

6

4

2

4

4

3

1

1

1

1

1

1

2

2

1

1

6

1

1

7

2005 7

169

16

IPC

3413985

94.09.29

A61M1/34,520

8.9 70

3644117

96.02.14

B01D71/68

(

)

x

2005

7

108

13

IPC

2894475

93.12.13

A61M1/18,523

3427658

97.02.10

B01D71/16

19931200312

2

3

7

2

6

1

1

2

2

1

6

12

2

5

1

4

2

1

1

3

12

1

2

2

1

6

4

2

1

1

1

3

2

3

2

1

xi

2005 7

75 14

IPC

3356844

93.11.12

A61M1/36,545

3640824

99.01.07

B01D71/82,510

19931200312

2

4

3

1

2

4

1

2

4

2

1

1

1

1

2

1

1

1

2

3

1

10

1

9

2

1

2 6

1

1

2

xii

2005 7

58 6

IPC

3633978

94.12.26

B01J20/26

TNF

3410849

95.01.27

B01J20/00

logP 2.50

19931200312

8

1

16

6

1

3

2

1

1

1

3

1

1

1

5

1

2

1

1

2

.

1.1 .....................................3

1.1.1 .................................3

1.1.2 ...............................4

1.1.3 ...........................7

1.1.4 ..........................26

1.1.5 ..............................49

1.1.6 ........................................50

1.2 ..................51

1.3 ..................................56

1.3.1 ......................56

1.3.2 ......................63

1.3.3 ......................64

1.3.4 ......................65

1.3.5 ......................66

1.3.6 ..............67

1.3.7 ......................68

1.3.8 ......................70

1.3.9 ......................71

1.3.10 .........................72

1.3.11 .....................73

1.3.12 .............74

1.3.13 .........................75

1.3.14 .................................76

1.4 ............................77

1.4.1

..........................80

1.4.2 ........84

1.4.3 .............120

Contents

Contents

1.5 .....................................124

1.5.1 ...........................124

1.5.2 .................128

1.5.3 .........................129

. .............137

2.1

2.1.1 .....................................138

2.1.2 .........................................138

2.1.3 ...........................139

2.1.4 .....................139

2.2

2.2.1 .....................................165

2.2.2 .........................................165

2.2.3 ...........................166

2.2.4 .....................166

2.3

2.3.1 .....................................186

2.3.2 .........................................186

2.3.3 ...........................187

2.3.4 .....................187

2.4

2.4.1 .....................................201

2.4.2 .........................................201

2.4.3 ...........................202

2.4.4 .....................202

2.5

2.5.1 .....................................211

2.5.2 .........................................211

2.5.3 ...........................212

2.5.4 .....................212

Contents

2.6

2.6.1 .....................................221

2.6.2 .........................................221

2.6.3 ...........................222

2.6.4 .....................222

2.

2.7.1 .....................................230

2.6.2 .........................................230

2.6.3 ...........................231

2.6.4 .....................231

2.8

2.8.1 .....................................238

2.8.2 .........................................238

2.8.3 ...........................238

2.8.4 .....................239

2.9

2.9.1 .....................................246

2.9.2 .........................................246

2.9.3 ...........................246

2.9.4 .....................247

2.10

2.10.1 ....................................254

2.10.2 ........................................254

2.10.3 ..........................254

2.10.4 ....................255

2.11

2.11.1 ....................................261

2.11.2 ........................................261

2.11.3 ..........................262

2.11.4 ....................262

2.12

2.12.1 ....................................269

2.12.2 ........................................269

2.12.3 ..........................270

2.12.4 ....................270

Contents

2.13

2.13.1 ....................................275

2.13.2 ........................................275

2.13.3 ..........................276

2.13.4 ....................276

2.14

2.14.1 ....................................280

2.14.2 ........................................280

2.14.3 ..........................281

2.14.4 ....................281

2.15

2.15.1 ....................................285

2.15.2 ........................................285

2.15.3 ..........................286

2.15.4 ....................286

2.16

2.16.1 ....................................290

2.16.2 ........................................290

2.16.3 ..........................290

2.16.4 ....................291

2.17

2.17.1 ....................................295

2.17.2 ........................................295

2.17.3 ..........................296

2.17.4 ....................296

2.18

2.18.1 ....................................300

2.18.2 ........................................300

2.18.3 ..........................300

2.18.4 ....................301

2.19

2.19.1 ....................................305

2.19.2 ........................................305

Contents

2.19.3 ..........................306

2.15.4 ....................306

2.20

2.20.1 ....................................310

2.20.2 ........................................310

2.20.3 ..........................311

2.20.4 ....................311

2.21

2.21.1 ..........................................315

2.21.2 ....................315

2.22 ...................... 319

.

3.1 ........................... 337

1. ....................343

Contents

1.

2.

3.

4

.

1.1

1.2

1.3

1.4

1.5

3

0

50,000

100,000

150,000

200,000

250,000

1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003

(

1.1.1

200324

1.1.1

110

200410

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.

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1.1.3

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1.1.3

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DNA DNA

DNA

DNA

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LDL

LDL

LDL

3497195

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LDL

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10

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DNA

2002331237)

)

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3271357

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3410849

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2004121857

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ACE RAGE(receptor for

advanced glycation endproducts) AGE

2004236792

.

06218050

06218051

40040,000 0.1100m

06233815

.

21

2001112861

2001212434

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()()

22

100

2001316420

2003310752

.

23

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1.1.3-2 511512513 56

3200828

1.1.3-2

( 3200828)

2003070904

24

1.1.3-3

2003070904

280m 200m

50m

2003290340

2004254941

1.1.3-4

( 2003290340)

25

(4)

20

20 3001774

3533013

0.01500ng/cm2

3651195

11332980

26

1.1.4

1.1.4-1 1.1.4-2

1.1.4-3 1.1.4-4

(1) 1.1.4-1

97

02

94 99

93 98

(2) 1.1.4-2

93

99 01

(3) 1.1.4-3

93

(4) 1.1.4-4

93 96

96

93 00

94

27

1.1.4-1 (1/10)

/

/

1993 1994 1995 1996 1997

48-004461 69.03.02

N

07-148252 93.12.01

09-135898 95.04.20

()()

08-302018 95.04.28

/

WO97/01357595.10.09

/

3145965 96.08.09

/

11-188247 97.10.27

/

11-106593 97.09.30

07-051362 93.08.20

/

07-116248 93.10.20

09-029080 95.07.25

3630729 93.10.06

0.00110m /

361719495.06.30

/

3314861 96.12.24

/

347420597.05.19

/

28

1.1.4-1 (2/10)

/

/

1998 1999 2000 2001 2002 2003

2001-286743 00.04.10 NOK

2002-03012500.04.17

2005-51120801.12.07

PPO/PEO

2004-06775802.08.02

/

2001-029762 99.07.27

/()

2000-042383 98.07.31

2000-288372 99.04.05 NOK

/

29

1.1.4-1 (3/10)

1993 1994 1995 1996 1997

2688564 93.04.12

//

331614596.09.05

3253875 96.12.05

342765897.02.10

3413985 94.09.29

8.9 70

2792556 94.12.16

/

30

1.1.4-1 (4/10)

1998 1999 2000 2001 2002 2003

3424807 98.06.26

2003-038940 01.07.30

3431622 02.09.12

11-309353 98.04.28

2000-126286 98.10.21

0.1 0.5m

2000-288365 99.04.07

31

1.1.4-1 (5/10)

1993 1994 1995 1996 1997

3297707 93.02.01

2874742 93.04.20

291813793.04.20

-

3548354 96.10.15

342145594.11.16

3193819 93.12.24

3496382 96.02.05

/

10-235171 96.12.25

3415222 93.10.20

3356844 93.11.12

3392707 97.05.28

305912797.09.02

335072296.03.29

32

1.1.4-1 (6/10)

()

1998 1999 2000 2001 2002 2003

2000-32576399.05.24

2004-209423 03.01.07

DNA

2000-31271699.04.30

2000-024474 98.07.15

2004-08998800.05.15

2000-135421 98.11.02

/

WO01/03607299.11.17

-500mV

2003-080590 01.09.10

WO03/03153303.02.27

33

1.1.4-1 (7/10)

1993 1994 1995 1996 1997

3442842 93.2.18

/ pH

302649397.12.30

()/

349446694.03.11

320526796.09.18

353753995.06.09

2818352 93.04.12

3226188 93.08.06

34

1.1.4-1 (8/10)

1998 1999 2000 2001 2002 2003

2003-17532001.10.05

/

11-347384 98.06.12

2003-11735901.10.10

2005-16292603.12.04

35

1.1.4-1 (9/10)

1993 1994 1995 1996 1997

2694848 93.07.26

3068424 94.12.12

/

346090095.12.27

0.2

3353284 93.08.09

NCO 1.4

3455269 94.01.28

3250655 96.12.24

2961481 93.08.30

1 1015 1 1015

349900294.06.09

328402894.09.02

3574902 96.11.15

36

1.1.4-1 (10/10)

1998 1999 2000 2001 2002 2003

2000-024104 98.07.08

mV

2001-26954500.03.24

352450900.04.27

11-332979 98.05.27

2004-52966800.11.13

2003-079721 01.09.11

10 2040 20

37

1.1.4-2 (1/8)

