23 May 2002 - 2 June 2002
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Transcript of 23 May 2002 - 2 June 2002
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23 May 2002 - 2 June 2002
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24 May 2002 From genes to drugs via crystallography
19 May 1996 Experimental and computational approaches
to structure based drug design
11 June 1989 Three dimensional molecular structure and drug action
01 April 1983X-ray crystallography and drug action
Course 9 Series 1
Course 15 Series 2
Course 24 Series 3
Course 33Series 4
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Function
Sequence Structure
Sequence
Function Structure
Genomic data
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Function
Sequence Structure
Sequence
Function Structure
Genomic data
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Completed sequences of genomes (>60)
find all folds structural biology
functionalgenomics
Diagnosis Treatment Screening
Target identificationSelectivity
Modelling
Fundamental understanding of biology
protein evolution
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Better sourcesNew detectors
Automation :qualityCrystal freezing MAD phasing
Automatic map interpretationSoftware integration
CRYSTALLISATIONScreening Kits
RoboticsImproved Plate designs
Mini incubatorsData tracking Software
ImagingLiquid handling : nL
Automation
base
• Limited proteolysis, MS• Recombinant DNA
technology• Constructs operating in
more than one system• Miniaturisation :
expression & purification
CLONING &
PURIFICATION
Data Collection
Structure solution
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Form to function•Motifs•Alignments•Classification•Mechanisms
Structure Analyses
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Genomics
MolecularBiology
PhysicsBioinformatics
Computational Science
Chemistry
Pharmacology
MathematicsStatistics
Crystallography
NMR
Molecular Modelling
Structural Biology
Biochemistry
EM
Proteomics
Synergy of several disciplines
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Sequence
Function Structure
GenomeGenes
Empirical MethodsPredictive Techniques
Approaches
ProspectsMethods Tools
Achievements
Overviewof the genetics-based drug design process
Sequence
Function Structure
Genomic data
Diagnosis TreatmentScreening
Target identificationSelectivity
Modelling
Drug design
Powers Pitfalls
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SequenceExpressionPrediction
Genes DMPK propertiesCase studies
Drugs
Screening DockingOptimisation
Crystallography
Mass spectroscopyElectron microscopyNMR spectroscopy
Crystallography
Plenary Lectures
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SequenceExpressionPrediction
Genes
DMPK propertiesCase studies
Drugs
Screening DockingOptimisation
Crystallography
Mass spectroscopyElectron microscopyNMR spectroscopy
Crystallography Crystallisation (W1)
Metal ions (W8)
NorthWestern
DOCK(W5)
PDB (W2)
WHATCHECK (W6)
Bioinformatics (W7)CSD (W4)
FlexX (W3)
Workshops
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SequenceExpressionPrediction
Genes
DMPK propertiesCase studies
Drugs
Screening DockingOptimisation
Crystallography
Mass spectroscopyElectron microscopyNMR spectroscopy
Crystallography
Crystallisation (W1)
Metal ions (W8)
NorthWesternDOCK(W5)
PDB (W2)
WHATCHECK (W6)
Bioinformatics (W7)
CSD (W4)
FlexX (W3)
Posters Discussions
Recreation
ProfessionalContacts
Plenary Lectures
Workshops
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A NATO Advanced Research Workshop
Cosmetic and Therapeutic Chemicals
Professor Janus LipkowskiInstitute of Physical ChemistryAcademy of Sciences,Warsaw, Poland
Professor Georges TsoucarisCentre de recherche et de Restauration des Musees de FranceCNRS, Paris France
Directors
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Elsevier
Sponsors