W W W . I M E D E X . C O M

3-4 September 2010 Hong Kong, China

2nd Announcement

This Conference is endorsed by:

Chairs:

Tony Mok, MDChinese University of Hong Kong

Hong Kong, China

Giorgio V. Scagliotti, MD, PhDUniversity of Turin Orbassano, Italy

Local Chairs:

KC Lam, MD Prince of Wales Hospital

Hong Kong, China

Yi-Long Wu, MD Guangdong General Hospital

Guangzhou, China

3-4 September 2010 Hong Kong, China

Letter from the Chairs Dear Colleague,

It is our pleasure to invite you to the Fourth Asian Pacific Conference: Perspectives in Lung Cancer. Held 3-4 September 2010 in Hong Kong, China, attendees from all lung cancer-related disciplines will find it to be a stimulating interactive and educational experience!

Created to provide state-of-the-art diagnosis and treatment information, this comprehensive conference focuses on the multimodal management of lung cancer. Guided by expert faculty from Asia, Europe, and North America, this program features interactive case presentations that focus on innovations in diagnosis and staging, and the latest therapies and techniques in the multidisciplinary management of lung cancer.

As lung cancer research and treatment are constantly evolving, there are many issues in disease biology, management, and research that are intensely debated among those involved in these fields. Attendees will not only update their knowledge, but confirm their current practices, focus on the trends and evolutions worth watching, and receive valuable take-home information on exciting new treatments and approaches.

We look forward to welcoming you in Hong Kong, one of the most cosmopolitan, contrasting, and compelling cities in Asia. We know you will find the Fourth Asian Pacific Conference: Perspectives in Lung Cancer to be a world-class educational event.

Sincerely,

Tony Mok, MD, Chair Giorgio V. Scagliotti, MD, PhD, Chair KC Lam, MD, Local Chair Yi-Long Wu, MD, Local Chair

Conference Organizer

4325 Alexander Drive Alpharetta, Georgia 30022-3740, USA Tel: +1 (770) 751 7332 Fax: +1 (770) 751 7334 Email: meetings@imedex.com www.imedex.com

Michael Boyer, MB, BS, PhD Sydney Cancer Center Sydney, Australia

Gouri Shankar Bhattacharyya,MD AMRI Hospitals Dhakuria, Kolkata, India

Allen KC Chan, MD Chinese University of Hong Kong Hong Kong, China

Anthony Chan, MD, FRCP Chinese University of Hong Kong Hong Kong, China

George Chen, MD Chinese University of Hong Kong Hong Kong, China

Ming Chen, MD Sun Yat University Guangzhou, China

Wilfried Eberhardt, MD West German Cancer Center Essen, Germany

Min Fan, MD Fudan University Shanghai, China

Maya Gottfried, MD Meir Medical Center Kfar Saba, Israel

David Harpole, Jr, MD Duke University Durham, North Carolina, United States

Daniel SY Ho, MD The University of Hong Kong Hong Kong, China

Wang Jie, MD Academy of Chinese Medical Sciences Beijing, China

KC Lam, MD Prince of Wales Hospital Hong Kong, China

Zhang Li, MD Sun Yat Sin University Guangzhou, China

Gilberto Lopes, MD Johns Hopkins Singapore International Medical Center Singapore, Malaysia

Brigette Ma, MD Chinese University of Hong Kong Hong Kong, China

Tetsuya Mitsudomi, MD Aichi Cancer Center Hospital Nagoya, Japan

Tony Mok, MD Chinese University of Hong Kong Hong Kong, China

Hiroshi Onishsi, MD University of Yamanashi Nakakoma, Japan

Keunchil Park, MD Samsung Medical Center Seoul, South Korea

Nick Pavlakis, MD Royal Northshore Hospital Sydney, Australia

Giorgio V. Scagliotti, MD, PhD University of Torino Orbassano, Italy

Frances A. Shepherd, MD, FRCPC University Health Network Toronto, Ontario, Canada

Lu Shun, MD, PhD Shanghai Chest Hospital Shanghai, China

Patrick Therasse, MD GlaxoSmithKline Brussels, Belgium

Sumitra Thongprasert, MD Maharach Nakorn Chiang Mai Hospital Chiang Mai, Thailand

KF To, MD Chinese University of Hong Kong Hong Kong, China

WK Tsang, MD The University of Hong Kong Hong Kong, China

Masahiro Tsuboi, MD Tokyo Medical University Tokyo, Japan

Innes Wan, MD Chinese University of Hong Kong Hong Kong, China

Matthew Wong, MD Queen Mary Hospital Hong Kong, China

Yi-Long Wu, MD Guangdong General Hospital Guangzhou, China

James Yang, MD Taiwan National University Taipei, Taiwan

Who Should Attend

This educational activity is intended for medical oncologists, radiation oncologists, thoracic surgeons, pulmonologists, and other physicians in active clinical practice interested and/or involved in the management of patients with lung cancer.