2-

1993 1994 1995 1996 1997

3276456 93.04.28

2739903 95.03.13

280492095.04.27

TNF

363397894.12.26

TNF

08-31943195.05.16

2001-525200 97.07.30

()

2-

3330420 93.04.19

3333309 94.04.08

09-234246 95.12.28

2-

3615785 94.04.28

HIV

08-242849 95.02.09

10-323387 97.03.25

3633979 94.12.26

38

1.1.4-2 (2/8)

2-

1998 1999 2000 2001 2002 2003

2001-299904 00.03.09

2.6 ( )

2004-51398800.11.13

FVIII

2003-339855 02.05.24

( )

2000-245831 99.03.03

WO00/06946699.05.12

39

1.1.4-2 (3/8)

1993 1994 1995 1996 1997

3497195 93.02.10

3574471 94.05.18

353354195.01.25

/

10-225515 97.02.17

/

3271357 93.03.15

3515802 93.01.09

2854857 97.06.04

()

3272099 93.04.14

364416996.12.26

50m

2004-12185794.10.18

WO99/010025 97.08.22

3040

40

1.1.4-2 (4/8)

1998 1999 2000 2001 2002 2003

2000-217909 98.11.24

WO01/01806099.09.08

2002-331237 01.05.09

352795499.11.30

2002-32700101.04.27

2003-8200201.09.14

WO01/06617100.03.10

(A) (B)

2005-12004403.10.17

41

1.1.4-2 (5/8)

1993 1994 1995 1996 1997

07-025776 93.07.15

11-15807697.12.01

/

42

1.1.4-2 (6/8)

1998 1999 2000 2001 2002 2003

2001-046844 99.08.09

2001-198215 00.01.21

2002-291875 01.03.30

2005-03420503.07.15

2002-543898 99.05.10

()

2004-180703 02.11.29

2004-22311803.01.27

2002-238997 01.02.21

/

3560934 01.05.28

100

2003-310752 02.04.25

43

1.1.4-2 (7/8)

1993 1994 1995 1996 1997

3270193 93.04.30

322349895.11.01

3049182 93.04.28

301491694.03.28

10m

44

1.1.4-2 (8/8)

1998 1999 2000 2001 2002 2003

2002-31600801.04.19

2004-16674702.11.15

45

1.1.4-3 (1/2)

3200828 93.12.10

1993 1994 1995 1996 1997

46

1.1.4-3 (2/2)

2003-07090401.09.07

2003-290340 02.02.01

50m

2004-25494103.02.26

1998 1999 2000 2001 2002 2003

47

1.1.4-4 (1/2)

3315785 93.11.09

07-25584193.12.14

()()

2000-51000396.03.29

() HCV HCV

2000-50642096.11.19

() 30mW/cm2

07-163814 93.12.10

//

317237394.08.05

HIV HIV HIV

10-005328 96.04.26

HIV

1993 1994 1995 1996 1997

319329595.07.07

48

1.1.4-4 (2/2)

1998 1999 2000 2001 2002 2003

2003-22528901.10.25

()

282+/-15nm UV

2000-288086 99.04.02

/HIV

2001-034045100.06.01

0.2 3.0V

2000-245832 99.03.02

HIV HBV HCV HTLV HTLV

2005-516978 02.02.01

() 470nm

2004-14103202.10.23

( )12

2003-11740501.10.10

CVD 17m

49

1.1.5

2004 248,166

10,456

3,882 165

97,366

1.1.5

0

20,000

40,000

60,000

80,000

100,000

120,000

80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04

P.6 (2004)

2005 4,700 1,400

http://www.enplanet.com/Ja/Market/Data/y025.html

50

1.1.6

1.1.6

1.1.6

URL

http://www.jsdt.or.jp/

http://jsbpcc.umin.jp/

http://www.jsn.or.jp/

http://www.jyouka.com/

HDF

http://www.i-hive.co.jp/~hdf/

http://www.jmed.jp/proceedings/proceed

ings_jinzou.htm

http://www.jsao.org/

51

IPC

IPC

A61M

B01D

IPC 1.2-1

1.2-1 IPC

IPC

A61M1/00

A61M1/02

A61M1/14

A61M1/16

A61M1/34

A61M1/36

B01D61/00

B01D67/00

B01D69/00

B01D71/00

B01D39/00

B01D41/00

B01J

1.2

52

FI

1.2-2 FI

1.2-2 FI

FI

A61M1/00

A61M1/02 500 510 540 550

A61M1/14 511 520

A61M1/16

A61M1/34

A61M1/36 530 540 550

B01D61/00 500

B01D67/00

B01D69/00 500

B01D71/00

B01D39/00 A B C D Z

B01D41/00

B01J

53

FT

1.2-3 FT

1.2-3 FT

A61M1/00-1/36,569

FT

4C077

AA05

BB01

BB02

BB03

LL00

MM00

B01D53/22;61/00-71/82,510;C02F1/44-1/44@Z

FT

4D006

PB09

PC44

PC46

PC47

PB42

PB43

GA01

GA02

GA12

B01D39/00-41/04

FT

4D019

B01J20/00-20/34@Z

FT

4G066

EA04

B01D15/00-15/08

FT

4D017

AA01

AA11

54

IPCFI

1.2-4

1.2-4

IPC FI F

A61M1/16 A61M1/34 A61M1/02 B01D61/00 B01D67/00 B01D69/00 B01D71/00 B01D39/00 B01D41/00

A61M1/16 A61M1/34 A61M1/02,540 B01D61/00 B01D67/00 B01D69/00 B01D71/00 B01D39/00 B01D41/00

4D006PC47 4D006PB09 4D006PB42 4D006PB43 4D006GA02 4D006GA12 4D019

A61M1/02,550 A61M1/36,530 A61M1/36,540 A61M1/36,550

A61M1/02,550 A61M1/36,530 A61M1/36,540 A61M1/36,550

4G066EA04 4D017AA11

55

1.2-5

1.2-5

USC

210/646 Hemodialysis

210/650 Filtering through membrane

210/651 Removing specified material

210/652 Hyperfiltration

1.2-6

1.2-6

ECla

A61M25 Catheters; Hollow probes

B01D63 Apparatus in general for separation processes using semi-permeable membranes

B01D67 Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus

B01D69 Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties

B01D71 Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted

B01J20 Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating

56

1993 2003 12

1,553

1.3.1

(1)

1.3.1-1

1997 150

60

0203

22

1.3.1-1

1.3.1-2

93 97 209899 30

9300 102001 02 30

93

10 95 96

1.3

93

96

9900

0302

01

94

95

97

98

0

50

100

150

200

0 20 40 60 80 100

57

1.3.1-2

1.3.1-1

1993

2001 02 30 93

03 30 93 23 10

03 31

507

30.0 1.3.1-1 30 1,124

66.5 384

303 80

56.4

63.5

52.6

63.3

47.3 45.242.3

46.1

37.9

48.3

63.2

17.8

13.5

20.4

11.4

21.8

16.8

12.5

21.6

28.7

31.0

19.4

3.1

6.1

3.6 1.3 10.0

6.5

4.2

3.0

12.1

5.5

10.322.1

16.2

23.4 24.1 18.2

30.3

38.7

26.3

17.2

13.8

4.5

0.6 0.7 0.0 0.0 2.7 1.3 2.4 3.0 4.01.4 2.6

0%

20%

40%

60%

80%

100%

93 94 95 96 97 98 99 2000 2001 2002 2003

58

1.3.1-1

93 94 95 96 97 98 99 00 01 02 03

1 16 9 24 9 23 25 15 20 38 34 17 230

2 8 6 10 14 10 16 13 21 15 26 30 169

3 23 9 5 6 3 10 6 7 5 3 31 108

4 6 13 6 2 6 7 15 8 4 2 6 75

5 3 12 6 15 5 4 9 3 1 58

6 1 3 8 5 4 2 7 5 2 7 8 52

7 8 8 3 15 3 3 1 1 42

8 2 5 7 3 1 4 7 6 4 1 40

8 3 2 5 5 2 4 1 3 12 3 40

10 7 3 1 4 1 5 6 6 5 1 39

10 6 7 3 4 8 1 5 1 2 2 39

12 2 2 2 1 1 2 4 6 4 24

13 () 3 3 2 5 1 3 17

14 3 4 1 3 2 2 15

15 7 2 2 1 1 1 14

15 1 3 1 1 2 2 3 1 14

15

() 1 1 4 2 2 1 1 2 14

18 2 7 1 1 2 13

18 3 3 2 2 2 1 13

20 2 2 2 4 1 1 12

21 1 1 4 1 2 1 1 11

22 2 1 7 10

22 1 3 2 2 1 1 10

22 1 3 1 1 2 1 1 10

22 () 2 2 5 1 10

22 3 4 1 2 10

27 2 5 1 1 9

27 3 2 4 9

27 1 1 1 1 2 2 1 9

30 2 2 2 1 1 8

59

1.3.1-2

1.3.1-2

93 94 95 96 97 98 99 00 01 02 03

34 1 2 2 1 6

46 () 4 4

46 () 4 4

46 () 4 4

46 () 1 1 1 1 4

59

() 1 1 1 3

59 () 2 1 3

59 () 2 1 3

59 2 1 3

60

1.3.1-3 93

03 1,553 899 57.9

500 32.2 22 1.4

132 8.5

1.3.1-3

899 132 54

78

68

168

100

85 54

12

19

103 103

411 411

500 230 16

57

25

35

16

() 75

5

1

40 40

61 61

17 5

12

17 17

135 135

22 2 2

20 20

16 16

4 4

1 1

2 2

132

109 109

1993 1 2003 12

61

1.3.1-3

93 94 00

1.3.1-3

(2)

