2019 novel coronavirus disease (COVID-19) · 2020-06-12 · What we’ll discuss this morning •...
Transcript of 2019 novel coronavirus disease (COVID-19) · 2020-06-12 · What we’ll discuss this morning •...
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George W. Rutherford, M.D., A.M.Salvatore Pablo Lucia Professor of Epidemiology, Preventive Medicine, Pediatrics and History
Head, Division of Infectious Disease and Global EpidemiologyDepartment of Epidemiology and Biostatistics
School of MedicineInstitute for Global Health Sciences
University of California, San Francisco17 June 2020
2019 novel coronavirus disease (COVID-19)for Advances in Internal Medicine 2020
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What we’ll discuss this morning
• Human coronaviruses in general, SARS, MERS and the novel coronavirus, SARS-CoV-2
• The emergence of SARS-CoV-2 and its associated disease (COVID-19) in Wuhan, China
• Current epidemiology• Some historical and current
perspectives on face coverings
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Human coronaviruses, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and the novel 2019 coronavirus
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Coronaviruses
• Before SARS (2002), coronaviruses were considered relatively inconsequential pathogens that caused common colds
• Four human coronaviruses are endemic globally and cause 10-30% of upper respiratory tract infections in adults (alpha coronaviruses HCoV 2229E, NL 63, OC 43, HKU 1)
• Widely distributed in mammals and birds• Since 2002 we’ve recognized two highly pathogenic strains that
causes severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS)
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SARS and MERS• As opposed to the human coronaviruses that are associated with
upper respiratory tract infections, SARS and MERS are caused by beta coronaviruses
• Primarily cause lower respiratory tract infection (pneumonia)• Relatively high case fatality rates
SARS MERS
Cases 8098 2494
Deaths 774 858
Case fatality rate 9.5% 34.4%
Controlled Yes after reached pandemic No, continued transmission
Other features 58% from nosocomial transmission 70% of cases from nosocomial transmission
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SARS and MERS• Both closely related to bat
strains of coronavirus• Transmitted through other
secondarily infected species• SARS Himalayan palm civets • MERS dromedaries
• SARS originally associated with wet market in Guangzhou
• 26 countries• $10-$30B economic damage
SARS
MERS
SARS-CoV-2
From: Lu R, Li J, N P, et al. Genomic characterisation of and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020 Jan 29 [Epub ahead of print].
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SARS-CoV-2• Spike (S) protein binds to angiotensin-
converting enzyme 2 (ACE2) on the membranes of lung alveolar cells, upper airway epithelial cells and glandular cells of the GI tract
Binding site
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Emergence of SARS-CoV-2 and its associated disease (COVID-19 in Wuhan, China
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Emergence of the 2019 novel coronavirus (SARS-CoV-2)• First case (COVID-19) hospitalized 17 December 2019• Cluster reported on 30 December• Huanan Wholesale Seafood Market closed 1 January• COVID-19 isolated 7 January• COVID-19 sequenced 10 January• Rapid diagnostic tests developed and distributed• Cordon sanitaire implemented in Wuhan and surrounding cities on 23 January –
59 million people quarantined• WHO declared Public Health Emergency of International Concern 30 January• Outbreak grew from a handful of cases exposed at Huanan wholesale seafood
market to more than 2.5 million cases and 180 000 deaths in less than 4 months with ongoing person-to-person transmission primarily via respiratory droplet
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Epizoology of COVID-19
• Genetic sequence close to bat strains of coronavirus
• Suggestion of a secondary host, which acquired COVID-19 from bats and transmitted it to humans at Huanan Wholesale Seafood Market
• Possible candidate is the pangolin, a mammal whose scales used in traditional medicine
• Most illegally trafficked animal in the world
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COVID-19 cases by date of onset and date of report, China 2018-2019*
*Through 1 March 2020
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Transmission dynamics of COVID-19, China• The majority of cases arose from close contacts of symptomatic cases
• 1.5% of close contacts in China developed COVID-19
• Transmission was driven by family clusters (75-85% of infected contacts)• Secondary household attack rates with ~10% early in the outbreak and fell
to 3% with faster isolation• Transmission in closed settings happened but was not a major driver in
China (health facilities, nursing homes, prisons)• Transmission in schools was not been observed in China; this may simply
be because of the closure of schools during most of the outbreak• Did China underreport deaths, especially in the waning days of the
epidemic?
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Modeling unreported cases, Wuhan
• Wang and colleagues modeled the epidemiology of 25,961 laboratory-confirmed cases in Wuhan through 18 February
• Examined four periods: 1-10 January, 11-22 January, 23 January-1 February (first week of lockdown) and 2-18 February
• “Unascertained” = undiagnosed because they were asymptomatic or mildly symptomatic
• Major findings: Re decreased from 3.86 to 0.32 over the four periods
• 59% of cases were unascertained
Wang C, Liu L, Hao X, et al. Evolving epidemiology and impact of non-pharmaceutical interventions on the outbreak of coronavirus disease 2019 in Wuhan, China. medRxiv 2020 Mar 3 [Epub ahead of print].