Corporate Support

The following companies are supporters of this conference:

• Evaluate the use of at least two biomarkers to predict the efficacy of EGFR-inhibitors, antiangiogenic therapies, and antineoplastic agents in the treatment of patients with lung cancer

• Describe the epidemiology of lung cancer in Asia and evaluate emerging screening techniques

• Compare and contrast invasive versus non-invasive (MRI, CT, PET) procedures in the staging of lung cancer

• Discuss surgical issues and controversies related to the management and treatment of thoracic malignancies

• Examine the role of radiotherapy and emerging radiotherapeutic techniques in lung cancer

• Translate the results of at least three recent clinical trials in lung cancer and incorporate them into clinical practice

• Describe the role of at least three targeted therapies, specifically epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) inhibitors, in the treatment of thoracic malignancies

• Analyze current lung cancer research techniques and methodology utilized throughout Asia

Objectives

Upon completion of this activity, participants should be able to:

Faculty

Silver Corporate

3-4 September 2010 Hong Kong, China

Scientific Agenda

8:15 Opening remarks

Session I: State-of-the-art in surgery 8:30 The art of radical surgery

David Harpole, Jr, MD

8:55 The art of minimal invasive surgery Masahiro Tsuboi, MD

9:20 EBUS versus mediastinoscopy Innes Wan,MD

Session II: Tobacco and carcinogenesis9:45 Tobacco control in Asia

Daniel SY Ho, MD

10:20 Carcinogenesis of lung cancer: Smoker vs non-smoker George Chen, MD

10:45 Coffee break

Session III: State-of-the-art radiotherapy11:15 Novel radiotherapy technology

Min Fan, MD

11:40 Sterotactic radiotherapy for resectable lung cancer Hiroshi Onishsi, MD

12:05 Sterotactic and respiratory gated radiotherapy: Local experience WK Tsang, MD

12:30 Lunch break

Keynote lecture13:30 Clinical trial on molecular targeting agent:

What is right and what is wrong? ”Made possible by AstraZeneca” Frances A. Shepherd, MD, FRCPC

14:10 Panel discussion and case presentations Min Fan, MD and speaker invited

Session IV: Gene signature and biomarkers14:40 Gene signature for chemotherapy

Giorgio V Scagliotti, MD, PhD

15:15 Metagene or magic gene David Harpole, Jr, MD

15:30 Coffee break

Session V: Stage III disease16:15 Optimal radiotherapy for stage III NSCLC

Ming Chen, MD

16:40 Optimal combined modality for stage III NSCLC Wilfried Eberhardt, MD

17:05 Adjourn

Friday, 3 September 2010

Saturday, 4 September 2010

Session VI: State-of-the-art in chemotherapy 8:30 Novel development in cytotoxic chemotherapy

Speaker invited

8:55 Combination of chemotherapy with molecular target therapy: A good idea that is not so good Tony Mok, MD

9:20 Patient selection for maintenance therapy Keunchil Park, MD

Session VII: Novel targets9:35 MAGE A3

Patrick Therasse, MD

9:50 ELM-4 ALK: Clinical data Tetsuya Mitsudomi, MD

10:05 ELM-4 ALK: Defining a biomarker Yi-Long Wu, MD

10:20 IGF-R Speaker invited

10:45 Irreversible EGFR TKI James Yang, MD

11:00 Vascular disrupting agent and VEGF TKIs Nick Pavlakis, MD

11:15 Coffee break

Session VIII: State-of-the-art diagnosis11:45 Radial EBUS and pleuroscopy for diagnosis

of lung cancer Matthew Wong, MD

12:05 PET-Scan, MRI, or CT scan: Which is a better tool for early/late stage NSCLC? Michael Boyer, MB, BS, PhD

12:25 The challenge of histologic diagnosis in lung cancer: Is adenocarcinoma really an adenocarcinoma? KF To, MD

12:50 Panel discussion and case presentations Maya Gottfried, MD and Linda Leung, MBBS

13:15 Lunch break

Session IX: The unfinished EGFR story14:15 Cost-effectiveness of EGFR TKI

Gilberto Lopes, MD

14:30 Detecting EGFR mutation in plasma: DHPLC Wang Jie, MD

14:45 Detecting EGFR mutation in plasma: Digital PCR Allen Chan, MD

15:00 EGFR TKI resistance Lu Shun, MD, PhD

15:15 Pharmacokinetics of EGFR TKI and treatment out come Zhang Li, MD

15:30 Coffee break

Session X: Research and development15:50 The art and science of phase I study

Brigette Ma, MD

16:10 Getting published in a high impact journal Anthony Chan, MD

16:20 Current status of lung cancer research in Asia Sumitra Thongprasert, MD

Current status of lung cancer research in China Yi-Long Wu, MD

Current status of lung cancer research in Korea Speaker invited

Current status of lung cancer research in India Gouri Shankar Bhattacharyya, MD

17:00 Adjourn

* Please visit www.imedex.com for the most up-to-date agenda and to register.