1.3.1-4 1.3.1-5

1.3.1-6

2002

1.3.1-4 1.3.1-5

1999

93 94 95 96 97 98 99 00 01 0203

0

10

20

30

40

50

60

70

80

90

100

62

1.3.1-4 1.3.1-5

1.3.1-4

1 3-DIMENSIONAL PHARMACEUTICALS 10

2 NXSTAGE MEDICAL 5

2 SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE 5

4 COLIN MEDICAL TECHNOLOGY 4

4 GAMBRO 4

1.3.1-5

1 PALL CORPORATION 54

2 MILLIPORE CORPORATION 51

3 GKSS-FORSCHUNGSZENTRUM 37

4 NITTO DENKO CORPORATION 29

5 PRAXAIR TECHNOLOGY 27

0

50

100

150

200

250

300

1999 2000 2001 2002 2003

0

50

100

150

200

250

300

1999 2000 2001 2002 2003

0

50

100

150

200

250

300

1999 2000 2001 2002 2003

1.3.1-6

63

93

96

9995,00

03

02

01

9497

98

0

10

20

0 10 20

1.3.2

1993 2003 12

132

1.3.2

93 20 97 15

1.3.2

1.3.2

22 14 13

98 93 99

1.3.2

93 94 95 96 97 98 99 00 01 02 03

1 2 2 3 6 1 2 3 3 22

2 1 3 1 2 3 1 1 2 14

3 5 1 3 2 2 13

4 2 1 2 1 3 1 10

5 3 5 8

6 2 1 1 1 1 6

7 1 1 3 5

8 1 1 2 4

8 1 3 4

8 2 1 1 4

64

98

97

95

94 01

0203

00

99

96

93

0

10

20

30

0 10 20 30

1.3.3

1993 2003 12

168

1.3.3

99 24 93 01 12

1.3.3

1.3.3

34 23 16

03 14 02

96

1.3.3

93 94 95 96 97 98 99 00 01 02 03

1 2 2 2 2 1 3 3 3 1 1 14 34

2 1 4 1 2 3 4 2 6 23

3 1 1 2 1 1 3 2 2 1 2 16

4 2 1 9 2 14

5 2 2 3 1 1 9

5 1 5 3 9

7 1 1 1 1 1 5

7 2 1 1 1 5

7 1 2 2 5

10 1 2 1 4

11 1 2 3

65

98

97

95

94

01

02

03

00

99

9693

0

5

10

15

0 5 10 15

1.3.4

1993 2003 12

85

1.3.4

95 03 00

13 96 11

1.3.4

1.3.4

18 11

00

1.3.4

93 94 95 96 97 98 99 00 01 02 03

1 3 1 1 1 2 1 3 3 3 18

2 1 2 4 1 3 11

3 1 1 1 1 1 5

4 1 1 1 1 4

4 1 1 2 4

4 2 1 1 4

7 2 1 3

7 2 1 3

66

93

96

9900

03

02

0194

95

97

98

0

5

10

15

20

0 5 10 15 20

1.3.5

1993 2003 12

103

1.3.5

03 18 96 11

1.3.5

1.3.5

17 15 14

01 03 98

9396 03

1.3.5

93 94 95 96 97 98 99 00 01 02 03

1 1 2 1 1 6 3 3 17

2 1 2 2 1 1 2 6 15

3 4 4 5 1 14

4 2 1 1 8 12

4 1 4 1 1 1 2 2 12

6 1 1 1 1 4

6 1 1 1 1 4

8 1 1 1 3

8 1 1 1 3

67

98

97

95

94

01

02

03 00

99 96

93

0

10

20

30

40

50

0 10 20 30 40 50

1.3.6

1993 2003 12

411

1.3.6

94 50 96 35

1.3.6

1.3.6

42 34 33

98 03 03

1.3.6

93 94 95 96 97 98 99 00 01 02 03

1 5 3 3 3 1 7 5 2 5 3 5 42

2 1 3 6 2 3 2 4 2 4 7 34

3 2 1 2 1 5 6 2 3 3 8 33

4 2 5 2 2 4 1 2 2 20

5 3 3 1 1 3 1 1 4 17

5 1 5 3 2 3 2 1 17

7

()

1 1 4 2 1 1 1 1 12

8 () 3 2 1 3 1 1 11

8 3 2 2 2 2 11

10 1 2 1 1 1 3 1 10

68

93

9699

00

03

02

0194

95

97

98

0

5

10

15

20

25

30

35

0 5 10 15 20 25 30 35

1.3.7

1993 2003 12

230

1.3.7-1

93 00 31 99 21

1.3.7-1

1.3.7

52 34 29 02

11 96 95

1.3.7

93 94 95 96 97 98 99 00 01 02 03

1 3 1 2 7 3 5 3 6 5 11 6 52

2 3 2 5 8 4 3 7 1 1 34

3 3 2 7 3 6 1 1 3 1 2 29

4 2 2 3 2 1 1 11

5 2 4 6

6 2 1 2 5

6 4 1 5

6 3 1 1 5

9 2 1 1 4

9 2 1 1 4

9 () 1 1 1 1 4

69

1.3.7-2

1.3.7-2 ()

93 94 95 96 97 98 9900 01

0203

0

1

2

3

4

5

6

7

8

9

10

70

93

96

00

03

02

01 94

95,99

97

98

0

5

10

0 5 10

1.3.8

1993 2003 12

40

1.3.8

02 93

10

1.3.8

1.3.8

13

03 93

00

1.3.8

93 94 95 96 97 98 99 00 01 02 03

1 3 2 2 1 3 2 13

2 1 4 5

3 1 1 1 3

3 () 1 1 1 3

71

93,96,98

99

00 03

02

01

94

95

97

0

10

20

0 10 20

1.3.9

1993 2003 12

61

1.3.9

93 94 00

01 01 15

1.3.9

1.3.9

25

01 10

1.3.9

93 94 95 96 97 98 99 00 01 02 03

1 1 1 1 1 1 4 3 10 2 1 25

2 1 1 3 3 8

3 1 2 1 4

4 2 1 3

72

95 94

0096,97,98,9901,02,03

93

0

10

20

0 10 20

1.3.10

1993 2003 12

17

1.3.10

93 94 93

12

1.3.10

1.3.10

10 93 95

95

1.3.10

93 94 95 96 97 98 99 00 01 02 03

1 9 1 10

2 2 2 4

73

1.3.11

1993 2003 12

17

1.3.11

93 96

99

1.3.11

1.3.11

1.3.11

93 94 95 96 97 98 99 00 01 02 03

1 1 1 1 3

2 2 2

2

() 2 2

93,96

99

03 02

94,95,00

97,98,01

0

1

2

3

4

5

0 1 2 3 4 5

74

93

96

99

00

03

02

01

94

95

97 98

0

10

20

0 10 20

1.3.12

1993 2003 12

135

1.3.12

93 96 01

01 21 13

1.3.12

1.3.12

39 13

11

02 97

1.3.12

93 94 95 96 97 98 99 00 01 02 03

1 1 6 2 4 2 6 7 9 2 39

2 3 1 1 3 2 3 13

3 () 3 1 1 3 2 1 11

3 1 1 2 5 1 1 11

5 3 1 1 5

5 1 1 1 2 5

7 1 1 2 4

75

1.3.13

1993 2003 12

22

1.3.13

02 03

1.3.13

1.3.13

1.3.13

00

1.3.13

93 94 95 96 97 98 99 00 01 02 03

1 2 2 4

2 1 2 3

2 1 1 1 3

4 2 2

4 1 1 2

94,95,97,01

02

03

0093

0

5

10

0 5 10

76

1.3.14

1993 2003 12 132

1.3.14

01 20 24

1.3.14

1.3.14

12 10

1.3.14

93 94 95 96 97 98 99 00 01 02 03

1 1 3 1 1 1 1 3 1 12

2 () 1 1 2 1 3 2 10

3 1 2 1 2 2 8

4 1 1 1 1 1 1 6

4 1 5 6

6 () 1 3 1 5

6 1 4 5

6 3 2 5

9 1 2 3

93

96

99

00

03

02

01

94 95

97

98

0

10

20

30

0 10 20 30

77

1.4-1

1.4-1 (1/2)

1.4

78

1.4-1 (2/2)

()

79

1.4-1 1.4-2

1.4-2

()()

()

()

20

()

()

80

1.4.1

(1)