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Prevalence of SARS-CoV-2 asymptomatic infection
Oran DP, Topol EJ, Prevalence of asymptomatic SARS-CoV-2 infection. A narrative review. Ann Intern Med 2020 [Epub ahead of print].
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Is health-care resource availability associated with COVID-19 mortality?
Ji Y, Ma Z, Peppelenbosch MP, Pan Q. Potential association between COVID-19 mortality and health-care resource availability [Letter]. Lancet Global Health 2020 Feb 25 [E pub ahead of print].
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Worobey M, PikarJ, Larsen B, et al. The emergence of SARS-Co-V-2 in Europe and the US. bioRxiv 2020 May 23.
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COVID-19 cases and deaths, United States, 2020
1,956,499 cases 110,932 deaths
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COVID-19 cases by county, California, 2020
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COVID-19 cases by week.San Francisco County
0 0 0 0 0 832
68
232 228
304285
251
194
341
148
276
191 189
0
50
100
150
200
250
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350
400
27-Jan 3-Feb 10-Feb 17-Feb 24-Feb 2-Mar 9-Mar 16-Mar 23-Mar 30-Mar 6-Apr 13-Apr 20-Apr 27-Apr 4-May 11-May 18-May 25-May 1-Jun
Shelter in place
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2 0 0 0 650
184
490
1069
1622
12701226
1116
9781080
906
1397 1373 1389
0
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27-Jan 3-Feb 10-Feb 17-Feb 24-Feb 2-Mar 9-Mar 16-Mar 23-Mar 30-Mar 6-Apr 13-Apr 20-Apr 27-Apr 4-May 11-May 18-May 25-May 1-Jun
COVID-19 cases by week.Bay Area Counties
Shelter in place
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Infectious disease deaths, United States, 1900-1996
Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA 1999; 281:61-66.
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Two strategic goals
• Limit new cases by decreasing Re, the effective reproductive number• Flatten and prolong the outbreak to (1) assure adequacy of health
care resources and (2) buy time for antivirals and eventually vaccine
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Effective reproductive number (Re)
Courtesy of Dr. Wan Yang, Columbia University
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Effects of pandemic mitigation on health care needs
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Empirical evidence that social distancing works• Two adjacent Italian provinces in
Lombardy region• One (Lodi) began shelter-in-place on
26 February• Other (Bergamo) began shelter-in-
place on 9 March • Empirical evidence that shelter in
place orders can blunt transmission and new disease
https://www.ilsole24ore.com/art/coronavirus-dati-lodi-dimostrano-misure-lockdown-rallentano-contagio-ADo675B
COVID-19 cases by day, Lodi and Bergamo provinces, Italy, February-April, 2020
0
100
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26-F
eb5-
Mar
13-M
ar21
-Mar
29-M
ar6-
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14-A
pr22
-Apr
30-A
pr8-
May
16-M
ay24
-May
1-Ju
n
Lodi
INTERVENTION
26-F
eb5-
Mar
13-M
ar21
-Mar
29-M
ar6-
Apr
14-A
pr22
-Apr
30-A
pr8-
May
16-M
ay24
-May
1-Ju
n
Bergamo
INTERVENTION
Recalculation of prior weeks 419 cases
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Is social distancing working in San Francisco?COVID-19 cases by day, San Francisco and Los Angeles, March-June, 2020
San Francisco
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Los Angeles
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Shelter in place Shelter in place
First COVID-19 deathFirst COVID-19 death
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San Francisco and the 1918-19 influenza epidemic
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Comparative excess mortality per 100 000 by days since 7 September 1918, United States
Bootsma MCJ, Ferguson MN. The effect of public health measures on the 1918 influenza pandemic in U.S. cities. Proc Natl Acad Sci 2007; 104:7488-93.
Predicted excess mortality
Actual excess mortality
PH closures, masks
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Kimberly A. Prather et al. Science 2020;science.abc6197
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• Masks as droplet source control (rather than PPE)• Effectiveness of blocking droplets during speech
when droplets are at low pressure and have not desiccated to smaller sizes (<1µm)
• Surgical masks block coronaviruses of all sizes (Leung, Nat Med 2020)
• Cotton masks block 96% of viral load within 8 inches of mask of COVID-19 patient (Base, Ann Intern Med 2020)
• 0 of 25 passengers and flight attendants near a COVID-19 patient with a mask developed infection on flight from China to Toronto (Schwartz, CMAJ 2020)
• Compliance increased in Mexico City in 2009 when masks became mandatory rather than voluntary (Condon, Health Pol 2010)
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Modeling benefit of universal masking post-shelter-in-place
Kai D, Goldstein G-P, Morgunov A, Nangalia V, Rotkirch A. Universal masking is urgent in the COIVD-19 pandemic: SEIR and agent based models, empirical validation, policy recommendations. arXiv 2020 Apr 22; 2004.13553v1.
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Crowd events and potential for SARS-CoV-2 transmission, Texas and Arizona, Memorial Day, 2020
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Will protests increase transmission of SARS-CoV-2?
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