3-4 September 2010 Hong Kong, China

Hotel Accommodations Hyatt Regency Hong Kong, Sha Tin 18 Chak Cheung Street Sha Tin, New Territories Hong Kong, China Tel: +852 3723 1234 Fax: +852 3723 1235 www.hongkong.shatin.hyatt.com

The Hyatt Regency Hong Kong, Sha Tin, is the first international hotel in the New Territories. The hotel is situated adjacent to the Chinese University of Hong Kong (CUHK), in the Sha Tin district. Conveniently located at University Station, the hotel offers direct access to Tsim Sha Tsui, Hong Kong Island, Lo Wu, and Lok Ma Chau via the Mass Transit Railway (MTR).

The Hyatt Regency Hong Kong, Sha Tin, is only 2 km from Hong Kong Science Park and 30 minutes by taxi from the Hong Kong International Airport. The cost to get from the Hong Kong International Airport to the hotel via taxi is approximately HK$300 (US $40) including tolls, and excluding fee for luggage and traffic.

For the convenience of attendees, a limited number of rooms have been reserved until 2 August 2010 at a discounted rate of HK$1000 single/double occupancy, plus service charge, currently at 10%. The rate includes one breakfast buffet and an additional breakfast buffet is HK$188 + 10% service charge per person. This rate is not guaranteed outside the conference dates or after 2 August 2010.

To reserve your room please contact the Hyatt Regency Hong Kong, Sha Tin reservations department at +852 3723 1234 or visit the hotel’s website at www.hongkong.shatin.hyatt.com. To receive the group rate, callers must identify themselves as being with the Fourth Annual Meeting: Asia Pacific Perspectives in Lung Cancer group. Internet users must enter the meeting promotional code: G-LC30. Reservation requests received after 2 August 2010 may not be guaranteed the group rate.

Check in is after 14:00 and check out is at12:00.

Imedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda’s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualified medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES’ RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS, OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED.

In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual’s own physician.

Neither Imedex nor any of its subsidiaries or affiliates is affiliated with or formally endorsed by a medical society.

© 2010 Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty.

Registration Procedures

To Register: You may register online by 26 August 2010 at www.imedex.com, by calling Imedex at +1 (678) 242 0906 or by returning the registration form in this announcement by mail or fax. If you mail the form, please keep a copy for your records. Registration confirmations will be issued before the meeting.

To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specified.

Group Discounts: Each one of multiple registrants from the same institute or practice will receive a $50 discount off the published registration fees, provided all registration forms and payments are received together. Only one discount will apply per physician. Discounts are not available for nurses, residents, or students.

Payment: To pre-register, registration and payment must be received no later than 26 August 2010. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure the course is being held as scheduled and to confirm that the meeting is not full. Registration fees must be remitted by credit card or check. Checks should be payable to Imedex. Attendee is not registered until full payment is received.

Registration Fee Inclusions: Registration fees include admittance to all scientific sessions, conference materials, processing of certificates of attendance or continuing medical education, and all event functions as specified in the agenda.

Cancellation: For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than 26 August 2010. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after 26 August 2010.

Imedex does not accept responsibility for covering travel, accommodation, or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice.

Registration FeesRegular $299 If payment received by 26 August 2010

Full/Onsite $349 If payment received after 26 August 2010

Group discount (physicians only)*-$50 *cannot be combined with any other discounts

Nurses/Residents/Students*$99 *proof of eligibility must accompany registration *cannot be combined with any other discounts

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3-4 September 2010 Hong Kong, China

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Presentation Dates 3-4 September 2010

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A177.01

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To pre-register, registration and payment must be received no later than 26 August 2010. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure that the meeting is being held as scheduled and to confirm that the meeting is not full.

For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than 26 August 2010. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after 26 August 2010.

Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda content is subject to change without notice.

O Regular ............................................ $299 If payment received by 26 August 2010

O Full/onsite ........................................ $349 If payment received after 26 August 2010

O Group discount (physicians only)* ... -$50 *cannot be combined with any other discounts

O nurses/Residents/Students* ............ $99 *proof of eligibility must accompany registration *cannot be combined with any other discounts

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