1.4.1-1

9303 9700

1.4.1-1

1.4.1-2 9300 0103

9300 0103

44

2

64

20

99

109

20

24

52

66

18

57

53

25

29

47

30

8

9

3

7

58

4

20

8

30

30

76

4

17

8

14

2

10

8

7

12

2

1

2

1

4

2

7

4

1

5

3

22

9

1

3

13

1

1

5

5

2

2

2

1

2 2

2

2

3

31

24

22

32

1

3

24

7

7

2

1

1

3

1

2

3

1

33

1

1

1

2

1

37

21

4

1

6

25

5

5

2

32

3

1

1

1

1

01 03 50

97 00 50

93 96 50

50

19931200312

81

1.4.1-2

8

1

7

9

3

5

24

22

5

8

15

21

1

2

1

8

3

2

13

15

12

14

1010

11

2

4

4

3

1

2

13

1

6

4

2

6

11

8

3

20

4

3

14

2

5

5

9

4

1

2

1

2

5

1

4

2

1

4

2

1

7

2

1

1

3

3

6

6

2

(0103

1

2

1

36

1

2

2

1

1

30

55

18

15

75

87

15

16

4

2

37

45

10

1

1

44

38

13

15

1937

19

6

3

6

2

5

1

2

5

2

45

4

2

3

14

1

6

25

19

22

22

56

20

8

5

2

17

4

23

13

1

6

4

1

3

19

7

6

2

2

1

28

12

3

1

6

6

1

6

5

3

2

1

1

2

1

3

1

1

2

6

27

2

1

(9300

82

(2) 1.4.1-3

0103

1.4.1-3

56

25

54

66

2

38

51

40

43

25

43

11

6

6

78

10

7

44

58

8

14

66

20

2

2

14

2

2

8

4

42

2

2

2

18

7

6

33

3

1

25

1

2

1

2

1

5

4

35

4

2

2

1

1

6

30

21 12

3

26

1

2

9

2

3

2

4

2

1

1

6

1

86

68

6

7

14

1

1 19

30

2

5

3

3

1

1

1

56

95

4

35

3

01 03 50

97 00 50

93 96 50

50

19931200312

83

1.4.1-4 9300 0103

9300

0103

1.4.1-4

(0103

8

1

16

14

12

2

6

22

6

13

27

1

3

1

13

13

18

19

1

11

7

14

1

4

1

1

2

18

3

3

1

8

17

21

2

2

3

4

6

5

2

1

1

4

3

1

1

2

3

1

1

8

1

3

1

3

1

1

9

3

1

3

8

2

19

(9300

27

4

4

1

6

1

2

2

70

42

44

2

62

73

19

6

41

39

1 12

25

33

21

6

32

18

29

13

7

5

1

1

1

5

4

60

1

7

4

22

27

37

6

12

47

16

26

15

15

1

2

10

9

2

3

1

7

23

2

1

5

3

2

3

34

3

8

2

2

1

1

1

1

9

3

1

2

1

1

4

2

6

3

25

1

1

84

1.4.2

(1)

1.4.2-1

1.4.2-1

1 11

12

4

6

3

1

1

20

18

3

2

6

7

1

9

17

3

2

2

1

2

19931200312

85

1.4.2-1

1.4.2-1

1.4.2-2

1.4.2-1

1 1 1 1 5 1 1 3 8 1 2 5 1 1 6 1 1 1 1 5 2 1 1 2 1 3 1 1 2 4 1 3 3 1 4 2 1 1 2 1 2 1 4 2 1 1 1 1 1 2 1 1 1 1

2

1 1 1 1 2 1

3 1 1

1 1 1 2 1 3

1

1 1 1

1.4.2-2

1993 1 2003 12

86

1.4.2-2 1/2

2003-321543 2000-237306 () 08-302018(2) 3281363 2002-030125

3281364 (2) 2002-3484012005-144330

07-100345 08-319431 09-141070() 09-194590

1.4.2-2 2/2

1993 1 2003 12

1993 1 2003 12

(2) 2000-308814 2004-267833 USA() 2005-51120807-100344 07-148252

11-106593

3061197

() 2003-527173

87

(2)

1.4.2-2

1.4.2-2

1

1

20

4

1

36

1

1

1

2 25

21

6

1

1

6

15

6

7

1

1

1

2

1

1

3

2

19931200312

1.4.2-3

1.4.2-2

1.4.2-4

88

1.4.2-3

1 2 2 1 1 1 2 9 1 1 5 1 2 2 2 7 4 2 3 1 4 3 2 1 4 1 3 1 1 2 2 1 1 1 2

1

2 9 1 1 2 2 1 1 1 2 5 2 1 1 1 2

1 2 6 3 1 5 2 1 3 1 2 3 1 3 1 2 2 1

1 1

2 1 1 1 2 1 1 1

1 1

1.4.2-4

1993 1 2003 12

89

1.4.2-4 1/3

2003-275300 2002-143654 2792556 07-185274

()

3585175

()

2001-515402

WO03-026779 08-182921(4) 3295314

325386732953213253885

2003-001074 (2) 2000-354745

2004-502850 09-052030

07-289632 09-047645 10-057476 2003-149096

1.4.2-4 2/3

()

07-155559

06-279296 09-029080

06-254323

10-108907

1.4.2-4 3/3

1993 1 2003 12

1993 1 2003 12

1993 1 2003 12

()

2001-062266 07-255839

3647564 () 3396034 07-258915 (2) 09-266947 3528723 09-276400( 2003-526497 ()

2003-523819

2894475

90

(3)

1.4.2-3

1.4.2-3

1

4

2

12

1

2

21

4

2

1

2

24

3

3

1

1

1

19931200312

1.4.2-5

1.4.2-3

1.4.2-6

91

1.4.2-5

1 1 1 1 1 2 2 1 1 5 1 2 7 1 3 3 3 3 1 8 2 8 3 1 1 2 3 1 2 1 1

1 1 2 1 1 1 2 1

1 1

1.4.2-6

1993 1 2003 12

92

1.4.2-6 1/2

3421455 2000-334279 () 10-057479 2000-051623 2001-114802 2003-010655 (2) 11-178919

2000-312716 06-296686(2) 2003-010322

3297707 2003-135596

2002-001073 10-235171

1.4.2-6 2/2

1993 1 2003 12

1993 1 2003 12

11-300169 WO02-034374 3392707

08-510166

2003-515110 2003-220133 07-116248 2001-224680 2003-038639 3404514

93

(4)

1.4.2-4

1.4.2-4

1

18

1

1

1

26

1

1

1

14

8

1

1

1

12 3 6

5

1

19931200312

1.4.2-7

1.4.2-4

1.4.2-8

94

1.4.2-7

1 1

1

1 3 4 5 2 2 1 1 2 1 4 1 1 3 1 7 1 4 4 1 5 2 1 1 5 2 1 8 2 5

1

4 1 1 7 1 1 1 1

1

1.4.2-8

1993 1 2003 12

95

1.4.2-8 1/2

(3) 2003-175320 07-185278 10-015366

2003-175322 2004-321720

2003-175321 10-043292 2000-237557 2004-353142

1.4.2-8 2/2

1993 1 2003 12

1993 1 2003 12

2003-245524 (2) 09-021024 (2) 2003-080040 2000-107577 09-225274 2003-010654 2004-182919 2005-065725 2004-066233() 2002-537988 2002-066273 2002-253938()

11-506696

10-007835

2000-061277 2003-154240 11-217459

96

(5)

1.4.2-5

1.4.2-5

19931200312

2

4

60

5

20

7

1 18

3

4

18

3

10

4

3

1

1

46

9

3

1

1

4

34

1

20

8

6

1

10

7

1

3

19

1

1

23

2

5

1

2

2

3

5

28

1.4.2-9

1.4.2-5

1.4.2-10

97

1.4.2-9

1 1 1 1 1 1 1

1

1 2 2

1 1 1 2 2 1 4 2 1 3 10 1 1 1 1 2 5 9 1 3 3 1 2 3 1 1 2 2 1 3 1 4 1 3 1 1 1 3 1 6 1 3 3 3 3 2 2 1 5 1 1 1 3 5 13 2 3 2 5 3 1 6 2 12 1 1 1 4 9 1 2 1 1 2 1 3 1 5 1 1 1 1 1 1 1 1 1 1 4 2 1 1 1 2 1 2 1 3 1 1 3 1 2 2 8 1 2 20 2 3 4 1 4 3 2 1 2 1 2 1 1 2 3 1 2 2 2 1 1 1 1 2 2 1 1 5 17 1 1 1 1 1 1 1 2 1 1 4 1 1 2 2 1 2 1 1 1 1 8 1 10 1 1

1.4.2-10

1993 1 2003 12

98

1.4.2-10 1/3

2003-525736 (2) 2004-2161432003-334244

2005-058905

(2) 2004-231650

2001-238946

() 2004-532709

2000-005569

2003-052815

2() 2003-5189962002-528241

1997-206566 NOK 3307076

2001-503669

1996-193031 (2)() 2004-5128732004-512872

2003-299731

2003-265597

() 2003-519552

1.4.2-10 2/3

() 2004-524065

()

2004-5240683608745

()

10-50680611-004889

1.4.2-10 3/3

1993 1 2003 12

1993 1 2003 12

1993 1 2003 12

2003-159325 2005-000783 ()

2930428

11-000532 08-117563 09-135897 08-280796

2003-506159

() 2004-528140

2001-524022

(2) 09-10833809-108339

(2) 33315342005-169179

() 2003-519551

()

09-248335 (2)()

