3. Allergic Rhinitis.ppt [Read-Only] -...
Transcript of 3. Allergic Rhinitis.ppt [Read-Only] -...
Allergic Rhinitis
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Department of PediatricsUniversity of North Sumatera Medical Faculty
H. Adam Malik Hospital
“THE ALLERGIC MARCH”
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BMJ 2002
Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induce by an IgE-mediated inflamation after allergen exposure of the membrane of the nose
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The new classification of allergic rhinitis:• Uses symptoms and quality of life parameters• Is based on duration: intermitten or persistent• Is base on severity: mild or moderate-severe
Classification of allergic rhinitis
Intermittent
Symptoms
• <4 days per week
• Or<4 weeks
Persistent
Symptoms
• >4 days/ week
• and > 4 weeks
Moderate- Severe
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Mild
•Normal sleep
•Normal daily actvities,
sport, leisure
•Normal work and school
•No troublesome sympoms
Moderate- Severe
One or more items
•Abnormal sleep
• Impairment of daily activites,
sport, leisure
•Problems caused at work or scholl
•Troublesome symptoms
Allergic Rhinitis
• Seasonal allergic rhinitis/Hay fever :symptom complex that follows sensitization to windborne pollens of trees, grasses, and weeds.
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• Perennial allergic rhinitis : the patient has year-round symptoms, caused generally by allergens which exposed with the patient. Most often by indoor inhalant allergens.
The mediator in allergic rhinitis
MEDIATORSSneezing
Histamine
Nasal itch
Histamine
Nasal blockage
LTC4,LTD4,PGD2,PGI2
Kinins
Histamin
Rhinorrhoea
Histamine
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Basophil Mast cell Eosinophil
MEDIATORS HistamineHistamine
LTC4,LTD4
Pathogenesis
• Manifestasi alergi pada hidung lebih sering dibanding organ lain
• The important mediator : histamin• After histamin release, follow by leukotrien (LTB4, LTC4), PGD2 dan PAF (platelet
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(LTB4, LTC4), PGD2 dan PAF (platelet activating faktor) � vasodilatation and vascular permeability
• Other mediator : sitokin• 50% hypersensitivity reaction type I, late phase (manifestation 4-6 hr after exposure)
The pathogenesis in allergic rhinitis
Allergen APCAPC
Th2 cellTh2 cell
EosinophilMast cellBasophil
B cell
Chemoattractants
IgE Cytokines Cytokines
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Mediator/Cytokines
NervesVasodilatation
EdemaMucus
CHRONIC INFLAMATION
Etiology • Weather changes• Food• Dust• House mite, tick• Pollution• Scent of alcohol
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• Scent of alcohol• Chemical scent :ink, paint
• Detergent ,powder• Pollen• Animal fur� Iritan non spesifik
Diagnosis / clinical manifestations
• Atopy history, Allergic salute, Allergic crease, Dennie`s line, Allergic shiner, Allergic face� No one`s phatognomonic
• Clinical manifestatio : > 4-5 yo � by age
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• Paroxysmal sneezing• Rhinorrhea • Nasal obstrucion• Headache / lethargic
• Itching of the nose, palate, pharynx, & ears
• Itching, redness tearing of the eyes (conjunctive erythema)
Diagnosis / clinical manifestations………….
• The nasal mucous membranes are bluish, pale
• Clear mucoid nasal discharge, may become purulent (with secondary infection)
• Mannerisms (due to the itching nose /
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• Mannerisms (due to the itching nose / attempts to improve the airway)
• Mouth breathing• Fever (unusual)
Diagnosis / clinical manifestations…………
• SPT � < 3 yo (?)• In vitrro (ELISA, RAST) � sensitivity (-), expensive
• Total IgE • Eosinofil (nasal secret)
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• Eosinofil (nasal secret)
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Treatment
• General : avoidance of exposure to suspected allergens/ irritants, environment control
• Immunotheraphy (if cannot avoid the inhalant allergens)
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inhalant allergens)• Medicamentosa :
–Antihistamines (AH-1 oral, AH-1 lokal)– Pseudoephedrine (nasal obstruction)
•2-5 years : 15 mg / 6 hour•6-12 years : 30 mg / 6 hour•>12 years : 60 mg / 6 hour
Treatment …….cont- Topical nasal corticosteroid(beclomethasone, budesonide, fluticasone, mometasone) for children with nasal symptoms are resistant to antihistamine-decongestantInitial dosage : 1-2 spray in each nostril
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Initial dosage : 1-2 spray in each nostril (2-3 times) per day. After 3-4 days as symptoms improves, the dose / frequency of use are reduced until a minimal effective dosage is reached.Complications : local burning, irritation & epistaxis
Treatment …….cont
- Kortikosteroid oral /IM- Local chromones : kromoglikat,nedokromil � stabilize mast cell- Intra nasal anticholinergik
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- Intra nasal anticholinergik(ipratropium)- Antileukotrien : montelukast, zafirlukast � blok reseptor
Prognosis
• Depend on age � more severe• The problem in adult � old age
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