2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With...

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diabetes mellitus in the adult population,years, with the highest rate found in the North

, withfoot ulcer in the course of their life. Diabetic foothave high levels of morbidity and mortality and

related to diabetes and the economic cost ofcountries is estimated at $7,000 - $10,000, with4. In2007, the world was estimated to spend at least4

While prevention of the development of a

different options for treatment of a diabeticproper glucose management, off-loading, thetreatment of infection including osteomyelitis,surgical correction of a Charcot foot, vascularreconstruction, proper debridement and otheraspects of wound care.

thereby preventing wound healing. Importantly,

a central and crucial role.8 It is crucial in mostcellular functions associated with wound healing,-9that occurs to kill microorganisms. bactericidal activity of granulocytes depends on

tensile strength of incisional wounds wasconcentrations, with optimal wound healingpressure

vasculature, is a key factor that limits woundhealing.healing process to progress, but the macro- andmicroangiopathy occurring in diabetes maypressure.

Open access publishingThe Journal of Diabetic Foot Complications 2011, Volume 3, Issue 1; No.2, Pages 6-12


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Open access publishingThe Journal of Diabetic Foot Complications 2011; Volume 3, Issue 1, No.2, Pages 6-12

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to-heal diabetic foot ulcers in a Canadian out-patient clinic. Patients with a diabetic foot ulcerthat previously had been treated with standardof care methods, without success with regard towere included in the evaluation.

and when necessary, and including osteomyelitis-ed, off-loading, and local wound management,as well as proper diabetes management.

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directed onto the center of the wound. A smallfoam dressing was placed beneath the cannula

cannula from pitting the skin.

-gical tape and covered with an absorbent dress-dressing and the outside of the dressing wasto the study device and this was then usuallywere evaluated at least on a weekly basis for as-sessment of healing progress.

S

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-glycosaminoglycan production, and collagensynthesissetting, allowing the patient to be ambulatory.

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about two-ounces and can be attached to cloth-ing by a tape or strap, worn on a belt, or stored-

ode of the device is delivered to the wound siteend of the cannula is placed onto the wound site

and covered with an occlusive or compressiondressing. Additional dressings may be used,depending upon wound conditions such as theand/or maceration, and the depth and site of thewound. Dressing changes usually take place

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Open access publishingThe Journal of Diabetic Foot Complications 2011; Volume 3, Issue 1, No.2, Pages 6-12

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Eleven patients with an average ageaverage duration of the ulcers prior to enrollment

2

prior to enrollment in this evaluation, with

application of low intensity laser and hyperbaric

Many patients suffered from seriousco-morbidities, including peripheral vascular

compliance in these two patients was poor withregard to following off-loading guidelines.

R

Plantar surface 21

Heel 2

Distal leg 1 7

Meta-tarsal 2 14

Peripheral vascular disease 2

End stage renal disease 2

27

Edema 1 9

Coronary arterial disease 1 9

Smoking habit 1 9


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Open access publishing

is used in many different ways, including hyper-

-respiratory and relies on systemic perfusion anddays per week. Wound dressings are changedfor certain diabetic foot ulcers, particularly those

However,although cost effective -sivecan severely limit mobility.

disposable or reusable limb chamber connected

therapy, in combination with low level laser

However, as mentioned, both therapiesseverely restrict patient mobility. In addition, the

these types of treatment.

delivery device is small and portable, patients

possibilities to continue regular activities of daily

living, including work.

More important than continued mobility, theresults found in this study indicate the high leveldiabetic foot ulcers with a complete re-epithelial-one patient had an untreated contralateral

treated ulcer healed. When the second ulcer wastwo patients in whom healing was not complete,in spite of the fact that they were non-compliantwith regard to prescribed off-loading.

In addition to the positive healing results, the use

by promoting faster healing and reducing costscompared to both ways of delivering alternativemorbidity may also lead to a reduction of

day per bed. When the costs of medical care,such as nursing time, physician consultation,cost savings are even more substantial.

The Journal of Diabetic Foot Complications 2011; Volume 3, Issue 1, No.2, Pages 6-12


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wound healing. Annales Chirugiae et Gynaecologia. 90

pressure measurements in type I diabetic patients for early

microvascular complications among patients with type 2diabetes in Iran: a systematic review. Diabetes Res Clin Pract

diabetes mellitus. I. Its relation to the early functional changes

epithelial healing in a rabbit ear wound model. Arch Surg

investigating advanced treatment modalities in healing

and low energy laser therapy for chronic diabetic foot

containing ionic silver or calcium alginate dressingsin non-ischaemic diabetic foot ulcers. Diabet Med

controlled trial of autologous platelet-rich plasma gel for the

Comparison of negative pressure wound therapy usingvacuum-assisted closure with advanced moist woundtherapy in the treatment of diabetic foot ulcers: a multicenter

Surrogate end points for the treatment of diabetic neuropathic

neuropathic foot ulcers receiving standard treatment. A

Open access publishingThe Journal of Diabetic Foot Complications 2011, Volume 3, Issue 1, No.2, Pages 6-12

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