07-5091713621100

RL() 3609124

()

10-504228

LAB() 2914645 07-236885 ()

09-117502 08-206465

(2) 2004-321385 () 2004-52972309-187628 () 2000-189762

09-141062 2000-042099 08-289931(2) 08-057266

2000-126285(2) 2003-320025

2005-111445

99

(6)

1.4.2-6

1.4.2-6

34

3

3

1

2

1

62

15

15

4

3

6

4

1

12

1

9

3

1

1

2

1

1

3

12

1

5

1

5

1

1

1

1

1

2

1

4

3

1

1

1

19931200312

1.4.2-11

1.4.2-6

1.4.2-12

100

1.4.2-11

28 2 31 1 2 2 1 3 5 1 1 1 1 5 1 1 1 1 1 5 1 16 1 2 2 1 1 4

1 1 1 4 1 1 1 1 1 4 3 1 1 2 1 4 1 2 1 1 1 3 2 1 1 2 6 1 1 1 1 2 1

1

1 2 1 1 1 1 1 1 1

1 1 1 1 1 1 1 1 1 1

1

1 2 1 1 1 2 1 1 2 2 1 3 1 1 1 1 2 1 1 2 1

1

1.4.2-12

11

1993 1 2003 12

101

1.4.2-12 1/3

( 3515802 (8) 2001-286554 09-066102 3534361 2002-136591

2002-09573809-253200330803411-04758610-323387WO03-055545

2001-276611 3615785() 09-508823()

2005-525874

(4) 10-28630709-14108909-0777903285441

2004-321682 07-284660 09-048817(11) 11-104236

10-08533010-08532907-05136306-2259382002-1023382003-33985411-2446932003-1118342002-0178502000-237586

2003-135594 2004-249094 (6) 10-085328 3633978

2002-10269109-07572509-25320106-2461562000-288388

08-299788 2003-339855 3641301 2000-288084()

2804920

2000-014773 2004-073618(2) 2000-262612

2835923 07-100374

1.4.2-12 2/3

10-147518 (2) 35744713357139

2004-504126

08-108069(2) 06-228215

06-228216

1.4.2-12 3/3

1993 1 2003 12

1993 1 2003 12

1993 1 2003 12

2002-528233 07-289633

2002-528242

102

(7)

1.4.2-7

1.4.2-7

19931200312

1

1

3

1

2

1

12

1

1

2

5

2

3 1

2 1 1

1.4.2-13

1.4.2-7

1.4.2-14

103

1.4.2-13

2 1 1

1 1 1 1 1 2 1 1 1

1

2 1 2 3

1 2 2 1 1 1 2 2 1 1 2

1

1.4.2-14

1993 1 2003 12

104

1.4.2-14 1/2

1993 1 2003 12

1.4.2-14 2/2

1993 1 2003 12

2002-238996

() 08-509991

11-009923 3276456 07-155374

11-216360 () 3435494

11-194126 11-290060

() 2004-520087

2000-180444 WO02-015964

105

(8)

1.4.2-8

1.4.2-8

19931200312

1

1

3

3

16

1

1

5

2

1

2

15

3

1

1

1 1

1

1

1

1.4.2-15

1.4.2-8

1.4.2-16

106

1.4.2-15

1 2

3 2 1 1 10 2 1 2 1 1 1 4 1 1 5 1 1 1 1 1 1 3 1

2 1

1 1

1 1

1 1

1 1

1

1.4.2-16

1993 1 2003 12

107

1.4.2-16 1/2

3147343 10-328295 10-076004 2001-198215 09-248446

2001-046844WO02-0605572001-2124342001-2188342002-263420WO01-0322362003-070905

2002-113097

1.4.2-16 2/2

1993 1 2003 12

1993 1 2003 12

11-267463

2001-198213 11-140189

1993 1 2003 12

108

(9)

1.4.2-9

1.4.2-9

2

1

1

2

2

1

2

1

3

2

19931200312

1.4.2-17

1.4.2-9

1.4.2-18

109

1.4.2-17

1 1

1 1 3

1 2

1 1

1 1 1 2

1.4.2-18

1.4.2-18

1993 1 2003 12

1993 1 2003 12

(3) 06-237997

06-23799606-237995

110

(10)

1.4.2-10

1.4.2-10

1

1

1

1

1

2

1 1

2

1

1

1

3

19931200312

1.4.2-19

1.4.2-10

1.4.2-20

111

1.4.2-19

2 1

1

1

1 1 1

1 1 1 1 1 3

1

1.4.2-20

1.4.2-20

1993 1 2003 12

1993 1 2003 12

()

2004-514640

(2) 2005-172601

2005-160816

112

(11)

1.4.2-11

1.4.2-11

1

2

2

19

22

5

1 4

4

1

3

1

13

1

1

4

1

20

2

3

5

4

3

10

1

2

19931200312

1.4.2-21

1.4.2-11

113

1.4.2-22

1.4.2-21

1

1 1

1 1 1 2 1 2 1 2 1 2 2 3 3 1 2 3 3 1 1 1 1 1 1 1 1 2 3 2 1 1 3 1 2 3 1 2 1 2 3 6 1 1 1 1

1

1 1 5 1 1 4 2 2 2 1 1 1 1 1 1 5 1 1 3 3 1 3 1 1 1 1 1 1 1 1

1 4

1.4.2-22

1993 1 2003 12

114

1.4.2-22 1/2

10-510739 () 2003-512594

2002-503672

()

2004-522937

(2) 2002-0879712002-080377

2004-173853

1.4.2-22 2/2

2001-129078 2005-052239 06-327769 11-267196 2003-245342() 09-507414 2002-320669(5) 09-000624

09-000623

09-000622

09-000621

09-000620

(3) 2004-1667492004-1667472004-166748

1993 1 2003 12

1993 1 2003 12

115

(12)

1.4.2-12

1.4.2-12

2

2

1

1

5

5

3

1

2

19931200312

1.4.2-23

1.4.2-12

1.4.2-24

116

1.4.2-23

1 2 1 3

1 2

1

1

3 1 1 2

2 1

1.4.2-24

1.4.2-24 1/2

1.4.2-24 2/2

2003-265934 2005-000521 08-247319 2004-187746 2004-254941

1993 1 2003 12

1993 1 2003 12

1993 1 2003 12

2004-222831

09-135896 3495802(2) 2002-105136

2004-161954

117

(13)

1.4.2-13

1.4.2-13

1

2

10

1

4

49

1

1

1

8

3

1

1

1

8

1

1

4

12

1

1

1

2

1

4

2

7

1 1 1

19931200312

118

1.4.2-25

1.4.2-13 1.4.2-26

1.4.2-25

1 1 1 1 1 1 1 1 1

1

1 1 1 2 1 1 4 1 1 2 1 1 2 1 1 4 1 2 1 1 1 1 1 1 1 1 1

1 1

1

1 1 2 1 1 1 2 3

1 3 1 1 40 4 3 8 1 2 2 1 1 1 1

1993 1 2003 12

119

1.4.2-26

1.4.2-26

1993 1 2003 12

(3) 07-32767408-051973

()

3568953 2002-506708 ()

2003-225289 2003-521289

08-038167 (2)

2004-5003162005-516978

(2)() 2000-5100032001-509427

2004-535912

2003-265582 2004-141574 2003-052816 07-163814

2003-1174052003-1285022003-1169872003-116988WO02-034301

2003-116534

(5)() 08-50804709-5047282000-5064202000-5084282003-5206422003-5011482003-501175

()

2005-506152

()

3164827

2004-141032 2003-310750(3) 10-231249

2004-3234832004-323484

2003-235967

(8) 08-33208609-23902511-3226192001-0090302001-3145022001-2862792001-3404522002-325842

08-231431(2)

2005-1524862005-152487

2001-340451

()

DEV

(5)

(2)()

120

1.4.3

1.4.3

1.4.3 (1/2)

641 (

)

10

7

11

613

31 1

(2

)

9

() 3

18

130 20

24

86

52 5

(2

)

3

() 1

43

64

64

121

1.4.3 (2/2)

436 TNF 23

FN()

32

IgE 22

(/

)

()

42

(IAP)2

28

2 9

193

HIVHBVHCV 16

14

E2( LDL) 17

40

199 10

36

153

1.4.3-1 41

30

1.4.3-1

1.4.3-2

9900

1993 1 2003 12

3%

41%

30%

13%

4%

7%

2%

122

1.4.3-2

1.4.3-3

1.4.3-3

1993 1 2003 12

93 94 95 9697

9899

0001

0203

0

10

20

30

40

50

60

70

80

617

8

6

25

0

101

0

3

38

0

10

22

35

0

11

16

442

0

7

80

11

14

95

21

0

54

0% 20% 40% 60% 80% 100%

123

1.4.3-4

1.4.3-4

01 03

50

97 00

50

93 96

50

50 19931200312

3

51

150

14

40

11

210

72

153

26

59

36

52

8

12

136

21

18

15

73

49

9

2

6

9

2

4

10

15

8

9

9

19

19

6

4

2

5020

5

1

4

1

1

21

1

8

3

26

2

22

2

4

4

1

2

1

1

1

1 5

1 1

2 1

4

10

1 1

1

2

124

1.5.1

1993

1.5.1 10 25

1.5.1

() 05-054373

3097149

1.5.3-1 1.5.3-2

1.5

125

1.5.1 (1/3)

No.

1

05-054373 () 84.07.17

45 0 45 (11) (11) (10) (7) (3) (2) (1)

2

3097149 91.03.28

31 4 27 (15) (7) (4) (2) (1) (1) (1)

3

1771033 () 81.12.17

29 0 29 (11) (8) (6) (3) (1)

4

2131936 () 88.02.17

21 0 21 (21)

5

3117575 92.04.29

18 1 17 (11) (2) (1) (1) (1) (1) (1)

6

04-208856 90.12.03

17 0 17 (9) (8)

126

1.5.1 (2/3)

No.

7

06-296686 ; 93.04.19

16 10 6 (10) (2) (2) (2)

8

2133556 85.04.17

15 5 10 (5) (4) (2) (1) (1) (1) (1)

9

3366040 93.02.16

13 1 12 (7) (2) (2) (1) (1)

9

1575364 81.12.28

13 1 12 (5) (5) (2) (1)

11

1189979 77.11.30

12 0 12 (12)

11

1202225 75.02.14

12 0 12 (11) (1)

11

11-332980 98.05.27

12 2 10 (6) (3) (2) (1)

11

61-232860 85.04.08

12 2 10 (5) (5) (2)

11

02-211229 88.10.14

12 4 8 (4) (4) (3) (1)

127

1.5.1 (3/3)

No.

16

3076080 ; 91.05.16

11 7 4 (7) (2) (1) (1)

16

11-309355 98.04.28

11 3 8 (7) (3) (1)

16

02-135130 88.07.20

11 4 7 (6) (4) (1)

16

1723513 84.03.15

11 3 8 (5) (3) (2) (1)

20

1925313 86.03.28

10 9 1 (9) (1)

10m

20

08-009668 86.10.14

10 0 10 (8) (2)

20

1671925 84.04.02

10 8 2 (8) (1) (1)

20

1837949 84.07.31

10 10 0 (10)

20

62-041738 82.09.09

10 3 7 (4) (3) (3)

20

2135744 () 84.07.17

10 0 10 (4) (3) (2) (1)

128

1.5.2

1.5.2

1.5.2

1671925()[10]

2133556()[15]

04-208856 3117575 06-296686() () (;

[17] [18] )[16]

1771033 05-054373 11-309355(()) (()) ()

[29] [45] [11]1925313 62-041738

() ()[10] [10]

3366040()

[13]3076080 08-009668

()[10]

[11]

3097149()[31]

1723513 2131936() (())

[11] [21]

61-232860()[12]

1837949()

[10]02-211229 2135744 11-332980() (()) ()[12] [10] [12]

02-135130()[11]

1575364()[13]

1189979()[12]

1202225()[12]

13 3 6 1 1 1 175 73 100 10 12 12

(;)

333

352

344

112

225

6136

110

670

129

1.5.3

1.5.3-1 05-054373

()

11 10

1.5.3-2 3097149

15

130

1.5.3-1 05-054373 (1/2)

()

1994 1995 1996 1997 1998

3548354

10-151196

10-243999

11-309355

07-289863

3357262

3317876

3474205

3617194

3489372

09-070431

11-104235

10-230148

2792556

09-220455

10-108907

2001-038172

10-109023

09-308684

09-308685

3205268

3205267

3253861

3345260

10-263375

2000-107577

3295314

3253885

3253867

3295321

3236233

05-054373()

84.7.17

(A)

(B)

(C)

(D)

(E)

(F)

(G)

(H)

131

1.5.3-1 05-054373 (2/2)

1999 2000 2001 2002 2003

2000-325763

2001-162143

2003-010322

2004-223384

2000-334281

3431622

2005-007004

2000-254222

3431623

2005-144347

2003-154240

2001-170172

2004-216328

2005-066168

2000-225326

2004-305677

2000-300663

2005-074019

2004-305561

2005-137996

2005-058365

2005-131177

2005-052362

2005-066389

2005-169376

2005-169377

3551971

3580314

2005-021510

2005-065725

(A)

(B)

(C)

(D)

(E)

(F)

(G)

(H)

132

1.5.3-2 3097149 (1/2)

()

1993 1994 1995 1996 1997 1998

09-070431

09-206570

09-070525

3651121

3297707

07-289866

3640737

10-243999

2000-135422

3366040

3357262

11-309355

3474205

11-309356

2000-135421

11-309353

06-296686

09-047645

3314861

2000-042383

3442842

10-057787

3097149

91.3.28

(A)

(B)

(C)

(D)

(E)

(F)

(G)

133

1.5.3-2 3097149 (2/2)

1999 2000 2001 2002 2003

2003-126664

2005-156249

2002-030125

2003-154240

2005-144347

3431622

2004-321720

3431623

2003-320229

2004-248905

2005-087350

2005-118196

2004-305677

2004-305840

2000-300663

2001-205052

2005-137996

2005-058365

2005-131177

2005-074019

2005-066389

2005-169376

2005-169377

3551971

3580314

(A)

(B)

(C)

(D)

(E)

(F)

(G)

.

2.1

2.2

2.3

2.4

2.5

2.6

2.7

2.8

2.9

2.10

2.11

2.12

2.13 ()

2.14

2.15

2.16

2.17 ()

2.18

2.19

2.20

2.21

2.22

137

20

1993 2003 12

20

2006

20

1 230

2 169

3 108

4 75

5 58

6 52

7 42

8 40

8 40

10 39

10 39

12 24

13 () 17

14 15

15 14

15 14

15 () 14

18 13

18 13

20 12

138

2.1.1

101-0053

1974 49

8 2005 10

1,700 (2005 10 )

100

1974

2000 2002

2.1.2

QOL

http://www.asahi-kasei.co.jp/medical/index.html

2.1

139

2.1.3

2.1.3

1999 2001

2111

354

3400

2.1.3

0

5

10

15

20

25

30

35

40

45

50

93 94 95 96 97 98 99 00 01 02 03

0

10

20

30

40

50

60

70

80

90

100

2.1.4

2.1.4-1 2.1.4-2

140

2.1.4-1

19931200312

1

1

1

1

6

3

3

10

18

6

12

1

20

2

4

2

11

8

6

8

3

4

3

6

4

1

5

1

6

1

2

3

1

10

8

9

4

5

3

6

2

1

1

1

1

2

2

1

1

1

1

1

5

1

2.1.4-2

19931200312

3

11

8

15

12

13

5

13

2

1 8

6

11

14

2

6

4

8

4

4

1

12

1

5

14

13

1

3

3

4

3

1

2

1

1

3

1

1

1

1

1

2

1

3

1

141

2.1.4 230

27

2.1.4 1/24)

/

/

/

IPC

[]

2005-144347

03.11.17

B01D69/08

2002-030125

00.04.17

C08F291/00

3281363

01.07.24

B01D69/08

[]

3281364

01.07.24

B01D69/08

[]

2000-140589

98.11.16

B01D71/68

[]

3594946

02.09.12

B01D69/08

2004-248905

03.02.20

A61M 1/18,500

2000-135421

98.11.02

B01D71/68

2000-135422

98.11.02

B01D71/68

2005-058906

03.08.12

B01D69/12

142

2.1.4 2/24)

/

/

/

IPC

[]

3317876

97.05.16

B01D71/68

/

3432240

93.04.05

A61M1/14,567

2004-067758

02.08.02

C08G81/00

2004-075741

02.08.12

C08G81/00

08-099028

()

94.09.29

B01D71/10

10-243999

()

97.03.07

A61M1/18,500

[]

11-309356

98.04.28

B01D71/68

[]

3357262

97.03.07

A61M1/18,500

UV

07-289866

()

94.04.27

B01D71/68

143

2.1.4 3/24)

/

/

/

IPC

[]

11-309355

98.04.28

B01D71/68

[ 11 ]

2000-157852

98.11.25

B01D71/68

[]

3741319

93.06.02

A61K35/16

11-309353

98.04.28

B01D69/02

[]

08-318143

()

95.05.24

B01D71/10

2003-220135

02.01.29

A61M1/18,510

2003-220134

02.01.29

A61M1/18,500

11-197239

()

98.01.14

A61M1/16,513

2003-275300

02.03.26

A61M1/18,500

09-029080

()

95.07.25

B01D 71/10

144

2.1.4 4/24)

/

/

/

IPC

[]

2000-254222

99.03.12

A61M1/18,500

[]

3640737

96.06.04

B01D71/68

/

2000-296318

99.04.12

B01D71/68

[]

3464000

02.09.12

B01D69/08

3431622

02.09.12

B01D69/08

3431623

02.09.12

B01D69/08

2000-334281

99.05.28

B01D71/68

09-122231

()

95.10.30

A61M1/18,500

3474205

97.05.19

B01D71/68

10

50

30

45

WO02/087735

01.04.18

A61M1/16,500

145

2.1.4 5/24)

/

/

/

IPC

[]

2002-224545

01.02.05

B01D69/08

WO01/036072

99.11.17

B01D61/24

3228758

97.02.07

B01D69/08

11-347117

98.06.09

A61M1/18,500

3714686

94.04.27

B01D69/08

09-164199

95.12.14

A61M1/18,500

3366040

93.02.16

B01D71/68

2002-238999

01.02.19

A61M1/18,523

2001-137337

99.11.18

A61M1/34

2002-224215

01.02.06

A61M1/18,517

146

2.1.4 6/24)

/

/

/

IPC

[]

2002-143299

00.11.13

A61M1/18,517

2003-320229

()

02.04.30

B01D71/68

2003-245346

()

02.02.25

A61M1/18,510

2003-245345

()

02.02.25

A61M1/18,500

2002-085551

00.09.19

A61M1/02,540

06-296686

()

93.04.19

A61M1/18,300

[]

11-178919

()

97.12.17

A61M1/16,500

3297707

93.02.01

D06M15/53

[]

2003-010322

01.06.29

A61M1/18,500

11-300169

98.04.17

B01D61/24

147

2.1.4 7/24)

/

/

/

IPC

[]

2001-224680

00.02.17

A61M1/16,500

10-235171

96.12.25

B01D69/08

3404514

94.02.22

A61M1/16,500

2000-024104

98.07.08

A61M1/22,500

2002-239355

01.02.19

B01D71/12

2003-284930

02.03.27

B01D67/00,500

2003-284931

02.03.27

B01D69/08

2003-175322

01.10.05

B01D69/08

[]

2003-175321

01.10.05

B01D69/08

[]

2003-175320

01.10.05

B01D69/08

[]

148

2.1.4 8/24)

/

/

/

IPC

[]

2004-321720

03.04.30

A61M1/18,500

2003-245524

01.12.18

B01D61/24

2003-154240

01.11.21

B01D71/68

2002-066273

00.09.01

B01D69/08

2004-305953

03.04.09

B01D69/08

3494466

94.03.11

D01F2/04

09-066225

()

95.06.22

B01D69/08

3533013

95.08.09

B01D69/08

11-347384

98.06.12

B01D71/10

2004-223384

03.01.22

B01D69/08

149

2.1.4 9/24)

/

/

/

IPC

[]

2003-245529

02.02.26

B01D69/08

[]

2005-007004

03.06.20

A61M1/18,500

2005-058905

03.08.12

B01D63/02

2003-299731

02.04.11

A61M1/34,500

2003-265597

02.03.14

A61M1/14,500

3608745

94.08.11

A61M1/36,500

pH

pH

2003-159325

01.11.29

A61M1/18,515

[]

2005-000783

03.06.11

B01D63/02

150

2.1.4 10/24)

/

/

/

IPC

[]

2000-042099

98.05.25

A61M1/18,500

09-164196

95.12.18

A61M1/14,523

2005-131123

03.10.30

A61M1/18,523

2004-248844

03.02.19

A61M1/34,505

2004-081833

02.06.27

A61M1/02,540

11-009685

97.06.25

A61M1/14,570

2003-053158

01.06.08

B01D63/02

2000-288085

99.04.12

A61M1/34

[]

2005-046727

03.07.29

B01D63/02

2005-052716

03.08.01

B01D63/02

151

2.1.4 11/24)

/

/

/

IPC

[]

2000-126284

98.10.29

A61M1/14,510

10-290832

97.04.21

A61M1/18,510

11-207150

()

98.01.21

B01D61/14,500

2912801

93.10.06

A61M1/14,511

WO00-027447

98.11.09

A61M1/14,523

2005-087432

03.09.17

A61M1/18,517

2000-126283

98.10.29

A61M1/14,510

2000-167045

98.12.07

A61M1/34,505

2000-245828

99.02.25

A61M1/14,557

152

2.1.4 12/24)

/

/

/

IPC

[]

07-136253

()

93.11.17

A61M1/18,500

11-000394

()

97.06.13

A61M1/14,555

11-009684

()

97.06.25

A61M1/14,570

3020188

()

95.07.05

A61M1/18,510

11-090186

97.09.18

B01D63/02

10-015060

()

96.07.01

A61M1/18,517

2003-080037

01.09.10

B01D63/02

3330420

93.04.19

B01J20/26

2000-014773

98.07.03

A61M1/36,545

153

2.1.4 13/24)

/

/

/

IPC

[]

09-141089

()

95.11.24

B01J20/22

3534361

95.04.14

A61K35/14

3285441

93.11.17

A61M1/36,540

10-286307

97.04.11

A61M1/36,545

3748927

95.09.11

C07K1/16

09-066102

()

95.08.31

A61M1/36,545

07-289633

()

94.04.22

A61M1/36,545

2004-159769

02.11.11

A61M1/36,545

2001-300221

00.04.27

B01D39/14

154

2.1.4 14/24)

/

/

/

IPC

[]

11-042406

()

97.06.26

B01D39/18

2001-310917

00.04.27

C08F290/04

2003-190276

01.10.16

A61M1/02,550

2001-286551

00.04.07

A61M1/02,540

11-012183

()

97.06.26

A61K35/14

11-009687

()

97.06.26

A61M1/34,500

09-075076

95.09.11

C12N5/06

09-075450

95.09.19

A61M1/34

2000-245833

99.02.25

A61M1/36,540

[]

WO99/011304

97.08.28

A61M1/02,540

155

2.1.4 15/24)

/

/

/

IPC

[]

2004-105529

02.09.19

A61M1/36,545

10-080479

96.09.09

A61M1/34,503

3246620

93.02.22

A61M1/34,500

11-060595

()

97.08.22

C07K5/10

10-179733

()

96.12.20

A61M1/36,545

10-182694

()

96.12.20

C07K5/06

3722523

95.08.25

A61M1/34

08-010321

()

94.06.28

A61M1/16,517

3272099

93.04.14

B01J20/20

2002-291875

01.03.30

A61M1/02,540

156

2.1.4 16/24)

/

/

/

IPC

[]

11-009923

()

97.06.26

B01D39/18

2002-238996

01.02.15

A61M1/02,540

3276456

93.04.28

A61M1/36,530

07-155374

()

93.12.03

A61M51/65

11-290060

98.04.06

C12M1/12

WO99/010025

97.08.22

A61M1/02,540

WO01/066171

00.03.10

A61M1/02,550

10-057477

()

96.08.26

A61M1/34

WO02/004045

00.07.10

A61M1/02,540

WO02/003909

()

00.07.10

A61M1/02,540

157

2.1.4 17/24)

/

/

/

IPC

[]

10-014565

()

96.07.01

C12N5/06

WO03/011924

01.07.31

C08F220/10

2001-218834

99.12.03

A61M1/02,540

[]

WO02/060557

01.01.29

B01D39/14

2001-046844

99.08.09

B01D69/12

2003-070905

01.09.07

A61M1/02,550

WO01/032236

99.11.01

A61M1/02,540

2001-212434

00.01.31

B01D61/24

[]

2002-263420

01.03.14

B01D3916

[]

2001-198215

00.01.21

A61M1/34,500

158

2.1.4 18/24)

/

/

/

IPC

[]

2001-198213

00.01.17

A61M1/34,500

09-075449

()

95.09.19

A61M1/34

2003-010611

01.07.03

B01D39/00

10-033668

()

96.07.23

A61M1/34

3741320

93.07.15

A61K35/14

WO03/047655

01.12.03

B01D39/16

11-158076

97.12.01

A61K35/14

2003-230627

()

02.02.08

A61M1/02,540

2002-282351

01.03.26

A61M1/02,550

2003-164522

01.12.03

A61M1/02,550

159

2.1.4 19/24)

/

/

/

IPC

[]

2003-164521

01.12.03

A61M1/02,540

2004-129941

02.10.11

A61M1/02,540

2003-038641

01.07.31

A61M1/02,540

2004-339165

03.05.16

A61K35/14

2000-185094

98.12.21

A61M1/34,501

2001-112861

99.10.15

A61M1/02,540

[]

08-196627

()

95.01.25

A61M1/36,545

3353945

93.04.19

B01J20/26

06-296860

()

93.04.19

B01J20/26

3533541

95.01.25

G01N33/53

/

160

2.1.4 20/24)

/

/

/

IPC

[]

11-012182

()

97.06.26

A61K35/14

2001-161812

99.12.03

A61M1/34,500

2004-208932

02.12.27

A61M1/02,540

2003-320026

02.04.30

A61M1/34,500

2000-217908

99.01.29

A61M1/36,500

2005-137453

03.11.04

A61M1/34,500

2000-051347

()

98.08.04

A61M1/02,540

2001-347116

00.06.09

B01D39/14

2003-052808

01.08.13

A61M1/02,540

2002-080377

00.09.07

A61K35/12

161

2.1.4 21/24)

/

/

/

IPC

[]

2002-087971

00.09.07

A61K35/14

2001-129078

99.11.01

A61M1/02,540

2004-166749

02.11.15

A61M1/02,540

2004-166747

02.11.15

A61M1/02,540

2004-166748

02.11.15

A61M1/34,500

2002-320669

01.04.26

A61M1/02,540

09-000624

()

95.06.16

A61M1/34

09-000620

()

95.06.16

A61M1/34

09-000621

()

95.06.16

A61M1/34

09-000623

()

95.06.16

A61M1/34

162

2.1.4 22/24)

/

/

/

IPC

[]

09-000622

()

95.06.16

A61M1/34

2003-245342

()

02.02.25

A61M1/02,540

2002-322070

01.04.26

A61K35/14

2004-101256

02.09.06

G01N33/44

2003-265596

02.03.12

A61M1/02,540

11-076396

97.09.09

A61M1/34,500

2002-325836

01.04.27

A61M1/02,540

11-076397

97.09.12

A61M1/34,501

09-140787

95.09.19

A61M1/34

08-103493

()

94.10.04

A61M1/16,517

163

2.1.4 23/24)

/

/

/

IPC

[]

2004-113551

02.09.27

A61M1/34,500

2005-143973

03.11.18

A61M1/02,540

2004-537330

00.05.26

A61M1/02,540

2001-269545

00.03.24

B01D63/00,500

2004-081296

02.08.23

A61M1/02,540

WO99/058172

98.05.13

A61M1/34,501

11-332979

98.05.27

A61M1/16,510

2003-070903

01.08.31

A61M1/02,540

2002-191691

00.12.25

A61M1/36,540

2003-070904

01.09.07

A61M1/02,540

164

2.1.4 24/24)

/

/

/

IPC

[]

11-319084

98.05.08

A61M5/14,345

WO02/083200

01.04.13

B01D29/00

2003-043033

01.08.03

G01N334/83

WO03/014394

01.08.03

C12N15/09

WO03/059611

02.01.09

B32B3/02

2003-265934

02.03.18

B01D63/02

165

2.2.1

103-8666 2-1-1

1926

969 37 2005 3

6,638 2005 3 33,707

http://www.toray.co.jp

2.2.2

RO

Reverse Osmosis

RO RO

http://www.toray.co.jp/tmc/merch/index.html

2.2

166

2.2.3

2.2.3 93 03

2.2.3

0

5

10

15

20

25

30

35

40

45

50

93 94 95 96 97 98 99 00 01 02 03

0

5

10

15

20

25

30

35

40

45

50

2.2.4

2.2.4-1 2.2.4-2

167

2.2.4-1

10

1

9

7

2

3

9

1

5

1

7

3

4

6

3

5

13

1

2

2

8

1

1

1

3

1

4

1

2

1

1

2

1

1

2

2

1

5

3

1

4

4

25

19931200312

2.2.4-2

19931200312

7

2

2

17

15

12

2

9

2

1

1

2

1

7

7

3

13

1

4

1

4

2

1

2

1

6

4

2

4

4

3

1

1

1

1

1

1

2

2

1

1

6

1

1

7

168

2.2.4 169

16

2.2.4 1/18

/

/

/

IPC

[]

2002-102339

00.09.29

A61M1/36,545

2002-102340

00.09.29

A61M1/36,545

2002-102341

00.09.29

A61M1/36,545

2004-216328

03.01.17

B01D69/08

2003-126664

01.10.23

B01D71/68

2003-290638

02.01.31

B01D71/68

3651121

95.06.30

B01D71/68

/

3617194

95.06.30

B01D71/68

/

169

2.2.4 2/18

/

/

/

IPC

[]

3489372

97.02.18

B01D69/02

2004-309206

03.04.03

G01N24/08

08-319431

95.05.16

C08L101/02

09-206570

()

96.02.05

B01D71/68

08-099026

()

94.09.29

B01D69/08

10-230148

()

97.02.18

B01D71/68

[]

11-104235

()

97.09.30

A61M1/18,523

09-070525

()

95.06.30

B01D71/68

2001-170171

99.12.21

A61M1/16,500

[]

2001-170172

99.12.21

A61M1/16,500

170

2.2.4 3/18

/

/

/

IPC

[]

2002-102692

00.09.29

B01J20/26

10-057476

()

96.08.26

A61M1/16,500

3413985

94.09.29

A61M1/34,520

8.9

70

2003-260340

02.03.13

B01D71/68

2003-201383

01.10.04

C08L39/06

2000-126286

98.10.21

A61M1/18,511

[]

2000-288365

99.04.07

B01D69/08

2002-143298

00.11.16

A61M1/18,500

[]

10-080477

96.09.09

A61M1/18,500

171

2.2.4 4/18

/

/

/

IPC

[]

2003-245526

01.12.19

B01D63/02

2005-066168

03.08.27

A61M1/18,500

2005-131482

03.10.29

B01D69/02

2002-028461

00.07.14

B01D69/08

2003-250885

02.03.06

A61M1/18,500

3651195

97.08.05

B01D69/12

3498543

97.08.05

B01D71/68

WO03/031533

01.10.04

C08J7/00,305

3496382

96.02.05

B01D71/68

/

2003-290339

02.03.29

A61M1/18,500

172

2.2.4 5/18

/

/

/

IPC

[]

2004-049965

()

02.07.17

B01D63/02

2002-035118

00.07.26

A61M1/36,545

2002-035117

00.07.26

A61M1/36,545

2002-001073

00.06.16

B01D71/82,500

2001-254221

00.03.10

D01D5/24

2005-095607

03.08.29

A61M1/18,500

3684676

95.06.30

A61M1/18,523

2000-237557

98.12.21

B01D69/02

[]

2004-182919

02.12.05

C08J9/28,101

2002-253938

01.03.05

B01D69/08

[]

173

2.2.4 6/18

/

/

/

IPC

[]

2005-162926

03.12.04

C08J7/04

2000-210544

99.01.26

B01D7/168

[]

2005-087945

03.09.19

B01D69/08

2003-275549

()

02.03.25

B01D69/08

11-332980

98.05.27

A61M1/18,500

[ 12 ]

2000-325759

99.05.17

B01D67/00

2004-351246

03.05.27

B01D 63/00,500

2004-290670

03.03.12

A61M1/18,513

2004-275994

03.03.19

B01D 63/00,500

2001-238946

99.12.24

A61M1/18,500

174

2.2.4 7/18

/

/

/

IPC

[]

2004-231650

03.01.09

A61K38/00

11-000532

()

97.06.12

B01D63/02

09-108338

()

95.10.16

A61M1/18,510

09-108339

()

95.10.16

A61M1/18,510

2000-126285

98.10.21

A61M1/18,511

08-057266

()

94.08.24

B01D63/02

2000-126767

98.10.21

C02F1/44,

2005-156249

03.11.21

G01N33/48

3259426

93.03.19

B01D65/10

175

2.2.4 8/18

/

/

/

IPC

[]

3218789

93.03.29

G01N21/88

[]

2004-105874

02.09.19

B01D65/10

2003-067724

01.08.24

G06T1/00,300

3254883

93.03.19

G01N21/88

3254888

93.03.24

G01N21/88

2004-167384

02.11.20

B01D65/10

2000-218140

98.11.27

B01D69/00

2000-126287

98.10.21

A61M1/18,517

2004-243263

03.02.17

B01D63/02

2000-202248

99.01.12

B01D63/00,500

176

2.2.4 9/18

/

/

/

IPC

[]

10-099652

()

96.09.25

B01D63/02

2004-154772

02.10.16

B01D63/02

10-165777

()

96.12.13

B01D63/02

[]

2002-282656

01.03.29

B01D63/02

2000-005301

98.06.17

A61M1/14,593

10-165773

96.12.10

B01D63/02

2964848

93.07.26

B01D63/02

177

2.2.4 10/18

/

/

/

IPC

[]

2000-202250

99.01.12

B01D63/02

2000-202251

99.01.14

B01D63/02

2003-154237

()

01.11.20

B01D63/02

2003-071253

01.09.03

B01D63/02

2000-070680

()

98.08.27

B01D63/00,500

2004-275945

03.03.18

B01D65/02,500

08-164202

()

94.12.12

A61M1/36,543

11-277062

98.03.30

C02F1/44

[]

3700643

01.12.11

B01D63/02

2001-252535

00.03.13

B01D63/02

[]

178

2.2.4 11/18

/

/

/

IPC

[]

3239693

95.06.15

B01D69/08

2000-334271

99.05.25

B01D63/02

2004-223423

03.01.23

B01D63/02

08-010591

()

94.07.05

B01D69/08

2001-259380

00.03.23

B01D63/02

WO01/018060

99.09.08

C07K17/02

3271357

93.03.15

A61M1/36,545

179

2.2.4 12/18

/

/

/

IPC

[]

2000-245831

99.03.03

A61M1/36,530

2003-310751

02.04.25

A61M1/36,545

2003-052817

01.05.25

A61M1/36,545

2004-057536

02.07.30

A61M1/36,545

2003-284774

02.03.28

A61M1/36,545

10-225515

97.02.17

A61M1/36,540

2000-217909

98.11.24

A61M1/36,545

WO01/074420

00.04.05

A61M1/02,550

11-244693

()

98.02.26

B01J20/26

[]

2002-102338

00.09.27

A61M1/36,545

180

2.2.4 13/18

/

/

/

IPC

[]

11-104236

97.10.01

A61M1/36,545

2002-017850

00.07.11

A61M1/36,530

2000-237586

98.12.22

B01J20/26

2003-111834

01.10.03

A61M1/02,550

2003-339854

02.05.30

A61M1/36,545

3733657

96.09.12

A61M1/36,545

07-051363

()

93.08.12

A61M1/36,530

06-225938

()

93.02.03

A61M1/36,333

10-085330

96.09.18

A61